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Q8N2C3 (DEPD4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DEP domain-containing protein 4
Gene names
Name:DEPDC4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 DEP domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular signal transduction

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N2C3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N2C3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     53-57: GCSGP → DQDMK
     58-294: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294DEP domain-containing protein 4
PRO_0000284783

Regions

Domain71 – 16292DEP

Natural variations

Alternative sequence53 – 575GCSGP → DQDMK in isoform 2.
VSP_024646
Alternative sequence58 – 294237Missing in isoform 2.
VSP_024647
Natural variant1221H → R.
Corresponds to variant rs7307415 [ dbSNP | Ensembl ].
VAR_031815

Experimental info

Sequence conflict341L → G in AAH15117. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 0073B8E83402EA43

FASTA29433,694
        10         20         30         40         50         60 
MVPGEEPARE LMAVLLTPRF RRLVSQNELP GPGLNGPSSR NRRDGFCRKR RTGCSGPFQA 

        70         80         90        100        110        120 
TQLWDGIIHS LQAQVEIKRR RHHLQTYKDC FTGSDAVDVV LSHLMQNTCL SSNDISCLKG 

       130        140        150        160        170        180 
VHLCQVLMNH KVFEPVGMKK LFKKEKELEF EDSNISLYRF LGNKSSYDCC KRQKDAENEF 

       190        200        210        220        230        240 
NETLRPGYEM ISNPLAQEIG EERIEELIHT INGNPALCPN ITVQKPFLRL SKEDVWKEQT 

       250        260        270        280        290 
LLCLLQLIHL PFLDNILEPP VKTQNLQLNK EEDLVITNTC LDRELIPSLC LPEK 

« Hide

Isoform 2 [UniParc].

Checksum: 5377D7B9ABAA55E2
Show »

FASTA576,538

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Amygdala.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-294 (ISOFORM 1).
Tissue: Urinary bladder.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK090824 mRNA. Translation: BAC03525.1.
BC015117 mRNA. Translation: AAH15117.1.
BC100929 mRNA. Translation: AAI00930.1.
CCDSCCDS9075.1. [Q8N2C3-1]
RefSeqNP_689530.1. NM_152317.2. [Q8N2C3-1]
UniGeneHs.653118.

3D structure databases

ProteinModelPortalQ8N2C3.
SMRQ8N2C3. Positions 52-160.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000367490.

PTM databases

PhosphoSiteQ8N2C3.

Polymorphism databases

DMDM74728709.

Proteomic databases

PaxDbQ8N2C3.
PRIDEQ8N2C3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299185; ENSP00000299185; ENSG00000166153. [Q8N2C3-2]
ENST00000378244; ENSP00000367490; ENSG00000166153. [Q8N2C3-1]
ENST00000416321; ENSP00000396234; ENSG00000166153. [Q8N2C3-1]
ENST00000549341; ENSP00000447392; ENSG00000166153. [Q8N2C3-2]
GeneID120863.
KEGGhsa:120863.
UCSCuc001thi.3. human. [Q8N2C3-1]

Organism-specific databases

CTD120863.
GeneCardsGC12M100597.
HGNCHGNC:22952. DEPDC4.
HPAHPA039323.
neXtProtNX_Q8N2C3.
PharmGKBPA134981607.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42573.
HOGENOMHOG000112195.
HOVERGENHBG098176.
OrthoDBEOG715Q5C.
PhylomeDBQ8N2C3.

Gene expression databases

ArrayExpressQ8N2C3.
BgeeQ8N2C3.
CleanExHS_DEPDC4.
GenevestigatorQ8N2C3.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR000591. DEP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00610. DEP. 1 hit.
[Graphical view]
SMARTSM00049. DEP. 1 hit.
[Graphical view]
PROSITEPS50186. DEP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi120863.
NextBio80634.
PROQ8N2C3.

Entry information

Entry nameDEPD4_HUMAN
AccessionPrimary (citable) accession number: Q8N2C3
Secondary accession number(s): Q496C8, Q96BW0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM