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Protein

von Willebrand factor D and EGF domain-containing protein

Gene

VWDE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor D and EGF domain-containing protein
Gene namesi
Name:VWDE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21897. VWDE.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiVWDE.
DMDMi327478608.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 15901570von Willebrand factor D and EGF domain-containing proteinPRO_0000329441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi703 – 7031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi968 – 9681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1181 ↔ 1189By similarity
Disulfide bondi1183 ↔ 1204By similarity
Disulfide bondi1206 ↔ 1215By similarity
Disulfide bondi1298 ↔ 1308By similarity
Disulfide bondi1302 ↔ 1314By similarity
Disulfide bondi1316 ↔ 1325By similarity
Disulfide bondi1362 ↔ 1372By similarity
Disulfide bondi1366 ↔ 1378By similarity
Disulfide bondi1380 ↔ 1389By similarity
Disulfide bondi1426 ↔ 1436By similarity
Disulfide bondi1430 ↔ 1442By similarity
Disulfide bondi1444 ↔ 1453By similarity
Disulfide bondi1458 ↔ 1468By similarity
Disulfide bondi1462 ↔ 1474By similarity
Disulfide bondi1522 ↔ 1532By similarity
Disulfide bondi1526 ↔ 1538By similarity
Disulfide bondi1540 ↔ 1549By similarity
Disulfide bondi1554 ↔ 1564By similarity
Disulfide bondi1558 ↔ 1570By similarity
Disulfide bondi1572 ↔ 1581By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8N2E2.
PaxDbiQ8N2E2.
PRIDEiQ8N2E2.

PTM databases

PhosphoSiteiQ8N2E2.

Expressioni

Gene expression databases

BgeeiQ8N2E2.
CleanExiHS_VWDE.
ExpressionAtlasiQ8N2E2. baseline and differential.
GenevisibleiQ8N2E2. HS.

Organism-specific databases

HPAiHPA026619.
HPA036044.

Interactioni

Protein-protein interaction databases

BioGridi128755. 4 interactions.
STRINGi9606.ENSP00000275358.

