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Protein

Basic leucine zipper transcriptional factor ATF-like 2

Gene

BATF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.By similarity1 Publication

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. defense response to protozoan Source: UniProtKB
  2. myeloid dendritic cell differentiation Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 2
Short name:
B-ATF-2
Alternative name(s):
Suppressor of AP-1 regulated by IFN
Short name:
SARI
Gene namesi
Name:BATF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:25163. BATF2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Basic leucine zipper transcriptional factor ATF-like 2PRO_0000288681Add
BLAST

Proteomic databases

PRIDEiQ8N1L9.

Expressioni

Inductioni

By type I interferon. Down-regulated in most hepatocellular carcinoma tumorous tissues (at protein level).2 Publications

Gene expression databases

BgeeiQ8N1L9.
CleanExiHS_BATF2.
ExpressionAtlasiQ8N1L9. baseline and differential.
GenevestigatoriQ8N1L9.

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DAZAP2Q150383EBI-742695,EBI-724310
JUNBP172753EBI-742695,EBI-748062

Protein-protein interaction databases

BioGridi125470. 17 interactions.
DIPiDIP-48662N.
IntActiQ8N1L9. 8 interactions.
MINTiMINT-1447095.
STRINGi9606.ENSP00000301887.

Structurei

3D structure databases

ProteinModelPortaliQ8N1L9.
SMRiQ8N1L9. Positions 22-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 8064bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 4122Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni45 – 6622Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG76085.
GeneTreeiENSGT00390000016869.
HOGENOMiHOG000070120.
HOVERGENiHBG103463.
InParanoidiQ8N1L9.
KOiK09034.
OMAiRSRQKHT.
OrthoDBiEOG7H794S.
PhylomeDBiQ8N1L9.
TreeFamiTF332340.

Family and domain databases

InterProiIPR000837. AP-1.
IPR029857. BATF2.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF11. PTHR23351:SF11. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N1L9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHLCGGNGLL TQTDPKEQQR QLKKQKNRAA AQRSRQKHTD KADALHQQHE
60 70 80 90 100
SLEKDNLALR KEIQSLQAEL AWWSRTLHVH ERLCPMDCAS CSAPGLLGCW
110 120 130 140 150
DQAEGLLGPG PQGQHGCREQ LELFQTPGSC YPAQPLSPGP QPHDSPSLLQ
160 170 180 190 200
CPLPSLSLGP AVVAEPPVQL SPSPLLFASH TGSSLQGSSS KLSALQPSLT
210 220 230 240 250
AQTAPPQPLE LEHPTRGKLG SSPDNPSSAL GLARLQSREH KPALSAATWQ
260 270
GLVVDPSPHP LLAFPLLSSA QVHF
Length:274
Mass (Da):29,398
Last modified:October 1, 2002 - v1
Checksum:iCC4BDAA61A681B14
GO
Isoform 2 (identifier: Q8N1L9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:189
Mass (Da):19,503
Checksum:iBC1D0F5B688D62E7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61G → S.
Corresponds to variant rs12419103 [ dbSNP | Ensembl ].
VAR_048443

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585Missing in isoform 2. 2 PublicationsVSP_025752Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM134154 mRNA. Translation: ADJ55304.1.
AK092453 mRNA. Translation: BAC03894.2.
AK092761 mRNA. Translation: BAC03968.2.
AK096702 mRNA. Translation: BAC04846.1.
CH471076 Genomic DNA. Translation: EAW74330.1.
BC012330 mRNA. Translation: AAH12330.1.
CCDSiCCDS73317.1. [Q8N1L9-2]
CCDS8087.1. [Q8N1L9-1]
RefSeqiNP_001287736.1. NM_001300807.1.
NP_001287737.1. NM_001300808.1. [Q8N1L9-2]
NP_612465.3. NM_138456.3. [Q8N1L9-1]
UniGeneiHs.124840.

Genome annotation databases

EnsembliENST00000301887; ENSP00000301887; ENSG00000168062. [Q8N1L9-1]
ENST00000435842; ENSP00000398911; ENSG00000168062. [Q8N1L9-2]
GeneIDi116071.
KEGGihsa:116071.
UCSCiuc001oce.1. human. [Q8N1L9-1]

Polymorphism databases

DMDMi74750901.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM134154 mRNA. Translation: ADJ55304.1.
AK092453 mRNA. Translation: BAC03894.2.
AK092761 mRNA. Translation: BAC03968.2.
AK096702 mRNA. Translation: BAC04846.1.
CH471076 Genomic DNA. Translation: EAW74330.1.
BC012330 mRNA. Translation: AAH12330.1.
CCDSiCCDS73317.1. [Q8N1L9-2]
CCDS8087.1. [Q8N1L9-1]
RefSeqiNP_001287736.1. NM_001300807.1.
NP_001287737.1. NM_001300808.1. [Q8N1L9-2]
NP_612465.3. NM_138456.3. [Q8N1L9-1]
UniGeneiHs.124840.

3D structure databases

ProteinModelPortaliQ8N1L9.
SMRiQ8N1L9. Positions 22-68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125470. 17 interactions.
DIPiDIP-48662N.
IntActiQ8N1L9. 8 interactions.
MINTiMINT-1447095.
STRINGi9606.ENSP00000301887.

Polymorphism databases

DMDMi74750901.

Proteomic databases

PRIDEiQ8N1L9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301887; ENSP00000301887; ENSG00000168062. [Q8N1L9-1]
ENST00000435842; ENSP00000398911; ENSG00000168062. [Q8N1L9-2]
GeneIDi116071.
KEGGihsa:116071.
UCSCiuc001oce.1. human. [Q8N1L9-1]

Organism-specific databases

CTDi116071.
GeneCardsiGC11M064755.
HGNCiHGNC:25163. BATF2.
MIMi614983. gene.
neXtProtiNX_Q8N1L9.
PharmGKBiPA143485315.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG76085.
GeneTreeiENSGT00390000016869.
HOGENOMiHOG000070120.
HOVERGENiHBG103463.
InParanoidiQ8N1L9.
KOiK09034.
OMAiRSRQKHT.
OrthoDBiEOG7H794S.
PhylomeDBiQ8N1L9.
TreeFamiTF332340.

Miscellaneous databases

ChiTaRSiBATF2. human.
GenomeRNAii116071.
NextBioi79747.
PROiQ8N1L9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N1L9.
CleanExiHS_BATF2.
ExpressionAtlasiQ8N1L9. baseline and differential.
GenevestigatoriQ8N1L9.

Family and domain databases

InterProiIPR000837. AP-1.
IPR029857. BATF2.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF11. PTHR23351:SF11. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN)."
    Su Z.Z., Lee S.G., Emdad L., Lebdeva I.V., Gupta P., Valerie K., Sarkar D., Fisher P.B.
    Proc. Natl. Acad. Sci. U.S.A. 105:20906-20911(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pericardium, Placenta and Small intestine.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  5. "Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1."
    Dash R., Su Z.Z., Lee S.G., Azab B., Boukerche H., Sarkar D., Fisher P.B.
    Oncogene 29:4412-4423(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Decreased expression of BATF2 is associated with a poor prognosis in hepatocellular carcinoma."
    Ma H., Liang X., Chen Y., Pan K., Sun J., Wang H., Wang Q., Li Y., Zhao J., Li J., Chen M., Xia J.
    Int. J. Cancer 128:771-777(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiBATF2_HUMAN
AccessioniPrimary (citable) accession number: Q8N1L9
Secondary accession number(s): D9IC56
, Q8NAF4, Q8NAL8, Q96EH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.