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Q8N2F6 (ARM10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Armadillo repeat-containing protein 10
Alternative name(s):
Splicing variant involved in hepatocarcinogenesis protein
Gene names
Name:ARMC10
Synonyms:SVH
ORF Names:PSEC0198
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. Ref.1 Ref.6

Subunit structure

Interacts with the DNA-binding domain of p53/TP53. Ref.6

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein Ref.1.

Tissue specificity

Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain. Ref.1

Miscellaneous

Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity.

Sequence similarities

Contains 1 ARM repeat.

Sequence caution

The sequence AAS07482.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N2F6-1)

Also known as: SVH-A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N2F6-2)

Also known as: SVH-B;

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
Note: Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.
Isoform 3 (identifier: Q8N2F6-3)

Also known as: SVH-C;

The sequence of this isoform differs from the canonical sequence as follows:
     176-234: Missing.
Isoform 4 (identifier: Q8N2F6-4)

Also known as: SVH-D;

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     176-234: Missing.
Note: Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.
Isoform 5 (identifier: Q8N2F6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     236-259: Missing.
Note: No experimental confirmation available. Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.
Isoform 6 (identifier: Q8N2F6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     177-259: Missing.
Note: Gene prediction based on EST data. Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Armadillo repeat-containing protein 10
PRO_0000297707

Regions

Transmembrane5 – 2723Helical; Potential
Repeat138 – 18043ARM

Amino acid modifications

Modified residue451Phosphoserine By similarity

Natural variations

Alternative sequence47 – 8135Missing in isoform 2, isoform 4, isoform 5 and isoform 6.
VSP_027361
Alternative sequence176 – 23459Missing in isoform 3 and isoform 4.
VSP_027362
Alternative sequence177 – 25983Missing in isoform 6.
VSP_047404
Alternative sequence236 – 25924Missing in isoform 5.
VSP_043290
Natural variant1901P → S. Ref.5
Corresponds to variant rs17849774 [ dbSNP | Ensembl ].
VAR_034681

Experimental info

Sequence conflict3431I → V in BAF84507. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (SVH-A) [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 8DCA090DF3BBE759

FASTA34337,540
        10         20         30         40         50         60 
MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAGALE EGTSEGQLCG 

        70         80         90        100        110        120 
RSARPQTGGT WESQWSKTSQ PEDLTDGSYD DVLNAEQLQK LLYLLESTED PVIIERALIT 

       130        140        150        160        170        180 
LGNNAAFSVN QAIIRELGGI PIVANKINHS NQSIKEKALN ALNNLSVNVE NQIKIKIYIS 

       190        200        210        220        230        240 
QVCEDVFSGP LNSAVQLAGL TLLTNMTVTN DHQHMLHSYI TDLFQVLLTG NGNTKVQVLK 

       250        260        270        280        290        300 
LLLNLSENPA MTEGLLRAQV DSSFLSLYDS HVAKEILLRV LTLFQNIKNC LKIEGHLAVQ 

       310        320        330        340 
PTFTEGSLFF LLHGEECAQK IRALVDHHDA EVKEKVVTII PKI 

« Hide

Isoform 2 (SVH-B) [UniParc].

Checksum: 9F74718D8B96C102
Show »

FASTA30833,850
Isoform 3 (SVH-C) [UniParc].

Checksum: 73BCB20169E74F90
Show »

FASTA28431,080
Isoform 4 (SVH-D) [UniParc].

Checksum: D83F237CF42AD097
Show »

FASTA24927,390
Isoform 5 [UniParc].

Checksum: D7C4BCDE0E6E888D
Show »

FASTA28431,217
Isoform 6 [UniParc].

