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Protein

Ankyrin repeat domain-containing protein 35

Gene

ANKRD35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32739-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 35
Gene namesi
Name:ANKRD35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26323. ANKRD35.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134896362.

Polymorphism and mutation databases

DMDMi109940222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002439101 – 1001Ankyrin repeat domain-containing protein 35Add BLAST1001

Proteomic databases

EPDiQ8N283.
MaxQBiQ8N283.
PaxDbiQ8N283.
PeptideAtlasiQ8N283.
PRIDEiQ8N283.

PTM databases

iPTMnetiQ8N283.
PhosphoSitePlusiQ8N283.

Expressioni

Gene expression databases

BgeeiENSG00000198483.
CleanExiHS_ANKRD35.
ExpressionAtlasiQ8N283. baseline and differential.
GenevisibleiQ8N283. HS.

Organism-specific databases

HPAiHPA035452.
HPA035453.

Interactioni

Protein-protein interaction databases

BioGridi127165. 2 interactors.
IntActiQ8N283. 7 interactors.
MINTiMINT-8247627.
STRINGi9606.ENSP00000347802.

Structurei

3D structure databases

ProteinModelPortaliQ8N283.
SMRiQ8N283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 82ANK 1Add BLAST30
Repeati86 – 115ANK 2Add BLAST30
Repeati119 – 148ANK 3Add BLAST30
Repeati152 – 181ANK 4Add BLAST30
Repeati185 – 214ANK 5Add BLAST30
Repeati218 – 247ANK 6Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili295 – 344Sequence analysisAdd BLAST50
Coiled coili610 – 696Sequence analysisAdd BLAST87
Coiled coili733 – 810Sequence analysisAdd BLAST78
Coiled coili851 – 968Sequence analysisAdd BLAST118

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi527 – 533Poly-Ala7

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IK6X. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000033962.
HOVERGENiHBG080850.
InParanoidiQ8N283.
OrthoDBiEOG091G025R.
PhylomeDBiQ8N283.
TreeFamiTF331274.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N283-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRIFSCSST QVAVERWNRH DQKLLEAVHR GDVGRVAALA SRKSARPTKL
60 70 80 90 100
DSNGQSPFHL AASKGLTECL TILLANGADI NSKNEDGSTA LHLATISCQP
110 120 130 140 150
QCVKVLLQHG ANEDAVDAEN RSPLHWAASS GCASSVLLLC DHEAFLDVLD
160 170 180 190 200
NDGRTPLMIA SLGGHAAICS QLLQRGARVN VTDKNDKSAL ILACEKGSAE
210 220 230 240 250
VAELLLSHGA DAGAVDSTGH DALHYALHTQ DKALWRHLQQ ALSRRRRGGQ
260 270 280 290 300
RLVQHPDLAS QASPSEPQAG SPPKSSWRAE PEEEQEEKED EDPCSEEWRW
310 320 330 340 350
KYEEERRKVV RLEQELVQKT EECKTQAAAY LDLENQIREQ AQELGVLLSW
360 370 380 390 400
EPRASGKQGS SLRPGGDGME QGCPKDLLAE STQELKKQQQ AAATVNPVLA
410 420 430 440 450
PKKAEDSAPG KIQYEVHGRS QPEEQGPPQS PASETIRKAT GQQLTTNGAQ
460 470 480 490 500
TFGPDHADQL PAGQKESSQV LGVEPGGTVA EPVGPAAMNQ LLLQLREELA
510 520 530 540 550
AVWREKDAAR GALSRPVMEG ALGTPRAEAA AAAWEKMEAR LERVLARLEW
560 570 580 590 600
AKAGLQVKPE VPSQESREGA LKAAPGSIKQ DEEKEKRVPG ARGEPLGALG
610 620 630 640 650
GEKALGGLAK GQLEKEMSVL RLSNSNLLEE LGELGRERQR LQRELQSLSQ
660 670 680 690 700
RLQREFVPKP EAQVQLQQLR QSVGLLTNEL AMEKEATEKL RKLLASQSSG
710 720 730 740 750
LRGLWDCLPA DLVGERSAQS KAAESLEELR ACISTLVDRH REAQQVLARL
760 770 780 790 800
QEENQQLRGS LSPCREPGTS LKAPASPQVA ALEQDLGKLE EELRAVQATM
810 820 830 840 850
SGKSQEIGKL KQLLYQATEE VAELRAREAA SLRQHEKTRG SLVAQAQAWG
860 870 880 890 900
QELKALLEKY NTACREVGRL REAVAEERRR SGDLAAQAAE QERQASEMRG
910 920 930 940 950
RSEQFEKTAE LLKEKMEHLI GACRDKEAKI KELLKKLEQL SEEVLAIRGE
960 970 980 990 1000
NARLALQLQD SQKNHEEIIS TYRNHLLNAA RGYMEHEVYN ILLQILSMEE

