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Protein

Rho guanine nucleotide exchange factor 28

Gene

ARHGEF28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri652 – 69948Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3928662. EPHB-mediated forward signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 28
Alternative name(s):
190 kDa guanine nucleotide exchange factor
Short name:
p190-RhoGEF
Short name:
p190RhoGEF
Rho guanine nucleotide exchange factor
Gene namesi
Name:ARHGEF28
Synonyms:KIAA1998, RGNEF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30322. ARHGEF28.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell membrane By similarity

  • Note: Colocalizes with the microtubule radial and cortical systems.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiARHGEF28.
DMDMi327478563.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17051705Rho guanine nucleotide exchange factor 28PRO_0000324119Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei313 – 3131PhosphoserineBy similarity
Modified residuei478 – 4781PhosphoserineBy similarity
Modified residuei624 – 6241PhosphoserineCombined sources
Modified residuei1538 – 15381PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated on tyrosine upon stimulation of cells by laminin.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N1W1.
MaxQBiQ8N1W1.
PaxDbiQ8N1W1.
PeptideAtlasiQ8N1W1.
PRIDEiQ8N1W1.

PTM databases

iPTMnetiQ8N1W1.
PhosphoSiteiQ8N1W1.

Expressioni

Gene expression databases

BgeeiENSG00000214944.
ExpressionAtlasiQ8N1W1. baseline and differential.
GenevisibleiQ8N1W1. HS.

Organism-specific databases

HPAiHPA037602.

Interactioni

Subunit structurei

Homooligomer; forms cytoplasmic aggregates. Forms a complex with MAPK8 and MAPK8IP1. Interacts with RHOA. Interacts with microtubules. Interacts with YWHAE and YWHAH. Interacts with PTK2/FAK1. Interacts with NEFL (By similarity). Interacts with CTNND2; prevents interaction with RHOA.By similarity2 Publications

Protein-protein interaction databases

BioGridi122127. 5 interactions.
IntActiQ8N1W1. 1 interaction.
MINTiMINT-3039308.
STRINGi9606.ENSP00000411459.

