Q8N2F6 (ARM10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Armadillo repeat-containing protein 10

Alternative name(s):
Splicing variant involved in hepatocarcinogenesis protein

Gene names

Name:	ARMC10
Synonyms:	SVH
ORF Names:	PSEC0198

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. Ref.1 Ref.6
Subunit structure	Interacts with the DNA-binding domain of p53/TP53. Ref.6
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein Ref.1.
Tissue specificity	Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain. Ref.1
Miscellaneous	Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity.
Sequence similarities	Contains 1 ARM repeat.
Sequence caution	The sequence AAS07482.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Growth regulation
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N2F6-1)

Also known as: SVH-A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N2F6-2)

Also known as: SVH-B;

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.

Note: Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.

Isoform 3 (identifier: Q8N2F6-3)

Also known as: SVH-C;

The sequence of this isoform differs from the canonical sequence as follows:
     176-234: Missing.

Isoform 4 (identifier: Q8N2F6-4)

Also known as: SVH-D;

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     176-234: Missing.

Note: Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.

Isoform 5 (identifier: Q8N2F6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     236-259: Missing.

Note: No experimental confirmation available. Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Armadillo repeat-containing protein 10		PRO_0000297707
Regions
	Transmembrane	5 – 27	23	Helical; Potential
	Repeat	138 – 180	43	ARM
Amino acid modifications
	Modified residue	45	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	47 – 81	35	Missing in isoform 2, isoform 4 and isoform 5.		VSP_027361
	Alternative sequence	176 – 234	59	Missing in isoform 3 and isoform 4.		VSP_027362
	Alternative sequence	236 – 259	24	Missing in isoform 5.		VSP_043290
	Natural variant	190	1	P → S. Ref.5 Corresponds to variant rs17849774 [ dbSNP | Ensembl ].		VAR_034681
Experimental info
	Sequence conflict	343	1	I → V in BAF84507. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (SVH-A) [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 8DCA090DF3BBE759	FASTA	343	37,540
	10 20 30 40 50 60 MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAGALE EGTSEGQLCG 70 80 90 100 110 120 RSARPQTGGT WESQWSKTSQ PEDLTDGSYD DVLNAEQLQK LLYLLESTED PVIIERALIT 130 140 150 160 170 180 LGNNAAFSVN QAIIRELGGI PIVANKINHS NQSIKEKALN ALNNLSVNVE NQIKIKIYIS 190 200 210 220 230 240 QVCEDVFSGP LNSAVQLAGL TLLTNMTVTN DHQHMLHSYI TDLFQVLLTG NGNTKVQVLK 250 260 270 280 290 300 LLLNLSENPA MTEGLLRAQV DSSFLSLYDS HVAKEILLRV LTLFQNIKNC LKIEGHLAVQ 310 320 330 340 PTFTEGSLFF LLHGEECAQK IRALVDHHDA EVKEKVVTII PKI
	Isoform 2 (SVH-B) [UniParc]. Checksum: 9F74718D8B96C102	FASTA	308	33,850
	10 20 30 40 50 60 MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAEDLT DGSYDDVLNA 70 80 90 100 110 120 EQLQKLLYLL ESTEDPVIIE RALITLGNNA AFSVNQAIIR ELGGIPIVAN KINHSNQSIK 130 140 150 160 170 180 EKALNALNNL SVNVENQIKI KIYISQVCED VFSGPLNSAV QLAGLTLLTN MTVTNDHQHM 190 200 210 220 230 240 LHSYITDLFQ VLLTGNGNTK VQVLKLLLNL SENPAMTEGL LRAQVDSSFL SLYDSHVAKE 250 260 270 280 290 300 ILLRVLTLFQ NIKNCLKIEG HLAVQPTFTE GSLFFLLHGE ECAQKIRALV DHHDAEVKEK VVTIIPKI
	Isoform 3 (SVH-C) [UniParc]. Checksum: 73BCB20169E74F90	FASTA	284	31,080
	10 20 30 40 50 60 MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAGALE EGTSEGQLCG 70 80 90 100 110 120 RSARPQTGGT WESQWSKTSQ PEDLTDGSYD DVLNAEQLQK LLYLLESTED PVIIERALIT 130 140 150 160 170 180 LGNNAAFSVN QAIIRELGGI PIVANKINHS NQSIKEKALN ALNNLSVNVE NQIKIKVQVL 190 200 210 220 230 240 KLLLNLSENP AMTEGLLRAQ VDSSFLSLYD SHVAKEILLR VLTLFQNIKN CLKIEGHLAV 250 260 270 280 QPTFTEGSLF FLLHGEECAQ KIRALVDHHD AEVKEKVVTI IPKI
	Isoform 4 (SVH-D) [UniParc]. Checksum: D83F237CF42AD097	FASTA	249	27,390
