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Q8N1Q1

- CAH13_HUMAN

UniProt

Q8N1Q1 - CAH13_HUMAN

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Protein

Carbonic anhydrase 13

Gene

CA13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zinc.By similarity

Enzyme regulationi

Inhibited by acetazolamide.1 Publication

Kineticsi

  1. KM=13.8 mM for CO21 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Proton acceptorBy similarity
Active sitei68 – 681By similarity
Metal bindingi95 – 951Zinc; catalytic
Metal bindingi97 – 971Zinc; catalytic
Metal bindingi120 – 1201Zinc; catalytic
Active sitei129 – 1291By similarity

GO - Molecular functioni

  1. carbonate dehydratase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. bicarbonate transport Source: Reactome
  2. one-carbon metabolic process Source: InterPro
  3. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi4.2.1.1. 3474.
ReactomeiREACT_121123. Reversible hydration of carbon dioxide.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 13 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase XIII
Carbonic anhydrase XIII
Short name:
CA-XIII
Gene namesi
Name:CA13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:14914. CA13.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. myelin sheath Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891311.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Carbonic anhydrase 13PRO_0000077440Add
BLAST

Proteomic databases

MaxQBiQ8N1Q1.
PaxDbiQ8N1Q1.
PeptideAtlasiQ8N1Q1.
PRIDEiQ8N1Q1.

2D gel databases

OGPiQ8N1Q1.

PTM databases

PhosphoSiteiQ8N1Q1.

Expressioni

Tissue specificityi

Expressed in thymus, small intestine, spleen, prostate, ovary, colon and testis.1 Publication

Gene expression databases

BgeeiQ8N1Q1.
CleanExiHS_CA13.
GenevestigatoriQ8N1Q1.

Organism-specific databases

HPAiCAB025567.
HPA024689.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000318912.

Structurei

Secondary structure

1
262
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni10 – 123
Helixi14 – 207
Helixi22 – 254
Beta strandi26 – 283
Turni36 – 383
Beta strandi48 – 514
Beta strandi56 – 627
Beta strandi64 – 718
Beta strandi74 – 829
Beta strandi89 – 9810
Beta strandi107 – 1104
Beta strandi116 – 12510
Turni126 – 1283
Helixi132 – 1354
Beta strandi141 – 15111
Helixi156 – 1627
Helixi163 – 1686
Beta strandi174 – 1763
Helixi182 – 1854
Beta strandi192 – 1976
Beta strandi208 – 2158
Beta strandi217 – 2193
Helixi221 – 2277
Beta strandi230 – 2345
Beta strandi258 – 2603

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CZVX-ray2.00A/B1-262[»]
3D0NX-ray1.55A/B1-262[»]
3DA2X-ray2.05A/B1-261[»]
4HU1X-ray1.95A/B1-262[»]
4KNMX-ray1.90A/B1-262[»]
4KNNX-ray1.40A/B1-262[»]
ProteinModelPortaliQ8N1Q1.
SMRiQ8N1Q1. Positions 5-262.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N1Q1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni200 – 2012Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Phylogenomic databases

eggNOGiCOG3338.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiQ8N1Q1.
KOiK01672.
OMAiQIGEPNS.
OrthoDBiEOG7WMCK7.
PhylomeDBiQ8N1Q1.
TreeFamiTF316425.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N1Q1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRLSWGYRE HNGPIHWKEF FPIADGDQQS PIEIKTKEVK YDSSLRPLSI
60 70 80 90 100
KYDPSSAKII SNSGHSFNVD FDDTENKSVL RGGPLTGSYR LRQVHLHWGS
110 120 130 140 150
ADDHGSEHIV DGVSYAAELH VVHWNSDKYP SFVEAAHEPD GLAVLGVFLQ
160 170 180 190 200
IGEPNSQLQK ITDTLDSIKE KGKQTRFTNF DLLSLLPPSW DYWTYPGSLT
210 220 230 240 250
VPPLLESVTW IVLKQPINIS SQQLAKFRSL LCTAEGEAAA FLVSNHRPPQ
260
PLKGRKVRAS FH
Length:262
Mass (Da):29,443
Last modified:October 1, 2002 - v1
Checksum:iAE677F028ED729FE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681N → S.
Corresponds to variant rs4740046 [ dbSNP | Ensembl ].
VAR_059207

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095314 mRNA. Translation: BAC04528.1.
BC052602 mRNA. Translation: AAH52602.1.
CCDSiCCDS6236.1.
RefSeqiNP_940986.1. NM_198584.2.
UniGeneiHs.127189.