Structurei

3D structure databases

ProteinModelPortaliQ8N1W1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini849 – 1044196DHPROSITE-ProRule annotationAdd
BLAST
Domaini1086 – 1188103PHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1295 – 130410Interaction with PTK2/FAK1; required for regulation of axonal branching and synapse formationBy similarity
Regioni1372 – 138312Mediates cytoplasmic retention and interaction with YWHAHBy similarityAdd
BLAST
Regioni1425 – 1705281Interaction with microtubulesBy similarityAdd
BLAST
Regioni1496 – 152732RNA-bindingBy similarityAdd
BLAST
Regioni1566 – 157914Mediates cytoplasmic retention and interaction with MAPK8IP1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1488 – 152538Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri652 – 69948Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3520. Eukaryota.
KOG4305. Eukaryota.
ENOG410XT68. LUCA.
GeneTreeiENSGT00760000119193.
HOGENOMiHOG000154109.
HOVERGENiHBG079129.
InParanoidiQ8N1W1.
OMAiHQFQQEQ.
OrthoDBiEOG091G00G7.
PhylomeDBiQ8N1W1.
TreeFamiTF334740.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N1W1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELSCSEAPL YGQMMIYAKF DKNVYLPEDA EFYFTYDGSH QRHVMIAERI
60 70 80 90 100
EDNVLQSSVP GHGLQETVTV SVCLCSEGYS PVTMGSGSVT YVDNMACRLA
110 120 130 140 150
RLLVTQANRL TACSHQTLLT PFALTAGALP ALDEELVLAL THLELPLEWT
160 170 180 190 200
VLGSSSLEVS SHRESLLHLA MRWGLAKLSQ FFLCLPGGVQ ALALPNEEGA
210 220 230 240 250
TPLDLALREG HSKLVEDVTN FQGRWSPSFS RVQLSEEASL HYIHSSETLT
260 270 280 290 300
LTLNHTAEHL LEADIKLFRK YFWDRAFLVK AFEPEARPEE RTAMPSSGAE
310 320 330 340 350
TEEEIKNSVS SRSAAEKEDI KRVKSLVVQH NEHEDQHSLD LDRSFDILKK
360 370 380 390 400
SKPPSTLLAA GRLSDMLNGG DEVYANCMVI DQVGDLDISY INIEGITATT
410 420 430 440 450
SPESRGCTLW PQSSKHTLPT ETSPSVYPLS ENVEGTAHTE AQQSFMSPSS
460 470 480 490 500
SCASNLNLSF GWHGFEKEQS HLKKRSSSLD ALDADSEGEG HSEPSHICYT
510 520 530 540 550
PGSQSSSRTG IPSGDELDSF ETNTEPDFNI SRAESLPLSS NLQSKESLLS
560 570 580 590 600
GVRSRSYSCS SPKISLGKTR LVRELTVCSS SEEQRAYSLS EPPRENRIQE
610 620 630 640 650
EEWDKYIIPA KSESEKYKVS RTFSFLMNRM TSPRNKSKTK SKDAKDKEKL
660 670 680 690 700
NRHQFAPGTF SGVLQCLVCD KTLLGKESLQ CSNCNANVHK GCKDAAPACT
710 720 730 740 750
KKFQEKYNKN KPQTILGNSS FRDIPQPGLS LHPSSSVPVG LPTGRRETVG
760 770 780 790 800
QVHPLSRSVP GTTLESFRRS ATSLESESDH NSCRSRSHSD ELLQSMGSSP
810 820 830 840 850
STESFIMEDV VDSSLWSDLS SDAQEFEAES WSLVVDPSFC NRQEKDVIKR
860 870 880 890 900
QDVIFELMQT EMHHIQTLFI MSEIFRKGMK EELQLDHSTV DKIFPCLDEL
910 920 930 940 950
LEIHRHFFYS MKERRQESCA GSDRNFVIDR IGDILVQQFS EENASKMKKI
960 970 980 990 1000
YGEFCCHHKE AVNLFKELQQ NKKFQNFIKL RNSNLLARRR GIPECILLVT
1010 1020 1030 1040 1050
QRITKYPVLV ERILQYTKER TEEHKDLRKA LCLIKDMIAT VDLKVNEYEK
1060 1070 1080 1090 1100
NQKWLEILNK IENKTYTKLK NGHVFRKQAL MSEERTLLYD GLVYWKTATG
1110 1120 1130 1140 1150
RFKDILALLL TDVLLFLQEK DQKYIFAAVD QKPSVISLQK LIAREVANEE
1160 1170 1180 1190 1200
RGMFLISASS AGPEMYEIHT NSKEERNNWM RRIQQAVESC PEEKGGRTSE
1210 1220 1230 1240 1250
SDEDKRKAEA RVAKIQQCQE ILTNQDQQIC AYLEEKLHIY AELGELSGFE
1260 1270 1280 1290 1300
DVHLEPHLLI KPDPGEPPQA ASLLAAALKE AESLQVAVKA SQMGAVSQSC
1310 1320 1330 1340 1350
EDSCGDSVLA DTLSSHDVPG SPTASLVTGG REGRGCSDVD PGIQGVVTDL
1360 1370 1380 1390 1400
AVSDAGEKVE CRNFPGSSQS EIIQAIQNLT RLLYSLQAAL TIQDSHIEIH
1410 1420 1430 1440 1450
RLVLQQQEGL SLGHSILRGG PLQDQKSRDA DRQHEELANV HQLQHQLQQE
1460 1470 1480 1490 1500
QRRWLRRCEQ QQRAQATRES WLQERERECQ SQEELLLRSR GELDLQLQEY
1510 1520 1530 1540 1550
QHSLERLREG QRLVEREQAR MRAQQSLLGH WKHGRQRSLP AVLLPGGPEV
1560 1570 1580 1590 1600
MELNRSESLC HENSFFINEA LVQMSFNTFN KLNPSVIHQD ATYPTTQSHS
1610 1620 1630 1640 1650
DLVRTSEHQV DLKVDPSQPS NVSHKLWTAA GSGHQILPFH ESSKDSCKND
1660 1670 1680 1690 1700
LDTSHTESPT PHDSNSHRPQ LQAFITEAKL NLPTRTMTRQ DGETGDGAKE

NIVYL
Length:1,705
Mass (Da):191,891
Last modified:April 5, 2011 - v3
Checksum:iD4DD6331BD259CC7
GO
Isoform 2 (identifier: Q8N1W1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     583-602: EQRAYSLSEPPRENRIQEEE → GKHHLTFGFENTLFQNRFFS
     603-1705: Missing.

Note: No experimental confirmation available.
Show »
Length:602
Mass (Da):66,373
Checksum:i7A7A0474CC0A9D43
GO
Isoform 3 (identifier: Q8N1W1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1282-1325: Missing.
     1649-1649: N → NGSSMTKCSCTLTSPPGLWTGTTSTLK

Note: No experimental confirmation available.
Show »
Length:1,687
Mass (Da):190,184
Checksum:iB1CD6ACC1DE291B1
GO
Isoform 4 (identifier: Q8N1W1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1650-1705: DLDTSHTESPTPHDSNSHRPQLQAFITEAKLNLPTRTMTRQDGETGDGAKENIVYL → GN

Show »
Length:1,651
Mass (Da):185,844
Checksum:i880C23E7F41826D4
GO
Isoform 5 (identifier: Q8N1W1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MELSCSEAPLYGQMMIYAKFDKNVYLPE → MDSDSDSPFNYSWPSFPKMKIRRRTSKQ
     29-341: Missing.

