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Q8N2E6

- TOR2X_HUMAN

UniProt

Q8N2E6 - TOR2X_HUMAN

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Protein

Prosalusin

Gene

TOR2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusins may also be potent hypotensive peptides.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi93 – 1008ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. chaperone mediated protein folding requiring cofactor Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Prosalusin
Alternative name(s):
Torsin family 2 member A
Torsin-2A
Cleaved into the following 2 chains:
Gene namesi
Name:TOR2A
ORF Names:HEMBA1005096, PSEC0218
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:11996. TOR2A.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36677.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 242216ProsalusinPRO_0000228825Add
BLAST
Propeptidei27 – 189163Sequence AnalysisPRO_0000228826Add
BLAST
Peptidei192 – 21120Salusin-betaPRO_0000228827Add
BLAST
Peptidei214 – 24128Salusin-alphaPRO_0000228828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
Modified residuei241 – 2411Lysine amide1 Publication

Post-translational modificationi

Amidation of salusin-alpha(29-Gly) by peptidylglycine alpha-amidating monooxygenase, PAM, converts Lys-241-Gly-242 to Lys-241-NH2 and gives raise to salusin-alpha.1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiQ8N2E6.
PRIDEiQ8N2E6.

Expressioni

Tissue specificityi

Isoform 4 is ubiquitously expressed, with high level in vascular endothelial cells and vascular smooth muscle cells.1 Publication

Gene expression databases

BgeeiQ8N2E6.
CleanExiHS_TOR2A.
ExpressionAtlasiQ8N2E6. baseline and differential.
GenevestigatoriQ8N2E6.

Interactioni

Protein-protein interaction databases

BioGridi118167. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8N2E6.
SMRiQ8N2E6. Positions 46-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpA/ClpB family. Torsin subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000001920.
HOGENOMiHOG000115770.
HOVERGENiHBG094082.
OrthoDBiEOG7TF791.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR010448. Torsin.
[Graphical view]
PANTHERiPTHR10760. PTHR10760. 1 hit.
PfamiPF06309. Torsin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 4 (identifier: Q8N2E6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAATRGCRP WGSLLGLLGL VSAAAAAWDL ASLRCTLGAF CECDFRPDLP
60 70 80 90 100
GLECDLAQHL AGQHLAKALV VKALKAFVRD PAPTKPLVLS LHGWTGTGKS
110 120 130 140 150
YVSSLLAHYL FQGGLRSPRV HHFSPVLHFP HPSHIERYKK DLKSWVQGNL
160 170 180 190 200
TACGRSLFLF DEMDKMPPGL MEVLRPFLGS SWVVYGTNYR KAIFIFIRWL
210 220 230 240
LKLGHHGRAP PRRSGALPPA PAAPRPALRA QRAGPAGPGA KG

Note: Salusins -alpha and -beta peptides are derived from isoform 4.

Length:242
Mass (Da):26,262
Last modified:October 1, 2002 - v1
Checksum:i8118353CE5A0D628
GO
Isoform 1 (identifier: Q5JU69-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q5JU69.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:321
Mass (Da):35,714
GO
Isoform 2 (identifier: Q5JU69-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q5JU69.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:253
Mass (Da):27,867
GO
Isoform 3 (identifier: Q5JU69-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q5JU69.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:72
Mass (Da):7,704
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK075520 mRNA. Translation: BAC11667.1.
AL162426 Genomic DNA. Translation: CAI41185.1.
CCDSiCCDS48024.1. [Q8N2E6-1]
RefSeqiNP_001127902.1. NM_001134430.2. [Q8N2E6-1]
UniGeneiHs.444106.

Genome annotation databases

EnsembliENST00000336067; ENSP00000338317; ENSG00000160404. [Q8N2E6-1]
GeneIDi27433.
KEGGihsa:27433.
UCSCiuc004brt.4. human. [Q8N2E6-1]

Polymorphism databases

DMDMi74750929.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK075520 mRNA. Translation: BAC11667.1 .
AL162426 Genomic DNA. Translation: CAI41185.1 .
CCDSi CCDS48024.1. [Q8N2E6-1 ]
RefSeqi NP_001127902.1. NM_001134430.2. [Q8N2E6-1 ]
UniGenei Hs.444106.

3D structure databases

ProteinModelPortali Q8N2E6.
SMRi Q8N2E6. Positions 46-202.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118167. 4 interactions.

Polymorphism databases

DMDMi 74750929.

Proteomic databases

MaxQBi Q8N2E6.
PRIDEi Q8N2E6.

Protocols and materials databases

DNASUi 27433.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336067 ; ENSP00000338317 ; ENSG00000160404 . [Q8N2E6-1 ]
GeneIDi 27433.
KEGGi hsa:27433.
UCSCi uc004brt.4. human. [Q8N2E6-1 ]

Organism-specific databases

CTDi 27433.
GeneCardsi GC09M130493.
HGNCi HGNC:11996. TOR2A.
MIMi 608052. gene.
neXtProti NX_Q8N2E6.
PharmGKBi PA36677.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00390000001920.
HOGENOMi HOG000115770.
HOVERGENi HBG094082.
OrthoDBi EOG7TF791.

Miscellaneous databases

GenomeRNAii 27433.
NextBioi 50475.
SOURCEi Search...

Gene expression databases

Bgeei Q8N2E6.
CleanExi HS_TOR2A.
ExpressionAtlasi Q8N2E6. baseline and differential.
Genevestigatori Q8N2E6.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR010448. Torsin.
[Graphical view ]
PANTHERi PTHR10760. PTHR10760. 1 hit.
Pfami PF06309. Torsin. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Embryo.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities."
    Shichiri M., Ishimaru S., Ota T., Nishikawa T., Isogai T., Hirata Y.
    Nat. Med. 9:1166-1172(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF SALUSINS, TISSUE SPECIFICITY, AMIDATION AT LYS-241, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTOR2X_HUMAN
AccessioniPrimary (citable) accession number: Q8N2E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3