Reviewed, UniProtKB/Swiss-Prot Q8N2F6 (ARM10_HUMAN)

Names and origin

Protein names

Recommended name:
    Armadillo repeat-containing protein 10
Alternative name(s):
    Splicing variant involved in hepatocarcinogenesis protein

Gene names

Name:	ARMC10
Synonyms:	SVH
ORF Names:	PSEC0198

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. Ref.1 Ref.6
Subunit structure	Interacts with the DNA-binding domain of p53/TP53. Ref.6
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein.
Tissue specificity	Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain. Ref.1
Miscellaneous	Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity.
Sequence similarities	Contains 1 ARM repeat.
Sequence caution	The sequence AAS07482.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Growth regulation
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N2F6-1)

Also known as: SVH-A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N2F6-2)

Also known as: SVH-B;

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.

Isoform 3 (identifier: Q8N2F6-3)

Also known as: SVH-C;

The sequence of this isoform differs from the canonical sequence as follows:
     176-234: Missing.

Isoform 4 (identifier: Q8N2F6-4)

Also known as: SVH-D;

The sequence of this isoform differs from the canonical sequence as follows:
     47-81: Missing.
     176-234: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Armadillo repeat-containing protein 10		PRO_0000297707
Regions
	Transmembrane	5 – 27	23	Potential
	Repeat	138 – 180	43	ARM
Amino acid modifications
	Modified residue	45	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	47 – 81	35	Missing in isoform 2 and isoform 4.		VSP_027361
	Alternative sequence	176 – 234	59	Missing in isoform 3 and isoform 4.		VSP_027362
	Natural variant	190	1	P → S: dbSNP rs17849774. Ref.5		VAR_034681
Experimental info
	Sequence conflict	343	1	I → V in BAF84507. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (SVH-A) [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 8DCA090DF3BBE759	FASTA	343	37,540
	10 20 30 40 50 60 MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAGALE EGTSEGQLCG 70 80 90 100 110 120 RSARPQTGGT WESQWSKTSQ PEDLTDGSYD DVLNAEQLQK LLYLLESTED PVIIERALIT 130 140 150 160 170 180 LGNNAAFSVN QAIIRELGGI PIVANKINHS NQSIKEKALN ALNNLSVNVE NQIKIKIYIS 190 200 210 220 230 240 QVCEDVFSGP LNSAVQLAGL TLLTNMTVTN DHQHMLHSYI TDLFQVLLTG NGNTKVQVLK 250 260 270 280 290 300 LLLNLSENPA MTEGLLRAQV DSSFLSLYDS HVAKEILLRV LTLFQNIKNC LKIEGHLAVQ 310 320 330 340 PTFTEGSLFF LLHGEECAQK IRALVDHHDA EVKEKVVTII PKI
	Isoform 2 (SVH-B). Checksum: 9F74718D8B96C102	FASTA	308	33,850
	10 20 30 40 50 60 MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAEDLT DGSYDDVLNA 70 80 90 100 110 120 EQLQKLLYLL ESTEDPVIIE RALITLGNNA AFSVNQAIIR ELGGIPIVAN KINHSNQSIK 130 140 150 160 170 180 EKALNALNNL SVNVENQIKI KIYISQVCED VFSGPLNSAV QLAGLTLLTN MTVTNDHQHM 190 200 210 220 230 240 LHSYITDLFQ VLLTGNGNTK VQVLKLLLNL SENPAMTEGL LRAQVDSSFL SLYDSHVAKE 250 260 270 280 290 300 ILLRVLTLFQ NIKNCLKIEG HLAVQPTFTE GSLFFLLHGE ECAQKIRALV DHHDAEVKEK VVTIIPKI
	Isoform 3 (SVH-C). Checksum: 73BCB20169E74F90	FASTA	284	31,080
	10 20 30 40 50 60 MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAGALE EGTSEGQLCG 70 80 90 100 110 120 RSARPQTGGT WESQWSKTSQ PEDLTDGSYD DVLNAEQLQK LLYLLESTED PVIIERALIT 130 140 150 160 170 180 LGNNAAFSVN QAIIRELGGI PIVANKINHS NQSIKEKALN ALNNLSVNVE NQIKIKVQVL 190 200 210 220 230 240 KLLLNLSENP AMTEGLLRAQ VDSSFLSLYD SHVAKEILLR VLTLFQNIKN CLKIEGHLAV 250 260 270 280 QPTFTEGSLF FLLHGEECAQ KIRALVDHHD AEVKEKVVTI IPKI