Genome annotation databases

EnsembliENST00000321764; ENSP00000318912; ENSG00000185015.
GeneIDi377677.
KEGGihsa:377677.
UCSCiuc003ydg.2. human.

Polymorphism databases

DMDMi30580350.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095314 mRNA. Translation: BAC04528.1 .
BC052602 mRNA. Translation: AAH52602.1 .
CCDSi CCDS6236.1.
RefSeqi NP_940986.1. NM_198584.2.
UniGenei Hs.127189.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CZV X-ray 2.00 A/B 1-262 [» ]
3D0N X-ray 1.55 A/B 1-262 [» ]
3DA2 X-ray 2.05 A/B 1-261 [» ]
4HU1 X-ray 1.95 A/B 1-262 [» ]
4KNM X-ray 1.90 A/B 1-262 [» ]
4KNN X-ray 1.40 A/B 1-262 [» ]
ProteinModelPortali Q8N1Q1.
SMRi Q8N1Q1. Positions 5-262.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000318912.

Chemistry

BindingDBi Q8N1Q1.
ChEMBLi CHEMBL2095180.
DrugBanki DB00909. Zonisamide.

PTM databases

PhosphoSitei Q8N1Q1.

Polymorphism databases

DMDMi 30580350.

2D gel databases

OGPi Q8N1Q1.

Proteomic databases

MaxQBi Q8N1Q1.
PaxDbi Q8N1Q1.
PeptideAtlasi Q8N1Q1.
PRIDEi Q8N1Q1.

Protocols and materials databases

DNASUi 377677.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000321764 ; ENSP00000318912 ; ENSG00000185015 .
GeneIDi 377677.
KEGGi hsa:377677.
UCSCi uc003ydg.2. human.

Organism-specific databases

CTDi 377677.
GeneCardsi GC08P086232.
HGNCi HGNC:14914. CA13.
HPAi CAB025567.
HPA024689.
MIMi 611436. gene.
neXtProti NX_Q8N1Q1.
PharmGKBi PA134891311.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3338.
GeneTreei ENSGT00760000118915.
HOGENOMi HOG000112637.
HOVERGENi HBG002837.
InParanoidi Q8N1Q1.
KOi K01672.
OMAi QIGEPNS.
OrthoDBi EOG7WMCK7.
PhylomeDBi Q8N1Q1.
TreeFami TF316425.

Enzyme and pathway databases

BRENDAi 4.2.1.1. 3474.
Reactomei REACT_121123. Reversible hydration of carbon dioxide.

Miscellaneous databases

ChiTaRSi CA13. human.
EvolutionaryTracei Q8N1Q1.
GenomeRNAii 377677.
NextBioi 100682.
PROi Q8N1Q1.
SOURCEi Search...

Gene expression databases

Bgeei Q8N1Q1.
CleanExi HS_CA13.
Genevestigatori Q8N1Q1.

Family and domain databases

Gene3Di 3.10.200.10. 1 hit.
InterProi IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view ]
PANTHERi PTHR18952. PTHR18952. 1 hit.
Pfami PF00194. Carb_anhydrase. 1 hit.
[Graphical view ]
SMARTi SM01057. Carb_anhydrase. 1 hit.
[Graphical view ]
SUPFAMi SSF51069. SSF51069. 1 hit.
PROSITEi PS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  3. Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
  4. "Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide."
    Di Fiore A., Monti S.M., Hilvo M., Parkkila S., Romano V., Scaloni A., Pedone C., Scozzafava A., Supuran C.T., De Simone G.
    Proteins 74:164-175(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) IN COMPLEX WITH THE INHIBITOR ACETAZOLAMIDE, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION.
  5. "X-ray structure of human carbonic anhydrase 13 in complex with inhibitor."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 1-261 IN COMPLEX WITH INHIBITOR.

Entry informationi

Entry nameiCAH13_HUMAN
AccessioniPrimary (citable) accession number: Q8N1Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3