Structurei

3D structure databases

ProteinModelPortaliQ8N2E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini424 – 641218VWFDPROSITE-ProRule annotationAdd
BLAST
Domaini1177 – 121640EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini1294 – 132633EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini1358 – 139033EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini1422 – 145433EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini1455 – 148632EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini1518 – 155033EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini1551 – 158232EGF-like 7PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 7 EGF-like domains.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG287151.
GeneTreeiENSGT00760000119131.
HOGENOMiHOG000169576.
InParanoidiQ8N2E2.
OMAiQTSSCAN.
OrthoDBiEOG7GXP9M.
PhylomeDBiQ8N2E2.
TreeFamiTF351702.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF12661. hEGF. 3 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 10 hits.
SM00216. VWD. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 9 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 7 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N2E2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGGACVLVI ALMFLAWGEA QECSPGGHQF LRSPYRSVRF DSWHLQQSAV
60 70 80 90 100
QDLICDHSLS PGWYRFLILD RPAEMPTKCV EMNHCGTQAP IWLSLRDSET
110 120 130 140 150
LPSPGEIKQL TACATWQFLF STTKDCCLFQ IPVSVRNCGN FSVYLLQPTQ
160 170 180 190 200
GCMGYCAEAI SDARLHPCGS DETETGGDCV RQLAASLPPP PAGRPEVLVE
210 220 230 240 250
LIESRLFCRC SFDVPATKNS VGFHIAWSRL SSQEVKEELT QETTVQAFSL
260 270 280 290 300
LELDGINLRL GDRIFCSASV FFLENPHVQS VAIESQEFFA GFKLQPELST
310 320 330 340 350
ISEDGKEYYL RIESTVPIIC SEFSELDQEC KISLKLKTIG QGREHLGLNL
360 370 380 390 400
ALSSCHVDLL QTSSCANGTC SHTFVYYTAV TDFSRDGDRV SNIVVQPIVN
410 420 430 440 450
EDFLWNNYIP DSIQIKVKDV PTAYCYTFTD PHIITFDGRV YDNFKTGTFV
460 470 480 490 500
LYKSMSRDFE VHVRQWDCRS LHYPVSCNCG FVAQEGGDIV TFDMCNGQLR
510 520 530 540 550
ESQPYLFIKS QDVTRNIKIS ESYLGRKVTI WFSSGAFIRA DLGEWGMSLT
560 570 580 590 600
IRAPSVDYRN TLGLCGTFDE NPENDFHDKN GMQIDQNFNN YVAFINEWRI
610 620 630 640 650
LPGKSMSDTL PVSMTSPGKP SYCSCSLDTA AYPSSEDLDS VSRSEIALGC
660 670 680 690 700
KDLNHVSLSS LIPELDVTSE YINSDTLVRE INKHTSPEEY NLNLFLQEKK
710 720 730 740 750
HINLTKLGLN VQKHPGNEKE DSLQYLANKK YTQGRGSHSQ EMRYNRQNRW
760 770 780 790 800
KRQNFHEFPP LFAFPSLSQT DLEELTYFFP EDHAEDVQQE FFPSWPTPSG
810 820 830 840 850
LTEYSTLTLC QETLANSSIG RLCLAFLGKR LDSVIEMCVK DVLLKDDLSW
860 870 880 890 900
AEAGVALLEN ECEKRIVEEG KYNTEEYGTS IEDILSVLKC PNLCSGNGQC
910 920 930 940 950
MEWGCACSPS FSSYDCSDSY DKAPEITELG NAGFCDVQKY NCMMVRVFGK
960 970 980 990 1000
GFKELPSIKC EVTKLQYNSS EWMPGEPIYT QTVFHNSRAV DCQLPTDVQQ
1010 1020 1030 1040 1050
FDTMDLVGGK PTGKWQLKVS NDGYKFSNPK ITVIYDGACQ VCGLYKNDSC
1060 1070 1080 1090 1100
TIKENVCIID GLCYVEGDKN PTSPCLICRP KISRFTWSFL ENNQPPVIQA
1110 1120 1130 1140 1150
LQDKLQTFYG ENFEYQFVAF DPEGSDIHFT LDSGPEGASV SSAGLFMWKT
1160 1170 1180 1190 1200
DLLTTQQITV RLNDDCDAET RVTIEVTVKS CDCLNGGSCV SDRNFSPGSG
1210 1220 1230 1240 1250
VYLCVCLPGF HGSLCEVDIS GCQSNPCGLG SYISGFHSYS CDCPPELKVE
1260 1270 1280 1290 1300
TQFVNQFTTQ TVVLTRSDKS VNKEEDDKNA QGRKRHVKPT SGNAFTICKY
1310 1320 1330 1340 1350
PCGKSRECVA PNICKCKPGY IGSNCQTALC DPDCKNHGKC IKPNICQCLP
1360 1370 1380 1390 1400
GHGGATCDEE HCNPPCQHGG TCLAGNLCTC PYGFVGPRCE TMVCNRHCEN
1410 1420 1430 1440 1450
GGQCLTPDIC QCKPGWYGPT CSTALCDPVC LNGGSCNKPN TCLCPNGFFG
1460 1470 1480 1490 1500
EHCQNAFCHP PCKNGGHCMR NNVCVCREGY TGRRFQKSIC DPTCMNGGKC
1510 1520 1530 1540 1550
VGPSTCSCPS GWSGKRCNTP ICLQKCKNGG ECIAPSICHC PSSWEGVRCQ
1560 1570 1580 1590
IPICNPKCLY GGRCIFPNVC SCRTEYSGVK CEKKIQIRRH
Length:1,590
Mass (Da):176,780
Last modified:April 5, 2011 - v4
Checksum:i58BAB222EE4D3F04
GO
Isoform 2 (identifier: Q8N2E2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-546: Missing.

