Q8N1S5 (S39AB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc transporter ZIP11

Alternative name(s):
Solute carrier family 39 member 11
Zrt- and Irt-like protein 11
Short name=ZIP-11

Gene names

Name:	SLC39A11
Synonyms:	C17orf26, ZIP11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a zinc-influx transporter By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport Zinc transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	zinc ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	metal ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N1S5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N1S5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     144-150: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Zinc transporter ZIP11		PRO_0000308410
Regions
	Transmembrane	12 – 32	21	Helical; Potential
	Transmembrane	44 – 64	21	Helical; Potential
	Transmembrane	72 – 92	21	Helical; Potential
	Transmembrane	194 – 214	21	Helical; Potential
	Transmembrane	263 – 285	23	Helical; Potential
	Transmembrane	290 – 307	18	Helical; Potential
	Transmembrane	322 – 342	21	Helical; Potential
Natural variations
	Alternative sequence	144 – 150	7	Missing in isoform 2.		VSP_028976
	Natural variant	111	1	T → A. Ref.1 Ref.2 Ref.4 Ref.5 Corresponds to variant rs2466517 [ dbSNP | Ensembl ].		VAR_036812
Experimental info
	Sequence conflict	113	1	A → T in BAC04504. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 30, 2010. Version 3. Checksum: 89268838281345D5	FASTA	342	35,396
	10 20 30 40 50 60 MLQGHSSVFQ ALLGTFFTWG MTAAGAALVF VFSSGQRRIL DGSLGFAAGV MLAASYWSLL 70 80 90 100 110 120 APAVEMATSS GGFGAFAFFP VAVGFTLGAA FVYLADLLMP HLGAAEDPQT TLALNFGSTL 130 140 150 160 170 180 MKKKSDPEGP ALLFPESELS IRIGRAGLLS DKSENGEAYQ RKKAAATGLP EGPAVPVPSR 190 200 210 220 230 240 GNLAQPGGSS WRRIALLILA ITIHNVPEGL AVGVGFGAIE KTASATFESA RNLAIGIGIQ 250 260 270 280 290 300 NFPEGLAVSL PLRGAGFSTW RAFWYGQLSG MVEPLAGVFG AFAVVLAEPI LPYALAFAAG 310 320 330 340 AMVYVVMDDI IPEAQISGNG KLASWASILG FVVMMSLDVG LG
	Isoform 2 [UniParc]. Checksum: FC84EF7DCA4DD60A	FASTA	335	34,741
	10 20 30 40 50 60 MLQGHSSVFQ ALLGTFFTWG MTAAGAALVF VFSSGQRRIL DGSLGFAAGV MLAASYWSLL 70 80 90 100 110 120 APAVEMATSS GGFGAFAFFP VAVGFTLGAA FVYLADLLMP HLGAAEDPQT TLALNFGSTL 130 140 150 160 170 180 MKKKSDPEGP ALLFPESELS IRIDKSENGE AYQRKKAAAT GLPEGPAVPV PSRGNLAQPG 190 200 210 220 230 240 GSSWRRIALL ILAITIHNVP EGLAVGVGFG AIEKTASATF ESARNLAIGI GIQNFPEGLA 250 260 270 280 290 300 VSLPLRGAGF STWRAFWYGQ LSGMVEPLAG VFGAFAVVLA EPILPYALAF AAGAMVYVVM 310 320 330 DDIIPEAQIS GNGKLASWAS ILGFVVMMSL DVGLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative genomics of the SOX9 region in human and Fugu rubripes: conservation of short regulatory sequence elements within large intergenic regions." Bagheri-Fam S., Ferraz C., Demaille J., Scherer G., Pfeifer D. Genomics 78:73-82(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ALA-111.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-111. Tissue: Kidney and Tongue.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-111.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-111. Tissue: Blood.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF331643 mRNA. Translation: AAL32175.1. AK095227 mRNA. Translation: BAC04504.1. AK313376 mRNA. Translation: BAG36174.1. AC011120 Genomic DNA. No translation available. AC025198 Genomic DNA. No translation available. AC080037 Genomic DNA. No translation available. AC138336 Genomic DNA. No translation available. CH471099 Genomic DNA. Translation: EAW89107.1. BC035631 mRNA. Translation: AAH35631.1.
IPI	IPI00410249. IPI00477112.
RefSeq	NP_001153242.1. NM_001159770.1. NP_631916.2. NM_139177.3.
UniGene	Hs.221127.
3D structure databases
ProteinModelPortal	Q8N1S5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000255559.
PTM databases
PhosphoSite	Q8N1S5.
Polymorphism databases
DMDM	160177555.
Proteomic databases
PaxDb	Q8N1S5.
PRIDE	Q8N1S5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255559; ENSP00000255559; ENSG00000133195. ENST00000542342; ENSP00000445829; ENSG00000133195.
GeneID	201266.
KEGG	hsa:201266.
UCSC	uc002jja.3. human. uc002jjb.3. human.
Organism-specific databases
CTD	201266.
GeneCards	GC17M070644.
H-InvDB	HIX0014131.
HGNC	HGNC:14463. SLC39A11.
neXtProt	NX_Q8N1S5.
PharmGKB	PA25581.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0428.
HOGENOM	HOG000232703.
HOVERGEN	HBG108448.
InParanoid	Q8N1S5.
KO	K14717.
OMA	KTSWQRS.
OrthoDB	EOG44TP8M.
Gene expression databases
Bgee	Q8N1S5.
CleanEx	HS_SLC39A11.
Genevestigator	Q8N1S5.
Family and domain databases
InterPro	IPR003689. ZIP. [Graphical view]
Pfam	PF02535. Zip. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC39A11. human.
GenomeRNAi	201266.
NextBio	90114.

Entry information

Entry name

S39AB_HUMAN

Accession

Primary (citable) accession number: Q8N1S5
Secondary accession number(s): B2R8H7, Q8WZ81

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	November 30, 2010
Last modified:	April 3, 2013
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.