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Q8N283

- ANR35_HUMAN

UniProt

Q8N283 - ANR35_HUMAN

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Protein
Ankyrin repeat domain-containing protein 35
Gene
ANKRD35
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 35
Gene namesi
Name:ANKRD35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:26323. ANKRD35.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134896362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10011001Ankyrin repeat domain-containing protein 35
PRO_0000243910Add
BLAST

Proteomic databases

MaxQBiQ8N283.
PaxDbiQ8N283.
PRIDEiQ8N283.

PTM databases

PhosphoSiteiQ8N283.

Expressioni

Gene expression databases

ArrayExpressiQ8N283.
BgeeiQ8N283.
CleanExiHS_ANKRD35.
GenevestigatoriQ8N283.

Organism-specific databases

HPAiHPA035452.
HPA035453.

Interactioni

Protein-protein interaction databases

BioGridi127165. 2 interactions.
IntActiQ8N283. 7 interactions.
MINTiMINT-8247627.
STRINGi9606.ENSP00000347802.

Structurei

3D structure databases

ProteinModelPortaliQ8N283.
SMRiQ8N283. Positions 19-233.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati53 – 8230ANK 1
Add
BLAST
Repeati86 – 11530ANK 2
Add
BLAST
Repeati119 – 14830ANK 3
Add
BLAST
Repeati152 – 18130ANK 4
Add
BLAST
Repeati185 – 21430ANK 5
Add
BLAST
Repeati218 – 24730ANK 6
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili295 – 34450 Reviewed prediction
Add
BLAST
Coiled coili610 – 69687 Reviewed prediction
Add
BLAST
Coiled coili733 – 81078 Reviewed prediction
Add
BLAST
Coiled coili851 – 968118 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi527 – 5337Poly-Ala

Sequence similaritiesi

Contains 6 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000033962.
HOVERGENiHBG080850.
InParanoidiQ8N283.
OMAiERWNRRD.
OrthoDBiEOG7X9G6C.
PhylomeDBiQ8N283.
TreeFamiTF331274.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N283-1 [UniParc]FASTAAdd to Basket

« Hide

MKRIFSCSST QVAVERWNRH DQKLLEAVHR GDVGRVAALA SRKSARPTKL     50
DSNGQSPFHL AASKGLTECL TILLANGADI NSKNEDGSTA LHLATISCQP 100
QCVKVLLQHG ANEDAVDAEN RSPLHWAASS GCASSVLLLC DHEAFLDVLD 150
NDGRTPLMIA SLGGHAAICS QLLQRGARVN VTDKNDKSAL ILACEKGSAE 200
VAELLLSHGA DAGAVDSTGH DALHYALHTQ DKALWRHLQQ ALSRRRRGGQ 250
RLVQHPDLAS QASPSEPQAG SPPKSSWRAE PEEEQEEKED EDPCSEEWRW 300
KYEEERRKVV RLEQELVQKT EECKTQAAAY LDLENQIREQ AQELGVLLSW 350
EPRASGKQGS SLRPGGDGME QGCPKDLLAE STQELKKQQQ AAATVNPVLA 400
PKKAEDSAPG KIQYEVHGRS QPEEQGPPQS PASETIRKAT GQQLTTNGAQ 450
TFGPDHADQL PAGQKESSQV LGVEPGGTVA EPVGPAAMNQ LLLQLREELA 500
AVWREKDAAR GALSRPVMEG ALGTPRAEAA AAAWEKMEAR LERVLARLEW 550
AKAGLQVKPE VPSQESREGA LKAAPGSIKQ DEEKEKRVPG ARGEPLGALG 600
GEKALGGLAK GQLEKEMSVL RLSNSNLLEE LGELGRERQR LQRELQSLSQ 650
RLQREFVPKP EAQVQLQQLR QSVGLLTNEL AMEKEATEKL RKLLASQSSG 700
LRGLWDCLPA DLVGERSAQS KAAESLEELR ACISTLVDRH REAQQVLARL 750
QEENQQLRGS LSPCREPGTS LKAPASPQVA ALEQDLGKLE EELRAVQATM 800
SGKSQEIGKL KQLLYQATEE VAELRAREAA SLRQHEKTRG SLVAQAQAWG 850
QELKALLEKY NTACREVGRL REAVAEERRR SGDLAAQAAE QERQASEMRG 900
RSEQFEKTAE LLKEKMEHLI GACRDKEAKI KELLKKLEQL SEEVLAIRGE 950
NARLALQLQD SQKNHEEIIS TYRNHLLNAA RGYMEHEVYN ILLQILSMEE 1000
E 1001
Length:1,001
Mass (Da):109,966
Last modified:June 27, 2006 - v2
Checksum:iFA7B90CF32E3F842
GO

