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Q8N2C3

- DEPD4_HUMAN

UniProt

Q8N2C3 - DEPD4_HUMAN

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Protein
DEP domain-containing protein 4
Gene
DEPDC4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
DEP domain-containing protein 4
Gene namesi
Name:DEPDC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:22952. DEPDC4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294DEP domain-containing protein 4
PRO_0000284783Add
BLAST

Proteomic databases

PaxDbiQ8N2C3.
PRIDEiQ8N2C3.

PTM databases

PhosphoSiteiQ8N2C3.

Expressioni

Gene expression databases

ArrayExpressiQ8N2C3.
BgeeiQ8N2C3.
CleanExiHS_DEPDC4.
GenevestigatoriQ8N2C3.

Organism-specific databases

HPAiHPA039323.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367490.

Structurei

3D structure databases

ProteinModelPortaliQ8N2C3.
SMRiQ8N2C3. Positions 52-160.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 16292DEP
Add
BLAST

Sequence similaritiesi

Contains 1 DEP domain.

Phylogenomic databases

eggNOGiNOG42573.
HOGENOMiHOG000112195.
HOVERGENiHBG098176.
OrthoDBiEOG715Q5C.
PhylomeDBiQ8N2C3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
PROSITEiPS50186. DEP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N2C3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVPGEEPARE LMAVLLTPRF RRLVSQNELP GPGLNGPSSR NRRDGFCRKR    50
RTGCSGPFQA TQLWDGIIHS LQAQVEIKRR RHHLQTYKDC FTGSDAVDVV 100
LSHLMQNTCL SSNDISCLKG VHLCQVLMNH KVFEPVGMKK LFKKEKELEF 150
EDSNISLYRF LGNKSSYDCC KRQKDAENEF NETLRPGYEM ISNPLAQEIG 200
EERIEELIHT INGNPALCPN ITVQKPFLRL SKEDVWKEQT LLCLLQLIHL 250
PFLDNILEPP VKTQNLQLNK EEDLVITNTC LDRELIPSLC LPEK 294
Length:294
Mass (Da):33,694
Last modified:October 1, 2002 - v1
Checksum:i0073B8E83402EA43
GO
Isoform 2 (identifier: Q8N2C3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-57: GCSGP → DQDMK
     58-294: Missing.

Note: No experimental confirmation available.

Show »
Length:57
Mass (Da):6,538
Checksum:i5377D7B9ABAA55E2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221H → R.
Corresponds to variant rs7307415 [ dbSNP | Ensembl ].
VAR_031815

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei53 – 575GCSGP → DQDMK in isoform 2.
VSP_024646
Alternative sequencei58 – 294237Missing in isoform 2.
VSP_024647Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341L → G in AAH15117. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090824 mRNA. Translation: BAC03525.1.
BC015117 mRNA. Translation: AAH15117.1.
BC100929 mRNA. Translation: AAI00930.1.
CCDSiCCDS9075.1. [Q8N2C3-1]
RefSeqiNP_689530.1. NM_152317.2. [Q8N2C3-1]
UniGeneiHs.653118.

Genome annotation databases

EnsembliENST00000299185; ENSP00000299185; ENSG00000166153. [Q8N2C3-2]
ENST00000378244; ENSP00000367490; ENSG00000166153. [Q8N2C3-1]
ENST00000416321; ENSP00000396234; ENSG00000166153. [Q8N2C3-1]
ENST00000549341; ENSP00000447392; ENSG00000166153. [Q8N2C3-2]
GeneIDi120863.
KEGGihsa:120863.
UCSCiuc001thi.3. human. [Q8N2C3-1]

Polymorphism databases

DMDMi74728709.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090824 mRNA. Translation: BAC03525.1 .
BC015117 mRNA. Translation: AAH15117.1 .
BC100929 mRNA. Translation: AAI00930.1 .
CCDSi CCDS9075.1. [Q8N2C3-1 ]
RefSeqi NP_689530.1. NM_152317.2. [Q8N2C3-1 ]
UniGenei Hs.653118.

3D structure databases

ProteinModelPortali Q8N2C3.
SMRi Q8N2C3. Positions 52-160.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000367490.

PTM databases

PhosphoSitei Q8N2C3.

Polymorphism databases

DMDMi 74728709.

Proteomic databases

PaxDbi Q8N2C3.
PRIDEi Q8N2C3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000299185 ; ENSP00000299185 ; ENSG00000166153 . [Q8N2C3-2 ]
ENST00000378244 ; ENSP00000367490 ; ENSG00000166153 . [Q8N2C3-1 ]
ENST00000416321 ; ENSP00000396234 ; ENSG00000166153 . [Q8N2C3-1 ]
ENST00000549341 ; ENSP00000447392 ; ENSG00000166153 . [Q8N2C3-2 ]
GeneIDi 120863.
KEGGi hsa:120863.
UCSCi uc001thi.3. human. [Q8N2C3-1 ]

Organism-specific databases

CTDi 120863.
GeneCardsi GC12M100597.
HGNCi HGNC:22952. DEPDC4.
HPAi HPA039323.
neXtProti NX_Q8N2C3.
PharmGKBi PA134981607.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42573.
HOGENOMi HOG000112195.
HOVERGENi HBG098176.
OrthoDBi EOG715Q5C.
PhylomeDBi Q8N2C3.

Miscellaneous databases

GenomeRNAii 120863.
NextBioi 80634.
PROi Q8N2C3.

Gene expression databases

ArrayExpressi Q8N2C3.
Bgeei Q8N2C3.
CleanExi HS_DEPDC4.
Genevestigatori Q8N2C3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00610. DEP. 1 hit.
[Graphical view ]
SMARTi SM00049. DEP. 1 hit.
[Graphical view ]
PROSITEi PS50186. DEP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-294 (ISOFORM 1).
    Tissue: Urinary bladder.

Entry informationi

Entry nameiDEPD4_HUMAN
AccessioniPrimary (citable) accession number: Q8N2C3
Secondary accession number(s): Q496C8, Q96BW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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