ID   PLD6_HUMAN              Reviewed;         252 AA.
AC   Q8N2A8; Q8N5Y1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   07-JUL-2009, entry version 45.
DE   RecName: Full=Phospholipase D6;
DE            Short=PLD 6;
DE            EC=3.1.4.4;
DE   AltName: Full=Choline phosphatase 6;
DE   AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D6;
GN   Name=PLD6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Amygdala;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PRO-42 AND
RP   HIS-108.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: A phosphatidylcholine + H(2)O = choline + a
CC       phosphatidate.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the Phospholipase D family.
CC   -!- SIMILARITY: Contains 1 PLD phosphodiesterase domain.
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DR   EMBL; AK090899; BAC03541.1; -; mRNA.
DR   EMBL; BC031263; AAH31263.1; -; mRNA.
DR   IPI; IPI00251454; -.
DR   RefSeq; NP_849158.1; -.
DR   UniGene; Hs.31652; -.
DR   HSSP; Q46707; 1BYR.
DR   PRIDE; Q8N2A8; -.
DR   Ensembl; ENSG00000179598; Homo sapiens.
DR   GeneID; 201164; -.
DR   KEGG; hsa:201164; -.
DR   UCSC; uc002gqz.1; human.
DR   GeneCards; GC17M017048; -.
DR   HGNC; HGNC:30447; PLD6.
DR   HOGENOM; Q8N2A8; -.
DR   HOVERGEN; Q8N2A8; -.
DR   OMA; Q8N2A8; FPSQVTC.
DR   BRENDA; 3.1.4.4; 247.
DR   NextBio; 90067; -.
DR   ArrayExpress; Q8N2A8; -.
DR   Bgee; Q8N2A8; -.
DR   CleanEx; HS_PLD6; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070290; F:NAPE-specific phospholipase D activity; IEA:EC.
DR   GO; GO:0004630; F:phospholipase D activity; IEA:EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   Pfam; PF00614; PLDc; 1.
DR   SMART; SM00155; PLDc; 1.
DR   PROSITE; PS50035; PLD; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Hydrolase; Lipid degradation;
KW   Membrane; Polymorphism; Transmembrane.
FT   CHAIN         1    252       Phospholipase D6.
FT                                /FTId=PRO_0000325910.
FT   TRANSMEM      5     27       Potential.
FT   DOMAIN      151    178       PLD phosphodiesterase.
FT   ACT_SITE    156    156       Potential.
FT   ACT_SITE    158    158       Potential.
FT   ACT_SITE    163    163       Potential.
FT   CARBOHYD    132    132       N-linked (GlcNAc...) (Potential).
FT   VARIANT      42     42       L -> P (in dbSNP:rs17856924).
FT                                /FTId=VAR_039951.
FT   VARIANT     108    108       R -> H (in dbSNP:rs11551966).
FT                                /FTId=VAR_039952.
SQ   SEQUENCE   252 AA;  28273 MW;  CE3A205C1D42B497 CRC64;
     MGRLSWQVAA AAAVGLALTL EALPWVLRWL RSRRRRPRRE ALFFPSQVTC TEALLRAPGA
     ELAELPEGCP CGLPHGESAL SRLLRALLAA RASLDLCLFA FSSPQLGRAV QLLHQRGVRV
     RVVTDCDYMA LNGSQIGLLR KAGIQVRHDQ DPGYMHHKFA IVDKRVLITG SLNWTTQAIQ
     NNRENVLITE DDEYVRLFLE EFERIWEQFN PTKYTFFPPK KSHGSCAPPV SRAGGRLLSW
     HRTCGTSSES QT
//