ID   BATF2_HUMAN             Reviewed;         274 AA.
AC   Q8N1L9; D9IC56; Q8NAF4; Q8NAL8; Q96EH4;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 152.
DE   RecName: Full=Basic leucine zipper transcriptional factor ATF-like 2;
DE            Short=B-ATF-2;
DE   AltName: Full=Suppressor of AP-1 regulated by IFN;
DE            Short=SARI;
GN   Name=BATF2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INDUCTION.
RX   PubMed=19074269; DOI=10.1073/pnas.0807975106;
RA   Su Z.Z., Lee S.G., Emdad L., Lebdeva I.V., Gupta P., Valerie K., Sarkar D.,
RA   Fisher P.B.;
RT   "Cloning and characterization of SARI (suppressor of AP-1, regulated by
RT   IFN).";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:20906-20911(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Pericardium, Placenta, and Small intestine;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION.
RX   PubMed=20531301; DOI=10.1038/onc.2010.194;
RA   Dash R., Su Z.Z., Lee S.G., Azab B., Boukerche H., Sarkar D., Fisher P.B.;
RT   "Inhibition of AP-1 by SARI negatively regulates transformation progression
RT   mediated by CCN1.";
RL   Oncogene 29:4412-4423(2010).
RN   [6]
RP   INDUCTION.
RX   PubMed=20473897; DOI=10.1002/ijc.25407;
RA   Ma H., Liang X., Chen Y., Pan K., Sun J., Wang H., Wang Q., Li Y., Zhao J.,
RA   Li J., Chen M., Xia J.;
RT   "Decreased expression of BATF2 is associated with a poor prognosis in
RT   hepatocellular carcinoma.";
RL   Int. J. Cancer 128:771-777(2011).
CC   -!- FUNCTION: AP-1 family transcription factor that controls the
CC       differentiation of lineage-specific cells in the immune system.
CC       Following infection, participates in the differentiation of CD8(+)
CC       thymic conventional dendritic cells in the immune system. Acts via the
CC       formation of a heterodimer with JUN family proteins that recognizes and
CC       binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target
CC       genes (By similarity). Selectively suppresses CCN1 transcription and
CC       hence blocks the downstream cell proliferation signals produced by CCN1
CC       and inhibits CCN1-induced anchorage-independent growth and invasion in
CC       several cancer types, such as breast cancer, malignant glioma and
CC       metastatic melanoma. Possibly acts by interfering with AP-1 binding to
CC       CCN1 promoter. {ECO:0000250, ECO:0000269|PubMed:20531301}.
CC   -!- SUBUNIT: Heterodimer; heterodimerizes with JUN family proteins.
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8N1L9; P49715: CEBPA; NbExp=2; IntAct=EBI-742695, EBI-1172054;
CC       Q8N1L9; P53567: CEBPG; NbExp=2; IntAct=EBI-742695, EBI-740209;
CC       Q8N1L9; Q15038: DAZAP2; NbExp=3; IntAct=EBI-742695, EBI-724310;
CC       Q8N1L9; P35638: DDIT3; NbExp=2; IntAct=EBI-742695, EBI-742651;
CC       Q8N1L9; O75593: FOXH1; NbExp=3; IntAct=EBI-742695, EBI-1759806;
CC       Q8N1L9; Q12951-2: FOXI1; NbExp=3; IntAct=EBI-742695, EBI-12018822;
CC       Q8N1L9; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-742695, EBI-347538;
CC       Q8N1L9; P49639: HOXA1; NbExp=3; IntAct=EBI-742695, EBI-740785;
CC       Q8N1L9; P05412: JUN; NbExp=2; IntAct=EBI-742695, EBI-852823;
CC       Q8N1L9; P17275: JUNB; NbExp=5; IntAct=EBI-742695, EBI-748062;
CC       Q8N1L9; O76011: KRT34; NbExp=3; IntAct=EBI-742695, EBI-1047093;
CC       Q8N1L9; Q9ULX9: MAFF; NbExp=2; IntAct=EBI-742695, EBI-721128;
CC       Q8N1L9; Q13064: MKRN3; NbExp=3; IntAct=EBI-742695, EBI-2340269;
CC       Q8N1L9; Q96I34: PPP1R16A; NbExp=3; IntAct=EBI-742695, EBI-710402;
CC       Q8N1L9; O75360: PROP1; NbExp=3; IntAct=EBI-742695, EBI-9027467;
CC       Q8N1L9; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-742695, EBI-11959123;
CC       Q8N1L9; O95231: VENTX; NbExp=3; IntAct=EBI-742695, EBI-10191303;
CC       Q8N1L9; Q9BYJ9: YTHDF1; NbExp=3; IntAct=EBI-742695, EBI-1051237;
CC       Q8N1L9-1; P05412: JUN; NbExp=3; IntAct=EBI-15746052, EBI-852823;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N1L9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N1L9-2; Sequence=VSP_025752;
CC   -!- INDUCTION: By type I interferon. Down-regulated in most hepatocellular
CC       carcinoma tumorous tissues (at protein level).
