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Protein

Cysteine-rich PAK1 inhibitor

Gene

CRIPAK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence.1 Publication

GO - Biological processi

  • negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
  • negative regulation of protein kinase activity Source: HGNC
  • regulation of cytoskeleton organization Source: HGNC
  • response to estrogen Source: HGNC
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8N1N5.
SIGNORiQ8N1N5.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich PAK1 inhibitor
Short name:
CRIPak
Gene namesi
Name:CRIPAK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26619. CRIPAK.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Membrane 1 Publication
  • Nucleus 1 Publication

  • Note: Translocated to the nuclear compartment upon hormonal treatment by estrogen.

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • endoplasmic reticulum Source: HGNC
  • nucleus Source: HGNC
  • plasma membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi285464.
OpenTargetsiENSG00000179979.
PharmGKBiPA145149095.

Polymorphism and mutation databases

BioMutaiCRIPAK.
DMDMi74728555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003185941 – 446Cysteine-rich PAK1 inhibitorAdd BLAST446

Proteomic databases

PaxDbiQ8N1N5.
PRIDEiQ8N1N5.

Expressioni

Tissue specificityi

Widely expressed with a highest expression observed in trachea, prostate and adrenal glands. Expressed in many cancer cell lines including breast cancer cells.1 Publication

Inductioni

Up-regulated by estrogen.1 Publication

Gene expression databases

BgeeiENSG00000179979.
CleanExiHS_CRIPAK.
GenevisibleiQ8N1N5. HS.

Interactioni

Subunit structurei

Interacts with PAK1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PAK1Q131536EBI-1205846,EBI-1307

Protein-protein interaction databases

BioGridi130121. 6 interactors.
IntActiQ8N1N5. 14 interactors.
STRINGi9606.ENSP00000323978.

Structurei

3D structure databases

ProteinModelPortaliQ8N1N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 501Add BLAST17
Repeati106 – 1222Add BLAST17
Repeati137 – 1533Add BLAST17
Repeati168 – 1844Add BLAST17
Repeati199 – 2155Add BLAST17
Repeati230 – 2466Add BLAST17
Repeati250 – 2667Add BLAST17
Repeati270 – 2868Add BLAST17
Repeati321 – 3379Add BLAST17
Repeati374 – 39010Add BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni367 – 446Interaction with PAK11 PublicationAdd BLAST80

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1075. Eukaryota.
ENOG410Y65V. LUCA.
GeneTreeiENSGT00570000080097.
HOGENOMiHOG000207913.
HOVERGENiHBG064261.
InParanoidiQ8N1N5.
OMAiMWSARLL.
OrthoDBiEOG091G07JZ.
PhylomeDBiQ8N1N5.
TreeFamiTF343857.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
[Graphical view]
SMARTiSM00508. PostSET. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N1N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHEPSLCANV ECPPAHTCPC GVPACSCAHV ECPPAHTCRC GVPACSHMPM
60 70 80 90 100
WSARLLTRAH VECPPAHTRV HVECPPAHVP MWSAHLLTCA DVECHLLTHV
110 120 130 140 150
PMWSARLLTC PCGVPACSHV PMRSARLLTR AHAECPPAHT CPCGVPACSH
160 170 180 190 200
VPMRSARLLT RADVECPPAH TCPCGVPACS HVPTWSARLI TRAHVECSPA
210 220 230 240 250
HTCRCGVPAC SHVPMWSVRL LTRADAECPP AHTCRCGVPA CSHVPMWSAR
260 270 280 290 300
LLTCRCGVPA CSHVPMWSAR LLTCRCGVPA CSHVPMWSAR LLTRAHVECP
310 320 330 340 350
PAHTCRRGVP ACSRAHMECP PAHTCHCGVP ACSHTCRCGV PACSHVPMWS
360 370 380 390 400
ARLLTRAHVE CPPAHTRAHV ECPPAHTCPC GVPACSHTCP CGVPACSHKA
410 420 430 440
LAWWFCRFPV LPAESDAVTV HSTHGGFLIR FYVKDPFYIS LHLEIT
Length:446
Mass (Da):48,076
Last modified:October 1, 2002 - v1
Checksum:i92EDA1B7B8037FDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti358H → Y in BAC03741 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03879489C → Y.Corresponds to variant rs13097dbSNPEnsembl.1
Natural variantiVAR_03879595H → P.Corresponds to variant rs9328733dbSNPEnsembl.1
Natural variantiVAR_06162895H → R.Corresponds to variant rs9328733dbSNPEnsembl.1
Natural variantiVAR_050908120V → M.Corresponds to variant rs141796647dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091762 mRNA. Translation: BAC03741.1.
AK096209 mRNA. Translation: BAC04725.1.
CCDSiCCDS3349.1.
RefSeqiNP_787114.2. NM_175918.3.
UniGeneiHs.26410.

Genome annotation databases

EnsembliENST00000324803; ENSP00000323978; ENSG00000179979.
GeneIDi285464.
KEGGihsa:285464.
UCSCiuc003gdf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091762 mRNA. Translation: BAC03741.1.
AK096209 mRNA. Translation: BAC04725.1.
CCDSiCCDS3349.1.
RefSeqiNP_787114.2. NM_175918.3.
UniGeneiHs.26410.

3D structure databases

ProteinModelPortaliQ8N1N5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130121. 6 interactors.
IntActiQ8N1N5. 14 interactors.
STRINGi9606.ENSP00000323978.

Polymorphism and mutation databases

BioMutaiCRIPAK.
DMDMi74728555.

Proteomic databases

PaxDbiQ8N1N5.
PRIDEiQ8N1N5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324803; ENSP00000323978; ENSG00000179979.
GeneIDi285464.
KEGGihsa:285464.
UCSCiuc003gdf.3. human.

Organism-specific databases

CTDi285464.
DisGeNETi285464.
GeneCardsiCRIPAK.
H-InvDBHIX0004022.
HGNCiHGNC:26619. CRIPAK.
MIMi610203. gene.
neXtProtiNX_Q8N1N5.
OpenTargetsiENSG00000179979.
PharmGKBiPA145149095.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1075. Eukaryota.
ENOG410Y65V. LUCA.
GeneTreeiENSGT00570000080097.
HOGENOMiHOG000207913.
HOVERGENiHBG064261.
InParanoidiQ8N1N5.
OMAiMWSARLL.
OrthoDBiEOG091G07JZ.
PhylomeDBiQ8N1N5.
TreeFamiTF343857.

Enzyme and pathway databases

SignaLinkiQ8N1N5.
SIGNORiQ8N1N5.

Miscellaneous databases

ChiTaRSiCRIPAK. human.
GenomeRNAii285464.
PROiQ8N1N5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179979.
CleanExiHS_CRIPAK.
GenevisibleiQ8N1N5. HS.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
[Graphical view]
SMARTiSM00508. PostSET. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRPAK_HUMAN
AccessioniPrimary (citable) accession number: Q8N1N5
Secondary accession number(s): Q8NB03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.