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Q8N2F6

- ARM10_HUMAN

UniProt

Q8N2F6 - ARM10_HUMAN

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Protein
Armadillo repeat-containing protein 10
Gene
ARMC10, SVH, PSEC0198
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.2 Publications

GO - Biological processi

  1. regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 10
Alternative name(s):
Splicing variant involved in hepatocarcinogenesis protein
Gene namesi
Name:ARMC10
Synonyms:SVH
ORF Names:PSEC0198
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21706. ARMC10.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2723Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376895.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Armadillo repeat-containing protein 10
PRO_0000297707Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N2F6.
PaxDbiQ8N2F6.
PRIDEiQ8N2F6.

PTM databases

PhosphoSiteiQ8N2F6.

Expressioni

Tissue specificityi

Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain.1 Publication

Gene expression databases

ArrayExpressiQ8N2F6.
BgeeiQ8N2F6.
GenevestigatoriQ8N2F6.

Organism-specific databases

HPAiHPA011036.
HPA011057.

Interactioni

Subunit structurei

Interacts with the DNA-binding domain of p53/TP53.1 Publication

Protein-protein interaction databases

BioGridi123762. 2 interactions.
IntActiQ8N2F6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8N2F6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati138 – 18043ARM
Add
BLAST

Sequence similaritiesi

Contains 1 ARM repeat.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG18524.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiQ8N2F6.
OMAiCLKIEGH.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ8N2F6.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N2F6-1) [UniParc]FASTAAdd to Basket

Also known as: SVH-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAGALE    50
EGTSEGQLCG RSARPQTGGT WESQWSKTSQ PEDLTDGSYD DVLNAEQLQK 100
LLYLLESTED PVIIERALIT LGNNAAFSVN QAIIRELGGI PIVANKINHS 150
NQSIKEKALN ALNNLSVNVE NQIKIKIYIS QVCEDVFSGP LNSAVQLAGL 200
TLLTNMTVTN DHQHMLHSYI TDLFQVLLTG NGNTKVQVLK LLLNLSENPA 250
MTEGLLRAQV DSSFLSLYDS HVAKEILLRV LTLFQNIKNC LKIEGHLAVQ 300
PTFTEGSLFF LLHGEECAQK IRALVDHHDA EVKEKVVTII PKI 343
Length:343
Mass (Da):37,540
Last modified:October 1, 2002 - v1
Checksum:i8DCA090DF3BBE759
GO
Isoform 2 (identifier: Q8N2F6-2) [UniParc]FASTAAdd to Basket

Also known as: SVH-B

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.

Note: Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.

Show »
Length:308
Mass (Da):33,850
Checksum:i9F74718D8B96C102
GO
Isoform 3 (identifier: Q8N2F6-3) [UniParc]FASTAAdd to Basket

Also known as: SVH-C

The sequence of this isoform differs from the canonical sequence as follows:
     176-234: Missing.

Show »
Length:284
Mass (Da):31,080
Checksum:i73BCB20169E74F90
GO
Isoform 4 (identifier: Q8N2F6-4) [UniParc]FASTAAdd to Basket

Also known as: SVH-D

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     176-234: Missing.

Note: Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.

Show »
Length:249
Mass (Da):27,390
Checksum:iD83F237CF42AD097
GO
Isoform 5 (identifier: Q8N2F6-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     236-259: Missing.

Note: No experimental confirmation available. Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.

Show »
Length:284
Mass (Da):31,217
Checksum:iD7C4BCDE0E6E888D
GO
Isoform 6 (identifier: Q8N2F6-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     177-259: Missing.

Note: Gene prediction based on EST data. Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50.