CC       {ECO:0000269|PubMed:19074269, ECO:0000269|PubMed:20473897}.
CC   -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR   EMBL; HM134154; ADJ55304.1; -; mRNA.
DR   EMBL; AK092453; BAC03894.2; -; mRNA.
DR   EMBL; AK092761; BAC03968.2; -; mRNA.
DR   EMBL; AK096702; BAC04846.1; -; mRNA.
DR   EMBL; CH471076; EAW74330.1; -; Genomic_DNA.
DR   EMBL; BC012330; AAH12330.1; -; mRNA.
DR   CCDS; CCDS73317.1; -. [Q8N1L9-2]
DR   CCDS; CCDS8087.1; -. [Q8N1L9-1]
DR   RefSeq; NP_001287736.1; NM_001300807.1.
DR   RefSeq; NP_001287737.1; NM_001300808.1. [Q8N1L9-2]
DR   RefSeq; NP_612465.3; NM_138456.3. [Q8N1L9-1]
DR   AlphaFoldDB; Q8N1L9; -.
DR   SMR; Q8N1L9; -.
DR   BioGRID; 125470; 29.
DR   ComplexPortal; CPX-6523; bZIP transcription factor complex, ATF4-BATF2.
DR   ComplexPortal; CPX-7061; bZIP transcription factor complex, BATF2-JUNB.
DR   ComplexPortal; CPX-7063; bZIP transcription factor complex, BATF2-JUN.
DR   ComplexPortal; CPX-7064; bZIP transcription factor complex, BATF2-DDIT3.
DR   ComplexPortal; CPX-7065; bZIP transcription factor complex, BATF2-CEBPA.
DR   ComplexPortal; CPX-7066; bZIP transcription factor complex, BATF2-CEBPG.
DR   ComplexPortal; CPX-7067; bZIP transcription factor complex, BATF2-CEBPE.
DR   ComplexPortal; CPX-7068; bZIP transcription factor complex, BATF2-DBP.
DR   ComplexPortal; CPX-7081; bZIP transcription factor complex, BATF2-HLF.
DR   ComplexPortal; CPX-7085; bZIP transcription factor complex, BATF2-MAFF.
DR   DIP; DIP-48662N; -.
DR   IntAct; Q8N1L9; 29.
DR   STRING; 9606.ENSP00000301887; -.
DR   GlyGen; Q8N1L9; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8N1L9; -.
DR   PhosphoSitePlus; Q8N1L9; -.
DR   BioMuta; BATF2; -.
DR   DMDM; 74750901; -.
DR   MassIVE; Q8N1L9; -.
DR   PaxDb; 9606-ENSP00000301887; -.
DR   PeptideAtlas; Q8N1L9; -.
DR   Antibodypedia; 29580; 225 antibodies from 28 providers.
DR   DNASU; 116071; -.
DR   Ensembl; ENST00000301887.9; ENSP00000301887.4; ENSG00000168062.10. [Q8N1L9-1]
DR   Ensembl; ENST00000435842.2; ENSP00000398911.2; ENSG00000168062.10. [Q8N1L9-2]
DR   GeneID; 116071; -.
