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Protein

Zinc finger protein 710

Gene

ZNF710

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri295 – 31723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri323 – 34523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 42923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri435 – 45723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri519 – 54123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri547 – 56923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri575 – 59824C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.
SignaLinkiQ8N1W2.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 710
Gene namesi
Name:ZNF710
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:25352. ZNF710.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670470.

Polymorphism and mutation databases

BioMutaiZNF710.
DMDMi94730692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 664664Zinc finger protein 710PRO_0000233708Add
BLAST

Proteomic databases

MaxQBiQ8N1W2.
PaxDbiQ8N1W2.
PRIDEiQ8N1W2.

PTM databases

iPTMnetiQ8N1W2.
PhosphoSiteiQ8N1W2.

Expressioni

Gene expression databases

BgeeiQ8N1W2.
CleanExiHS_ZNF710.
ExpressionAtlasiQ8N1W2. baseline and differential.
GenevisibleiQ8N1W2. HS.

Organism-specific databases

HPAiHPA030226.
HPA030227.
HPA030228.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000268154.

Structurei

3D structure databases

ProteinModelPortaliQ8N1W2.
SMRiQ8N1W2. Positions 292-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi115 – 1206Poly-Glu
Compositional biasi175 – 24268Pro-richAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri295 – 31723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri323 – 34523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 42923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri435 – 45723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri519 – 54123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri547 – 56923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri575 – 59824C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117653.
HOGENOMiHOG000155808.
HOVERGENiHBG066266.
InParanoidiQ8N1W2.
OrthoDBiEOG7MPRDM.
PhylomeDBiQ8N1W2.
TreeFamiTF331510.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N1W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGFMDSGTQ TDAVVVLSLA QAAVLGLVSE NELFGATISA EAFYPDLGPE
60 70 80 90 100
LSGAAMGEPE PPGPDVYQLA CNGRALEEPA EEEVLEVEAA CEKHTRRKTR
110 120 130 140 150
PPVRLVPKVK FEKVEEEEQE VYEVSVPGDD KDAGPAEAPA EAASGGCDAL
160 170 180 190 200
VQSSAVKMID LSAFSRKPRT LRHLPRTPRP ELNVAPYDPH FPAPARDGFP
210 220 230 240 250
EPSMALPGPE ALPTECGFEP PHLAPLSDPE APSMESPEPV KPEQGFVWQE
260 270 280 290 300
ASEFEADTAG STVERHKKAQ LDRLDINVQI DDSYLVEAGD RQKRWQCRMC
310 320 330 340 350
EKSYTSKYNL VTHILGHNGI KPHSCPHCSK LFKQPSHLQT HLLTHQGTRP
360 370 380 390 400
HKCQVCHKAF TQTSHLKRHM LLHSEVKPYS CHFCGRGFAY PSELKAHEVK
410 420 430 440 450
HESGRCHVCV ECGLDFSTLT QLKRHLASHQ GPTLYQCLEC DKSFHYRSQL
460 470 480 490 500
QNHMLKHQNV RPFVCTECGM EFSQIHHLKQ HSLTHKGVKE FKCEVCGREF
510 520 530 540 550
TLQANMKRHM LIHTSVRPYQ CHICFKTFVQ KQTLKTHMIV HSPVKPFKCK
560 570 580 590 600
VCGKSFNRMY NLLGHMHLHA GSKPFKCPYC SSKFNLKGNL SRHMKVKHGV
610 620 630 640 650
MDIGLDSQDP MMELTGTDPS ELDGQQEMED FEENAYSYAS VDSSAEASVL
660
TEQAMKEMAY YNVL
Length:664
Mass (Da):74,461
Last modified:May 2, 2006 - v2
Checksum:iD7EF1DB9CD6F8429
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti601 – 6011M → I in BAC04404 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094712 mRNA. Translation: BAC04404.1.
BC126476 mRNA. Translation: AAI26477.1.
BC130541 mRNA. Translation: AAI30542.1.
AK160373 mRNA. Translation: BAD18716.1.
AL831826 mRNA. Translation: CAD38540.1.
CCDSiCCDS10358.1.
RefSeqiNP_940928.2. NM_198526.3.
UniGeneiHs.459311.

Genome annotation databases

EnsembliENST00000268154; ENSP00000268154; ENSG00000140548.
GeneIDi374655.
KEGGihsa:374655.
UCSCiuc002bov.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094712 mRNA. Translation: BAC04404.1.
BC126476 mRNA. Translation: AAI26477.1.
BC130541 mRNA. Translation: AAI30542.1.
AK160373 mRNA. Translation: BAD18716.1.
AL831826 mRNA. Translation: CAD38540.1.
CCDSiCCDS10358.1.
RefSeqiNP_940928.2. NM_198526.3.
UniGeneiHs.459311.

3D structure databases

ProteinModelPortaliQ8N1W2.
SMRiQ8N1W2. Positions 292-599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000268154.

PTM databases

iPTMnetiQ8N1W2.
PhosphoSiteiQ8N1W2.

Polymorphism and mutation databases

BioMutaiZNF710.
DMDMi94730692.

Proteomic databases

MaxQBiQ8N1W2.
PaxDbiQ8N1W2.
PRIDEiQ8N1W2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268154; ENSP00000268154; ENSG00000140548.
GeneIDi374655.
KEGGihsa:374655.
UCSCiuc002bov.3. human.

Organism-specific databases

CTDi374655.
GeneCardsiZNF710.
HGNCiHGNC:25352. ZNF710.
HPAiHPA030226.
HPA030227.
HPA030228.
neXtProtiNX_Q8N1W2.
PharmGKBiPA142670470.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117653.
HOGENOMiHOG000155808.
HOVERGENiHBG066266.
InParanoidiQ8N1W2.
OrthoDBiEOG7MPRDM.
PhylomeDBiQ8N1W2.
TreeFamiTF331510.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.
SignaLinkiQ8N1W2.

Miscellaneous databases

ChiTaRSiZNF710. human.
GenomeRNAii374655.
PROiQ8N1W2.

Gene expression databases

BgeeiQ8N1W2.
CleanExiHS_ZNF710.
ExpressionAtlasiQ8N1W2. baseline and differential.
GenevisibleiQ8N1W2. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 387-664.
    Tissue: Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 460-664.
    Tissue: Brain.

Entry informationi

Entry nameiZN710_HUMAN
AccessioniPrimary (citable) accession number: Q8N1W2
Secondary accession number(s): A0AVS3, Q6ZMK9, Q8NDU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: June 8, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.