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Protein

Ankyrin repeat domain-containing protein 35

Gene

ANKRD35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 35
Gene namesi
Name:ANKRD35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26323. ANKRD35.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134896362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10011001Ankyrin repeat domain-containing protein 35PRO_0000243910Add
BLAST

Proteomic databases

MaxQBiQ8N283.
PaxDbiQ8N283.
PRIDEiQ8N283.

PTM databases

PhosphoSiteiQ8N283.

Expressioni

Gene expression databases

BgeeiQ8N283.
CleanExiHS_ANKRD35.
GenevestigatoriQ8N283.

Organism-specific databases

HPAiHPA035452.
HPA035453.

Interactioni

Protein-protein interaction databases

BioGridi127165. 2 interactions.
IntActiQ8N283. 7 interactions.
MINTiMINT-8247627.
STRINGi9606.ENSP00000347802.

Structurei

3D structure databases

ProteinModelPortaliQ8N283.
SMRiQ8N283. Positions 19-233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati53 – 8230ANK 1Add
BLAST
Repeati86 – 11530ANK 2Add
BLAST
Repeati119 – 14830ANK 3Add
BLAST
Repeati152 – 18130ANK 4Add
BLAST
Repeati185 – 21430ANK 5Add
BLAST
Repeati218 – 24730ANK 6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili295 – 34450Sequence AnalysisAdd
BLAST
Coiled coili610 – 69687Sequence AnalysisAdd
BLAST
Coiled coili733 – 81078Sequence AnalysisAdd
BLAST
Coiled coili851 – 968118Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi527 – 5337Poly-Ala

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000033962.
HOVERGENiHBG080850.
InParanoidiQ8N283.
OMAiERWNRRD.
OrthoDBiEOG7X9G6C.
PhylomeDBiQ8N283.
TreeFamiTF331274.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N283-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRIFSCSST QVAVERWNRH DQKLLEAVHR GDVGRVAALA SRKSARPTKL
60 70 80 90 100
DSNGQSPFHL AASKGLTECL TILLANGADI NSKNEDGSTA LHLATISCQP
110 120 130 140 150
QCVKVLLQHG ANEDAVDAEN RSPLHWAASS GCASSVLLLC DHEAFLDVLD
160 170 180 190 200
NDGRTPLMIA SLGGHAAICS QLLQRGARVN VTDKNDKSAL ILACEKGSAE
210 220 230 240 250
VAELLLSHGA DAGAVDSTGH DALHYALHTQ DKALWRHLQQ ALSRRRRGGQ
260 270 280 290 300
RLVQHPDLAS QASPSEPQAG SPPKSSWRAE PEEEQEEKED EDPCSEEWRW
310 320 330 340 350
KYEEERRKVV RLEQELVQKT EECKTQAAAY LDLENQIREQ AQELGVLLSW
360 370 380 390 400
EPRASGKQGS SLRPGGDGME QGCPKDLLAE STQELKKQQQ AAATVNPVLA
410 420 430 440 450
PKKAEDSAPG KIQYEVHGRS QPEEQGPPQS PASETIRKAT GQQLTTNGAQ
460 470 480 490 500
TFGPDHADQL PAGQKESSQV LGVEPGGTVA EPVGPAAMNQ LLLQLREELA
510 520 530 540 550
AVWREKDAAR GALSRPVMEG ALGTPRAEAA AAAWEKMEAR LERVLARLEW
560 570 580 590 600
AKAGLQVKPE VPSQESREGA LKAAPGSIKQ DEEKEKRVPG ARGEPLGALG
610 620 630 640 650
GEKALGGLAK GQLEKEMSVL RLSNSNLLEE LGELGRERQR LQRELQSLSQ
660 670 680 690 700
RLQREFVPKP EAQVQLQQLR QSVGLLTNEL AMEKEATEKL RKLLASQSSG
710 720 730 740 750
LRGLWDCLPA DLVGERSAQS KAAESLEELR ACISTLVDRH REAQQVLARL
760 770 780 790 800
QEENQQLRGS LSPCREPGTS LKAPASPQVA ALEQDLGKLE EELRAVQATM
810 820 830 840 850
SGKSQEIGKL KQLLYQATEE VAELRAREAA SLRQHEKTRG SLVAQAQAWG
860 870 880 890 900
QELKALLEKY NTACREVGRL REAVAEERRR SGDLAAQAAE QERQASEMRG
910 920 930 940 950
RSEQFEKTAE LLKEKMEHLI GACRDKEAKI KELLKKLEQL SEEVLAIRGE
960 970 980 990 1000
NARLALQLQD SQKNHEEIIS TYRNHLLNAA RGYMEHEVYN ILLQILSMEE

E
Length:1,001
Mass (Da):109,966
Last modified:June 26, 2006 - v2
Checksum:iFA7B90CF32E3F842
GO
Isoform 2 (identifier: Q8N283-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-137: HGANEDAVDAENRSPLHWAASSGCASSVL → PPLAVPQVCSCCVTTKPSWTCWIMMDVHP
     138-1001: Missing.

