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Q8N283

- ANR35_HUMAN

UniProt

Q8N283 - ANR35_HUMAN

Protein

Ankyrin repeat domain-containing protein 35

Gene

ANKRD35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (27 Jun 2006)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat domain-containing protein 35
    Gene namesi
    Name:ANKRD35
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26323. ANKRD35.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134896362.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10011001Ankyrin repeat domain-containing protein 35PRO_0000243910Add
    BLAST

    Proteomic databases

    MaxQBiQ8N283.
    PaxDbiQ8N283.
    PRIDEiQ8N283.

    PTM databases

    PhosphoSiteiQ8N283.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N283.
    BgeeiQ8N283.
    CleanExiHS_ANKRD35.
    GenevestigatoriQ8N283.

    Organism-specific databases

    HPAiHPA035452.
    HPA035453.

    Interactioni

    Protein-protein interaction databases

    BioGridi127165. 2 interactions.
    IntActiQ8N283. 7 interactions.
    MINTiMINT-8247627.
    STRINGi9606.ENSP00000347802.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N283.
    SMRiQ8N283. Positions 19-233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati53 – 8230ANK 1Add
    BLAST
    Repeati86 – 11530ANK 2Add
    BLAST
    Repeati119 – 14830ANK 3Add
    BLAST
    Repeati152 – 18130ANK 4Add
    BLAST
    Repeati185 – 21430ANK 5Add
    BLAST
    Repeati218 – 24730ANK 6Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili295 – 34450Sequence AnalysisAdd
    BLAST
    Coiled coili610 – 69687Sequence AnalysisAdd
    BLAST
    Coiled coili733 – 81078Sequence AnalysisAdd
    BLAST
    Coiled coili851 – 968118Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi527 – 5337Poly-Ala

    Sequence similaritiesi

    Contains 6 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000033962.
    HOVERGENiHBG080850.
    InParanoidiQ8N283.
    OMAiERWNRRD.
    OrthoDBiEOG7X9G6C.
    PhylomeDBiQ8N283.
    TreeFamiTF331274.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 5 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N283-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRIFSCSST QVAVERWNRH DQKLLEAVHR GDVGRVAALA SRKSARPTKL     50
    DSNGQSPFHL AASKGLTECL TILLANGADI NSKNEDGSTA LHLATISCQP 100
    QCVKVLLQHG ANEDAVDAEN RSPLHWAASS GCASSVLLLC DHEAFLDVLD 150
    NDGRTPLMIA SLGGHAAICS QLLQRGARVN VTDKNDKSAL ILACEKGSAE 200
    VAELLLSHGA DAGAVDSTGH DALHYALHTQ DKALWRHLQQ ALSRRRRGGQ 250
    RLVQHPDLAS QASPSEPQAG SPPKSSWRAE PEEEQEEKED EDPCSEEWRW 300
    KYEEERRKVV RLEQELVQKT EECKTQAAAY LDLENQIREQ AQELGVLLSW 350
    EPRASGKQGS SLRPGGDGME QGCPKDLLAE STQELKKQQQ AAATVNPVLA 400
    PKKAEDSAPG KIQYEVHGRS QPEEQGPPQS PASETIRKAT GQQLTTNGAQ 450
    TFGPDHADQL PAGQKESSQV LGVEPGGTVA EPVGPAAMNQ LLLQLREELA 500
    AVWREKDAAR GALSRPVMEG ALGTPRAEAA AAAWEKMEAR LERVLARLEW 550
    AKAGLQVKPE VPSQESREGA LKAAPGSIKQ DEEKEKRVPG ARGEPLGALG 600
    GEKALGGLAK GQLEKEMSVL RLSNSNLLEE LGELGRERQR LQRELQSLSQ 650
    RLQREFVPKP EAQVQLQQLR QSVGLLTNEL AMEKEATEKL RKLLASQSSG 700
    LRGLWDCLPA DLVGERSAQS KAAESLEELR ACISTLVDRH REAQQVLARL 750
    QEENQQLRGS LSPCREPGTS LKAPASPQVA ALEQDLGKLE EELRAVQATM 800
    SGKSQEIGKL KQLLYQATEE VAELRAREAA SLRQHEKTRG SLVAQAQAWG 850
    QELKALLEKY NTACREVGRL REAVAEERRR SGDLAAQAAE QERQASEMRG 900
    RSEQFEKTAE LLKEKMEHLI GACRDKEAKI KELLKKLEQL SEEVLAIRGE 950
    NARLALQLQD SQKNHEEIIS TYRNHLLNAA RGYMEHEVYN ILLQILSMEE 1000
    E 1001
    Length:1,001
    Mass (Da):109,966
    Last modified:June 27, 2006 - v2
    Checksum:iFA7B90CF32E3F842
    GO

