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Protein

Unconventional myosin-Ih

Gene

MYO1H

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 112ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ih
Alternative name(s):
Myosin-1H
Gene namesi
Name:MYO1H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000174527.9
HGNCiHGNC:13879 MYO1H
MIMi614636 gene
neXtProtiNX_Q8N1T3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

MalaCardsiMYO1H
OpenTargetsiENSG00000174527

Polymorphism and mutation databases

DMDMi189083206

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003332371 – 1032Unconventional myosin-IhAdd BLAST1032

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei365PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8N1T3
PeptideAtlasiQ8N1T3
PRIDEiQ8N1T3

PTM databases

iPTMnetiQ8N1T3
PhosphoSitePlusiQ8N1T3

Expressioni

Gene expression databases

BgeeiENSG00000174527
CleanExiHS_MYO1H
ExpressionAtlasiQ8N1T3 baseline and differential
GenevisibleiQ8N1T3 HS

Organism-specific databases

HPAiHPA039516

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000439182

Structurei

3D structure databases

ProteinModelPortaliQ8N1T3
SMRiQ8N1T3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 701Myosin motorPROSITE-ProRule annotationAdd BLAST690
Domaini704 – 726IQ 1PROSITE-ProRule annotationAdd BLAST23
Domaini727 – 756IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini855 – 1029TH1PROSITE-ProRule annotationAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni578 – 600Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140778
HOVERGENiHBG062373
InParanoidiQ8N1T3
OrthoDBiEOG091G0136
PhylomeDBiQ8N1T3

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N1T3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGALTARDK VGVQDFVLLD AYTSESAFVD NLRKRFSENL IYTYIGTLLV
60 70 80 90 100
SVNPYQELGI YTVSQMELYQ GVNFFELPPH VYAIADNAYR MMCAELNNHF
110 120 130 140 150
ILISGESGAG KTEASKKILE YFAVTCPMTQ SLQIARDRLL FSNPVLEAFG
160 170 180 190 200
NARTLRNDNS SRFGKYMDIQ FDFQGIPVGG HIISYLIEKS RVVYQNEGER
210 220 230 240 250
NFHIFYQLLA GGEEERLSYL GLERDPQLYK YLSQGHCAKE SSISDKNDWK
260 270 280 290 300
TVSNAFSVID FTEADLENLF GIIASVLHLG NIGFEEDDQG CATIPDTHEI
310 320 330 340 350
KWIAKLLGVH PSVLLEALTH RKIEAKTEEV ICPLTLELSV YARDAMAKAV
360 370 380 390 400
YGRTFTWLVN KINSSLVNKV GQRILDPLLL LTWKTVIGLL DIYGFEVFDK
410 420 430 440 450
NGFEQFCINY CNEKLQQLLI ERTLKAEQAE YEMEGIEWEP IKYFNNKIIC
460 470 480 490 500
DLVEERHKGI ISILDEECIR PGPATDLSFL EKLEEKVGKH AHFETRKLAG
510 520 530 540 550
PKGRKRIGWM EFRLLHYAGE VTYCTKGFLE KNNDLLYRHL KEVLCKSKNI
560 570 580 590 600
ILRECFLLAE LENRRRPPTV GTQFKNSLSS LLETLISKEP SYIRCIKPND
610 620 630 640 650
RKEPSKFDDF LIRHQIKYLG LMEHLRVRRA GFAYRRKYEH FLQRYKSLCP
660 670 680 690 700
DTWPHWHGPP AEGVERLIKY IGYKPEEYKL GKTKIFIRFP RTLFATEDAF
710 720 730 740 750
EFSKHQLVAR IQATYKRCLG RREYVKKRQA AIKLEAHWRG ALARKAIQRR
760 770 780 790 800
KWAVRIIRKF IKGFISRNKP LCPDNEEFIV FVRKNYILNL RYHLPKTVLD
810 820 830 840 850
KSWLRPPGIL ENASDLLRKM CVRNLVQKYC RGITAERKAM MQQKVVTSEI
860 870 880 890 900
FRGRKDGYTE SLNQPFVNSR IDEGDINPKV LQLISHEKIQ YGVPVIKYDR
910 920 930 940 950
KGFKARQRQL ILTQKAAYVV ELAKIKQKIE YSALKGVSTS NLSDGILVIH
960 970 980 990 1000
VSPEDSKQKG DAVLQCGHVF EAVTKLVMLV KKENIVNVVQ GSLQFFISPG
1010 1020 1030
KEGTIVFDTG LEEQVYKNKN GQLTVVSVRR KS
Length:1,032
Mass (Da):119,037
Last modified:May 20, 2008 - v2
Checksum:i60BD256AD1220A2C
GO
Isoform 2 (identifier: Q8N1T3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-819: Missing.
     937-946: VSTSNLSDGI → KKWAIFKTMH
     947-1032: Missing.

Show »
Length:127
Mass (Da):14,805
Checksum:iB0D1030F99A3617B
GO
Isoform 3 (identifier: Q8N1T3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     370-383: VGQRILDPLLLLTW → DFTR

Note: May be due to intron retention.
Show »
Length:1,022
Mass (Da):117,937
Checksum:i8A63373A5C57264A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti348K → T in DV080460 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04313137S → R. Corresponds to variant dbSNP:rs11611277Ensembl.1
Natural variantiVAR_043132705H → Y. Corresponds to variant dbSNP:rs34725387Ensembl.1
Natural variantiVAR_0502131011L → P. Corresponds to variant dbSNP:rs3825393Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0334971 – 819Missing in isoform 2. 1 PublicationAdd BLAST819
Alternative sequenceiVSP_053792370 – 383VGQRI…LLLTW → DFTR in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_033498937 – 946VSTSNLSDGI → KKWAIFKTMH in isoform 2. 1 Publication10
Alternative sequenceiVSP_033499947 – 1032Missing in isoform 2. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094906 mRNA Translation: BAC04454.1
AC007570 Genomic DNA No translation available.
AC012384 Genomic DNA No translation available.
DV080460 mRNA No translation available.
CCDSiCCDS53826.1 [Q8N1T3-3]
UniGeneiHs.512008

Genome annotation databases

EnsembliENST00000431443; ENSP00000444076; ENSG00000174527 [Q8N1T3-3]
UCSCiuc010sxn.1 human [Q8N1T3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMYO1H_HUMAN
AccessioniPrimary (citable) accession number: Q8N1T3
Secondary accession number(s): F5H3C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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