Note: No experimental confirmation available.

Show »
Length:137
Mass (Da):14,894
Checksum:i47DCC2F764124DE8
GO

Sequence cautioni

The sequence BAB71597.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881S → A in BAB71597 (PubMed:14702039).Curated
Sequence conflicti820 – 8201E → G in BAC03587 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531N → K.
Corresponds to variant rs6658371 [ dbSNP | Ensembl ].
VAR_048278
Natural varianti428 – 4281P → S.2 Publications
Corresponds to variant rs6670984 [ dbSNP | Ensembl ].
VAR_026870
Natural varianti592 – 5921R → Q.
Corresponds to variant rs41315701 [ dbSNP | Ensembl ].
VAR_061017
Natural varianti978 – 9781N → D.
Corresponds to variant rs16827032 [ dbSNP | Ensembl ].
VAR_033506

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei109 – 13729HGANE…ASSVL → PPLAVPQVCSCCVTTKPSWT CWIMMDVHP in isoform 2. 1 PublicationVSP_056916Add
BLAST
Alternative sequencei138 – 1001864Missing in isoform 2. 1 PublicationVSP_056917Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057853 mRNA. Translation: BAB71597.1. Different initiation.
AK091120 mRNA. Translation: BAC03587.1.
AK296861 mRNA. Translation: BAG59424.1.
AL160282 Genomic DNA. No translation available.
BC101618 mRNA. Translation: AAI01619.1.
BC101620 mRNA. Translation: AAI01621.1.
CCDSiCCDS72867.1. [Q8N283-1]
RefSeqiNP_653299.4. NM_144698.4.
UniGeneiHs.710624.

Genome annotation databases

EnsembliENST00000355594; ENSP00000347802; ENSG00000198483.
GeneIDi148741.
KEGGihsa:148741.
UCSCiuc001eob.1. human. [Q8N283-1]

Polymorphism databases

DMDMi109940222.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057853 mRNA. Translation: BAB71597.1. Different initiation.
AK091120 mRNA. Translation: BAC03587.1.
AK296861 mRNA. Translation: BAG59424.1.
AL160282 Genomic DNA. No translation available.
BC101618 mRNA. Translation: AAI01619.1.
BC101620 mRNA. Translation: AAI01621.1.
CCDSiCCDS72867.1. [Q8N283-1]
RefSeqiNP_653299.4. NM_144698.4.
UniGeneiHs.710624.

3D structure databases

ProteinModelPortaliQ8N283.
SMRiQ8N283. Positions 19-233.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127165. 2 interactions.
IntActiQ8N283. 7 interactions.
MINTiMINT-8247627.
STRINGi9606.ENSP00000347802.

PTM databases

PhosphoSiteiQ8N283.

Polymorphism databases

DMDMi109940222.

Proteomic databases

MaxQBiQ8N283.
PaxDbiQ8N283.
PRIDEiQ8N283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355594; ENSP00000347802; ENSG00000198483.
GeneIDi148741.
KEGGihsa:148741.
UCSCiuc001eob.1. human. [Q8N283-1]

Organism-specific databases

CTDi148741.
GeneCardsiGC01P145549.
HGNCiHGNC:26323. ANKRD35.
HPAiHPA035452.
HPA035453.
neXtProtiNX_Q8N283.
PharmGKBiPA134896362.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000033962.
HOVERGENiHBG080850.
InParanoidiQ8N283.
OMAiERWNRRD.
OrthoDBiEOG7X9G6C.
PhylomeDBiQ8N283.
TreeFamiTF331274.

Miscellaneous databases

GenomeRNAii148741.
NextBioi35472966.
PROiQ8N283.

Gene expression databases

BgeeiQ8N283.
CleanExiHS_ANKRD35.
GenevestigatoriQ8N283.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-428.
    Tissue: Brain and Tongue.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-428.
    Tissue: Heart, Lung and Tongue.

Entry informationi

Entry nameiANR35_HUMAN
AccessioniPrimary (citable) accession number: Q8N283
Secondary accession number(s): A6NEU0
, B4DL62, Q3MJ10, Q96LS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2006
Last sequence update: June 26, 2006
Last modified: February 3, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.