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Protein

Armadillo repeat-containing protein 10

Gene

ARMC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.2 Publications

Miscellaneous

Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity.

GO - Biological processi

Keywordsi

Biological processGrowth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 10
Alternative name(s):
Splicing variant involved in hepatocarcinogenesis protein
Gene namesi
Name:ARMC10
Synonyms:SVH
ORF Names:PSEC0198
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21706. ARMC10.

Subcellular locationi

  • Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 27HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83787.
OpenTargetsiENSG00000170632.
PharmGKBiPA162376895.

Polymorphism and mutation databases

BioMutaiARMC10.
DMDMi74714720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002977071 – 343Armadillo repeat-containing protein 10Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineCombined sources1
Modified residuei85PhosphothreonineBy similarity1
Isoform 2 (identifier: Q8N2F6-2)
Modified residuei45PhosphoserineCombined sources1
Modified residuei50PhosphothreonineCombined sources1
Isoform 4 (identifier: Q8N2F6-4)
Modified residuei45PhosphoserineCombined sources1
Modified residuei50PhosphothreonineCombined sources1
Isoform 5 (identifier: Q8N2F6-5)
Modified residuei45PhosphoserineCombined sources1
Modified residuei50PhosphothreonineCombined sources1
Isoform 6 (identifier: Q8N2F6-6)
Modified residuei45PhosphoserineCombined sources1
Modified residuei50PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N2F6.
MaxQBiQ8N2F6.
PaxDbiQ8N2F6.
PeptideAtlasiQ8N2F6.
PRIDEiQ8N2F6.

PTM databases

iPTMnetiQ8N2F6.
PhosphoSitePlusiQ8N2F6.

Expressioni

Tissue specificityi

Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain.1 Publication

Gene expression databases

BgeeiENSG00000170632.
ExpressionAtlasiQ8N2F6. baseline and differential.
GenevisibleiQ8N2F6. HS.

Organism-specific databases

HPAiHPA011036.
HPA011057.

Interactioni

Subunit structurei

Interacts with the DNA-binding domain of p53/TP53.1 Publication

Protein-protein interaction databases

BioGridi123762. 2 interactors.
IntActiQ8N2F6. 2 interactors.
STRINGi9606.ENSP00000319412.

Structurei

3D structure databases

ProteinModelPortaliQ8N2F6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati138 – 180ARMAdd BLAST43

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVCU. Eukaryota.
ENOG4112958. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiQ8N2F6.
OMAiCLKIEGH.
OrthoDBiEOG091G0PCU.
PhylomeDBiQ8N2F6.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
PfamiView protein in Pfam
PF04826. Arm_2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N2F6-1) [UniParc]FASTAAdd to basket
Also known as: SVH-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAGALE
60 70 80 90 100
EGTSEGQLCG RSARPQTGGT WESQWSKTSQ PEDLTDGSYD DVLNAEQLQK
110 120 130 140 150
LLYLLESTED PVIIERALIT LGNNAAFSVN QAIIRELGGI PIVANKINHS
160 170 180 190 200
NQSIKEKALN ALNNLSVNVE NQIKIKIYIS QVCEDVFSGP LNSAVQLAGL
210 220 230 240 250
TLLTNMTVTN DHQHMLHSYI TDLFQVLLTG NGNTKVQVLK LLLNLSENPA
260 270 280 290 300
MTEGLLRAQV DSSFLSLYDS HVAKEILLRV LTLFQNIKNC LKIEGHLAVQ
310 320 330 340
PTFTEGSLFF LLHGEECAQK IRALVDHHDA EVKEKVVTII PKI
Length:343
Mass (Da):37,540
Last modified:October 1, 2002 - v1
Checksum:i8DCA090DF3BBE759
GO
Isoform 2 (identifier: Q8N2F6-2) [UniParc]FASTAAdd to basket
Also known as: SVH-B

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.

Show »
Length:308
Mass (Da):33,850
Checksum:i9F74718D8B96C102
GO
Isoform 3 (identifier: Q8N2F6-3) [UniParc]FASTAAdd to basket
Also known as: SVH-C

The sequence of this isoform differs from the canonical sequence as follows:
     176-234: Missing.

Show »
Length:284
Mass (Da):31,080
Checksum:i73BCB20169E74F90
GO
Isoform 4 (identifier: Q8N2F6-4) [UniParc]FASTAAdd to basket
Also known as: SVH-D

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     176-234: Missing.

Show »
Length:249
Mass (Da):27,390
Checksum:iD83F237CF42AD097
GO
Isoform 5 (identifier: Q8N2F6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     236-259: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:284
Mass (Da):31,217
Checksum:iD7C4BCDE0E6E888D
GO
Isoform 6 (identifier: Q8N2F6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     177-259: Missing.

Note: Gene prediction based on EST data.Combined sources
Show »
Length:225
Mass (Da):24,757
Checksum:i73CD707988B2FE82
GO