E
Length:1,001
Mass (Da):109,966
Last modified:June 27, 2006 - v2
Checksum:iFA7B90CF32E3F842
GO
Isoform 2 (identifier: Q8N283-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-137: HGANEDAVDAENRSPLHWAASSGCASSVL → PPLAVPQVCSCCVTTKPSWTCWIMMDVHP
     138-1001: Missing.

Note: No experimental confirmation available.
Show »
Length:137
Mass (Da):14,894
Checksum:i47DCC2F764124DE8
GO

Sequence cautioni

The sequence BAB71597 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188S → A in BAB71597 (PubMed:14702039).Curated1
Sequence conflicti820E → G in BAC03587 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04827853N → K.Corresponds to variant rs6658371dbSNPEnsembl.1
Natural variantiVAR_026870428P → S.2 PublicationsCorresponds to variant rs6670984dbSNPEnsembl.1
Natural variantiVAR_061017592R → Q.Corresponds to variant rs41315701dbSNPEnsembl.1
Natural variantiVAR_033506978N → D.Corresponds to variant rs16827032dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056916109 – 137HGANE…ASSVL → PPLAVPQVCSCCVTTKPSWT CWIMMDVHP in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_056917138 – 1001Missing in isoform 2. 1 PublicationAdd BLAST864

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057853 mRNA. Translation: BAB71597.1. Different initiation.
AK091120 mRNA. Translation: BAC03587.1.
AK296861 mRNA. Translation: BAG59424.1.
AL160282 Genomic DNA. No translation available.
BC101618 mRNA. Translation: AAI01619.1.
BC101620 mRNA. Translation: AAI01621.1.
CCDSiCCDS72867.1. [Q8N283-1]
RefSeqiNP_653299.4. NM_144698.4.
UniGeneiHs.710624.

Genome annotation databases

EnsembliENST00000355594; ENSP00000347802; ENSG00000198483.
GeneIDi148741.
KEGGihsa:148741.
UCSCiuc001eob.2. human. [Q8N283-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057853 mRNA. Translation: BAB71597.1. Different initiation.
AK091120 mRNA. Translation: BAC03587.1.
AK296861 mRNA. Translation: BAG59424.1.
AL160282 Genomic DNA. No translation available.
BC101618 mRNA. Translation: AAI01619.1.
BC101620 mRNA. Translation: AAI01621.1.
CCDSiCCDS72867.1. [Q8N283-1]
RefSeqiNP_653299.4. NM_144698.4.
UniGeneiHs.710624.

3D structure databases

ProteinModelPortaliQ8N283.
SMRiQ8N283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127165. 2 interactors.
IntActiQ8N283. 7 interactors.
MINTiMINT-8247627.
STRINGi9606.ENSP00000347802.

PTM databases

iPTMnetiQ8N283.
PhosphoSitePlusiQ8N283.

Polymorphism and mutation databases

DMDMi109940222.

Proteomic databases

EPDiQ8N283.
MaxQBiQ8N283.
PaxDbiQ8N283.
PeptideAtlasiQ8N283.
PRIDEiQ8N283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355594; ENSP00000347802; ENSG00000198483.
GeneIDi148741.
KEGGihsa:148741.
UCSCiuc001eob.2. human. [Q8N283-1]

Organism-specific databases

CTDi148741.
GeneCardsiANKRD35.
HGNCiHGNC:26323. ANKRD35.
HPAiHPA035452.
HPA035453.
neXtProtiNX_Q8N283.
PharmGKBiPA134896362.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK6X. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000033962.
HOVERGENiHBG080850.
InParanoidiQ8N283.
OrthoDBiEOG091G025R.
PhylomeDBiQ8N283.
TreeFamiTF331274.

Enzyme and pathway databases

BioCyciZFISH:G66-32739-MONOMER.

Miscellaneous databases

GenomeRNAii148741.
PROiQ8N283.

Gene expression databases

BgeeiENSG00000198483.
CleanExiHS_ANKRD35.
ExpressionAtlasiQ8N283. baseline and differential.
GenevisibleiQ8N283. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR35_HUMAN
AccessioniPrimary (citable) accession number: Q8N283
Secondary accession number(s): A6NEU0
, B4DL62, Q3MJ10, Q96LS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.