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Protein

Prominin-2

Gene

PROM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cholesterol binding Source: UniProtKB

GO - Biological processi

  • negative regulation of caveolin-mediated endocytosis Source: UniProtKB
  • negative regulation of pinocytosis Source: UniProtKB
  • positive regulation of cell projection organization Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
  • regulation of GTPase activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Prominin-2
Short name:
PROM-2
Alternative name(s):
Prominin-like protein 2
Short name:
hPROML2
Gene namesi
Name:PROM2
Synonyms:PROML2
ORF Names:UNQ2521/PRO6014
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20685. PROM2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 106ExtracellularSequence analysisAdd BLAST80
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 153CytoplasmicSequence analysisAdd BLAST26
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 426ExtracellularSequence analysisAdd BLAST252
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 472CytoplasmicSequence analysisAdd BLAST25
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 779ExtracellularSequence analysisAdd BLAST286
Transmembranei780 – 800HelicalSequence analysisAdd BLAST21
Topological domaini801 – 834CytoplasmicSequence analysisAdd BLAST34

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB-SubCell
  • basolateral plasma membrane Source: UniProtKB-SubCell
  • cell projection Source: UniProtKB
  • cell surface Source: UniProtKB
  • ciliary membrane Source: UniProtKB-SubCell
  • cilium Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • microspike Source: UniProtKB
  • microvillus Source: UniProtKB
  • microvillus membrane Source: UniProtKB-SubCell
  • prominosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi150696.
OpenTargetsiENSG00000155066.
PharmGKBiPA134861956.

Polymorphism and mutation databases

BioMutaiPROM2.
DMDMi74728673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000033123927 – 834Prominin-2Add BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi270N-linked (GlcNAc...)Sequence analysis1
Modified residuei727PhosphoserineCombined sources1
Modified residuei818PhosphoserineBy similarity1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8N271.
PaxDbiQ8N271.
PeptideAtlasiQ8N271.
PRIDEiQ8N271.

PTM databases

iPTMnetiQ8N271.
PhosphoSitePlusiQ8N271.

Expressioni

Tissue specificityi

Present in saliva within small membrane particles (at protein level). Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosal tumor, expressed in spindle-shaped or stellate stromal cells. Expressed in prostate cancer cell lines.4 Publications

Gene expression databases

BgeeiENSG00000155066.
CleanExiHS_PROM2.
ExpressionAtlasiQ8N271. baseline and differential.
GenevisibleiQ8N271. HS.

Organism-specific databases

HPAiCAB046005.
HPA063728.

Interactioni

Subunit structurei

Binds cholesterol.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000318270.

Structurei

3D structure databases

ProteinModelPortaliQ8N271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prominin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4331. Eukaryota.
ENOG410XRG0. LUCA.
GeneTreeiENSGT00530000063586.
HOGENOMiHOG000115705.
HOVERGENiHBG101108.
InParanoidiQ8N271.
KOiK15602.
OMAiMGVGFSF.
OrthoDBiEOG091G07PX.
PhylomeDBiQ8N271.
TreeFamiTF324631.

Family and domain databases

InterProiIPR008795. Prominin.
[Graphical view]
PANTHERiPTHR22730. PTHR22730. 1 hit.
PfamiPF05478. Prominin. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N271-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKHTLALLAP LLGLGLGLAL SQLAAGATDC KFLGPAEHLT FTPAARARWL
60 70 80 90 100
APRVRAPGLL DSLYGTVRRF LSVVQLNPFP SELVKALLNE LASVKVNEVV
110 120 130 140 150
RYEAGYVVCA VIAGLYLLLV PTAGLCFCCC RCHRRCGGRV KTEHKALACE
160 170 180 190 200
RAALMVFLLL TTLLLLIGVV CAFVTNQRTH EQMGPSIEAM PETLLSLWGL
210 220 230 240 250
VSDVPQELQA VAQQFSLPQE QVSEELDGVG VSIGSAIHTQ LRSSVYPLLA
260 270 280 290 300
AVGSLGQVLQ VSVHHLQTLN ATVVELQAGQ QDLEPAIREH RDRLLELLQE
310 320 330 340 350
ARCQGDCAGA LSWARTLELG ADFSQVPSVD HVLHQLKGVP EANFSSMVQE
360 370 380 390 400
ENSTFNALPA LAAMQTSSVV QELKKAVAQQ PEGVRTLAEG FPGLEAASRW
410 420 430 440 450
AQALQEVEES SRPYLQEVQR YETYRWIVGC VLCSVVLFVV LCNLLGLNLG
460 470 480 490 500
IWGLSARDDP SHPEAKGEAG ARFLMAGVGL SFLFAAPLIL LVFATFLVGG
510 520 530 540 550
NVQTLVCQSW ENGELFEFAD TPGNLPPSMN LSQLLGLRKN ISIHQAYQQC
560 570 580 590 600
KEGAALWTVL QLNDSYDLEE HLDINQYTNK LRQELQSLKV DTQSLDLLSS
610 620 630 640 650
AARRDLEALQ SSGLQRIHYP DFLVQIQRPV VKTSMEQLAQ ELQGLAQAQD
660 670 680 690 700
NSVLGQRLQE EAQGLRNLHQ EKVVPQQSLV AKLNLSVRAL ESSAPNLQLE
710 720 730 740 750
TSDVLANVTY LKGELPAWAA RILRNVSECF LAREMGYFSQ YVAWVREEVT
760 770 780 790 800
QRIATCQPLS GALDNSRVIL CDMMADPWNA FWFCLAWCTF FLIPSIIFAV
810 820 830
KTSKYFRPIR KRLSSTSSEE TQLFHIPRVT SLKL
Length:834
Mass (Da):91,883
Last modified:October 1, 2002 - v1
Checksum:i95C4D88AED2806A3
GO
Isoform 2 (identifier: Q8N271-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-624: Missing.

