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Protein

Zinc finger protein 710

Gene

ZNF710

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri295 – 317C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri547 – 569C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 598C2H2-type 11PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.
SignaLinkiQ8N1W2.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 710
Gene namesi
Name:ZNF710
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140548.9.
HGNCiHGNC:25352. ZNF710.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140548.
PharmGKBiPA142670470.

Polymorphism and mutation databases

BioMutaiZNF710.
DMDMi94730692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002337081 – 664Zinc finger protein 710Add BLAST664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki377Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8N1W2.
MaxQBiQ8N1W2.
PaxDbiQ8N1W2.
PeptideAtlasiQ8N1W2.
PRIDEiQ8N1W2.

PTM databases

iPTMnetiQ8N1W2.
PhosphoSitePlusiQ8N1W2.

Expressioni

Gene expression databases

BgeeiENSG00000140548.
CleanExiHS_ZNF710.
ExpressionAtlasiQ8N1W2. baseline and differential.
GenevisibleiQ8N1W2. HS.

Organism-specific databases

HPAiHPA030226.
HPA030227.
HPA030228.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000268154.

Structurei

3D structure databases

ProteinModelPortaliQ8N1W2.
SMRiQ8N1W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi115 – 120Poly-Glu6
Compositional biasi175 – 242Pro-richAdd BLAST68

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri295 – 317C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri547 – 569C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 598C2H2-type 11PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117653.
HOGENOMiHOG000155808.
HOVERGENiHBG066266.
InParanoidiQ8N1W2.
OrthoDBiEOG091G02N1.
PhylomeDBiQ8N1W2.
TreeFamiTF331510.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 11 hits.
SUPFAMiSSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.

Sequencei

Sequence statusi: Complete.

Q8N1W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGFMDSGTQ TDAVVVLSLA QAAVLGLVSE NELFGATISA EAFYPDLGPE
60 70 80 90 100
LSGAAMGEPE PPGPDVYQLA CNGRALEEPA EEEVLEVEAA CEKHTRRKTR
110 120 130 140 150
PPVRLVPKVK FEKVEEEEQE VYEVSVPGDD KDAGPAEAPA EAASGGCDAL
160 170 180 190 200
VQSSAVKMID LSAFSRKPRT LRHLPRTPRP ELNVAPYDPH FPAPARDGFP
210 220 230 240 250
EPSMALPGPE ALPTECGFEP PHLAPLSDPE APSMESPEPV KPEQGFVWQE
260 270 280 290 300
ASEFEADTAG STVERHKKAQ LDRLDINVQI DDSYLVEAGD RQKRWQCRMC
310 320 330 340 350
EKSYTSKYNL VTHILGHNGI KPHSCPHCSK LFKQPSHLQT HLLTHQGTRP
360 370 380 390 400
HKCQVCHKAF TQTSHLKRHM LLHSEVKPYS CHFCGRGFAY PSELKAHEVK
410 420 430 440 450
HESGRCHVCV ECGLDFSTLT QLKRHLASHQ GPTLYQCLEC DKSFHYRSQL
460 470 480 490 500
QNHMLKHQNV RPFVCTECGM EFSQIHHLKQ HSLTHKGVKE FKCEVCGREF
510 520 530 540 550
TLQANMKRHM LIHTSVRPYQ CHICFKTFVQ KQTLKTHMIV HSPVKPFKCK
560 570 580 590 600
VCGKSFNRMY NLLGHMHLHA GSKPFKCPYC SSKFNLKGNL SRHMKVKHGV
610 620 630 640 650
MDIGLDSQDP MMELTGTDPS ELDGQQEMED FEENAYSYAS VDSSAEASVL
660
TEQAMKEMAY YNVL
Length:664
Mass (Da):74,461
Last modified:May 2, 2006 - v2
Checksum:iD7EF1DB9CD6F8429
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti601M → I in BAC04404 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094712 mRNA. Translation: BAC04404.1.
BC126476 mRNA. Translation: AAI26477.1.
BC130541 mRNA. Translation: AAI30542.1.
AK160373 mRNA. Translation: BAD18716.1.
AL831826 mRNA. Translation: CAD38540.1.
CCDSiCCDS10358.1.
RefSeqiNP_940928.2. NM_198526.3.
UniGeneiHs.459311.

Genome annotation databases

EnsembliENST00000268154; ENSP00000268154; ENSG00000140548.
GeneIDi374655.
KEGGihsa:374655.
UCSCiuc002bov.3. human.

Similar proteinsi

Entry informationi

Entry nameiZN710_HUMAN
AccessioniPrimary (citable) accession number: Q8N1W2
Secondary accession number(s): A0AVS3, Q6ZMK9, Q8NDU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: September 27, 2017
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families