ID SCML4_HUMAN Reviewed; 414 AA. AC Q8N228; B0QZ10; B0QZ11; B7ZBX3; Q5JXD0; Q5T0T6; Q8IYY6; DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot. DT 20-MAY-2008, sequence version 2. DT 24-JAN-2024, entry version 155. DE RecName: Full=Sex comb on midleg-like protein 4; GN Name=SCML4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT GLN-126. RC TISSUE=Thymus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by CC forming multiprotein complexes, which are required to maintain the CC transcriptionally repressive state of homeotic genes throughout CC development (By similarity). {ECO:0000250}. CC -!- INTERACTION: CC Q8N228-3; O95833: CLIC3; NbExp=3; IntAct=EBI-17182094, EBI-10192241; CC Q8N228-3; Q96MK2: RIPOR3; NbExp=3; IntAct=EBI-17182094, EBI-12010512; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q8N228-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8N228-2; Sequence=VSP_033943; CC Name=3; CC IsoId=Q8N228-3; Sequence=VSP_033944, VSP_033945, VSP_033946; CC -!- SIMILARITY: Belongs to the SCM family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK093571; BAC04198.1; -; mRNA. DR EMBL; AL512592; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL096816; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471051; EAW48394.1; -; Genomic_DNA. DR EMBL; CH471051; EAW48395.1; -; Genomic_DNA. DR EMBL; BC033286; AAH33286.1; -; mRNA. DR CCDS; CCDS5060.2; -. [Q8N228-1] DR CCDS; CCDS69163.1; -. [Q8N228-2] DR RefSeq; NP_001273337.1; NM_001286408.1. [Q8N228-2] DR RefSeq; NP_932347.2; NM_198081.4. [Q8N228-1] DR RefSeq; XP_011534008.1; XM_011535706.1. [Q8N228-2] DR RefSeq; XP_016866167.1; XM_017010678.1. DR RefSeq; XP_016866168.1; XM_017010679.1. DR RefSeq; XP_016866169.1; XM_017010680.1. DR RefSeq; XP_016866170.1; XM_017010681.1. DR RefSeq; XP_016866172.1; XM_017010683.1. DR AlphaFoldDB; Q8N228; -. DR SMR; Q8N228; -. DR BioGRID; 129164; 49. DR IntAct; Q8N228; 5. DR STRING; 9606.ENSP00000358016; -. DR iPTMnet; Q8N228; -. DR PhosphoSitePlus; Q8N228; -. DR SwissPalm; Q8N228; -. DR BioMuta; SCML4; -. DR DMDM; 189046183; -. DR jPOST; Q8N228; -. DR MassIVE; Q8N228; -. DR PaxDb; 9606-ENSP00000358016; -. DR PeptideAtlas; Q8N228; -. DR ProteomicsDB; 71650; -. [Q8N228-1] DR ProteomicsDB; 71651; -. [Q8N228-2] DR ProteomicsDB; 71652; -. [Q8N228-3] DR Antibodypedia; 32183; 81 antibodies from 19 providers. DR DNASU; 256380; -. DR Ensembl; ENST00000369020.8; ENSP00000358016.3; ENSG00000146285.15. [Q8N228-1] DR Ensembl; ENST00000369022.6; ENSP00000358018.2; ENSG00000146285.15. [Q8N228-2] DR GeneID; 256380; -. DR KEGG; hsa:256380; -. DR MANE-Select; ENST00000369020.8; ENSP00000358016.3; NM_198081.5; NP_932347.2. DR UCSC; uc003prz.6; human. [Q8N228-1] DR AGR; HGNC:21397; -. DR CTD; 256380; -. DR DisGeNET; 256380; -. DR GeneCards; SCML4; -. DR HGNC; HGNC:21397; SCML4. DR HPA; ENSG00000146285; Tissue enhanced (intestine, lymphoid tissue). DR neXtProt; NX_Q8N228; -. DR OpenTargets; ENSG00000146285; -. DR PharmGKB; PA134946179; -. DR VEuPathDB; HostDB:ENSG00000146285; -. DR eggNOG; KOG3766; Eukaryota. DR GeneTree; ENSGT00940000157463; -. DR