Note: No experimental confirmation available.
Show »
Length:1,392
Mass (Da):157,251
Checksum:i0D9EB6EF948012B8
GO
Isoform 6 (identifier: Q8N1W1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1649-1649: N → NGSSMTKCSCTLTSPPGLWTGTTSTLK

Note: Gene prediction based on EST data.
Show »
Length:1,731
Mass (Da):194,519
Checksum:i302A50B721ABB567
GO

Sequence cautioni

The sequence AAH12946 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15243 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC02707 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1450 – 14501E → G in BAB15141 (PubMed:14702039).Curated
Sequence conflicti1540 – 15401P → S in BAB15141 (PubMed:14702039).Curated
Sequence conflicti1598 – 15981S → F in AAH12946 (PubMed:15489334).Curated
Sequence conflicti1613 – 16131K → L in AAH12946 (PubMed:15489334).Curated
Sequence conflicti1620 – 16201S → L in AAH12946 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti98 – 981R → M.
Corresponds to variant rs12659447 [ dbSNP | Ensembl ].
VAR_039657
Natural varianti225 – 2251W → R.
Corresponds to variant rs7714670 [ dbSNP | Ensembl ].
VAR_039658
Natural varianti284 – 2841P → Q.1 Publication
Corresponds to variant rs6453022 [ dbSNP | Ensembl ].
VAR_039659
Natural varianti544 – 5441S → L.
Corresponds to variant rs2973571 [ dbSNP | Ensembl ].
VAR_039660
Natural varianti585 – 5851R → K.
Corresponds to variant rs2973566 [ dbSNP | Ensembl ].
VAR_039661
Natural varianti780 – 7801H → N.
Corresponds to variant rs2973558 [ dbSNP | Ensembl ].
VAR_039662
Natural varianti1548 – 15481P → S.
Corresponds to variant rs17634865 [ dbSNP | Ensembl ].
VAR_039663
Natural varianti1640 – 16401H → Q.2 Publications
Corresponds to variant rs1478453 [ dbSNP | Ensembl ].
VAR_039664

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2828MELSC…VYLPE → MDSDSDSPFNYSWPSFPKMK IRRRTSKQ in isoform 5. 1 PublicationVSP_044737Add
BLAST
Alternative sequencei29 – 341313Missing in isoform 5. 1 PublicationVSP_044738Add
BLAST
Alternative sequencei583 – 60220EQRAY…IQEEE → GKHHLTFGFENTLFQNRFFS in isoform 2. 1 PublicationVSP_032140Add
BLAST
Alternative sequencei603 – 17051103Missing in isoform 2. 1 PublicationVSP_032141Add
BLAST
Alternative sequencei1282 – 132544Missing in isoform 3. 1 PublicationVSP_032142Add
BLAST
Alternative sequencei1649 – 16491N → NGSSMTKCSCTLTSPPGLWT GTTSTLK in isoform 3 and isoform 6. 2 PublicationsVSP_032143
Alternative sequencei1650 – 170556DLDTS…NIVYL → GN in isoform 4. CuratedVSP_032144Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082529 mRNA. Translation: BAC02707.1. Different initiation.
AK025470 mRNA. Translation: BAB15141.1.
AK025816 mRNA. Translation: BAB15243.1. Different initiation.
AK094713 mRNA. Translation: BAC04405.1.
AK304761 mRNA. Translation: BAG65516.1.
AC008387 Genomic DNA. No translation available.
AC026702 Genomic DNA. No translation available.
AC091868 Genomic DNA. No translation available.
AC093283 Genomic DNA. No translation available.
BC012946 mRNA. Translation: AAH12946.1. Different initiation.
BC157846 mRNA. Translation: AAI57847.1.
BC171850 mRNA. Translation: AAI71850.1.
CCDSiCCDS47231.2. [Q8N1W1-6]
CCDS54870.1. [Q8N1W1-1]
CCDS58957.1. [Q8N1W1-5]
RefSeqiNP_001073948.2. NM_001080479.2. [Q8N1W1-6]
NP_001171164.1. NM_001177693.1. [Q8N1W1-1]
NP_001231293.1. NM_001244364.1. [Q8N1W1-5]
XP_011541848.1. XM_011543546.1. [Q8N1W1-6]
UniGeneiHs.482521.

