Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8N228

- SCML4_HUMAN

UniProt

Q8N228 - SCML4_HUMAN

Protein

Sex comb on midleg-like protein 4

Gene

SCML4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sex comb on midleg-like protein 4
    Gene namesi
    Name:SCML4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21397. SCML4.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134946179.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 414414Sex comb on midleg-like protein 4PRO_0000337171Add
    BLAST

    Proteomic databases

    PaxDbiQ8N228.
    PRIDEiQ8N228.

    PTM databases

    PhosphoSiteiQ8N228.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N228.
    BgeeiQ8N228.
    CleanExiHS_SCML4.
    GenevestigatoriQ8N228.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N228.
    SMRiQ8N228. Positions 343-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini288 – 35467SAMAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SCM family.Curated

    Phylogenomic databases

    eggNOGiNOG268239.
    HOVERGENiHBG056406.
    InParanoidiQ8N228.
    KOiK11466.
    OMAiMVMKYLG.
    OrthoDBiEOG73BVC2.
    PhylomeDBiQ8N228.
    TreeFamiTF106488.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    InterProiIPR017956. AT_hook_DNA-bd_motif.
    IPR021987. DUF3588.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PfamiPF12140. DUF3588. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    SMARTiSM00384. AT_hook. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N228-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQSQRIPGRK RGRPSLHSTP MKMAVHNLYS ASAGSLPAVK IPKKRGRKPG    50
    YKIKSRVLMT PLALSPPRST PEPDLSSIPQ DAATVPSLAA PQALTVCLYI 100
    NKQANAGPYL ERKKVQQLPE HFGPERPSAV LQQAVQACID CAHQQKLVFS 150
    LVKQGYGGEM VSVSASFDGK QHLRSLPVVN SIGYVLRFLA KLCRSLLCDD 200
    LFSHQPFPRG CSASEKVQEK EEGRMESVKT VTTEEYLVNP VGMNRYSVDT 250
    SASTFNHRGS LHPSSSLYCK RQNSGDSHLG GGPAATAGGP RTSPMSSGGP 300
    SAPGLRPPAS SPKRNTTSLE GNRCASSPSQ DAQDARRPRS RNPSAWTVED 350
    VVWFVKDADP QALGPHVELF RKHEIDGNAL LLLKSDMVMK YLGLKLGPAL 400
    KLCYHIDKLK QAKF 414
    Length:414
    Mass (Da):45,023
    Last modified:May 20, 2008 - v2
    Checksum:i666A3DEAAF2A82D0
    GO
    Isoform 2 (identifier: Q8N228-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-58: Missing.

    Show »
    Length:356
    Mass (Da):38,587
    Checksum:iE66C0BDE66D227CE
    GO
    Isoform 3 (identifier: Q8N228-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-58: MQSQRIPGRK...PGYKIKSRVL → MPCQRTAWIGCDRQRTPPFHWREIKSRVL
         325-334: ASSPSQDAQD → GNVMHASASH
         335-414: Missing.

    Show »
    Length:305
    Mass (Da):32,976
    Checksum:iE55703D2BE89FEA3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti126 – 1261R → Q.1 Publication
    Corresponds to variant rs6934505 [ dbSNP | Ensembl ].
    VAR_043669

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5858Missing in isoform 2. 1 PublicationVSP_033943Add
    BLAST
    Alternative sequencei1 – 5858MQSQR…KSRVL → MPCQRTAWIGCDRQRTPPFH WREIKSRVL in isoform 3. 1 PublicationVSP_033944Add
    BLAST
    Alternative sequencei325 – 33410ASSPSQDAQD → GNVMHASASH in isoform 3. 1 PublicationVSP_033945
    Alternative sequencei335 – 41480Missing in isoform 3. 1 PublicationVSP_033946Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093571 mRNA. Translation: BAC04198.1.
    AL512592, AL096816 Genomic DNA. Translation: CAX12112.1.
    AL096816 Genomic DNA. Translation: CAI42848.1.
    AL096816, AL512592 Genomic DNA. Translation: CAQ08122.1.
    AL096816, AL512592 Genomic DNA. Translation: CAQ08123.1.
    AL512592, AL096816 Genomic DNA. Translation: CAI13632.2.
    CH471051 Genomic DNA. Translation: EAW48394.1.
    CH471051 Genomic DNA. Translation: EAW48395.1.
    BC033286 mRNA. Translation: AAH33286.1.
    CCDSiCCDS5060.2. [Q8N228-1]
    CCDS69163.1. [Q8N228-2]
    RefSeqiNP_001273337.1. NM_001286408.1. [Q8N228-2]
    NP_932347.2. NM_198081.4. [Q8N228-1]
    UniGeneiHs.486109.