DR   KEGG; hsa:116071; -.
DR   MANE-Select; ENST00000301887.9; ENSP00000301887.4; NM_138456.4; NP_612465.3.
DR   UCSC; uc001oce.1; human. [Q8N1L9-1]
DR   AGR; HGNC:25163; -.
DR   CTD; 116071; -.
DR   DisGeNET; 116071; -.
DR   GeneCards; BATF2; -.
DR   HGNC; HGNC:25163; BATF2.
DR   HPA; ENSG00000168062; Low tissue specificity.
DR   MIM; 614983; gene.
DR   neXtProt; NX_Q8N1L9; -.
DR   OpenTargets; ENSG00000168062; -.
DR   PharmGKB; PA143485315; -.
DR   VEuPathDB; HostDB:ENSG00000168062; -.
DR   eggNOG; KOG1414; Eukaryota.
DR   GeneTree; ENSGT00940000162373; -.
DR   HOGENOM; CLU_088611_0_0_1; -.
DR   InParanoid; Q8N1L9; -.
DR   OMA; HGCQEQP; -.
DR   OrthoDB; 5300825at2759; -.
DR   PhylomeDB; Q8N1L9; -.
DR   TreeFam; TF332340; -.
DR   PathwayCommons; Q8N1L9; -.
DR   SignaLink; Q8N1L9; -.
DR   BioGRID-ORCS; 116071; 12 hits in 1179 CRISPR screens.
DR   ChiTaRS; BATF2; human.
DR   GenomeRNAi; 116071; -.
DR   Pharos; Q8N1L9; Tbio.
DR   PRO; PR:Q8N1L9; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8N1L9; Protein.
DR   Bgee; ENSG00000168062; Expressed in pancreatic ductal cell and 125 other cell types or tissues.
DR   ExpressionAtlas; Q8N1L9; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IPI:ComplexPortal.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0042832; P:defense response to protozoan; ISS:UniProtKB.
DR   GO; GO:0140467; P:integrated stress response signaling; NAS:ComplexPortal.
DR   GO; GO:0043011; P:myeloid dendritic cell differentiation; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd14701; bZIP_BATF; 1.
DR   Gene3D; 1.20.5.170; -; 1.
DR   InterPro; IPR000837; AP-1.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   PANTHER; PTHR23351:SF11; BASIC LEUCINE ZIPPER TRANSCRIPTIONAL FACTOR ATF-LIKE 2; 1.
DR   PANTHER; PTHR23351; FOS TRANSCRIPTION FACTOR-RELATED; 1.
DR   Pfam; PF00170; bZIP_1; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; Leucine zipper domain; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
DR   Genevisible; Q8N1L9; HS.
PE   1: Evidence at protein level;
KW   Activator; Alternative splicing; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..274
FT                   /note="Basic leucine zipper transcriptional factor ATF-like
FT                   2"
FT                   /id="PRO_0000288681"
FT   DOMAIN          17..80
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          20..41
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          45..66
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          128..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          187..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..47
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..147
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..205
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..85
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_025752"
FT   VARIANT         6
FT                   /note="G -> S (in dbSNP:rs12419103)"
FT                   /id="VAR_048443"
SQ   SEQUENCE   274 AA;  29398 MW;  CC4BDAA61A681B14 CRC64;
     MHLCGGNGLL TQTDPKEQQR QLKKQKNRAA AQRSRQKHTD KADALHQQHE SLEKDNLALR
     KEIQSLQAEL AWWSRTLHVH ERLCPMDCAS CSAPGLLGCW DQAEGLLGPG PQGQHGCREQ
     LELFQTPGSC YPAQPLSPGP QPHDSPSLLQ CPLPSLSLGP AVVAEPPVQL SPSPLLFASH
     TGSSLQGSSS KLSALQPSLT AQTAPPQPLE LEHPTRGKLG SSPDNPSSAL GLARLQSREH
     KPALSAATWQ GLVVDPSPHP LLAFPLLSSA QVHF
//