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Protein

DEP domain-containing protein 4

Gene

DEPDC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
DEP domain-containing protein 4
Gene namesi
Name:DEPDC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:22952. DEPDC4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981607.

Polymorphism and mutation databases

BioMutaiDEPDC4.
DMDMi74728709.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294DEP domain-containing protein 4PRO_0000284783Add
BLAST

Proteomic databases

PaxDbiQ8N2C3.
PRIDEiQ8N2C3.

PTM databases

PhosphoSiteiQ8N2C3.

Expressioni

Gene expression databases

BgeeiQ8N2C3.
CleanExiHS_DEPDC4.
ExpressionAtlasiQ8N2C3. baseline and differential.
GenevisibleiQ8N2C3. HS.

Organism-specific databases

HPAiHPA039323.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367490.

Structurei

3D structure databases

ProteinModelPortaliQ8N2C3.
SMRiQ8N2C3. Positions 52-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 16292DEPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG42573.
GeneTreeiENSGT00530000063030.
HOGENOMiHOG000112195.
HOVERGENiHBG098176.
InParanoidiQ8N2C3.
OrthoDBiEOG715Q5C.
PhylomeDBiQ8N2C3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
PROSITEiPS50186. DEP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N2C3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPGEEPARE LMAVLLTPRF RRLVSQNELP GPGLNGPSSR NRRDGFCRKR
60 70 80 90 100
RTGCSGPFQA TQLWDGIIHS LQAQVEIKRR RHHLQTYKDC FTGSDAVDVV
110 120 130 140 150
LSHLMQNTCL SSNDISCLKG VHLCQVLMNH KVFEPVGMKK LFKKEKELEF
160 170 180 190 200
EDSNISLYRF LGNKSSYDCC KRQKDAENEF NETLRPGYEM ISNPLAQEIG
210 220 230 240 250
EERIEELIHT INGNPALCPN ITVQKPFLRL SKEDVWKEQT LLCLLQLIHL
260 270 280 290
PFLDNILEPP VKTQNLQLNK EEDLVITNTC LDRELIPSLC LPEK
Length:294
Mass (Da):33,694
Last modified:October 1, 2002 - v1
Checksum:i0073B8E83402EA43
GO
Isoform 2 (identifier: Q8N2C3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-57: GCSGP → DQDMK
     58-294: Missing.

Note: No experimental confirmation available.
Show »
Length:57
Mass (Da):6,538
Checksum:i5377D7B9ABAA55E2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341L → G in AAH15117 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221H → R.
Corresponds to variant rs7307415 [ dbSNP | Ensembl ].
VAR_031815

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei53 – 575GCSGP → DQDMK in isoform 2. 1 PublicationVSP_024646
Alternative sequencei58 – 294237Missing in isoform 2. 1 PublicationVSP_024647Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090824 mRNA. Translation: BAC03525.1.
BC015117 mRNA. Translation: AAH15117.1.
BC100929 mRNA. Translation: AAI00930.1.
CCDSiCCDS9075.1. [Q8N2C3-1]
RefSeqiNP_689530.1. NM_152317.2. [Q8N2C3-1]
UniGeneiHs.653118.

Genome annotation databases

EnsembliENST00000299185; ENSP00000299185; ENSG00000166153. [Q8N2C3-2]
ENST00000378244; ENSP00000367490; ENSG00000166153. [Q8N2C3-1]
ENST00000416321; ENSP00000396234; ENSG00000166153. [Q8N2C3-1]
ENST00000549341; ENSP00000447392; ENSG00000166153. [Q8N2C3-2]
GeneIDi120863.
KEGGihsa:120863.
UCSCiuc001thi.3. human. [Q8N2C3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090824 mRNA. Translation: BAC03525.1.
BC015117 mRNA. Translation: AAH15117.1.
BC100929 mRNA. Translation: AAI00930.1.
CCDSiCCDS9075.1. [Q8N2C3-1]
RefSeqiNP_689530.1. NM_152317.2. [Q8N2C3-1]
UniGeneiHs.653118.

3D structure databases

ProteinModelPortaliQ8N2C3.
SMRiQ8N2C3. Positions 52-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367490.

PTM databases

PhosphoSiteiQ8N2C3.

Polymorphism and mutation databases

BioMutaiDEPDC4.
DMDMi74728709.

Proteomic databases

PaxDbiQ8N2C3.
PRIDEiQ8N2C3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299185; ENSP00000299185; ENSG00000166153. [Q8N2C3-2]
ENST00000378244; ENSP00000367490; ENSG00000166153. [Q8N2C3-1]
ENST00000416321; ENSP00000396234; ENSG00000166153. [Q8N2C3-1]
ENST00000549341; ENSP00000447392; ENSG00000166153. [Q8N2C3-2]
GeneIDi120863.
KEGGihsa:120863.
UCSCiuc001thi.3. human. [Q8N2C3-1]

Organism-specific databases

CTDi120863.
GeneCardsiGC12M100597.
HGNCiHGNC:22952. DEPDC4.
HPAiHPA039323.
neXtProtiNX_Q8N2C3.
PharmGKBiPA134981607.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42573.
GeneTreeiENSGT00530000063030.
HOGENOMiHOG000112195.
HOVERGENiHBG098176.
InParanoidiQ8N2C3.
OrthoDBiEOG715Q5C.
PhylomeDBiQ8N2C3.

Miscellaneous databases

GenomeRNAii120863.
NextBioi80634.
PROiQ8N2C3.

Gene expression databases

BgeeiQ8N2C3.
CleanExiHS_DEPDC4.
ExpressionAtlasiQ8N2C3. baseline and differential.
GenevisibleiQ8N2C3. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
PROSITEiPS50186. DEP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-294 (ISOFORM 1).
    Tissue: Urinary bladder.

Entry informationi

Entry nameiDEPD4_HUMAN
AccessioniPrimary (citable) accession number: Q8N2C3
Secondary accession number(s): Q496C8, Q96BW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.