Sequence cautioni

The sequence BAB71597.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531N → K.
Corresponds to variant rs6658371 [ dbSNP | Ensembl ].
VAR_048278
Natural varianti428 – 4281P → S.2 Publications
Corresponds to variant rs6670984 [ dbSNP | Ensembl ].
VAR_026870
Natural varianti592 – 5921R → Q.
Corresponds to variant rs41315701 [ dbSNP | Ensembl ].
VAR_061017
Natural varianti978 – 9781N → D.
Corresponds to variant rs16827032 [ dbSNP | Ensembl ].
VAR_033506

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881S → A in BAB71597. 1 Publication
Sequence conflicti820 – 8201E → G in BAC03587. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057853 mRNA. Translation: BAB71597.1. Different initiation.
AK091120 mRNA. Translation: BAC03587.1.
AL160282 Genomic DNA. No translation available.
BC101618 mRNA. Translation: AAI01619.1.
BC101620 mRNA. Translation: AAI01621.1.
CCDSiCCDS919.1.
RefSeqiNP_653299.4. NM_144698.4.
UniGeneiHs.710624.

Genome annotation databases

EnsembliENST00000355594; ENSP00000347802; ENSG00000198483.
GeneIDi148741.
KEGGihsa:148741.
UCSCiuc001eob.1. human.

Polymorphism databases

DMDMi109940222.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057853 mRNA. Translation: BAB71597.1 . Different initiation.
AK091120 mRNA. Translation: BAC03587.1 .
AL160282 Genomic DNA. No translation available.
BC101618 mRNA. Translation: AAI01619.1 .
BC101620 mRNA. Translation: AAI01621.1 .
CCDSi CCDS919.1.
RefSeqi NP_653299.4. NM_144698.4.
UniGenei Hs.710624.

3D structure databases

ProteinModelPortali Q8N283.
SMRi Q8N283. Positions 19-233.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127165. 2 interactions.
IntActi Q8N283. 7 interactions.
MINTi MINT-8247627.
STRINGi 9606.ENSP00000347802.

PTM databases

PhosphoSitei Q8N283.

Polymorphism databases

DMDMi 109940222.

Proteomic databases

MaxQBi Q8N283.
PaxDbi Q8N283.
PRIDEi Q8N283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355594 ; ENSP00000347802 ; ENSG00000198483 .
GeneIDi 148741.
KEGGi hsa:148741.
UCSCi uc001eob.1. human.

Organism-specific databases

CTDi 148741.
GeneCardsi GC01P145549.
HGNCi HGNC:26323. ANKRD35.
HPAi HPA035452.
HPA035453.
neXtProti NX_Q8N283.
PharmGKBi PA134896362.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
HOGENOMi HOG000033962.
HOVERGENi HBG080850.
InParanoidi Q8N283.
OMAi ERWNRRD.
OrthoDBi EOG7X9G6C.
PhylomeDBi Q8N283.
TreeFami TF331274.

Miscellaneous databases

GenomeRNAii 148741.
NextBioi 85988.
PROi Q8N283.

Gene expression databases

ArrayExpressi Q8N283.
Bgeei Q8N283.
CleanExi HS_ANKRD35.
Genevestigatori Q8N283.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 2 hits.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 5 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-428.
    Tissue: Brain and Tongue.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-428.
    Tissue: Heart and Lung.

Entry informationi

Entry nameiANR35_HUMAN
AccessioniPrimary (citable) accession number: Q8N283
Secondary accession number(s): A6NEU0, Q3MJ10, Q96LS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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