	Isoform 4 (SVH-D). Checksum: D83F237CF42AD097	FASTA	249	27,390
	10 20 30 40 50 60 MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAEDLT DGSYDDVLNA 70 80 90 100 110 120 EQLQKLLYLL ESTEDPVIIE RALITLGNNA AFSVNQAIIR ELGGIPIVAN KINHSNQSIK 130 140 150 160 170 180 EKALNALNNL SVNVENQIKI KVQVLKLLLN LSENPAMTEG LLRAQVDSSF LSLYDSHVAK 190 200 210 220 230 240 EILLRVLTLF QNIKNCLKIE GHLAVQPTFT EGSLFFLLHG EECAQKIRAL VDHHDAEVKE KVVTIIPKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas." Huang R., Xing Z., Luan Z., Wu T., Wu X., Hu G. Cancer Res. 63:3775-3782(2003) [PubMed: 12839973] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Hepatoma.
[2]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Embryo.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Prostate.
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-190. Tissue: Eye.
[6]	"SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53." Zhou X., Yang G., Huang R., Chen X., Hu G. FEBS Lett. 581:4943-4948(2007) [PubMed: 17904127] [Abstract] Cited for: PROTEIN SEQUENCE OF 45-100 (ISOFORM 2), INTERACTION WITH TP53, FUNCTION.
[7]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, MASS SPECTROMETRY. Tissue: Liver.
[8]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, MASS SPECTROMETRY. Tissue: T-cell.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY150851 mRNA. Translation: AAN72313.1. AY150852 mRNA. Translation: AAN72314.1. AY150853 mRNA. Translation: AAN72315.1. AY150854 mRNA. Translation: AAN72316.1. AK075500 mRNA. Translation: BAC11655.1. AK291818 mRNA. Translation: BAF84507.1. AC007683 Genomic DNA. Translation: AAS07531.1. AC073127 Genomic DNA. Translation: AAS07482.1. Sequence problems. AC108167 Genomic DNA. Translation: AAS07456.1. BC003586 mRNA. Translation: AAH03586.1.
IPI	IPI00166394. IPI00217968. IPI00420025. IPI00855858.
RefSeq	NP_001154481.1. NP_001154482.1. NP_001154483.1. NP_001154484.1. NP_001154485.1. NP_114111.2.
UniGene	Hs.287412 Hs.380752
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q8N2F6.
Proteomic databases
PRIDE	Q8N2F6.
Genome annotation databases
Ensembl	ENST00000323716; ENSP00000319412; ENSG00000170632; Homo sapiens. [Genome view]
GeneID	83787.
KEGG	hsa:83787.
UCSC	uc003vaw.1. human. uc003vax.1. human. uc003vay.1. human. uc003vbb.1. human.
Organism-specific databases
CTD	83787.
GeneCards	GC07P102503.
HGNC	HGNC:21706. ARMC10.
HPA	HPA011036. HPA011057.
MIM	611864. gene.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8N2F6.
HOVERGEN	Q8N2F6.
OMA	NQIKIKI
Gene expression databases
ArrayExpress	Q8N2F6.
Bgee	Q8N2F6.
Genevestigator	Q8N2F6.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR006911. DUF634. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 1 hit.
Pfam	PF04826. DUF634. 1 hit. [Graphical view]
PROSITE	PS50176. ARM_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	72803.
SOURCE	Search...

Entry information

Entry name

ARM10_HUMAN

Accession

Primary (citable) accession number: Q8N2F6
Secondary accession number(s): A8K703 , Q75K91, Q75MG6, Q75ML8, Q8IZC1, Q8IZC2, Q8IZC3, Q9BTM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	October 1, 2002
Last modified:	November 24, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.