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Q8N2C3

- DEPD4_HUMAN

UniProt

Q8N2C3 - DEPD4_HUMAN

Protein

DEP domain-containing protein 4

Gene

DEPDC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DEP domain-containing protein 4
    Gene namesi
    Name:DEPDC4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:22952. DEPDC4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134981607.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294DEP domain-containing protein 4PRO_0000284783Add
    BLAST

    Proteomic databases

    PaxDbiQ8N2C3.
    PRIDEiQ8N2C3.

    PTM databases

    PhosphoSiteiQ8N2C3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N2C3.
    BgeeiQ8N2C3.
    CleanExiHS_DEPDC4.
    GenevestigatoriQ8N2C3.

    Organism-specific databases

    HPAiHPA039323.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000367490.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N2C3.
    SMRiQ8N2C3. Positions 52-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini71 – 16292DEPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DEP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG42573.
    HOGENOMiHOG000112195.
    HOVERGENiHBG098176.
    OrthoDBiEOG715Q5C.
    PhylomeDBiQ8N2C3.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00610. DEP. 1 hit.
    [Graphical view]
    SMARTiSM00049. DEP. 1 hit.
    [Graphical view]
    PROSITEiPS50186. DEP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N2C3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPGEEPARE LMAVLLTPRF RRLVSQNELP GPGLNGPSSR NRRDGFCRKR    50
    RTGCSGPFQA TQLWDGIIHS LQAQVEIKRR RHHLQTYKDC FTGSDAVDVV 100
    LSHLMQNTCL SSNDISCLKG VHLCQVLMNH KVFEPVGMKK LFKKEKELEF 150
    EDSNISLYRF LGNKSSYDCC KRQKDAENEF NETLRPGYEM ISNPLAQEIG 200
    EERIEELIHT INGNPALCPN ITVQKPFLRL SKEDVWKEQT LLCLLQLIHL 250
    PFLDNILEPP VKTQNLQLNK EEDLVITNTC LDRELIPSLC LPEK 294
    Length:294
    Mass (Da):33,694
    Last modified:October 1, 2002 - v1
    Checksum:i0073B8E83402EA43
    GO
    Isoform 2 (identifier: Q8N2C3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         53-57: GCSGP → DQDMK
         58-294: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:57
    Mass (Da):6,538
    Checksum:i5377D7B9ABAA55E2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 341L → G in AAH15117. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti122 – 1221H → R.
    Corresponds to variant rs7307415 [ dbSNP | Ensembl ].
    VAR_031815

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei53 – 575GCSGP → DQDMK in isoform 2. 1 PublicationVSP_024646
    Alternative sequencei58 – 294237Missing in isoform 2. 1 PublicationVSP_024647Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090824 mRNA. Translation: BAC03525.1.
    BC015117 mRNA. Translation: AAH15117.1.
    BC100929 mRNA. Translation: AAI00930.1.
    CCDSiCCDS9075.1. [Q8N2C3-1]
    RefSeqiNP_689530.1. NM_152317.2. [Q8N2C3-1]
    UniGeneiHs.653118.

    Genome annotation databases

    EnsembliENST00000299185; ENSP00000299185; ENSG00000166153. [Q8N2C3-2]
    ENST00000378244; ENSP00000367490; ENSG00000166153. [Q8N2C3-1]
    ENST00000416321; ENSP00000396234; ENSG00000166153. [Q8N2C3-1]
    ENST00000549341; ENSP00000447392; ENSG00000166153. [Q8N2C3-2]
    GeneIDi120863.
    KEGGihsa:120863.
    UCSCiuc001thi.3. human. [Q8N2C3-1]

    Polymorphism databases

    DMDMi74728709.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090824 mRNA. Translation: BAC03525.1 .
    BC015117 mRNA. Translation: AAH15117.1 .
    BC100929 mRNA. Translation: AAI00930.1 .
    CCDSi CCDS9075.1. [Q8N2C3-1 ]
    RefSeqi NP_689530.1. NM_152317.2. [Q8N2C3-1 ]
    UniGenei Hs.653118.

    3D structure databases

    ProteinModelPortali Q8N2C3.
    SMRi Q8N2C3. Positions 52-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000367490.

    PTM databases

    PhosphoSitei Q8N2C3.

    Polymorphism databases

    DMDMi 74728709.

    Proteomic databases

    PaxDbi Q8N2C3.
    PRIDEi Q8N2C3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299185 ; ENSP00000299185 ; ENSG00000166153 . [Q8N2C3-2 ]
    ENST00000378244 ; ENSP00000367490 ; ENSG00000166153 . [Q8N2C3-1 ]
    ENST00000416321 ; ENSP00000396234 ; ENSG00000166153 . [Q8N2C3-1 ]
    ENST00000549341 ; ENSP00000447392 ; ENSG00000166153 . [Q8N2C3-2 ]
    GeneIDi 120863.
    KEGGi hsa:120863.
    UCSCi uc001thi.3. human. [Q8N2C3-1 ]

    Organism-specific databases

    CTDi 120863.
    GeneCardsi GC12M100597.
    HGNCi HGNC:22952. DEPDC4.
    HPAi HPA039323.
    neXtProti NX_Q8N2C3.
    PharmGKBi PA134981607.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42573.
    HOGENOMi HOG000112195.
    HOVERGENi HBG098176.
    OrthoDBi EOG715Q5C.
    PhylomeDBi Q8N2C3.

    Miscellaneous databases

    GenomeRNAii 120863.
    NextBioi 80634.
    PROi Q8N2C3.

    Gene expression databases

    ArrayExpressi Q8N2C3.
    Bgeei Q8N2C3.
    CleanExi HS_DEPDC4.
    Genevestigatori Q8N2C3.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00610. DEP. 1 hit.
    [Graphical view ]
    SMARTi SM00049. DEP. 1 hit.
    [Graphical view ]
    PROSITEi PS50186. DEP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-294 (ISOFORM 1).
      Tissue: Urinary bladder.

    Entry informationi

    Entry nameiDEPD4_HUMAN
    AccessioniPrimary (citable) accession number: Q8N2C3
    Secondary accession number(s): Q496C8, Q96BW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3