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Protein

Basic leucine zipper transcriptional factor ATF-like 2

Gene

BATF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 2
Short name:
B-ATF-2
Alternative name(s):
Suppressor of AP-1 regulated by IFN
Short name:
SARI
Gene namesi
Name:BATF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000168062.9
HGNCiHGNC:25163 BATF2
MIMi614983 gene
neXtProtiNX_Q8N1L9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi116071
OpenTargetsiENSG00000168062
PharmGKBiPA143485315

Polymorphism and mutation databases

BioMutaiBATF2
DMDMi74750901

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002886811 – 274Basic leucine zipper transcriptional factor ATF-like 2Add BLAST274

Proteomic databases

PaxDbiQ8N1L9
PeptideAtlasiQ8N1L9
PRIDEiQ8N1L9
ProteomicsDBi71615
71616 [Q8N1L9-2]

PTM databases

iPTMnetiQ8N1L9
PhosphoSitePlusiQ8N1L9

Expressioni

Inductioni

By type I interferon. Down-regulated in most hepatocellular carcinoma tumorous tissues (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000168062
CleanExiHS_BATF2
ExpressionAtlasiQ8N1L9 baseline and differential
GenevisibleiQ8N1L9 HS

Organism-specific databases

HPAiHPA062496

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125470, 17 interactors
DIPiDIP-48662N
IntActiQ8N1L9, 20 interactors
STRINGi9606.ENSP00000301887

Structurei

3D structure databases

ProteinModelPortaliQ8N1L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 80bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 41Basic motifPROSITE-ProRule annotationAdd BLAST22
Regioni45 – 66Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00390000016869
HOGENOMiHOG000070120
HOVERGENiHBG103463
InParanoidiQ8N1L9
KOiK09034
OMAiSSAQVHF
OrthoDBiEOG091G0YSM
PhylomeDBiQ8N1L9
TreeFamiTF332340

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR029857 BATF2
IPR004827 bZIP
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF11 PTHR23351:SF11, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N1L9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHLCGGNGLL TQTDPKEQQR QLKKQKNRAA AQRSRQKHTD KADALHQQHE
60 70 80 90 100
SLEKDNLALR KEIQSLQAEL AWWSRTLHVH ERLCPMDCAS CSAPGLLGCW
110 120 130 140 150
DQAEGLLGPG PQGQHGCREQ LELFQTPGSC YPAQPLSPGP QPHDSPSLLQ
160 170 180 190 200
CPLPSLSLGP AVVAEPPVQL SPSPLLFASH TGSSLQGSSS KLSALQPSLT
210 220 230 240 250
AQTAPPQPLE LEHPTRGKLG SSPDNPSSAL GLARLQSREH KPALSAATWQ
260 270
GLVVDPSPHP LLAFPLLSSA QVHF
Length:274
Mass (Da):29,398
Last modified:October 1, 2002 - v1
Checksum:iCC4BDAA61A681B14
GO
Isoform 2 (identifier: Q8N1L9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:189
Mass (Da):19,503
Checksum:iBC1D0F5B688D62E7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0484436G → S. Corresponds to variant dbSNP:rs12419103Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0257521 – 85Missing in isoform 2. 2 PublicationsAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM134154 mRNA Translation: ADJ55304.1
AK092453 mRNA Translation: BAC03894.2
AK092761 mRNA Translation: BAC03968.2
AK096702 mRNA Translation: BAC04846.1
CH471076 Genomic DNA Translation: EAW74330.1
BC012330 mRNA Translation: AAH12330.1
CCDSiCCDS73317.1 [Q8N1L9-2]
CCDS8087.1 [Q8N1L9-1]
RefSeqiNP_001287736.1, NM_001300807.1
NP_001287737.1, NM_001300808.1 [Q8N1L9-2]
NP_612465.3, NM_138456.3 [Q8N1L9-1]
UniGeneiHs.124840

Genome annotation databases

EnsembliENST00000301887; ENSP00000301887; ENSG00000168062 [Q8N1L9-1]
ENST00000435842; ENSP00000398911; ENSG00000168062 [Q8N1L9-2]
GeneIDi116071
KEGGihsa:116071
UCSCiuc001oce.1 human [Q8N1L9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBATF2_HUMAN
AccessioniPrimary (citable) accession number: Q8N1L9
Secondary accession number(s): D9IC56
, Q8NAF4, Q8NAL8, Q96EH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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