Show »
Length:225
Mass (Da):24,757
Checksum:i73CD707988B2FE82
GO

Sequence cautioni

The sequence AAS07482.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti190 – 1901P → S.1 Publication
Corresponds to variant rs17849774 [ dbSNP | Ensembl ].
VAR_034681

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei47 – 8135Missing in isoform 2, isoform 4, isoform 5 and isoform 6.
VSP_027361Add
BLAST
Alternative sequencei176 – 23459Missing in isoform 3 and isoform 4.
VSP_027362Add
BLAST
Alternative sequencei177 – 25983Missing in isoform 6.
VSP_047404Add
BLAST
Alternative sequencei236 – 25924Missing in isoform 5.
VSP_043290Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti343 – 3431I → V in BAF84507. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY150851 mRNA. Translation: AAN72313.1.
AY150852 mRNA. Translation: AAN72314.1.
AY150853 mRNA. Translation: AAN72315.1.
AY150854 mRNA. Translation: AAN72316.1.
AK075500 mRNA. Translation: BAC11655.1.
AK291818 mRNA. Translation: BAF84507.1.
AK301565 mRNA. Translation: BAG63060.1.
AC007683 Genomic DNA. Translation: AAS07531.1.
AC073127 Genomic DNA. Translation: AAS07482.1. Sequence problems.
AC108167 Genomic DNA. Translation: AAS07456.1.
BC003586 mRNA. Translation: AAH03586.1.
CCDSiCCDS55145.1. [Q8N2F6-3]
CCDS55146.1. [Q8N2F6-2]
CCDS55147.1. [Q8N2F6-5]
CCDS55148.1. [Q8N2F6-4]
CCDS55149.1. [Q8N2F6-6]
CCDS5728.1. [Q8N2F6-1]
RefSeqiNP_001154481.1. NM_001161009.2. [Q8N2F6-2]
NP_001154482.1. NM_001161010.2. [Q8N2F6-3]
NP_001154483.1. NM_001161011.2. [Q8N2F6-5]
NP_001154484.1. NM_001161012.2. [Q8N2F6-4]
NP_001154485.1. NM_001161013.2. [Q8N2F6-6]
NP_114111.2. NM_031905.4. [Q8N2F6-1]
UniGeneiHs.287412.

Genome annotation databases

EnsembliENST00000323716; ENSP00000319412; ENSG00000170632. [Q8N2F6-1]
ENST00000425331; ENSP00000397969; ENSG00000170632. [Q8N2F6-5]
ENST00000428183; ENSP00000396654; ENSG00000170632. [Q8N2F6-3]
ENST00000441711; ENSP00000413619; ENSG00000170632. [Q8N2F6-2]
ENST00000454559; ENSP00000405612; ENSG00000170632. [Q8N2F6-4]
ENST00000541300; ENSP00000440463; ENSG00000170632. [Q8N2F6-6]
GeneIDi83787.
KEGGihsa:83787.
UCSCiuc003vaw.2. human. [Q8N2F6-1]
uc003vax.2. human. [Q8N2F6-2]
uc003vay.2. human. [Q8N2F6-3]
uc003vbb.2. human. [Q8N2F6-4]
uc011kli.2. human. [Q8N2F6-5]

Polymorphism databases

DMDMi74714720.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY150851 mRNA. Translation: AAN72313.1 .
AY150852 mRNA. Translation: AAN72314.1 .
AY150853 mRNA. Translation: AAN72315.1 .
AY150854 mRNA. Translation: AAN72316.1 .
AK075500 mRNA. Translation: BAC11655.1 .
AK291818 mRNA. Translation: BAF84507.1 .
AK301565 mRNA. Translation: BAG63060.1 .
AC007683 Genomic DNA. Translation: AAS07531.1 .
AC073127 Genomic DNA. Translation: AAS07482.1 . Sequence problems.
AC108167 Genomic DNA. Translation: AAS07456.1 .
BC003586 mRNA. Translation: AAH03586.1 .
CCDSi CCDS55145.1. [Q8N2F6-3 ]
CCDS55146.1. [Q8N2F6-2 ]
CCDS55147.1. [Q8N2F6-5 ]
CCDS55148.1. [Q8N2F6-4 ]
CCDS55149.1. [Q8N2F6-6 ]
CCDS5728.1. [Q8N2F6-1 ]
RefSeqi NP_001154481.1. NM_001161009.2. [Q8N2F6-2 ]
NP_001154482.1. NM_001161010.2. [Q8N2F6-3 ]
NP_001154483.1. NM_001161011.2. [Q8N2F6-5 ]
NP_001154484.1. NM_001161012.2. [Q8N2F6-4 ]
NP_001154485.1. NM_001161013.2. [Q8N2F6-6 ]
NP_114111.2. NM_031905.4. [Q8N2F6-1 ]
UniGenei Hs.287412.