Checksum: 73CD707988B2FE82
Show »

FASTA22524,757

References

« Hide 'large scale' references
[1]"A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas."
Huang R., Xing Z., Luan Z., Wu T., Wu X., Hu G.
Cancer Res. 63:3775-3782(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Hepatoma.
[2]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Embryo.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
Tissue: Mammary gland and Prostate.
[4]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-190.
Tissue: Eye.
[6]"SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53."
Zhou X., Yang G., Huang R., Chen X., Hu G.
FEBS Lett. 581:4943-4948(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 45-100 (ISOFORM 2), INTERACTION WITH TP53, FUNCTION.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 (ISOFORMS 2; 4; 5 AND 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 (ISOFORMS 2; 4; 5 AND 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[9]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND THR-50 (ISOFORMS 2; 4; 5 AND 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[10]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 (ISOFORMS 2; 4; 5 AND 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY150851 mRNA. Translation: AAN72313.1.
AY150852 mRNA. Translation: AAN72314.1.
AY150853 mRNA. Translation: AAN72315.1.
AY150854 mRNA. Translation: AAN72316.1.
AK075500 mRNA. Translation: BAC11655.1.
AK291818 mRNA. Translation: BAF84507.1.
AK301565 mRNA. Translation: BAG63060.1.
AC007683 Genomic DNA. Translation: AAS07531.1.
AC073127 Genomic DNA. Translation: AAS07482.1. Sequence problems.
AC108167 Genomic DNA. Translation: AAS07456.1.
BC003586 mRNA. Translation: AAH03586.1.
RefSeqNP_001154481.1. NM_001161009.2.
NP_001154482.1. NM_001161010.2.
NP_001154483.1. NM_001161011.2.
NP_001154484.1. NM_001161012.2.
NP_001154485.1. NM_001161013.2.
NP_114111.2. NM_031905.4.
UniGeneHs.287412.

3D structure databases

ProteinModelPortalQ8N2F6.
SMRQ8N2F6. Positions 98-166.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123762. 2 interactions.
IntActQ8N2F6. 1 interaction.

PTM databases

PhosphoSiteQ8N2F6.

Polymorphism databases

DMDM74714720.

Proteomic databases

PaxDbQ8N2F6.
PRIDEQ8N2F6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000323716; ENSP00000319412; ENSG00000170632. [Q8N2F6-1]
ENST00000425331; ENSP00000397969; ENSG00000170632. [Q8N2F6-5]
ENST00000428183; ENSP00000396654; ENSG00000170632. [Q8N2F6-3]
ENST00000441711; ENSP00000413619; ENSG00000170632. [Q8N2F6-2]
ENST00000454559; ENSP00000405612; ENSG00000170632. [Q8N2F6-4]
ENST00000541300; ENSP00000440463; ENSG00000170632. [Q8N2F6-6]
GeneID83787.
KEGGhsa:83787.
UCSCuc003vaw.2. human. [Q8N2F6-1]
uc003vax.2. human. [Q8N2F6-2]
uc003vay.2. human. [Q8N2F6-3]
uc003vbb.2. human. [Q8N2F6-4]
uc011kli.2. human. [Q8N2F6-5]

Organism-specific databases

CTD83787.
GeneCardsGC07P102715.
HGNCHGNC:21706. ARMC10.
HPAHPA011036.
HPA011057.
MIM611864. gene.
neXtProtNX_Q8N2F6.
PharmGKBPA162376895.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG18524.
HOGENOMHOG000231611.
HOVERGENHBG080349.
InParanoidQ8N2F6.
OMACLKIEGH.
OrthoDBEOG70PBZ0.
PhylomeDBQ8N2F6.
TreeFamTF335652.

Gene expression databases

ArrayExpressQ8N2F6.
BgeeQ8N2F6.
GenevestigatorQ8N2F6.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Other

ChiTaRSARMC10. human.
GenomeRNAi83787.
NextBio72803.
PROQ8N2F6.
SOURCESearch...

Entry information

Entry nameARM10_HUMAN
AccessionPrimary (citable) accession number: Q8N2F6
Secondary accession number(s): A8K703 expand/collapse secondary AC list , B4DWJ8, F5GX65, Q75K91, Q75MG6, Q75ML8, Q8IZC1, Q8IZC2, Q8IZC3, Q9BTM6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 1, 2002
Last modified: March 19, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM