Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8N2E2

- VWDE_HUMAN

UniProt

Q8N2E2 - VWDE_HUMAN

Protein

von Willebrand factor D and EGF domain-containing protein

Gene

VWDE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 4 (05 Apr 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    von Willebrand factor D and EGF domain-containing protein
    Gene namesi
    Name:VWDE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21897. VWDE.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 15901570von Willebrand factor D and EGF domain-containing proteinPRO_0000329441Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi703 – 7031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi968 – 9681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1181 ↔ 1189By similarity
    Disulfide bondi1183 ↔ 1204By similarity
    Disulfide bondi1206 ↔ 1215By similarity
    Disulfide bondi1298 ↔ 1308By similarity
    Disulfide bondi1302 ↔ 1314By similarity
    Disulfide bondi1316 ↔ 1325By similarity
    Disulfide bondi1362 ↔ 1372By similarity
    Disulfide bondi1366 ↔ 1378By similarity
    Disulfide bondi1380 ↔ 1389By similarity
    Disulfide bondi1426 ↔ 1436By similarity
    Disulfide bondi1430 ↔ 1442By similarity
    Disulfide bondi1444 ↔ 1453By similarity
    Disulfide bondi1458 ↔ 1468By similarity
    Disulfide bondi1462 ↔ 1474By similarity
    Disulfide bondi1522 ↔ 1532By similarity
    Disulfide bondi1526 ↔ 1538By similarity
    Disulfide bondi1540 ↔ 1549By similarity
    Disulfide bondi1554 ↔ 1564By similarity
    Disulfide bondi1558 ↔ 1570By similarity
    Disulfide bondi1572 ↔ 1581By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ8N2E2.
    PaxDbiQ8N2E2.
    PRIDEiQ8N2E2.

    PTM databases

    PhosphoSiteiQ8N2E2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N2E2.
    BgeeiQ8N2E2.
    CleanExiHS_VWDE.
    GenevestigatoriQ8N2E2.

    Organism-specific databases

    HPAiHPA026619.
    HPA036044.

    Interactioni

    Protein-protein interaction databases

    BioGridi128755. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N2E2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini424 – 641218VWFDPROSITE-ProRule annotationAdd
    BLAST
    Domaini1177 – 121640EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1294 – 132633EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1358 – 139033EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1422 – 145433EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1455 – 148632EGF-like 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1518 – 155033EGF-like 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1551 – 158232EGF-like 7PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 7 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 VWFD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG287151.
    HOGENOMiHOG000169576.
    InParanoidiQ96SQ3.
    OMAiAICRHPC.
    OrthoDBiEOG7GXP9M.
    PhylomeDBiQ8N2E2.
    TreeFamiTF351702.

    Family and domain databases

    InterProiIPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF12661. hEGF. 3 hits.
    PF00094. VWD. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 10 hits.
    SM00216. VWD. 1 hit.
    [Graphical view]
    PROSITEiPS00022. EGF_1. 9 hits.
    PS01186. EGF_2. 6 hits.
    PS50026. EGF_3. 7 hits.
    PS51233. VWFD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N2E2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPGGACVLVI ALMFLAWGEA QECSPGGHQF LRSPYRSVRF DSWHLQQSAV     50
    QDLICDHSLS PGWYRFLILD RPAEMPTKCV EMNHCGTQAP IWLSLRDSET 100
    LPSPGEIKQL TACATWQFLF STTKDCCLFQ IPVSVRNCGN FSVYLLQPTQ 150
    GCMGYCAEAI SDARLHPCGS DETETGGDCV RQLAASLPPP PAGRPEVLVE 200
    LIESRLFCRC SFDVPATKNS VGFHIAWSRL SSQEVKEELT QETTVQAFSL 250
    LELDGINLRL GDRIFCSASV FFLENPHVQS VAIESQEFFA GFKLQPELST 300
    ISEDGKEYYL RIESTVPIIC SEFSELDQEC KISLKLKTIG QGREHLGLNL 350
    ALSSCHVDLL QTSSCANGTC SHTFVYYTAV TDFSRDGDRV SNIVVQPIVN 400
    EDFLWNNYIP DSIQIKVKDV PTAYCYTFTD PHIITFDGRV YDNFKTGTFV 450
    LYKSMSRDFE VHVRQWDCRS LHYPVSCNCG FVAQEGGDIV TFDMCNGQLR 500
    ESQPYLFIKS QDVTRNIKIS ESYLGRKVTI WFSSGAFIRA DLGEWGMSLT 550
    IRAPSVDYRN TLGLCGTFDE NPENDFHDKN GMQIDQNFNN YVAFINEWRI 600
    LPGKSMSDTL PVSMTSPGKP SYCSCSLDTA AYPSSEDLDS VSRSEIALGC 650
    KDLNHVSLSS LIPELDVTSE YINSDTLVRE INKHTSPEEY NLNLFLQEKK 700
    HINLTKLGLN VQKHPGNEKE DSLQYLANKK YTQGRGSHSQ EMRYNRQNRW 750
    KRQNFHEFPP LFAFPSLSQT DLEELTYFFP EDHAEDVQQE FFPSWPTPSG 800
    LTEYSTLTLC QETLANSSIG RLCLAFLGKR LDSVIEMCVK DVLLKDDLSW 850
    AEAGVALLEN ECEKRIVEEG KYNTEEYGTS IEDILSVLKC PNLCSGNGQC 900
    MEWGCACSPS FSSYDCSDSY DKAPEITELG NAGFCDVQKY NCMMVRVFGK 950
    GFKELPSIKC EVTKLQYNSS EWMPGEPIYT QTVFHNSRAV DCQLPTDVQQ 1000
    FDTMDLVGGK PTGKWQLKVS NDGYKFSNPK ITVIYDGACQ VCGLYKNDSC 1050
    TIKENVCIID GLCYVEGDKN PTSPCLICRP KISRFTWSFL ENNQPPVIQA 1100
    LQDKLQTFYG ENFEYQFVAF DPEGSDIHFT LDSGPEGASV SSAGLFMWKT 1150
    DLLTTQQITV RLNDDCDAET RVTIEVTVKS CDCLNGGSCV SDRNFSPGSG 1200
    VYLCVCLPGF HGSLCEVDIS GCQSNPCGLG SYISGFHSYS CDCPPELKVE 1250
    TQFVNQFTTQ TVVLTRSDKS VNKEEDDKNA QGRKRHVKPT SGNAFTICKY 1300
    PCGKSRECVA PNICKCKPGY IGSNCQTALC DPDCKNHGKC IKPNICQCLP 1350
    GHGGATCDEE HCNPPCQHGG TCLAGNLCTC PYGFVGPRCE TMVCNRHCEN 1400
    GGQCLTPDIC QCKPGWYGPT CSTALCDPVC LNGGSCNKPN TCLCPNGFFG 1450
    EHCQNAFCHP PCKNGGHCMR NNVCVCREGY TGRRFQKSIC DPTCMNGGKC 1500
    VGPSTCSCPS GWSGKRCNTP ICLQKCKNGG ECIAPSICHC PSSWEGVRCQ 1550
    IPICNPKCLY GGRCIFPNVC SCRTEYSGVK CEKKIQIRRH 1590
    Length:1,590
    Mass (Da):176,780
    Last modified:April 5, 2011 - v4
    Checksum:i58BAB222EE4D3F04
    GO
    Isoform 2 (identifier: Q8N2E2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-546: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,044
    Mass (Da):115,545
    Checksum:i706614BB6759EA78
    GO

    Sequence cautioni

    The sequence BAC11671.1 differs from that shown. Reason: Intron retention.
    The sequence AAI44320.1 differs from that shown. Reason: Frameshift at position 1487.
    The sequence BAB55237.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence EAW93644.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1078 – 10781C → F in AAI44320. (PubMed:15489334)Curated
    Sequence conflicti1106 – 11061Q → L in BAB55237. (PubMed:14702039)Curated
    Sequence conflicti1371 – 13711T → I in BAB55237. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti607 – 6071S → F.1 Publication
    Corresponds to variant rs963323 [ dbSNP | Ensembl ].
    VAR_071061
    Natural varianti964 – 9641K → N.1 Publication
    Corresponds to variant rs6460939 [ dbSNP | Ensembl ].
    VAR_047871
    Natural varianti1032 – 10321T → M.1 Publication
    Corresponds to variant rs2053380 [ dbSNP | Ensembl ].
    VAR_047872
    Natural varianti1256 – 12561Q → K.1 Publication
    Corresponds to variant rs6967385 [ dbSNP | Ensembl ].
    VAR_047873
    Natural varianti1485 – 14851F → C.1 Publication
    Corresponds to variant rs2192828 [ dbSNP | Ensembl ].
    VAR_047874

