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Q8N1S5

- S39AB_HUMAN

UniProt

Q8N1S5 - S39AB_HUMAN

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Protein

Zinc transporter ZIP11

Gene

SLC39A11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May act as a zinc-influx transporter.By similarity

GO - Molecular functioni

  1. metal ion transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. zinc ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Protein family/group databases

TCDBi2.A.5.5.2. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP11
Alternative name(s):
Solute carrier family 39 member 11
Zrt- and Irt-like protein 11
Short name:
ZIP-11
Gene namesi
Name:SLC39A11
Synonyms:C17orf26, ZIP11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:14463. SLC39A11.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25581.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Zinc transporter ZIP11PRO_0000308410Add
BLAST

Proteomic databases

MaxQBiQ8N1S5.
PaxDbiQ8N1S5.
PRIDEiQ8N1S5.

PTM databases

PhosphoSiteiQ8N1S5.

Expressioni

Gene expression databases

BgeeiQ8N1S5.
CleanExiHS_SLC39A11.
ExpressionAtlasiQ8N1S5. baseline and differential.
GenevestigatoriQ8N1S5.

Interactioni

Protein-protein interaction databases

BioGridi128379. 13 interactions.
STRINGi9606.ENSP00000255559.

Structurei

3D structure databases

ProteinModelPortaliQ8N1S5.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei44 – 6421HelicalSequence AnalysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Transmembranei263 – 28523HelicalSequence AnalysisAdd
BLAST
Transmembranei290 – 30718HelicalSequence AnalysisAdd
BLAST
Transmembranei322 – 34221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0428.
GeneTreeiENSGT00390000006167.
HOGENOMiHOG000232703.
HOVERGENiHBG108448.
InParanoidiQ8N1S5.
KOiK14717.
OMAiVWSLLIP.
PhylomeDBiQ8N1S5.
TreeFamiTF105905.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N1S5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQGHSSVFQ ALLGTFFTWG MTAAGAALVF VFSSGQRRIL DGSLGFAAGV
60 70 80 90 100
MLAASYWSLL APAVEMATSS GGFGAFAFFP VAVGFTLGAA FVYLADLLMP
110 120 130 140 150
HLGAAEDPQT TLALNFGSTL MKKKSDPEGP ALLFPESELS IRIGRAGLLS
160 170 180 190 200
DKSENGEAYQ RKKAAATGLP EGPAVPVPSR GNLAQPGGSS WRRIALLILA
210 220 230 240 250
ITIHNVPEGL AVGVGFGAIE KTASATFESA RNLAIGIGIQ NFPEGLAVSL
260 270 280 290 300
PLRGAGFSTW RAFWYGQLSG MVEPLAGVFG AFAVVLAEPI LPYALAFAAG
310 320 330 340
AMVYVVMDDI IPEAQISGNG KLASWASILG FVVMMSLDVG LG
Length:342
Mass (Da):35,396
Last modified:November 30, 2010 - v3
Checksum:i89268838281345D5
GO
Isoform 2 (identifier: Q8N1S5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-150: Missing.

Show »
Length:335
Mass (Da):34,741
Checksum:iFC84EF7DCA4DD60A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131A → T in BAC04504. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti111 – 1111T → A.4 Publications
Corresponds to variant rs2466517 [ dbSNP | Ensembl ].
VAR_036812

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei144 – 1507Missing in isoform 2. 3 PublicationsVSP_028976

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF331643 mRNA. Translation: AAL32175.1.
AK095227 mRNA. Translation: BAC04504.1.
AK313376 mRNA. Translation: BAG36174.1.
AC011120 Genomic DNA. No translation available.
AC025198 Genomic DNA. No translation available.
AC080037 Genomic DNA. No translation available.
AC138336 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89107.1.
BC035631 mRNA. Translation: AAH35631.1.
CCDSiCCDS11690.1. [Q8N1S5-2]
CCDS54160.1. [Q8N1S5-1]
RefSeqiNP_001153242.1. NM_001159770.1. [Q8N1S5-1]
NP_631916.2. NM_139177.3. [Q8N1S5-2]
XP_005257191.1. XM_005257134.1. [Q8N1S5-2]
XP_006721817.1. XM_006721754.1. [Q8N1S5-1]
XP_006721818.1. XM_006721755.1. [Q8N1S5-1]
UniGeneiHs.221127.