Show »
Length:785
Mass (Da):86,255
Checksum:i1D8CE2DDEDCAFF48
GO
Isoform 3 (identifier: Q8N271-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-474: Missing.

Show »
Length:360
Mass (Da):40,582
Checksum:i5290577CC0DFC262
GO

Sequence cautioni

The sequence BAC03657 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti340P → L in BAF83055 (PubMed:14702039).Curated1
Sequence conflicti513G → S in BAC03657 (PubMed:14702039).Curated1
Sequence conflicti701T → A in BAC03657 (PubMed:14702039).Curated1
Sequence conflicti704V → I in BAC03657 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042749508Q → R.4 PublicationsCorresponds to variant rs12992066dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0331481 – 474Missing in isoform 3. 1 PublicationAdd BLAST474
Alternative sequenceiVSP_033149576 – 624Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245303 mRNA. Translation: AAM10541.1.
AF245304 mRNA. Translation: AAM10542.1.
AY358377 mRNA. Translation: AAQ88743.1.
AK091175 mRNA. Translation: BAC03599.1.
AK091408 mRNA. Translation: BAC03657.1. Different initiation.
AK290366 mRNA. Translation: BAF83055.1.
AC009238 Genomic DNA. Translation: AAY14751.1.
CH471219 Genomic DNA. Translation: EAX10718.1.
BC113877 mRNA. Translation: AAI13878.1.
BC114525 mRNA. Translation: AAI14526.1.
CCDSiCCDS2012.1. [Q8N271-1]
RefSeqiNP_001159449.1. NM_001165977.2. [Q8N271-1]
NP_001159450.1. NM_001165978.2. [Q8N271-1]
NP_653308.2. NM_144707.3. [Q8N271-1]
UniGeneiHs.437376.
Hs.469313.

Genome annotation databases

EnsembliENST00000317620; ENSP00000318270; ENSG00000155066. [Q8N271-1]
ENST00000317668; ENSP00000318520; ENSG00000155066. [Q8N271-1]
ENST00000403131; ENSP00000385716; ENSG00000155066. [Q8N271-1]
GeneIDi150696.
KEGGihsa:150696.
UCSCiuc002suh.3. human. [Q8N271-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245303 mRNA. Translation: AAM10541.1.
AF245304 mRNA. Translation: AAM10542.1.
AY358377 mRNA. Translation: AAQ88743.1.
AK091175 mRNA. Translation: BAC03599.1.
AK091408 mRNA. Translation: BAC03657.1. Different initiation.
AK290366 mRNA. Translation: BAF83055.1.
AC009238 Genomic DNA. Translation: AAY14751.1.
CH471219 Genomic DNA. Translation: EAX10718.1.
BC113877 mRNA. Translation: AAI13878.1.
BC114525 mRNA. Translation: AAI14526.1.
CCDSiCCDS2012.1. [Q8N271-1]
RefSeqiNP_001159449.1. NM_001165977.2. [Q8N271-1]
NP_001159450.1. NM_001165978.2. [Q8N271-1]
NP_653308.2. NM_144707.3. [Q8N271-1]
UniGeneiHs.437376.
Hs.469313.

3D structure databases

ProteinModelPortaliQ8N271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000318270.

PTM databases

iPTMnetiQ8N271.
PhosphoSitePlusiQ8N271.

Polymorphism and mutation databases

BioMutaiPROM2.
DMDMi74728673.

Proteomic databases

MaxQBiQ8N271.
PaxDbiQ8N271.
PeptideAtlasiQ8N271.
PRIDEiQ8N271.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317620; ENSP00000318270; ENSG00000155066. [Q8N271-1]
ENST00000317668; ENSP00000318520; ENSG00000155066. [Q8N271-1]
ENST00000403131; ENSP00000385716; ENSG00000155066. [Q8N271-1]
GeneIDi150696.
KEGGihsa:150696.
UCSCiuc002suh.3. human. [Q8N271-1]

Organism-specific databases

CTDi150696.
DisGeNETi150696.
GeneCardsiPROM2.
HGNCiHGNC:20685. PROM2.
HPAiCAB046005.
HPA063728.
neXtProtiNX_Q8N271.
OpenTargetsiENSG00000155066.
PharmGKBiPA134861956.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4331. Eukaryota.
ENOG410XRG0. LUCA.
GeneTreeiENSGT00530000063586.
HOGENOMiHOG000115705.
HOVERGENiHBG101108.
InParanoidiQ8N271.
KOiK15602.
OMAiMGVGFSF.
OrthoDBiEOG091G07PX.
PhylomeDBiQ8N271.
TreeFamiTF324631.

Miscellaneous databases

ChiTaRSiPROM2. human.
GenomeRNAii150696.
PROiQ8N271.

Gene expression databases

BgeeiENSG00000155066.
CleanExiHS_PROM2.
ExpressionAtlasiQ8N271. baseline and differential.
GenevisibleiQ8N271. HS.

Family and domain databases

InterProiIPR008795. Prominin.
[Graphical view]
PANTHERiPTHR22730. PTHR22730. 1 hit.
PfamiPF05478. Prominin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPROM2_HUMAN
AccessioniPrimary (citable) accession number: Q8N271
Secondary accession number(s): A8K2V1
, Q2HIX6, Q8NB84, Q8TAE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.