    Genome annotation databases

    EnsembliENST00000369020; ENSP00000358016; ENSG00000146285. [Q8N228-1]
    ENST00000369021; ENSP00000358017; ENSG00000146285. [Q8N228-3]
    ENST00000369022; ENSP00000358018; ENSG00000146285. [Q8N228-2]
    GeneIDi256380.
    KEGGihsa:256380.
    UCSCiuc003prz.4. human. [Q8N228-1]
    uc003psa.3. human. [Q8N228-3]

    Polymorphism databases

    DMDMi189046183.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093571 mRNA. Translation: BAC04198.1 .
    AL512592 , AL096816 Genomic DNA. Translation: CAX12112.1 .
    AL096816 Genomic DNA. Translation: CAI42848.1 .
    AL096816 , AL512592 Genomic DNA. Translation: CAQ08122.1 .
    AL096816 , AL512592 Genomic DNA. Translation: CAQ08123.1 .
    AL512592 , AL096816 Genomic DNA. Translation: CAI13632.2 .
    CH471051 Genomic DNA. Translation: EAW48394.1 .
    CH471051 Genomic DNA. Translation: EAW48395.1 .
    BC033286 mRNA. Translation: AAH33286.1 .
    CCDSi CCDS5060.2. [Q8N228-1 ]
    CCDS69163.1. [Q8N228-2 ]
    RefSeqi NP_001273337.1. NM_001286408.1. [Q8N228-2 ]
    NP_932347.2. NM_198081.4. [Q8N228-1 ]
    UniGenei Hs.486109.

    3D structure databases

    ProteinModelPortali Q8N228.
    SMRi Q8N228. Positions 343-409.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8N228.

    Polymorphism databases

    DMDMi 189046183.

    Proteomic databases

    PaxDbi Q8N228.
    PRIDEi Q8N228.

    Protocols and materials databases

    DNASUi 256380.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369020 ; ENSP00000358016 ; ENSG00000146285 . [Q8N228-1 ]
    ENST00000369021 ; ENSP00000358017 ; ENSG00000146285 . [Q8N228-3 ]
    ENST00000369022 ; ENSP00000358018 ; ENSG00000146285 . [Q8N228-2 ]
    GeneIDi 256380.
    KEGGi hsa:256380.
    UCSCi uc003prz.4. human. [Q8N228-1 ]
    uc003psa.3. human. [Q8N228-3 ]

    Organism-specific databases

    CTDi 256380.
    GeneCardsi GC06M108071.
    HGNCi HGNC:21397. SCML4.
    neXtProti NX_Q8N228.
    PharmGKBi PA134946179.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG268239.
    HOVERGENi HBG056406.
    InParanoidi Q8N228.
    KOi K11466.
    OMAi MVMKYLG.
    OrthoDBi EOG73BVC2.
    PhylomeDBi Q8N228.
    TreeFami TF106488.

    Miscellaneous databases

    GenomeRNAii 256380.
    NextBioi 92801.
    PROi Q8N228.

    Gene expression databases

    ArrayExpressi Q8N228.
    Bgeei Q8N228.
    CleanExi HS_SCML4.
    Genevestigatori Q8N228.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    InterProi IPR017956. AT_hook_DNA-bd_motif.
    IPR021987. DUF3588.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    Pfami PF12140. DUF3588. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00384. AT_hook. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLN-126.
      Tissue: Thymus.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.

    Entry informationi

    Entry nameiSCML4_HUMAN
    AccessioniPrimary (citable) accession number: Q8N228
    Secondary accession number(s): B0QZ10
    , B0QZ11, B7ZBX3, Q5JXD0, Q5T0T6, Q8IYY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3