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 546546Missing in isoform 2. 1 PublicationVSP_055465Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007321 Genomic DNA. No translation available.
    AC013470 Genomic DNA. No translation available.
    CH471073 Genomic DNA. Translation: EAW93644.1. Sequence problems.
    BC144319 mRNA. Translation: AAI44320.1. Frameshift.
    AK075525 mRNA. Translation: BAC11671.1. Sequence problems.
    AK027618 mRNA. Translation: BAB55237.1. Different initiation.
    CCDSiCCDS47544.1.
    RefSeqiNP_001129396.1. NM_001135924.1.
    UniGeneiHs.669526.

    Genome annotation databases

    EnsembliENST00000275358; ENSP00000275358; ENSG00000146530. [Q8N2E2-1]
    ENST00000326715; ENSP00000317143; ENSG00000146530.
    GeneIDi221806.
    KEGGihsa:221806.
    UCSCiuc003ssj.2. human.

    Polymorphism databases

    DMDMi327478608.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007321 Genomic DNA. No translation available.
    AC013470 Genomic DNA. No translation available.
    CH471073 Genomic DNA. Translation: EAW93644.1 . Sequence problems.
    BC144319 mRNA. Translation: AAI44320.1 . Frameshift.
    AK075525 mRNA. Translation: BAC11671.1 . Sequence problems.
    AK027618 mRNA. Translation: BAB55237.1 . Different initiation.
    CCDSi CCDS47544.1.
    RefSeqi NP_001129396.1. NM_001135924.1.
    UniGenei Hs.669526.

    3D structure databases

    ProteinModelPortali Q8N2E2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128755. 1 interaction.

    PTM databases

    PhosphoSitei Q8N2E2.

    Polymorphism databases

    DMDMi 327478608.

    Proteomic databases

    MaxQBi Q8N2E2.
    PaxDbi Q8N2E2.
    PRIDEi Q8N2E2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000275358 ; ENSP00000275358 ; ENSG00000146530 . [Q8N2E2-1 ]
    ENST00000326715 ; ENSP00000317143 ; ENSG00000146530 .
    GeneIDi 221806.
    KEGGi hsa:221806.
    UCSCi uc003ssj.2. human.

    Organism-specific databases

    CTDi 221806.
    GeneCardsi GC07M012338.
    H-InvDB HIX0006489.
    HGNCi HGNC:21897. VWDE.
    HPAi HPA026619.
    HPA036044.
    neXtProti NX_Q8N2E2.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG287151.
    HOGENOMi HOG000169576.
    InParanoidi Q96SQ3.
    OMAi AICRHPC.
    OrthoDBi EOG7GXP9M.
    PhylomeDBi Q8N2E2.
    TreeFami TF351702.

    Miscellaneous databases

    GenomeRNAii 221806.
    NextBioi 91453.
    PROi Q8N2E2.

    Gene expression databases

    ArrayExpressi Q8N2E2.
    Bgeei Q8N2E2.
    CleanExi HS_VWDE.
    Genevestigatori Q8N2E2.

    Family and domain databases

    InterProi IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF12661. hEGF. 3 hits.
    PF00094. VWD. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 10 hits.
    SM00216. VWD. 1 hit.
    [Graphical view ]
    PROSITEi PS00022. EGF_1. 9 hits.
    PS01186. EGF_2. 6 hits.
    PS50026. EGF_3. 7 hits.
    PS51233. VWFD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS PHE-607; ASN-964 AND MET-1032.
    4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-342 (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 639-1590 (ISOFORM 1), VARIANTS LYS-1256 AND CYS-1485.
      Tissue: Teratocarcinoma.

    Entry informationi

    Entry nameiVWDE_HUMAN
    AccessioniPrimary (citable) accession number: Q8N2E2
    Secondary accession number(s): B7ZM77, Q96SQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 81 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3