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Reviewed, UniProtKB/Swiss-Prot Q8N2A8 (PLD6_HUMAN)

Last modified June 16, 2009. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Phospholipase D6
      Short name=PLD 6
    EC=3.1.4.4
Alternative name(s):
    Choline phosphatase 6
    Phosphatidylcholine-hydrolyzing phospholipase D6
Gene names
Name: PLD6
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

A phosphatidylcholine + H2O = choline + a phosphatidate.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the Phospholipase D family.

Contains 1 PLD phosphodiesterase domain.

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Ontologies

Keywords
   Biological processLipid degradation
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
   Molecular functionHydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNAPE-specific phospholipase D activity

Inferred from electronic annotation. Source: EC

phospholipase D activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Phospholipase D6
PRO_0000325910

Regions

Transmembrane5 – 2723 Potential
Domain151 – 17828PLD phosphodiesterase

Sites

Active site1561 Potential
Active site1581 Potential
Active site1631 Potential

Amino acid modifications

Glycosylation1321N-linked (GlcNAc...) Potential

Natural variations

Natural variant421L → P: dbSNP rs17856924. Ref.2
VAR_039951
Natural variant1081R → H: dbSNP rs11551966. Ref.2
VAR_039952

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Sequences

Sequence LengthMass (Da)Tools
Q8N2A8-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: CE3A205C1D42B497

FASTA25228,273
        10         20         30         40         50         60 
MGRLSWQVAA AAAVGLALTL EALPWVLRWL RSRRRRPRRE ALFFPSQVTC TEALLRAPGA 

        70         80         90        100        110        120 
ELAELPEGCP CGLPHGESAL SRLLRALLAA RASLDLCLFA FSSPQLGRAV QLLHQRGVRV 

       130        140        150        160        170        180 
RVVTDCDYMA LNGSQIGLLR KAGIQVRHDQ DPGYMHHKFA IVDKRVLITG SLNWTTQAIQ 

       190        200        210        220        230        240 
NNRENVLITE DDEYVRLFLE EFERIWEQFN PTKYTFFPPK KSHGSCAPPV SRAGGRLLSW 

       250 
HRTCGTSSES QT

« Hide

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References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-42 AND HIS-108.
Tissue: Brain.

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Cross-references

Sequence databases

AK090899 mRNA. Translation: BAC03541.1.
BC031263 mRNA. Translation: AAH31263.1.
IPIIPI00251454.
RefSeqNP_849158.1.
UniGeneHs.31652

3D structure databases

HSSPHSSP built from PDB template 1BYR based on UniProtKB Q46707.
ModBaseSearch...

Proteomic databases

PRIDEQ8N2A8.

Genome annotation databases

EnsemblENSG00000179598. Homo sapiens. [Contig view]
GeneID201164.
KEGGhsa:201164.

Organism-specific databases

GeneCardsGC17M017048.
HGNCHGNC:30447. PLD6.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ8N2A8.
HOVERGENQ8N2A8.
OMAQ8N2A8. FPSQVTC.

Enzyme and pathway databases

BRENDA3.1.4.4. 247.

Gene expression databases

ArrayExpressQ8N2A8.
BgeeQ8N2A8.
CleanExHS_PLD6.

Family and domain databases

InterProIPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamPF00614. PLDc. 1 hit.
[Graphical view]
SMARTSM00155. PLDc. 1 hit.
[Graphical view]
PROSITEPS50035. PLD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio90067.

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Entry information

Entry namePLD6_HUMAN
AccessionPrimary (citable) accession number: Q8N2A8
Secondary accession number(s): Q8N5Y1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents