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Q8N1S5

- S39AB_HUMAN

UniProt

Q8N1S5 - S39AB_HUMAN

Protein

Zinc transporter ZIP11

Gene

SLC39A11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    May act as a zinc-influx transporter.By similarity

    GO - Molecular functioni

    1. metal ion transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. zinc ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Protein family/group databases

    TCDBi2.A.5.5.2. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter ZIP11
    Alternative name(s):
    Solute carrier family 39 member 11
    Zrt- and Irt-like protein 11
    Short name:
    ZIP-11
    Gene namesi
    Name:SLC39A11
    Synonyms:C17orf26, ZIP11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:14463. SLC39A11.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25581.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Zinc transporter ZIP11PRO_0000308410Add
    BLAST

    Proteomic databases

    MaxQBiQ8N1S5.
    PaxDbiQ8N1S5.
    PRIDEiQ8N1S5.

    PTM databases

    PhosphoSiteiQ8N1S5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N1S5.
    BgeeiQ8N1S5.
    CleanExiHS_SLC39A11.
    GenevestigatoriQ8N1S5.

    Interactioni

    Protein-protein interaction databases

    BioGridi128379. 3 interactions.
    STRINGi9606.ENSP00000255559.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N1S5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei44 – 6421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei263 – 28523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 30718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei322 – 34221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0428.
    HOGENOMiHOG000232703.
    HOVERGENiHBG108448.
    InParanoidiQ8N1S5.
    KOiK14717.
    OMAiVWSLLIP.
    PhylomeDBiQ8N1S5.
    TreeFamiTF105905.

    Family and domain databases

    InterProiIPR003689. ZIP.
    [Graphical view]
    PfamiPF02535. Zip. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N1S5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLQGHSSVFQ ALLGTFFTWG MTAAGAALVF VFSSGQRRIL DGSLGFAAGV    50
    MLAASYWSLL APAVEMATSS GGFGAFAFFP VAVGFTLGAA FVYLADLLMP 100
    HLGAAEDPQT TLALNFGSTL MKKKSDPEGP ALLFPESELS IRIGRAGLLS 150
    DKSENGEAYQ RKKAAATGLP EGPAVPVPSR GNLAQPGGSS WRRIALLILA 200
    ITIHNVPEGL AVGVGFGAIE KTASATFESA RNLAIGIGIQ NFPEGLAVSL 250
    PLRGAGFSTW RAFWYGQLSG MVEPLAGVFG AFAVVLAEPI LPYALAFAAG 300
    AMVYVVMDDI IPEAQISGNG KLASWASILG FVVMMSLDVG LG 342
    Length:342
    Mass (Da):35,396
    Last modified:November 30, 2010 - v3
    Checksum:i89268838281345D5
    GO
    Isoform 2 (identifier: Q8N1S5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         144-150: Missing.

    Show »
    Length:335
    Mass (Da):34,741
    Checksum:iFC84EF7DCA4DD60A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti113 – 1131A → T in BAC04504. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti111 – 1111T → A.4 Publications
    Corresponds to variant rs2466517 [ dbSNP | Ensembl ].
    VAR_036812

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei144 – 1507Missing in isoform 2. 3 PublicationsVSP_028976

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF331643 mRNA. Translation: AAL32175.1.
    AK095227 mRNA. Translation: BAC04504.1.
    AK313376 mRNA. Translation: BAG36174.1.
    AC011120 Genomic DNA. No translation available.
    AC025198 Genomic DNA. No translation available.
    AC080037 Genomic DNA. No translation available.
    AC138336 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW89107.1.
    BC035631 mRNA. Translation: AAH35631.1.
    CCDSiCCDS11690.1. [Q8N1S5-2]
    CCDS54160.1. [Q8N1S5-1]
    RefSeqiNP_001153242.1. NM_001159770.1. [Q8N1S5-1]
    NP_631916.2. NM_139177.3. [Q8N1S5-2]
    XP_005257191.1. XM_005257134.1. [Q8N1S5-2]
    XP_006721817.1. XM_006721754.1. [Q8N1S5-1]
    XP_006721818.1. XM_006721755.1. [Q8N1S5-1]
    UniGeneiHs.221127.