	10 20 30 40 50 60 MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAEDLT DGSYDDVLNA 70 80 90 100 110 120 EQLQKLLYLL ESTEDPVIIE RALITLGNNA AFSVNQAIIR ELGGIPIVAN KINHSNQSIK 130 140 150 160 170 180 EKALNALNNL SVNVENQIKI KVQVLKLLLN LSENPAMTEG LLRAQVDSSF LSLYDSHVAK 190 200 210 220 230 240 EILLRVLTLF QNIKNCLKIE GHLAVQPTFT EGSLFFLLHG EECAQKIRAL VDHHDAEVKE KVVTIIPKI
	Isoform 5 [UniParc]. Checksum: D7C4BCDE0E6E888D	FASTA	284	31,217
	10 20 30 40 50 60 MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAEDLT DGSYDDVLNA 70 80 90 100 110 120 EQLQKLLYLL ESTEDPVIIE RALITLGNNA AFSVNQAIIR ELGGIPIVAN KINHSNQSIK 130 140 150 160 170 180 EKALNALNNL SVNVENQIKI KIYISQVCED VFSGPLNSAV QLAGLTLLTN MTVTNDHQHM 190 200 210 220 230 240 LHSYITDLFQ VLLTGNGNTK VDSSFLSLYD SHVAKEILLR VLTLFQNIKN CLKIEGHLAV 250 260 270 280 QPTFTEGSLF FLLHGEECAQ KIRALVDHHD AEVKEKVVTI IPKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas." Huang R., Xing Z., Luan Z., Wu T., Wu X., Hu G. Cancer Res. 63:3775-3782(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Hepatoma.
[2]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Embryo.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5). Tissue: Mammary gland and Prostate.
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-190. Tissue: Eye.
[6]	"SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53." Zhou X., Yang G., Huang R., Chen X., Hu G. FEBS Lett. 581:4943-4948(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 45-100 (ISOFORM 2), INTERACTION WITH TP53, FUNCTION.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 (ISOFORMS 2; 4 AND 5), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 (ISOFORMS 2; 4 AND 5), MASS SPECTROMETRY. Tissue: Liver.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND THR-50 (ISOFORMS 2; 4 AND 5), MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 (ISOFORMS 2; 4 AND 5), MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY150851 mRNA. Translation: AAN72313.1. AY150852 mRNA. Translation: AAN72314.1. AY150853 mRNA. Translation: AAN72315.1. AY150854 mRNA. Translation: AAN72316.1. AK075500 mRNA. Translation: BAC11655.1. AK291818 mRNA. Translation: BAF84507.1. AK301565 mRNA. Translation: BAG63060.1. AC007683 Genomic DNA. Translation: AAS07531.1. AC073127 Genomic DNA. Translation: AAS07482.1. Sequence problems. AC108167 Genomic DNA. Translation: AAS07456.1. BC003586 mRNA. Translation: AAH03586.1.
IPI	IPI00166394. IPI00217968. IPI00420025. IPI00855858. IPI00926087.
RefSeq	NP_001154481.1. NM_001161009.2. NP_001154482.1. NM_001161010.2. NP_001154483.1. NM_001161011.2. NP_001154484.1. NM_001161012.2. NP_001154485.1. NM_001161013.2. NP_114111.2. NM_031905.4.
UniGene	Hs.287412.
3D structure databases
ProteinModelPortal	Q8N2F6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N2F6. 1 interaction.
PTM databases
PhosphoSite	Q8N2F6.
Polymorphism databases
DMDM	74714720.
Proteomic databases
PaxDb	Q8N2F6.
PRIDE	Q8N2F6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000323716; ENSP00000319412; ENSG00000170632. ENST00000425331; ENSP00000397969; ENSG00000170632. ENST00000428183; ENSP00000396654; ENSG00000170632. ENST00000441711; ENSP00000413619; ENSG00000170632. ENST00000454559; ENSP00000405612; ENSG00000170632.
GeneID	83787.
KEGG	hsa:83787.
UCSC	uc003vaw.2. human. uc003vax.2. human. uc003vay.2. human. uc003vbb.2. human.
Organism-specific databases
CTD	83787.
GeneCards	GC07P102715.
HGNC	HGNC:21706. ARMC10.
HPA	HPA011036. HPA011057.
MIM	611864. gene.
neXtProt	NX_Q8N2F6.
PharmGKB	PA162376895.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG18524.
HOGENOM	HOG000231611.
HOVERGEN	HBG080349.
InParanoid	Q8N2F6.
OMA	ITDLFQV.
OrthoDB	EOG4NKBWH.
PhylomeDB	Q8N2F6.
Gene expression databases
ArrayExpress	Q8N2F6.
Bgee	Q8N2F6.
Genevestigator	Q8N2F6.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR006911. ARM-rpt_dom. IPR016024. ARM-type_fold. [Graphical view]
Pfam	PF04826. Arm_2. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50176. ARM_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ARMC10. human.
GenomeRNAi	83787.
NextBio	72803.
SOURCE	Search...

Entry information

Entry name

ARM10_HUMAN

Accession

Primary (citable) accession number: Q8N2F6
Secondary accession number(s): A8K703 , B4DWJ8, Q75K91, Q75MG6, Q75ML8, Q8IZC1, Q8IZC2, Q8IZC3, Q9BTM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.