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Q8N1L9

- BATF2_HUMAN

UniProt

Q8N1L9 - BATF2_HUMAN

Protein

Basic leucine zipper transcriptional factor ATF-like 2

Gene

BATF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes By similarity. Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. defense response to protozoan Source: UniProtKB
    2. myeloid dendritic cell differentiation Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Basic leucine zipper transcriptional factor ATF-like 2
    Short name:
    B-ATF-2
    Alternative name(s):
    Suppressor of AP-1 regulated by IFN
    Short name:
    SARI
    Gene namesi
    Name:BATF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:25163. BATF2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485315.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274Basic leucine zipper transcriptional factor ATF-like 2PRO_0000288681Add
    BLAST

    Proteomic databases

    PRIDEiQ8N1L9.

    Expressioni

    Inductioni

    By type I interferon. Down-regulated in most hepatocellular carcinoma tumorous tissues (at protein level).2 Publications

    Gene expression databases

    ArrayExpressiQ8N1L9.
    BgeeiQ8N1L9.
    CleanExiHS_BATF2.
    GenevestigatoriQ8N1L9.

    Interactioni

    Subunit structurei

    Heterodimer; heterodimerizes with JUN family proteins.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DAZAP2Q150383EBI-742695,EBI-724310
    JUNBP172753EBI-742695,EBI-748062

    Protein-protein interaction databases

    BioGridi125470. 17 interactions.
    DIPiDIP-48662N.
    IntActiQ8N1L9. 8 interactions.
    MINTiMINT-1447095.
    STRINGi9606.ENSP00000301887.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N1L9.
    SMRiQ8N1L9. Positions 22-68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 8064bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 4122Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni45 – 6622Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG76085.
    HOGENOMiHOG000070120.
    HOVERGENiHBG103463.
    InParanoidiQ8N1L9.
    KOiK09034.
    OMAiRSRQKHT.
    OrthoDBiEOG7H794S.
    PhylomeDBiQ8N1L9.
    TreeFamiTF332340.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N1L9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHLCGGNGLL TQTDPKEQQR QLKKQKNRAA AQRSRQKHTD KADALHQQHE    50
    SLEKDNLALR KEIQSLQAEL AWWSRTLHVH ERLCPMDCAS CSAPGLLGCW 100
    DQAEGLLGPG PQGQHGCREQ LELFQTPGSC YPAQPLSPGP QPHDSPSLLQ 150
    CPLPSLSLGP AVVAEPPVQL SPSPLLFASH TGSSLQGSSS KLSALQPSLT 200
    AQTAPPQPLE LEHPTRGKLG SSPDNPSSAL GLARLQSREH KPALSAATWQ 250
    GLVVDPSPHP LLAFPLLSSA QVHF 274
    Length:274
    Mass (Da):29,398
    Last modified:October 1, 2002 - v1
    Checksum:iCC4BDAA61A681B14
    GO
    Isoform 2 (identifier: Q8N1L9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-85: Missing.

    Show »
    Length:189
    Mass (Da):19,503
    Checksum:iBC1D0F5B688D62E7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61G → S.
    Corresponds to variant rs12419103 [ dbSNP | Ensembl ].
    VAR_048443

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8585Missing in isoform 2. 2 PublicationsVSP_025752Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM134154 mRNA. Translation: ADJ55304.1.
    AK092453 mRNA. Translation: BAC03894.2.
    AK092761 mRNA. Translation: BAC03968.2.
    AK096702 mRNA. Translation: BAC04846.1.
    CH471076 Genomic DNA. Translation: EAW74330.1.
    BC012330 mRNA. Translation: AAH12330.1.
    CCDSiCCDS8087.1. [Q8N1L9-1]
    RefSeqiNP_612465.3. NM_138456.3. [Q8N1L9-1]
    XP_005273796.1. XM_005273739.1. [Q8N1L9-2]
    UniGeneiHs.124840.

    Genome annotation databases

    EnsembliENST00000301887; ENSP00000301887; ENSG00000168062. [Q8N1L9-1]
    ENST00000435842; ENSP00000398911; ENSG00000168062. [Q8N1L9-2]
    GeneIDi116071.
    KEGGihsa:116071.
    UCSCiuc001oce.1. human. [Q8N1L9-1]

    Polymorphism databases

    DMDMi74750901.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM134154 mRNA. Translation: ADJ55304.1 .
    AK092453 mRNA. Translation: BAC03894.2 .
    AK092761 mRNA. Translation: BAC03968.2 .
    AK096702 mRNA. Translation: BAC04846.1 .
    CH471076 Genomic DNA. Translation: EAW74330.1 .
    BC012330 mRNA. Translation: AAH12330.1 .
    CCDSi CCDS8087.1. [Q8N1L9-1 ]
    RefSeqi NP_612465.3. NM_138456.3. [Q8N1L9-1 ]
    XP_005273796.1. XM_005273739.1. [Q8N1L9-2 ]
    UniGenei Hs.124840.

    3D structure databases

    ProteinModelPortali Q8N1L9.
    SMRi Q8N1L9. Positions 22-68.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125470. 17 interactions.
    DIPi DIP-48662N.
    IntActi Q8N1L9. 8 interactions.
    MINTi MINT-1447095.
    STRINGi 9606.ENSP00000301887.

    Polymorphism databases

    DMDMi 74750901.

    Proteomic databases

    PRIDEi Q8N1L9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301887 ; ENSP00000301887 ; ENSG00000168062 . [Q8N1L9-1 ]
    ENST00000435842 ; ENSP00000398911 ; ENSG00000168062 . [Q8N1L9-2 ]
    GeneIDi 116071.
    KEGGi hsa:116071.
    UCSCi uc001oce.1. human. [Q8N1L9-1 ]

    Organism-specific databases

    CTDi 116071.
    GeneCardsi GC11M064755.
    HGNCi HGNC:25163. BATF2.
    MIMi 614983. gene.
    neXtProti NX_Q8N1L9.
    PharmGKBi PA143485315.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG76085.
    HOGENOMi HOG000070120.
    HOVERGENi HBG103463.
    InParanoidi Q8N1L9.
    KOi K09034.
    OMAi RSRQKHT.
    OrthoDBi EOG7H794S.
    PhylomeDBi Q8N1L9.
    TreeFami TF332340.

    Miscellaneous databases

    GenomeRNAii 116071.
    NextBioi 79747.
    PROi Q8N1L9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N1L9.
    Bgeei Q8N1L9.
    CleanExi HS_BATF2.
    Genevestigatori Q8N1L9.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN)."
      Su Z.Z., Lee S.G., Emdad L., Lebdeva I.V., Gupta P., Valerie K., Sarkar D., Fisher P.B.
      Proc. Natl. Acad. Sci. U.S.A. 105:20906-20911(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Pericardium, Placenta and Small intestine.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung.
    5. "Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1."
      Dash R., Su Z.Z., Lee S.G., Azab B., Boukerche H., Sarkar D., Fisher P.B.
      Oncogene 29:4412-4423(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Decreased expression of BATF2 is associated with a poor prognosis in hepatocellular carcinoma."
      Ma H., Liang X., Chen Y., Pan K., Sun J., Wang H., Wang Q., Li Y., Zhao J., Li J., Chen M., Xia J.
      Int. J. Cancer 128:771-777(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiBATF2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N1L9
    Secondary accession number(s): D9IC56
    , Q8NAF4, Q8NAL8, Q96EH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3