    Genome annotation databases

    EnsembliENST00000255559; ENSP00000255559; ENSG00000133195. [Q8N1S5-2]
    ENST00000542342; ENSP00000445829; ENSG00000133195. [Q8N1S5-1]
    GeneIDi201266.
    KEGGihsa:201266.
    UCSCiuc002jja.3. human. [Q8N1S5-2]
    uc002jjb.3. human. [Q8N1S5-1]

    Polymorphism databases

    DMDMi313104189.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF331643 mRNA. Translation: AAL32175.1 .
    AK095227 mRNA. Translation: BAC04504.1 .
    AK313376 mRNA. Translation: BAG36174.1 .
    AC011120 Genomic DNA. No translation available.
    AC025198 Genomic DNA. No translation available.
    AC080037 Genomic DNA. No translation available.
    AC138336 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW89107.1 .
    BC035631 mRNA. Translation: AAH35631.1 .
    CCDSi CCDS11690.1. [Q8N1S5-2 ]
    CCDS54160.1. [Q8N1S5-1 ]
    RefSeqi NP_001153242.1. NM_001159770.1. [Q8N1S5-1 ]
    NP_631916.2. NM_139177.3. [Q8N1S5-2 ]
    XP_005257191.1. XM_005257134.1. [Q8N1S5-2 ]
    XP_006721817.1. XM_006721754.1. [Q8N1S5-1 ]
    XP_006721818.1. XM_006721755.1. [Q8N1S5-1 ]
    UniGenei Hs.221127.

    3D structure databases

    ProteinModelPortali Q8N1S5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128379. 3 interactions.
    STRINGi 9606.ENSP00000255559.

    Protein family/group databases

    TCDBi 2.A.5.5.2. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    PTM databases

    PhosphoSitei Q8N1S5.

    Polymorphism databases

    DMDMi 313104189.

    Proteomic databases

    MaxQBi Q8N1S5.
    PaxDbi Q8N1S5.
    PRIDEi Q8N1S5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255559 ; ENSP00000255559 ; ENSG00000133195 . [Q8N1S5-2 ]
    ENST00000542342 ; ENSP00000445829 ; ENSG00000133195 . [Q8N1S5-1 ]
    GeneIDi 201266.
    KEGGi hsa:201266.
    UCSCi uc002jja.3. human. [Q8N1S5-2 ]
    uc002jjb.3. human. [Q8N1S5-1 ]

    Organism-specific databases

    CTDi 201266.
    GeneCardsi GC17M070644.
    H-InvDB HIX0014131.
    HGNCi HGNC:14463. SLC39A11.
    neXtProti NX_Q8N1S5.
    PharmGKBi PA25581.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0428.
    HOGENOMi HOG000232703.
    HOVERGENi HBG108448.
    InParanoidi Q8N1S5.
    KOi K14717.
    OMAi VWSLLIP.
    PhylomeDBi Q8N1S5.
    TreeFami TF105905.

    Miscellaneous databases

    ChiTaRSi SLC39A11. human.
    GenomeRNAii 201266.
    NextBioi 90114.
    PROi Q8N1S5.

    Gene expression databases

    ArrayExpressi Q8N1S5.
    Bgeei Q8N1S5.
    CleanExi HS_SLC39A11.
    Genevestigatori Q8N1S5.

    Family and domain databases

    InterProi IPR003689. ZIP.
    [Graphical view ]
    Pfami PF02535. Zip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of the SOX9 region in human and Fugu rubripes: conservation of short regulatory sequence elements within large intergenic regions."
      Bagheri-Fam S., Ferraz C., Demaille J., Scherer G., Pfeifer D.
      Genomics 78:73-82(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ALA-111.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-111.
      Tissue: Kidney and Tongue.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-111.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-111.
      Tissue: Blood.

    Entry informationi

    Entry nameiS39AB_HUMAN
    AccessioniPrimary (citable) accession number: Q8N1S5
    Secondary accession number(s): B2R8H7, Q8WZ81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 83 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3