Genome annotation databases

EnsembliENST00000255559; ENSP00000255559; ENSG00000133195. [Q8N1S5-2]
ENST00000542342; ENSP00000445829; ENSG00000133195. [Q8N1S5-1]
GeneIDi201266.
KEGGihsa:201266.
UCSCiuc002jja.3. human. [Q8N1S5-2]
uc002jjb.3. human. [Q8N1S5-1]

Polymorphism databases

DMDMi313104189.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF331643 mRNA. Translation: AAL32175.1 .
AK095227 mRNA. Translation: BAC04504.1 .
AK313376 mRNA. Translation: BAG36174.1 .
AC011120 Genomic DNA. No translation available.
AC025198 Genomic DNA. No translation available.
AC080037 Genomic DNA. No translation available.
AC138336 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89107.1 .
BC035631 mRNA. Translation: AAH35631.1 .
CCDSi CCDS11690.1. [Q8N1S5-2 ]
CCDS54160.1. [Q8N1S5-1 ]
RefSeqi NP_001153242.1. NM_001159770.1. [Q8N1S5-1 ]
NP_631916.2. NM_139177.3. [Q8N1S5-2 ]
XP_005257191.1. XM_005257134.1. [Q8N1S5-2 ]
XP_006721817.1. XM_006721754.1. [Q8N1S5-1 ]
XP_006721818.1. XM_006721755.1. [Q8N1S5-1 ]
UniGenei Hs.221127.

3D structure databases

ProteinModelPortali Q8N1S5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128379. 13 interactions.
STRINGi 9606.ENSP00000255559.

Protein family/group databases

TCDBi 2.A.5.5.2. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

PhosphoSitei Q8N1S5.

Polymorphism databases

DMDMi 313104189.

Proteomic databases

MaxQBi Q8N1S5.
PaxDbi Q8N1S5.
PRIDEi Q8N1S5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255559 ; ENSP00000255559 ; ENSG00000133195 . [Q8N1S5-2 ]
ENST00000542342 ; ENSP00000445829 ; ENSG00000133195 . [Q8N1S5-1 ]
GeneIDi 201266.
KEGGi hsa:201266.
UCSCi uc002jja.3. human. [Q8N1S5-2 ]
uc002jjb.3. human. [Q8N1S5-1 ]

Organism-specific databases

CTDi 201266.
GeneCardsi GC17M070644.
H-InvDB HIX0014131.
HGNCi HGNC:14463. SLC39A11.
neXtProti NX_Q8N1S5.
PharmGKBi PA25581.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0428.
GeneTreei ENSGT00390000006167.
HOGENOMi HOG000232703.
HOVERGENi HBG108448.
InParanoidi Q8N1S5.
KOi K14717.
OMAi VWSLLIP.
PhylomeDBi Q8N1S5.
TreeFami TF105905.

Miscellaneous databases

ChiTaRSi SLC39A11. human.
GenomeRNAii 201266.
NextBioi 90114.
PROi Q8N1S5.

Gene expression databases

Bgeei Q8N1S5.
CleanExi HS_SLC39A11.
ExpressionAtlasi Q8N1S5. baseline and differential.
Genevestigatori Q8N1S5.

Family and domain databases

InterProi IPR003689. ZIP.
[Graphical view ]
Pfami PF02535. Zip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative genomics of the SOX9 region in human and Fugu rubripes: conservation of short regulatory sequence elements within large intergenic regions."
    Bagheri-Fam S., Ferraz C., Demaille J., Scherer G., Pfeifer D.
    Genomics 78:73-82(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ALA-111.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-111.
    Tissue: Kidney and Tongue.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-111.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-111.
    Tissue: Blood.

Entry informationi

Entry nameiS39AB_HUMAN
AccessioniPrimary (citable) accession number: Q8N1S5
Secondary accession number(s): B2R8H7, Q8WZ81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3