    Sequence cautioni

    The sequence BAB71597.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti188 – 1881S → A in BAB71597. (PubMed:14702039)Curated
    Sequence conflicti820 – 8201E → G in BAC03587. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531N → K.
    Corresponds to variant rs6658371 [ dbSNP | Ensembl ].
    VAR_048278
    Natural varianti428 – 4281P → S.2 Publications
    Corresponds to variant rs6670984 [ dbSNP | Ensembl ].
    VAR_026870
    Natural varianti592 – 5921R → Q.
    Corresponds to variant rs41315701 [ dbSNP | Ensembl ].
    VAR_061017
    Natural varianti978 – 9781N → D.
    Corresponds to variant rs16827032 [ dbSNP | Ensembl ].
    VAR_033506

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057853 mRNA. Translation: BAB71597.1. Different initiation.
    AK091120 mRNA. Translation: BAC03587.1.
    AL160282 Genomic DNA. No translation available.
    BC101618 mRNA. Translation: AAI01619.1.
    BC101620 mRNA. Translation: AAI01621.1.
    CCDSiCCDS919.1.
    RefSeqiNP_653299.4. NM_144698.4.
    UniGeneiHs.710624.

    Genome annotation databases

    EnsembliENST00000355594; ENSP00000347802; ENSG00000198483.
    GeneIDi148741.
    KEGGihsa:148741.
    UCSCiuc001eob.1. human.

    Polymorphism databases

    DMDMi109940222.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057853 mRNA. Translation: BAB71597.1 . Different initiation.
    AK091120 mRNA. Translation: BAC03587.1 .
    AL160282 Genomic DNA. No translation available.
    BC101618 mRNA. Translation: AAI01619.1 .
    BC101620 mRNA. Translation: AAI01621.1 .
    CCDSi CCDS919.1.
    RefSeqi NP_653299.4. NM_144698.4.
    UniGenei Hs.710624.

    3D structure databases

    ProteinModelPortali Q8N283.
    SMRi Q8N283. Positions 19-233.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127165. 2 interactions.
    IntActi Q8N283. 7 interactions.
    MINTi MINT-8247627.
    STRINGi 9606.ENSP00000347802.

    PTM databases

    PhosphoSitei Q8N283.

    Polymorphism databases

    DMDMi 109940222.

    Proteomic databases

    MaxQBi Q8N283.
    PaxDbi Q8N283.
    PRIDEi Q8N283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355594 ; ENSP00000347802 ; ENSG00000198483 .
    GeneIDi 148741.
    KEGGi hsa:148741.
    UCSCi uc001eob.1. human.

    Organism-specific databases

    CTDi 148741.
    GeneCardsi GC01P145549.
    HGNCi HGNC:26323. ANKRD35.
    HPAi HPA035452.
    HPA035453.
    neXtProti NX_Q8N283.
    PharmGKBi PA134896362.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000033962.
    HOVERGENi HBG080850.
    InParanoidi Q8N283.
    OMAi ERWNRRD.
    OrthoDBi EOG7X9G6C.
    PhylomeDBi Q8N283.
    TreeFami TF331274.

    Miscellaneous databases

    GenomeRNAii 148741.
    NextBioi 85988.
    PROi Q8N283.

    Gene expression databases

    ArrayExpressi Q8N283.
    Bgeei Q8N283.
    CleanExi HS_ANKRD35.
    Genevestigatori Q8N283.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 5 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-428.
      Tissue: Brain and Tongue.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-428.
      Tissue: Heart and Lung.

    Entry informationi

    Entry nameiANR35_HUMAN
    AccessioniPrimary (citable) accession number: Q8N283
    Secondary accession number(s): A6NEU0, Q3MJ10, Q96LS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3