Reviewed,
UniProtKB/Swiss-Prot Q8N2A8 (PLD6_HUMAN)
Last modified
June 16, 2009.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phospholipase D6 Short name=PLD 6 EC=3.1.4.4 Alternative name(s): Choline phosphatase 6 Phosphatidylcholine-hydrolyzing phospholipase D6 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 252 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | A phosphatidylcholine + H2O = choline + a phosphatidate. |
| Subcellular location | Membrane; Single-pass membrane protein Potential. |
| Sequence similarities | Belongs to the Phospholipase D family. Contains 1 PLD phosphodiesterase domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid degradation |
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane |
| Molecular function | Hydrolase |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phospholipase D activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 252 | 252 | Phospholipase D6 | PRO_0000325910 | |||||
Regions | |||||||||
| Transmembrane | 5 – 27 | 23 | Potential | ||||||
| Domain | 151 – 178 | 28 | PLD phosphodiesterase | ||||||
Sites | |||||||||
| Active site | 156 | 1 | Potential | ||||||
| Active site | 158 | 1 | Potential | ||||||
| Active site | 163 | 1 | Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 132 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 42 | 1 | L → P: dbSNP rs17856924. Ref.2 | VAR_039951 | |||||
| Natural variant | 108 | 1 | R → H: dbSNP rs11551966. Ref.2 | VAR_039952 | |||||
Sequences
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References
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Amygdala. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-42 AND HIS-108. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| AK090899 mRNA. Translation: BAC03541.1. BC031263 mRNA. Translation: AAH31263.1. | |
| IPI | IPI00251454. |
| RefSeq | NP_849158.1. |
| UniGene | Hs.31652 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BYR based on UniProtKB Q46707. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q8N2A8. |
Genome annotation databases | |
| Ensembl | ENSG00000179598. Homo sapiens. [Contig view] |
| GeneID | 201164. |
| KEGG | hsa:201164. |
Organism-specific databases | |
| GeneCards | GC17M017048. |
| HGNC | HGNC:30447. PLD6. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q8N2A8. |
| HOVERGEN | Q8N2A8. |
| OMA | Q8N2A8. FPSQVTC. |
Enzyme and pathway databases | |
| BRENDA | 3.1.4.4. 247. |
Gene expression databases | |
| ArrayExpress | Q8N2A8. |
| Bgee | Q8N2A8. |
| CleanEx | HS_PLD6. |
Family and domain databases | |
| InterPro | IPR001736. PLipase_D/transphosphatidylase. [Graphical view] |
| Pfam | PF00614. PLDc. 1 hit. [Graphical view] |
| SMART | SM00155. PLDc. 1 hit. [Graphical view] |
| PROSITE | PS50035. PLD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 90067. |
Entry information
| Entry name | PLD6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8N2A8 Secondary accession number(s): Q8N5Y1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with


