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Protein

Zinc transporter ZIP11

Gene

SLC39A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a cellular zinc transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Protein family/group databases

TCDBi2.A.5.5.2 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP11
Alternative name(s):
Solute carrier family 39 member 11
Zrt- and Irt-like protein 11
Short name:
ZIP-11
Gene namesi
Name:SLC39A11
Synonyms:C17orf26, ZIP11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000133195.11
HGNCiHGNC:14463 SLC39A11
MIMi616508 gene
neXtProtiNX_Q8N1S5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei263 – 285HelicalSequence analysisAdd BLAST23
Transmembranei290 – 307HelicalSequence analysisAdd BLAST18
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi201266
OpenTargetsiENSG00000133195
PharmGKBiPA25581

Polymorphism and mutation databases

BioMutaiSLC39A11
DMDMi313104189

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003084101 – 342Zinc transporter ZIP11Add BLAST342

Proteomic databases

MaxQBiQ8N1S5
PaxDbiQ8N1S5
PeptideAtlasiQ8N1S5
PRIDEiQ8N1S5

PTM databases

iPTMnetiQ8N1S5
PhosphoSitePlusiQ8N1S5

Expressioni

Gene expression databases

BgeeiENSG00000133195
CleanExiHS_SLC39A11
ExpressionAtlasiQ8N1S5 baseline and differential
GenevisibleiQ8N1S5 HS

Organism-specific databases

HPAiHPA021455

Interactioni

Protein-protein interaction databases

BioGridi128379, 36 interactors
STRINGi9606.ENSP00000445829

Structurei

3D structure databases

ProteinModelPortaliQ8N1S5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2474 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00390000006167
HOGENOMiHOG000232703
HOVERGENiHBG108448
InParanoidiQ8N1S5
KOiK14717
OMAiMIYVVVE
OrthoDBiEOG091G0LUY
PhylomeDBiQ8N1S5
TreeFamiTF105905

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N1S5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQGHSSVFQ ALLGTFFTWG MTAAGAALVF VFSSGQRRIL DGSLGFAAGV
60 70 80 90 100
MLAASYWSLL APAVEMATSS GGFGAFAFFP VAVGFTLGAA FVYLADLLMP
110 120 130 140 150
HLGAAEDPQT TLALNFGSTL MKKKSDPEGP ALLFPESELS IRIGRAGLLS
160 170 180 190 200
DKSENGEAYQ RKKAAATGLP EGPAVPVPSR GNLAQPGGSS WRRIALLILA
210 220 230 240 250
ITIHNVPEGL AVGVGFGAIE KTASATFESA RNLAIGIGIQ NFPEGLAVSL
260 270 280 290 300
PLRGAGFSTW RAFWYGQLSG MVEPLAGVFG AFAVVLAEPI LPYALAFAAG
310 320 330 340
AMVYVVMDDI IPEAQISGNG KLASWASILG FVVMMSLDVG LG
Length:342
Mass (Da):35,396
Last modified:November 30, 2010 - v3
Checksum:i89268838281345D5
GO
Isoform 2 (identifier: Q8N1S5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-150: Missing.

Show »
Length:335
Mass (Da):34,741
Checksum:iFC84EF7DCA4DD60A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113A → T in BAC04504 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036812111T → A4 PublicationsCorresponds to variant dbSNP:rs2466517Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028976144 – 150Missing in isoform 2. 3 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331643 mRNA Translation: AAL32175.1
AK095227 mRNA Translation: BAC04504.1
AK313376 mRNA Translation: BAG36174.1
AC011120 Genomic DNA No translation available.
AC025198 Genomic DNA No translation available.
AC080037 Genomic DNA No translation available.
AC138336 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89107.1
BC035631 mRNA Translation: AAH35631.1
CCDSiCCDS11690.1 [Q8N1S5-2]
CCDS54160.1 [Q8N1S5-1]
RefSeqiNP_001153242.1, NM_001159770.1 [Q8N1S5-1]
NP_631916.2, NM_139177.3 [Q8N1S5-2]
XP_005257191.1, XM_005257134.3
XP_006721817.1, XM_006721754.3
XP_006721818.1, XM_006721755.2 [Q8N1S5-1]
XP_011522795.1, XM_011524493.1 [Q8N1S5-1]
XP_011522796.1, XM_011524494.2 [Q8N1S5-1]
XP_016879819.1, XM_017024330.1 [Q8N1S5-2]
XP_016879820.1, XM_017024331.1
XP_016879821.1, XM_017024332.1 [Q8N1S5-2]
UniGeneiHs.221127

Genome annotation databases

EnsembliENST00000255559; ENSP00000255559; ENSG00000133195 [Q8N1S5-2]
ENST00000542342; ENSP00000445829; ENSG00000133195 [Q8N1S5-1]
GeneIDi201266
KEGGihsa:201266
UCSCiuc002jja.4 human [Q8N1S5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS39AB_HUMAN
AccessioniPrimary (citable) accession number: Q8N1S5
Secondary accession number(s): B2R8H7, Q8WZ81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 107 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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