3D structure databases

ProteinModelPortali Q8N2F6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123762. 2 interactions.
IntActi Q8N2F6. 1 interaction.

PTM databases

PhosphoSitei Q8N2F6.

Polymorphism databases

DMDMi 74714720.

Proteomic databases

MaxQBi Q8N2F6.
PaxDbi Q8N2F6.
PRIDEi Q8N2F6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323716 ; ENSP00000319412 ; ENSG00000170632 . [Q8N2F6-1 ]
ENST00000425331 ; ENSP00000397969 ; ENSG00000170632 . [Q8N2F6-5 ]
ENST00000428183 ; ENSP00000396654 ; ENSG00000170632 . [Q8N2F6-3 ]
ENST00000441711 ; ENSP00000413619 ; ENSG00000170632 . [Q8N2F6-2 ]
ENST00000454559 ; ENSP00000405612 ; ENSG00000170632 . [Q8N2F6-4 ]
ENST00000541300 ; ENSP00000440463 ; ENSG00000170632 . [Q8N2F6-6 ]
GeneIDi 83787.
KEGGi hsa:83787.
UCSCi uc003vaw.2. human. [Q8N2F6-1 ]
uc003vax.2. human. [Q8N2F6-2 ]
uc003vay.2. human. [Q8N2F6-3 ]
uc003vbb.2. human. [Q8N2F6-4 ]
uc011kli.2. human. [Q8N2F6-5 ]

Organism-specific databases

CTDi 83787.
GeneCardsi GC07P102715.
HGNCi HGNC:21706. ARMC10.
HPAi HPA011036.
HPA011057.
MIMi 611864. gene.
neXtProti NX_Q8N2F6.
PharmGKBi PA162376895.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG18524.
HOGENOMi HOG000231611.
HOVERGENi HBG080349.
InParanoidi Q8N2F6.
OMAi CLKIEGH.
OrthoDBi EOG70PBZ0.
PhylomeDBi Q8N2F6.
TreeFami TF335652.

Miscellaneous databases

ChiTaRSi ARMC10. human.
GenomeRNAii 83787.
NextBioi 72803.
PROi Q8N2F6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8N2F6.
Bgeei Q8N2F6.
Genevestigatori Q8N2F6.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view ]
Pfami PF04826. Arm_2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas."
    Huang R., Xing Z., Luan Z., Wu T., Wu X., Hu G.
    Cancer Res. 63:3775-3782(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Hepatoma.
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
    Tissue: Mammary gland and Prostate.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-190.
    Tissue: Eye.
  6. "SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53."
    Zhou X., Yang G., Huang R., Chen X., Hu G.
    FEBS Lett. 581:4943-4948(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 45-100 (ISOFORM 2), INTERACTION WITH TP53, FUNCTION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 (ISOFORMS 2; 4; 5 AND 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 (ISOFORMS 2; 4; 5 AND 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND THR-50 (ISOFORMS 2; 4; 5 AND 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 (ISOFORMS 2; 4; 5 AND 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARM10_HUMAN
AccessioniPrimary (citable) accession number: Q8N2F6
Secondary accession number(s): A8K703
, B4DWJ8, F5GX65, Q75K91, Q75MG6, Q75ML8, Q8IZC1, Q8IZC2, Q8IZC3, Q9BTM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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