Sequence cautioni

The sequence AAS07482 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti343I → V in BAF84507 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034681190P → S1 PublicationCorresponds to variant dbSNP:rs17849774Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02736147 – 81Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST35
Alternative sequenceiVSP_027362176 – 234Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_047404177 – 259Missing in isoform 6. CuratedAdd BLAST83
Alternative sequenceiVSP_043290236 – 259Missing in isoform 5. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150851 mRNA. Translation: AAN72313.1.
AY150852 mRNA. Translation: AAN72314.1.
AY150853 mRNA. Translation: AAN72315.1.
AY150854 mRNA. Translation: AAN72316.1.
AK075500 mRNA. Translation: BAC11655.1.
AK291818 mRNA. Translation: BAF84507.1.
AK301565 mRNA. Translation: BAG63060.1.
AC007683 Genomic DNA. Translation: AAS07531.1.
AC073127 Genomic DNA. Translation: AAS07482.1. Sequence problems.
AC108167 Genomic DNA. Translation: AAS07456.1.
BC003586 mRNA. Translation: AAH03586.1.
CCDSiCCDS55145.1. [Q8N2F6-3]
CCDS55146.1. [Q8N2F6-2]
CCDS55147.1. [Q8N2F6-5]
CCDS55148.1. [Q8N2F6-4]
CCDS55149.1. [Q8N2F6-6]
CCDS5728.1. [Q8N2F6-1]
RefSeqiNP_001154481.1. NM_001161009.2. [Q8N2F6-2]
NP_001154482.1. NM_001161010.2. [Q8N2F6-3]
NP_001154483.1. NM_001161011.2. [Q8N2F6-5]
NP_001154484.1. NM_001161012.2. [Q8N2F6-4]
NP_001154485.1. NM_001161013.2. [Q8N2F6-6]
NP_114111.2. NM_031905.4. [Q8N2F6-1]
UniGeneiHs.287412.

Genome annotation databases

EnsembliENST00000323716; ENSP00000319412; ENSG00000170632. [Q8N2F6-1]
ENST00000425331; ENSP00000397969; ENSG00000170632. [Q8N2F6-5]
ENST00000428183; ENSP00000396654; ENSG00000170632. [Q8N2F6-3]
ENST00000441711; ENSP00000413619; ENSG00000170632. [Q8N2F6-2]
ENST00000454559; ENSP00000405612; ENSG00000170632. [Q8N2F6-4]
ENST00000541300; ENSP00000440463; ENSG00000170632. [Q8N2F6-6]
GeneIDi83787.
KEGGihsa:83787.
UCSCiuc003vaw.3. human. [Q8N2F6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150851 mRNA. Translation: AAN72313.1.
AY150852 mRNA. Translation: AAN72314.1.
AY150853 mRNA. Translation: AAN72315.1.
AY150854 mRNA. Translation: AAN72316.1.
AK075500 mRNA. Translation: BAC11655.1.
AK291818 mRNA. Translation: BAF84507.1.
AK301565 mRNA. Translation: BAG63060.1.
AC007683 Genomic DNA. Translation: AAS07531.1.
AC073127 Genomic DNA. Translation: AAS07482.1. Sequence problems.
AC108167 Genomic DNA. Translation: AAS07456.1.
BC003586 mRNA. Translation: AAH03586.1.
CCDSiCCDS55145.1. [Q8N2F6-3]
CCDS55146.1. [Q8N2F6-2]
CCDS55147.1. [Q8N2F6-5]
CCDS55148.1. [Q8N2F6-4]
CCDS55149.1. [Q8N2F6-6]
CCDS5728.1. [Q8N2F6-1]
RefSeqiNP_001154481.1. NM_001161009.2. [Q8N2F6-2]
NP_001154482.1. NM_001161010.2. [Q8N2F6-3]
NP_001154483.1. NM_001161011.2. [Q8N2F6-5]
NP_001154484.1. NM_001161012.2. [Q8N2F6-4]
NP_001154485.1. NM_001161013.2. [Q8N2F6-6]
NP_114111.2. NM_031905.4. [Q8N2F6-1]
UniGeneiHs.287412.

3D structure databases

ProteinModelPortaliQ8N2F6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123762. 2 interactors.
IntActiQ8N2F6. 2 interactors.
STRINGi9606.ENSP00000319412.

PTM databases

iPTMnetiQ8N2F6.
PhosphoSitePlusiQ8N2F6.

Polymorphism and mutation databases

BioMutaiARMC10.
DMDMi74714720.

Proteomic databases

EPDiQ8N2F6.
MaxQBiQ8N2F6.
PaxDbiQ8N2F6.
PeptideAtlasiQ8N2F6.
PRIDEiQ8N2F6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323716; ENSP00000319412; ENSG00000170632. [Q8N2F6-1]
ENST00000425331; ENSP00000397969; ENSG00000170632. [Q8N2F6-5]
ENST00000428183; ENSP00000396654; ENSG00000170632. [Q8N2F6-3]
ENST00000441711; ENSP00000413619; ENSG00000170632. [Q8N2F6-2]
ENST00000454559; ENSP00000405612; ENSG00000170632. [Q8N2F6-4]
ENST00000541300; ENSP00000440463; ENSG00000170632. [Q8N2F6-6]
GeneIDi83787.
KEGGihsa:83787.
UCSCiuc003vaw.3. human. [Q8N2F6-1]

Organism-specific databases

CTDi83787.
DisGeNETi83787.
GeneCardsiARMC10.
HGNCiHGNC:21706. ARMC10.
HPAiHPA011036.
HPA011057.
MIMi611864. gene.
neXtProtiNX_Q8N2F6.
OpenTargetsiENSG00000170632.
PharmGKBiPA162376895.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVCU. Eukaryota.
ENOG4112958. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiQ8N2F6.
OMAiCLKIEGH.
OrthoDBiEOG091G0PCU.
PhylomeDBiQ8N2F6.
TreeFamiTF335652.

Miscellaneous databases

ChiTaRSiARMC10. human.
GenomeRNAii83787.
PROiPR:Q8N2F6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170632.
ExpressionAtlasiQ8N2F6. baseline and differential.
GenevisibleiQ8N2F6. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
PfamiView protein in Pfam
PF04826. Arm_2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARM10_HUMAN
AccessioniPrimary (citable) accession number: Q8N2F6
Secondary accession number(s): A8K703
, B4DWJ8, F5GX65, Q75K91, Q75MG6, Q75ML8, Q8IZC1, Q8IZC2, Q8IZC3, Q9BTM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 1, 2002
Last modified: March 15, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.