Note: No experimental confirmation available.
Show »
Length:1,044
Mass (Da):115,545
Checksum:i706614BB6759EA78
GO

Sequence cautioni

The sequence AAI44320.1 differs from that shown. Reason: Frameshift at position 1487. Curated
The sequence BAB55237.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11671.1 differs from that shown.Intron retention.Curated
The sequence EAW93644.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1078 – 10781C → F in AAI44320 (PubMed:15489334).Curated
Sequence conflicti1106 – 11061Q → L in BAB55237 (PubMed:14702039).Curated
Sequence conflicti1371 – 13711T → I in BAB55237 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti607 – 6071S → F.1 Publication
Corresponds to variant rs963323 [ dbSNP | Ensembl ].
VAR_071061
Natural varianti964 – 9641K → N.1 Publication
Corresponds to variant rs6460939 [ dbSNP | Ensembl ].
VAR_047871
Natural varianti1032 – 10321T → M.1 Publication
Corresponds to variant rs2053380 [ dbSNP | Ensembl ].
VAR_047872
Natural varianti1256 – 12561Q → K.1 Publication
Corresponds to variant rs6967385 [ dbSNP | Ensembl ].
VAR_047873
Natural varianti1485 – 14851F → C.1 Publication
Corresponds to variant rs2192828 [ dbSNP | Ensembl ].
VAR_047874

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 546546Missing in isoform 2. 1 PublicationVSP_055465Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007321 Genomic DNA. No translation available.
AC013470 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93644.1. Sequence problems.
BC144319 mRNA. Translation: AAI44320.1. Frameshift.
AK075525 mRNA. Translation: BAC11671.1. Sequence problems.
AK027618 mRNA. Translation: BAB55237.1. Different initiation.
CCDSiCCDS47544.1. [Q8N2E2-1]
RefSeqiNP_001129396.1. NM_001135924.1. [Q8N2E2-1]
XP_005249698.1. XM_005249641.1. [Q8N2E2-3]
UniGeneiHs.669526.

Genome annotation databases

EnsembliENST00000275358; ENSP00000275358; ENSG00000146530. [Q8N2E2-1]
GeneIDi221806.
KEGGihsa:221806.
UCSCiuc003ssj.2. human. [Q8N2E2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007321 Genomic DNA. No translation available.
AC013470 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93644.1. Sequence problems.
BC144319 mRNA. Translation: AAI44320.1. Frameshift.
AK075525 mRNA. Translation: BAC11671.1. Sequence problems.
AK027618 mRNA. Translation: BAB55237.1. Different initiation.
CCDSiCCDS47544.1. [Q8N2E2-1]
RefSeqiNP_001129396.1. NM_001135924.1. [Q8N2E2-1]
XP_005249698.1. XM_005249641.1. [Q8N2E2-3]
UniGeneiHs.669526.

3D structure databases

ProteinModelPortaliQ8N2E2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128755. 4 interactions.
STRINGi9606.ENSP00000275358.

PTM databases

PhosphoSiteiQ8N2E2.

Polymorphism and mutation databases

BioMutaiVWDE.
DMDMi327478608.

Proteomic databases

MaxQBiQ8N2E2.
PaxDbiQ8N2E2.
PRIDEiQ8N2E2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275358; ENSP00000275358; ENSG00000146530. [Q8N2E2-1]
GeneIDi221806.
KEGGihsa:221806.
UCSCiuc003ssj.2. human. [Q8N2E2-1]

Organism-specific databases

CTDi221806.
GeneCardsiGC07M012338.
H-InvDBHIX0006489.
HGNCiHGNC:21897. VWDE.
HPAiHPA026619.
HPA036044.
neXtProtiNX_Q8N2E2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG287151.
GeneTreeiENSGT00760000119131.
HOGENOMiHOG000169576.
InParanoidiQ8N2E2.
OMAiQTSSCAN.
OrthoDBiEOG7GXP9M.
PhylomeDBiQ8N2E2.
TreeFamiTF351702.

Miscellaneous databases

GenomeRNAii221806.
NextBioi35481391.
PROiQ8N2E2.

Gene expression databases

BgeeiQ8N2E2.
CleanExiHS_VWDE.
ExpressionAtlasiQ8N2E2. baseline and differential.
GenevisibleiQ8N2E2. HS.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF12661. hEGF. 3 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 10 hits.
SM00216. VWD. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 9 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 7 hits.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS PHE-607; ASN-964 AND MET-1032.
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-342 (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 639-1590 (ISOFORM 1), VARIANTS LYS-1256 AND CYS-1485.
    Tissue: Teratocarcinoma.

Entry informationi

Entry nameiVWDE_HUMAN
AccessioniPrimary (citable) accession number: Q8N2E2
Secondary accession number(s): B7ZM77, Q96SQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 88 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.