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Protein

Beta/gamma crystallin domain-containing protein 2

Gene

CRYBG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandLectin

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta/gamma crystallin domain-containing protein 2Imported
Alternative name(s):
Absent in melanoma 1-like protein
Gene namesi
Name:CRYBG2Imported
Synonyms:AIM1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000176092.13.
HGNCiHGNC:17295. CRYBG2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24650.

Polymorphism and mutation databases

BioMutaiAIM1L.
DMDMi74750904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002851051 – 616Beta/gamma crystallin domain-containing protein 2Add BLAST616

Proteomic databases

MaxQBiQ8N1P7.
PaxDbiQ8N1P7.
PeptideAtlasiQ8N1P7.
PRIDEiQ8N1P7.

PTM databases

iPTMnetiQ8N1P7.
PhosphoSitePlusiQ8N1P7.

Expressioni

Gene expression databases

BgeeiENSG00000176092.
CleanExiHS_AIM1L.
ExpressionAtlasiQ8N1P7. baseline and differential.
GenevisibleiQ8N1P7. HS.

Organism-specific databases

HPAiHPA029629.
HPA029631.

Interactioni

Protein-protein interaction databases

BioGridi120378. 26 interactors.
STRINGi9606.ENSP00000433931.

Structurei

3D structure databases

ProteinModelPortaliQ8N1P7.
SMRiQ8N1P7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 68Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST41
Domaini69 – 111Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini123 – 168Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST46
Domaini169 – 211Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43
Domaini217 – 257Beta/gamma crystallin 'Greek key' 5PROSITE-ProRule annotationAdd BLAST41
Domaini258 – 300Beta/gamma crystallin 'Greek key' 6PROSITE-ProRule annotationAdd BLAST43
Domaini311 – 348Beta/gamma crystallin 'Greek key' 7PROSITE-ProRule annotationAdd BLAST38
Domaini349 – 392Beta/gamma crystallin 'Greek key' 8PROSITE-ProRule annotationAdd BLAST44
Domaini398 – 438Beta/gamma crystallin 'Greek key' 9PROSITE-ProRule annotationAdd BLAST41
Domaini439 – 480Beta/gamma crystallin 'Greek key' 10PROSITE-ProRule annotationAdd BLAST42
Domaini485 – 614Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST130

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IERF. Eukaryota.
ENOG4110BHM. LUCA.
HOGENOMiHOG000033869.
HOVERGENiHBG106499.
InParanoidiQ8N1P7.
OrthoDBiEOG091G007H.
PhylomeDBiQ8N1P7.

Family and domain databases

InterProiView protein in InterPro
IPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-like.
IPR035992. Ricin_B-like_lectins.
IPR000772. Ricin_B_lectin.
PfamiView protein in Pfam
PF00030. Crystall. 5 hits.
PF00652. Ricin_B_lectin. 1 hit.
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiView protein in SMART
SM00458. RICIN. 1 hit.
SM00247. XTALbg. 5 hits.
SUPFAMiSSF49695. SSF49695. 3 hits.
SSF50370. SSF50370. 1 hit.
PROSITEiView protein in PROSITE
PS50915. CRYSTALLIN_BETA_GAMMA. 10 hits.
PS50231. RICIN_B_LECTIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N1P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRTPGTKW SPQGIGSLRR VVWDYSTPEI SLFSEEGLKG EQVKLTEALK
60 70 80 90 100
NSQGLEKPLQ VASATVSAGL WLLYPKPLFE DTPYILEPGE YPTSEAWGTS
110 120 130 140 150
DPSVGSLKPM RLGCPSVEKP GEPRAVVYEA PGFQGRSWEV SRDIYNLQQP
160 170 180 190 200
EDSQSPHLAS VGSLRVLGGC WVGYEKEGFR GHQYLLEEGE YPDWSHWGGY
210 220 230 240 250
DELLTSLRVI RTDFGDPAVV LFEAMDFEGH GVEVSKALPD VELVQHGPST
260 270 280 290 300
QAIHVLSGVW VAYQEVGFSG EQYVLEKGVY RNCEDWGAGN STLASLQPVL
310 320 330 340 350
QVGEHDLHFV SKIQLFSRPD FLGDHFSFED DQAALPASFR PQSCRVHGGS
360 370 380 390 400
WILFDETNFE GDQHILSEGE FPTLTAMGCL ASTVLGSLQK VSLHFSEPSI
410 420 430 440 450
FLYGLECFEG KEIELSREVR SLQAEGFNNH VLSVRIKGGI WVLCEHSDFR
460 470 480 490 500
GRQWLVGSCE ITNWLTYSGT QRVGSLYPIK QRRVYFRLWN AALGGFLAVP
510 520 530 540 550
DHVEDMKAGR VVVADPQAGG SCIWYYEDGL LKNQMAPTMS LQVIGPPSPG
560 570 580 590 600
SKVVLWAESR LPRQTWSISE SGHICSQMFE GQILDVKGGR GYDRDHVVLW
610
EPDEDRASQI WTIHVL
Length:616
Mass (Da):68,646
Last modified:October 1, 2002 - v1
Checksum:iF82253C6D5EC17B8
GO

Sequence cautioni

The sequence CAI15847 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI15850 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048835249S → N. Corresponds to variant dbSNP:rs10751735Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095339 mRNA. Translation: BAC04533.1.
AL451139 Genomic DNA. Translation: CAI15847.1. Sequence problems.
AL451139 Genomic DNA. Translation: CAI15850.2. Sequence problems.
BC136870 mRNA. Translation: AAI36871.1.
RefSeqiNP_001034864.2. NM_001039775.3.
UniGeneiHs.128738.

Genome annotation databases

EnsembliENST00000308182; ENSP00000310435; ENSG00000176092.
GeneIDi55057.
KEGGihsa:55057.
UCSCiuc001bmd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCRBG2_HUMAN
AccessioniPrimary (citable) accession number: Q8N1P7
Secondary accession number(s): B2RNG3, Q5T137, Q5T150
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families