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Q8N1L9

- BATF2_HUMAN

UniProt

Q8N1L9 - BATF2_HUMAN

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Protein
Basic leucine zipper transcriptional factor ATF-like 2
Gene
BATF2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes By similarity. Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. defense response to protozoan Source: UniProtKB
  2. myeloid dendritic cell differentiation Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 2
Short name:
B-ATF-2
Alternative name(s):
Suppressor of AP-1 regulated by IFN
Short name:
SARI
Gene namesi
Name:BATF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:25163. BATF2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Basic leucine zipper transcriptional factor ATF-like 2
PRO_0000288681Add
BLAST

Proteomic databases

PRIDEiQ8N1L9.

Expressioni

Inductioni

By type I interferon. Down-regulated in most hepatocellular carcinoma tumorous tissues (at protein level).2 Publications

Gene expression databases

ArrayExpressiQ8N1L9.
BgeeiQ8N1L9.
CleanExiHS_BATF2.
GenevestigatoriQ8N1L9.

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
DAZAP2Q150383EBI-742695,EBI-724310
JUNBP172753EBI-742695,EBI-748062

Protein-protein interaction databases

BioGridi125470. 17 interactions.
DIPiDIP-48662N.
IntActiQ8N1L9. 8 interactions.
MINTiMINT-1447095.
STRINGi9606.ENSP00000301887.

Structurei

3D structure databases

ProteinModelPortaliQ8N1L9.
SMRiQ8N1L9. Positions 22-68.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 8064bZIP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 4122Basic motif By similarity
Add
BLAST
Regioni45 – 6622Leucine-zipper By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the bZIP family.

Phylogenomic databases

eggNOGiNOG76085.
HOGENOMiHOG000070120.
HOVERGENiHBG103463.
InParanoidiQ8N1L9.
KOiK09034.
OMAiRSRQKHT.
OrthoDBiEOG7H794S.
PhylomeDBiQ8N1L9.
TreeFamiTF332340.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N1L9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MHLCGGNGLL TQTDPKEQQR QLKKQKNRAA AQRSRQKHTD KADALHQQHE    50
SLEKDNLALR KEIQSLQAEL AWWSRTLHVH ERLCPMDCAS CSAPGLLGCW 100
DQAEGLLGPG PQGQHGCREQ LELFQTPGSC YPAQPLSPGP QPHDSPSLLQ 150
CPLPSLSLGP AVVAEPPVQL SPSPLLFASH TGSSLQGSSS KLSALQPSLT 200
AQTAPPQPLE LEHPTRGKLG SSPDNPSSAL GLARLQSREH KPALSAATWQ 250
GLVVDPSPHP LLAFPLLSSA QVHF 274
Length:274
Mass (Da):29,398
Last modified:October 1, 2002 - v1
Checksum:iCC4BDAA61A681B14
GO
Isoform 2 (identifier: Q8N1L9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:189
Mass (Da):19,503
Checksum:iBC1D0F5B688D62E7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61G → S.
Corresponds to variant rs12419103 [ dbSNP | Ensembl ].
VAR_048443

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585Missing in isoform 2.
VSP_025752Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HM134154 mRNA. Translation: ADJ55304.1.
AK092453 mRNA. Translation: BAC03894.2.
AK092761 mRNA. Translation: BAC03968.2.
AK096702 mRNA. Translation: BAC04846.1.
CH471076 Genomic DNA. Translation: EAW74330.1.
BC012330 mRNA. Translation: AAH12330.1.
CCDSiCCDS8087.1. [Q8N1L9-1]
RefSeqiNP_612465.3. NM_138456.3. [Q8N1L9-1]
XP_005273796.1. XM_005273739.1. [Q8N1L9-2]
UniGeneiHs.124840.

Genome annotation databases

EnsembliENST00000301887; ENSP00000301887; ENSG00000168062. [Q8N1L9-1]
ENST00000435842; ENSP00000398911; ENSG00000168062. [Q8N1L9-2]
GeneIDi116071.
KEGGihsa:116071.
UCSCiuc001oce.1. human. [Q8N1L9-1]

Polymorphism databases

DMDMi74750901.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HM134154 mRNA. Translation: ADJ55304.1 .
AK092453 mRNA. Translation: BAC03894.2 .
AK092761 mRNA. Translation: BAC03968.2 .
AK096702 mRNA. Translation: BAC04846.1 .
CH471076 Genomic DNA. Translation: EAW74330.1 .
BC012330 mRNA. Translation: AAH12330.1 .
CCDSi CCDS8087.1. [Q8N1L9-1 ]
RefSeqi NP_612465.3. NM_138456.3. [Q8N1L9-1 ]
XP_005273796.1. XM_005273739.1. [Q8N1L9-2 ]
UniGenei Hs.124840.

3D structure databases

ProteinModelPortali Q8N1L9.
SMRi Q8N1L9. Positions 22-68.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125470. 17 interactions.
DIPi DIP-48662N.
IntActi Q8N1L9. 8 interactions.
MINTi MINT-1447095.
STRINGi 9606.ENSP00000301887.

Polymorphism databases

DMDMi 74750901.

Proteomic databases

PRIDEi Q8N1L9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301887 ; ENSP00000301887 ; ENSG00000168062 . [Q8N1L9-1 ]
ENST00000435842 ; ENSP00000398911 ; ENSG00000168062 . [Q8N1L9-2 ]
GeneIDi 116071.
KEGGi hsa:116071.
UCSCi uc001oce.1. human. [Q8N1L9-1 ]

Organism-specific databases

CTDi 116071.
GeneCardsi GC11M064755.
HGNCi HGNC:25163. BATF2.
MIMi 614983. gene.
neXtProti NX_Q8N1L9.
PharmGKBi PA143485315.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG76085.
HOGENOMi HOG000070120.
HOVERGENi HBG103463.
InParanoidi Q8N1L9.
KOi K09034.
OMAi RSRQKHT.
OrthoDBi EOG7H794S.
PhylomeDBi Q8N1L9.
TreeFami TF332340.

Miscellaneous databases

GenomeRNAii 116071.
NextBioi 79747.
PROi Q8N1L9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8N1L9.
Bgeei Q8N1L9.
CleanExi HS_BATF2.
Genevestigatori Q8N1L9.

Family and domain databases

InterProi IPR004827. bZIP.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN)."
    Su Z.Z., Lee S.G., Emdad L., Lebdeva I.V., Gupta P., Valerie K., Sarkar D., Fisher P.B.
    Proc. Natl. Acad. Sci. U.S.A. 105:20906-20911(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pericardium, Placenta and Small intestine.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  5. "Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1."
    Dash R., Su Z.Z., Lee S.G., Azab B., Boukerche H., Sarkar D., Fisher P.B.
    Oncogene 29:4412-4423(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Decreased expression of BATF2 is associated with a poor prognosis in hepatocellular carcinoma."
    Ma H., Liang X., Chen Y., Pan K., Sun J., Wang H., Wang Q., Li Y., Zhao J., Li J., Chen M., Xia J.
    Int. J. Cancer 128:771-777(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiBATF2_HUMAN
AccessioniPrimary (citable) accession number: Q8N1L9
Secondary accession number(s): D9IC56
, Q8NAF4, Q8NAL8, Q96EH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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