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Protein

Unconventional myosin-Ih

Gene

MYO1H

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi105 – 1128ATPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ih
Alternative name(s):
Myosin-1H
Gene namesi
Name:MYO1H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:13879. MYO1H.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi189083206.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10321032Unconventional myosin-IhPRO_0000333237Add
BLAST

Proteomic databases

PaxDbiQ8N1T3.
PRIDEiQ8N1T3.

PTM databases

PhosphoSiteiQ8N1T3.

Expressioni

Gene expression databases

BgeeiQ8N1T3.
CleanExiHS_MYO1H.
ExpressionAtlasiQ8N1T3. baseline and differential.
GenevisibleiQ8N1T3. HS.

Organism-specific databases

HPAiHPA039516.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000439182.

Structurei

3D structure databases

ProteinModelPortaliQ8N1T3.
SMRiQ8N1T3. Positions 9-725.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 701690Myosin motorAdd
BLAST
Domaini704 – 72623IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini727 – 75630IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini855 – 1029175TH1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOVERGENiHBG062373.
InParanoidiQ8N1T3.
OMAiGEVTYCT.
OrthoDBiEOG7V49XQ.
PhylomeDBiQ8N1T3.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N1T3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGALTARDK VGVQDFVLLD AYTSESAFVD NLRKRFSENL IYTYIGTLLV
60 70 80 90 100
SVNPYQELGI YTVSQMELYQ GVNFFELPPH VYAIADNAYR MMCAELNNHF
110 120 130 140 150
ILISGESGAG KTEASKKILE YFAVTCPMTQ SLQIARDRLL FSNPVLEAFG
160 170 180 190 200
NARTLRNDNS SRFGKYMDIQ FDFQGIPVGG HIISYLIEKS RVVYQNEGER
210 220 230 240 250
NFHIFYQLLA GGEEERLSYL GLERDPQLYK YLSQGHCAKE SSISDKNDWK
260 270 280 290 300
TVSNAFSVID FTEADLENLF GIIASVLHLG NIGFEEDDQG CATIPDTHEI
310 320 330 340 350
KWIAKLLGVH PSVLLEALTH RKIEAKTEEV ICPLTLELSV YARDAMAKAV
360 370 380 390 400
YGRTFTWLVN KINSSLVNKV GQRILDPLLL LTWKTVIGLL DIYGFEVFDK
410 420 430 440 450
NGFEQFCINY CNEKLQQLLI ERTLKAEQAE YEMEGIEWEP IKYFNNKIIC
460 470 480 490 500
DLVEERHKGI ISILDEECIR PGPATDLSFL EKLEEKVGKH AHFETRKLAG
510 520 530 540 550
PKGRKRIGWM EFRLLHYAGE VTYCTKGFLE KNNDLLYRHL KEVLCKSKNI
560 570 580 590 600
ILRECFLLAE LENRRRPPTV GTQFKNSLSS LLETLISKEP SYIRCIKPND
610 620 630 640 650
RKEPSKFDDF LIRHQIKYLG LMEHLRVRRA GFAYRRKYEH FLQRYKSLCP
660 670 680 690 700
DTWPHWHGPP AEGVERLIKY IGYKPEEYKL GKTKIFIRFP RTLFATEDAF
710 720 730 740 750
EFSKHQLVAR IQATYKRCLG RREYVKKRQA AIKLEAHWRG ALARKAIQRR
760 770 780 790 800
KWAVRIIRKF IKGFISRNKP LCPDNEEFIV FVRKNYILNL RYHLPKTVLD
810 820 830 840 850
KSWLRPPGIL ENASDLLRKM CVRNLVQKYC RGITAERKAM MQQKVVTSEI
860 870 880 890 900
FRGRKDGYTE SLNQPFVNSR IDEGDINPKV LQLISHEKIQ YGVPVIKYDR
910 920 930 940 950
KGFKARQRQL ILTQKAAYVV ELAKIKQKIE YSALKGVSTS NLSDGILVIH
960 970 980 990 1000
VSPEDSKQKG DAVLQCGHVF EAVTKLVMLV KKENIVNVVQ GSLQFFISPG
1010 1020 1030
KEGTIVFDTG LEEQVYKNKN GQLTVVSVRR KS
Length:1,032
Mass (Da):119,037
Last modified:May 20, 2008 - v2
Checksum:i60BD256AD1220A2C
GO
Isoform 2 (identifier: Q8N1T3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-819: Missing.
     937-946: VSTSNLSDGI → KKWAIFKTMH
     947-1032: Missing.