Genome annotation databases

EnsembliENST00000296794; ENSP00000296794; ENSG00000214944. [Q8N1W1-4]
ENST00000296799; ENSP00000296799; ENSG00000214944. [Q8N1W1-5]
ENST00000426542; ENSP00000412175; ENSG00000214944. [Q8N1W1-1]
ENST00000437974; ENSP00000411459; ENSG00000214944. [Q8N1W1-6]
ENST00000513042; ENSP00000441436; ENSG00000214944. [Q8N1W1-1]
ENST00000545377; ENSP00000441913; ENSG00000214944. [Q8N1W1-6]
GeneIDi64283.
KEGGihsa:64283.
UCSCiuc010izf.4. human. [Q8N1W1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082529 mRNA. Translation: BAC02707.1. Different initiation.
AK025470 mRNA. Translation: BAB15141.1.
AK025816 mRNA. Translation: BAB15243.1. Different initiation.
AK094713 mRNA. Translation: BAC04405.1.
AK304761 mRNA. Translation: BAG65516.1.
AC008387 Genomic DNA. No translation available.
AC026702 Genomic DNA. No translation available.
AC091868 Genomic DNA. No translation available.
AC093283 Genomic DNA. No translation available.
BC012946 mRNA. Translation: AAH12946.1. Different initiation.
BC157846 mRNA. Translation: AAI57847.1.
BC171850 mRNA. Translation: AAI71850.1.
CCDSiCCDS47231.2. [Q8N1W1-6]
CCDS54870.1. [Q8N1W1-1]
CCDS58957.1. [Q8N1W1-5]
RefSeqiNP_001073948.2. NM_001080479.2. [Q8N1W1-6]
NP_001171164.1. NM_001177693.1. [Q8N1W1-1]
NP_001231293.1. NM_001244364.1. [Q8N1W1-5]
XP_011541848.1. XM_011543546.1. [Q8N1W1-6]
UniGeneiHs.482521.

3D structure databases

ProteinModelPortaliQ8N1W1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122127. 5 interactions.
IntActiQ8N1W1. 1 interaction.
MINTiMINT-3039308.
STRINGi9606.ENSP00000411459.

PTM databases

iPTMnetiQ8N1W1.
PhosphoSiteiQ8N1W1.

Polymorphism and mutation databases

BioMutaiARHGEF28.
DMDMi327478563.

Proteomic databases

EPDiQ8N1W1.
MaxQBiQ8N1W1.
PaxDbiQ8N1W1.
PeptideAtlasiQ8N1W1.
PRIDEiQ8N1W1.

Protocols and materials databases

DNASUi64283.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296794; ENSP00000296794; ENSG00000214944. [Q8N1W1-4]
ENST00000296799; ENSP00000296799; ENSG00000214944. [Q8N1W1-5]
ENST00000426542; ENSP00000412175; ENSG00000214944. [Q8N1W1-1]
ENST00000437974; ENSP00000411459; ENSG00000214944. [Q8N1W1-6]
ENST00000513042; ENSP00000441436; ENSG00000214944. [Q8N1W1-1]
ENST00000545377; ENSP00000441913; ENSG00000214944. [Q8N1W1-6]
GeneIDi64283.
KEGGihsa:64283.
UCSCiuc010izf.4. human. [Q8N1W1-1]

Organism-specific databases

CTDi64283.
GeneCardsiARHGEF28.
H-InvDBHIX0017242.
HGNCiHGNC:30322. ARHGEF28.
HPAiHPA037602.
MIMi612790. gene.
neXtProtiNX_Q8N1W1.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3520. Eukaryota.
KOG4305. Eukaryota.
ENOG410XT68. LUCA.
GeneTreeiENSGT00760000119193.
HOGENOMiHOG000154109.
HOVERGENiHBG079129.
InParanoidiQ8N1W1.
OMAiHQFQQEQ.
OrthoDBiEOG091G00G7.
PhylomeDBiQ8N1W1.
TreeFamiTF334740.

Enzyme and pathway databases

ReactomeiR-HSA-3928662. EPHB-mediated forward signaling.

Miscellaneous databases

GenomeRNAii64283.
PROiQ8N1W1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000214944.
ExpressionAtlasiQ8N1W1. baseline and differential.
GenevisibleiQ8N1W1. HS.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARG28_HUMAN
AccessioniPrimary (citable) accession number: Q8N1W1
Secondary accession number(s): B2RXG7
, B4E3K4, B5MDA3, B7ZW32, E9PC75, Q8NCM7, Q96E37, Q9H6L3, Q9H6W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.