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Q8N1L9 (BATF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Basic leucine zipper transcriptional factor ATF-like 2

Short name=B-ATF-2
Alternative name(s):
Suppressor of AP-1 regulated by IFN
Short name=SARI
Gene names
Name:BATF2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes By similarity. Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter. Ref.5

Subunit structure

Heterodimer; heterodimerizes with JUN family proteins By similarity.

Subcellular location

Nucleus By similarity.

Induction

By type I interferon. Down-regulated in most hepatocellular carcinoma tumorous tissues (at protein level). Ref.1 Ref.6

Sequence similarities

Belongs to the bZIP family.

Contains 1 bZIP (basic-leucine zipper) domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DAZAP2Q150383EBI-742695,EBI-724310
JUNBP172753EBI-742695,EBI-748062

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N1L9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N1L9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Basic leucine zipper transcriptional factor ATF-like 2
PRO_0000288681

Regions

Domain17 – 8064bZIP
Region20 – 4122Basic motif By similarity
Region45 – 6622Leucine-zipper By similarity

Natural variations

Alternative sequence1 – 8585Missing in isoform 2.
VSP_025752
Natural variant61G → S.
Corresponds to variant rs12419103 [ dbSNP | Ensembl ].
VAR_048443

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: CC4BDAA61A681B14

FASTA27429,398
        10         20         30         40         50         60 
MHLCGGNGLL TQTDPKEQQR QLKKQKNRAA AQRSRQKHTD KADALHQQHE SLEKDNLALR 

        70         80         90        100        110        120 
KEIQSLQAEL AWWSRTLHVH ERLCPMDCAS CSAPGLLGCW DQAEGLLGPG PQGQHGCREQ 

       130        140        150        160        170        180 
LELFQTPGSC YPAQPLSPGP QPHDSPSLLQ CPLPSLSLGP AVVAEPPVQL SPSPLLFASH 

       190        200        210        220        230        240 
TGSSLQGSSS KLSALQPSLT AQTAPPQPLE LEHPTRGKLG SSPDNPSSAL GLARLQSREH 

       250        260        270 
KPALSAATWQ GLVVDPSPHP LLAFPLLSSA QVHF 

« Hide

Isoform 2 [UniParc].

Checksum: BC1D0F5B688D62E7
Show »

FASTA18919,503

References

« Hide 'large scale' references
[1]"Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN)."
Su Z.Z., Lee S.G., Emdad L., Lebdeva I.V., Gupta P., Valerie K., Sarkar D., Fisher P.B.
Proc. Natl. Acad. Sci. U.S.A. 105:20906-20911(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Pericardium, Placenta and Small intestine.
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lung.
[5]"Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1."
Dash R., Su Z.Z., Lee S.G., Azab B., Boukerche H., Sarkar D., Fisher P.B.
Oncogene 29:4412-4423(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Decreased expression of BATF2 is associated with a poor prognosis in hepatocellular carcinoma."
Ma H., Liang X., Chen Y., Pan K., Sun J., Wang H., Wang Q., Li Y., Zhao J., Li J., Chen M., Xia J.
Int. J. Cancer 128:771-777(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HM134154 mRNA. Translation: ADJ55304.1.
AK092453 mRNA. Translation: BAC03894.2.
AK092761 mRNA. Translation: BAC03968.2.
AK096702 mRNA. Translation: BAC04846.1.
CH471076 Genomic DNA. Translation: EAW74330.1.
BC012330 mRNA. Translation: AAH12330.1.
RefSeqNP_612465.3. NM_138456.3.
XP_005273796.1. XM_005273739.1.
UniGeneHs.124840.

3D structure databases

ProteinModelPortalQ8N1L9.
SMRQ8N1L9. Positions 19-79.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125470. 17 interactions.
DIPDIP-48662N.
IntActQ8N1L9. 8 interactions.
MINTMINT-1447095.
STRING9606.ENSP00000301887.

Polymorphism databases

DMDM74750901.

Proteomic databases

PRIDEQ8N1L9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301887; ENSP00000301887; ENSG00000168062. [Q8N1L9-1]
ENST00000435842; ENSP00000398911; ENSG00000168062. [Q8N1L9-2]
GeneID116071.
KEGGhsa:116071.
UCSCuc001oce.1. human. [Q8N1L9-1]

Organism-specific databases

CTD116071.
GeneCardsGC11M064755.
HGNCHGNC:25163. BATF2.
MIM614983. gene.
neXtProtNX_Q8N1L9.
PharmGKBPA143485315.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG76085.
HOGENOMHOG000070120.
HOVERGENHBG103463.
InParanoidQ8N1L9.
KOK09034.
OMARSRQKHT.
OrthoDBEOG7H794S.
PhylomeDBQ8N1L9.
TreeFamTF332340.

Gene expression databases

ArrayExpressQ8N1L9.
BgeeQ8N1L9.
CleanExHS_BATF2.
GenevestigatorQ8N1L9.

Family and domain databases

InterProIPR004827. bZIP.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi116071.
NextBio79747.
PROQ8N1L9.
SOURCESearch...

Entry information

Entry nameBATF2_HUMAN
AccessionPrimary (citable) accession number: Q8N1L9
Secondary accession number(s): D9IC56 expand/collapse secondary AC list , Q8NAF4, Q8NAL8, Q96EH4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2002
Last modified: March 19, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM