Q8N2C3 (DEPD4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DEP domain-containing protein 4

Gene names

Name:

DEPDC4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 DEP domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N2C3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N2C3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     53-57: GCSGP → DQDMK
     58-294: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	DEP domain-containing protein 4		PRO_0000284783
Regions
	Domain	71 – 162	92	DEP
Natural variations
	Alternative sequence	53 – 57	5	GCSGP → DQDMK in isoform 2.		VSP_024646
	Alternative sequence	58 – 294	237	Missing in isoform 2.		VSP_024647
	Natural variant	122	1	H → R. Corresponds to variant rs7307415 [ dbSNP | Ensembl ].		VAR_031815
Experimental info
	Sequence conflict	34	1	L → G in AAH15117. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 0073B8E83402EA43	FASTA	294	33,694
	10 20 30 40 50 60 MVPGEEPARE LMAVLLTPRF RRLVSQNELP GPGLNGPSSR NRRDGFCRKR RTGCSGPFQA 70 80 90 100 110 120 TQLWDGIIHS LQAQVEIKRR RHHLQTYKDC FTGSDAVDVV LSHLMQNTCL SSNDISCLKG 130 140 150 160 170 180 VHLCQVLMNH KVFEPVGMKK LFKKEKELEF EDSNISLYRF LGNKSSYDCC KRQKDAENEF 190 200 210 220 230 240 NETLRPGYEM ISNPLAQEIG EERIEELIHT INGNPALCPN ITVQKPFLRL SKEDVWKEQT 250 260 270 280 290 LLCLLQLIHL PFLDNILEPP VKTQNLQLNK EEDLVITNTC LDRELIPSLC LPEK
	Isoform 2 [UniParc]. Checksum: 5377D7B9ABAA55E2	FASTA	57	6,538
	10 20 30 40 50 MVPGEEPARE LMAVLLTPRF RRLVSQNELP GPGLNGPSSR NRRDGFCRKR RTDQDMK

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Amygdala.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-294 (ISOFORM 1). Tissue: Urinary bladder.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK090824 mRNA. Translation: BAC03525.1. BC015117 mRNA. Translation: AAH15117.1. BC100929 mRNA. Translation: AAI00930.1.
IPI	IPI00166375. IPI00640879.
RefSeq	NP_689530.1. NM_152317.2.
UniGene	Hs.653118.
3D structure databases
ProteinModelPortal	Q8N2C3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000367490.
PTM databases
PhosphoSite	Q8N2C3.
Polymorphism databases
DMDM	74728709.
Proteomic databases
PaxDb	Q8N2C3.
PRIDE	Q8N2C3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299185; ENSP00000299185; ENSG00000166153. ENST00000378244; ENSP00000367490; ENSG00000166153. ENST00000416321; ENSP00000396234; ENSG00000166153. ENST00000549341; ENSP00000447392; ENSG00000166153.
GeneID	120863.
KEGG	hsa:120863.
UCSC	uc001thi.3. human.
Organism-specific databases
CTD	120863.
GeneCards	GC12M100597.
HGNC	HGNC:22952. DEPDC4.
HPA	HPA039323.
neXtProt	NX_Q8N2C3.
PharmGKB	PA134981607.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42573.
HOGENOM	HOG000112195.
HOVERGEN	HBG098176.
PhylomeDB	Q8N2C3.
Gene expression databases
ArrayExpress	Q8N2C3.
Bgee	Q8N2C3.
CleanEx	HS_DEPDC4.
Genevestigator	Q8N2C3.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR000591. DEP_dom. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00610. DEP. 1 hit. [Graphical view]
SMART	SM00049. DEP. 1 hit. [Graphical view]
PROSITE	PS50186. DEP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	120863.
NextBio	80634.

Entry information

Entry name

DEPD4_HUMAN

Accession

Primary (citable) accession number: Q8N2C3
Secondary accession number(s): Q496C8, Q96BW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.