HOGENOM; CLU_045829_0_0_1; -. DR InParanoid; Q8N228; -. DR OMA; PFQQYSA; -. DR OrthoDB; 2908161at2759; -. DR PhylomeDB; Q8N228; -. DR TreeFam; TF106488; -. DR PathwayCommons; Q8N228; -. DR SignaLink; Q8N228; -. DR BioGRID-ORCS; 256380; 17 hits in 1153 CRISPR screens. DR ChiTaRS; SCML4; human. DR GenomeRNAi; 256380; -. DR Pharos; Q8N228; Tdark. DR PRO; PR:Q8N228; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; Q8N228; Protein. DR Bgee; ENSG00000146285; Expressed in granulocyte and 116 other cell types or tissues. DR ExpressionAtlas; Q8N228; baseline and differential. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central. DR GO; GO:0042393; F:histone binding; IBA:GO_Central. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central. DR CDD; cd09578; SAM_Scm; 1. DR Gene3D; 3.90.1150.190; SLED domain; 1. DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1. DR InterPro; IPR001660; SAM. DR InterPro; IPR013761; SAM/pointed_sf. DR InterPro; IPR047531; SAM_Scm-like. DR InterPro; IPR033763; SCML2_RBR. DR InterPro; IPR021987; SLED. DR InterPro; IPR038348; SLED_sf. DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1. DR PANTHER; PTHR12247:SF85; SEX COMB ON MIDLEG-LIKE PROTEIN 4; 1. DR Pfam; PF17208; RBR; 1. DR Pfam; PF00536; SAM_1; 1. DR Pfam; PF12140; SLED; 1. DR SMART; SM00454; SAM; 1. DR SUPFAM; SSF47769; SAM/Pointed domain; 1. DR Genevisible; Q8N228; HS. PE 1: Evidence at protein level; KW Alternative splicing; Nucleus; Phosphoprotein; Reference proteome; KW Repressor; Transcription; Transcription regulation. FT CHAIN 1..414 FT /note="Sex comb on midleg-like protein 4" FT /id="PRO_0000337171" FT DOMAIN 288..354 FT /note="SAM" FT REGION 257..343 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 257..273 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 310..333 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 55 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q80VG1" FT MOD_RES 65 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q80VG1" FT VAR_SEQ 1..58 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_033943" FT VAR_SEQ 1..58 FT /note="MQSQRIPGRKRGRPSLHSTPMKMAVHNLYSASAGSLPAVKIPKKRGRKPGYK FT IKSRVL -> MPCQRTAWIGCDRQRTPPFHWREIKSRVL (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_033944" FT VAR_SEQ 325..334 FT /note="ASSPSQDAQD -> GNVMHASASH (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_033945" FT VAR_SEQ 335..414 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_033946" FT VARIANT 126 FT /note="R -> Q (in dbSNP:rs6934505)" FT /evidence="ECO:0000269|PubMed:14702039" FT /id="VAR_043669" SQ SEQUENCE 414 AA; 45023 MW; 666A3DEAAF2A82D0 CRC64; MQSQRIPGRK RGRPSLHSTP MKMAVHNLYS ASAGSLPAVK IPKKRGRKPG YKIKSRVLMT PLALSPPRST PEPDLSSIPQ DAATVPSLAA PQALTVCLYI NKQANAGPYL ERKKVQQLPE HFGPERPSAV LQQAVQACID CAHQQKLVFS LVKQGYGGEM VSVSASFDGK QHLRSLPVVN SIGYVLRFLA KLCRSLLCDD LFSHQPFPRG CSASEKVQEK EEGRMESVKT VTTEEYLVNP VGMNRYSVDT SASTFNHRGS LHPSSSLYCK RQNSGDSHLG GGPAATAGGP RTSPMSSGGP SAPGLRPPAS SPKRNTTSLE GNRCASSPSQ DAQDARRPRS RNPSAWTVED VVWFVKDADP QALGPHVELF RKHEIDGNAL LLLKSDMVMK YLGLKLGPAL KLCYHIDKLK QAKF //