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Q8N2E6

- TOR2X_HUMAN

UniProt

Q8N2E6 - TOR2X_HUMAN

Protein

Prosalusin

Gene

TOR2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusins may also be potent hypotensive peptides.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi93 – 1008ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. chaperone mediated protein folding requiring cofactor Source: InterPro

    Keywords - Molecular functioni

    Hormone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prosalusin
    Alternative name(s):
    Torsin family 2 member A
    Torsin-2A
    Cleaved into the following 2 chains:
    Gene namesi
    Name:TOR2A
    ORF Names:HEMBA1005096, PSEC0218
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:11996. TOR2A.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36677.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 242216ProsalusinPRO_0000228825Add
    BLAST
    Propeptidei27 – 189163Sequence AnalysisPRO_0000228826Add
    BLAST
    Peptidei192 – 21120Salusin-betaPRO_0000228827Add
    BLAST
    Peptidei214 – 24128Salusin-alphaPRO_0000228828Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
    Modified residuei241 – 2411Lysine amide1 Publication

    Post-translational modificationi

    Amidation of salusin-alpha(29-Gly) by peptidylglycine alpha-amidating monooxygenase, PAM, converts Lys-241-Gly-242 to Lys-241-NH2 and gives raise to salusin-alpha.1 Publication

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    MaxQBiQ8N2E6.
    PRIDEiQ8N2E6.

    Expressioni

    Tissue specificityi

    Isoform 4 is ubiquitously expressed, with high level in vascular endothelial cells and vascular smooth muscle cells.1 Publication

    Gene expression databases

    ArrayExpressiQ8N2E6.
    BgeeiQ8N2E6.
    CleanExiHS_TOR2A.
    GenevestigatoriQ8N2E6.

    Interactioni

    Protein-protein interaction databases

    BioGridi118167. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N2E6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ClpA/ClpB family. Torsin subfamily.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000115770.
    HOVERGENiHBG094082.
    OrthoDBiEOG7TF791.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR010448. Torsin.
    [Graphical view]
    PANTHERiPTHR10760. PTHR10760. 1 hit.
    PfamiPF06309. Torsin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 4 (identifier: Q8N2E6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAATRGCRP WGSLLGLLGL VSAAAAAWDL ASLRCTLGAF CECDFRPDLP    50
    GLECDLAQHL AGQHLAKALV VKALKAFVRD PAPTKPLVLS LHGWTGTGKS 100
    YVSSLLAHYL FQGGLRSPRV HHFSPVLHFP HPSHIERYKK DLKSWVQGNL 150
    TACGRSLFLF DEMDKMPPGL MEVLRPFLGS SWVVYGTNYR KAIFIFIRWL 200
    LKLGHHGRAP PRRSGALPPA PAAPRPALRA QRAGPAGPGA KG 242

    Note: Salusins -alpha and -beta peptides are derived from isoform 4.

    Length:242
    Mass (Da):26,262
    Last modified:October 1, 2002 - v1
    Checksum:i8118353CE5A0D628
    GO
    Isoform 1 (identifier: Q5JU69-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q5JU69.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:321
    Mass (Da):35,714
    GO
    Isoform 2 (identifier: Q5JU69-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q5JU69.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: No experimental confirmation available.

    Length:253
    Mass (Da):27,867
    GO
    Isoform 3 (identifier: Q5JU69-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q5JU69.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: No experimental confirmation available.

    Length:72
    Mass (Da):7,704
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK075520 mRNA. Translation: BAC11667.1.
    AL162426 Genomic DNA. Translation: CAI41185.1.
    CCDSiCCDS48024.1. [Q8N2E6-1]
    RefSeqiNP_001127902.1. NM_001134430.2. [Q8N2E6-1]
    UniGeneiHs.444106.

    Genome annotation databases

    EnsembliENST00000336067; ENSP00000338317; ENSG00000160404. [Q8N2E6-1]
    GeneIDi27433.
    KEGGihsa:27433.
    UCSCiuc004brt.4. human. [Q8N2E6-1]

    Polymorphism databases

    DMDMi74750929.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK075520 mRNA. Translation: BAC11667.1 .
    AL162426 Genomic DNA. Translation: CAI41185.1 .
    CCDSi CCDS48024.1. [Q8N2E6-1 ]
    RefSeqi NP_001127902.1. NM_001134430.2. [Q8N2E6-1 ]
    UniGenei Hs.444106.

    3D structure databases

    ProteinModelPortali Q8N2E6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118167. 1 interaction.

    Polymorphism databases

    DMDMi 74750929.

    Proteomic databases

    MaxQBi Q8N2E6.
    PRIDEi Q8N2E6.

    Protocols and materials databases

    DNASUi 27433.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336067 ; ENSP00000338317 ; ENSG00000160404 . [Q8N2E6-1 ]
    GeneIDi 27433.
    KEGGi hsa:27433.
    UCSCi uc004brt.4. human. [Q8N2E6-1 ]

    Organism-specific databases

    CTDi 27433.
    GeneCardsi GC09M130493.
    HGNCi HGNC:11996. TOR2A.
    MIMi 608052. gene.
    neXtProti NX_Q8N2E6.
    PharmGKBi PA36677.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000115770.
    HOVERGENi HBG094082.
    OrthoDBi EOG7TF791.

    Miscellaneous databases

    GenomeRNAii 27433.
    NextBioi 50475.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N2E6.
    Bgeei Q8N2E6.
    CleanExi HS_TOR2A.
    Genevestigatori Q8N2E6.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR010448. Torsin.
    [Graphical view ]
    PANTHERi PTHR10760. PTHR10760. 1 hit.
    Pfami PF06309. Torsin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Embryo.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities."
      Shichiri M., Ishimaru S., Ota T., Nishikawa T., Isogai T., Hirata Y.
      Nat. Med. 9:1166-1172(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF SALUSINS, TISSUE SPECIFICITY, AMIDATION AT LYS-241, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiTOR2X_HUMAN
    AccessioniPrimary (citable) accession number: Q8N2E6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3