Show »
Length:127
Mass (Da):14,805
Checksum:iB0D1030F99A3617B
GO
Isoform 3 (identifier: Q8N1T3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     370-383: VGQRILDPLLLLTW → DFTR

Note: May be due to intron retention.
Show »
Length:1,022
Mass (Da):117,937
Checksum:i8A63373A5C57264A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti348 – 3481K → T in DV080460 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371S → R.
Corresponds to variant rs11611277 [ dbSNP | Ensembl ].
VAR_043131
Natural varianti705 – 7051H → Y.
Corresponds to variant rs34725387 [ dbSNP | Ensembl ].
VAR_043132
Natural varianti1011 – 10111L → P.
Corresponds to variant rs3825393 [ dbSNP | Ensembl ].
VAR_050213

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 819819Missing in isoform 2. 1 PublicationVSP_033497Add
BLAST
Alternative sequencei370 – 38314VGQRI…LLLTW → DFTR in isoform 3. 1 PublicationVSP_053792Add
BLAST
Alternative sequencei937 – 94610VSTSNLSDGI → KKWAIFKTMH in isoform 2. 1 PublicationVSP_033498
Alternative sequencei947 – 103286Missing in isoform 2. 1 PublicationVSP_033499Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094906 mRNA. Translation: BAC04454.1.
AC007570 Genomic DNA. No translation available.
AC012384 Genomic DNA. No translation available.
DV080460 mRNA. No translation available.
CCDSiCCDS53826.1. [Q8N1T3-3]
UniGeneiHs.512008.

Genome annotation databases

EnsembliENST00000431443; ENSP00000444076; ENSG00000174527. [Q8N1T3-3]
UCSCiuc010sxn.1. human. [Q8N1T3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094906 mRNA. Translation: BAC04454.1.
AC007570 Genomic DNA. No translation available.
AC012384 Genomic DNA. No translation available.
DV080460 mRNA. No translation available.
CCDSiCCDS53826.1. [Q8N1T3-3]
UniGeneiHs.512008.

3D structure databases

ProteinModelPortaliQ8N1T3.
SMRiQ8N1T3. Positions 9-725.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000439182.

PTM databases

PhosphoSiteiQ8N1T3.

Polymorphism and mutation databases

DMDMi189083206.

Proteomic databases

PaxDbiQ8N1T3.
PRIDEiQ8N1T3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431443; ENSP00000444076; ENSG00000174527. [Q8N1T3-3]
UCSCiuc010sxn.1. human. [Q8N1T3-1]

Organism-specific databases

GeneCardsiMYO1H.
HGNCiHGNC:13879. MYO1H.
HPAiHPA039516.
MIMi614636. gene.
neXtProtiNX_Q8N1T3.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOVERGENiHBG062373.
InParanoidiQ8N1T3.
OMAiGEVTYCT.
OrthoDBiEOG7V49XQ.
PhylomeDBiQ8N1T3.

Miscellaneous databases

NextBioi93911.
PROiQ8N1T3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N1T3.
CleanExiHS_MYO1H.
ExpressionAtlasiQ8N1T3. baseline and differential.
GenevisibleiQ8N1T3. HS.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Corpus callosum.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in human."
    Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 344-496 (ISOFORM 3).

Entry informationi

Entry nameiMYO1H_HUMAN
AccessioniPrimary (citable) accession number: Q8N1T3
Secondary accession number(s): F5H3C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 11, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.