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Protein

Basic leucine zipper transcriptional factor ATF-like 2

Gene

BATF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 2
Short name:
B-ATF-2
Alternative name(s):
Suppressor of AP-1 regulated by IFN
Short name:
SARI
Gene namesi
Name:BATF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25163. BATF2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi116071.
OpenTargetsiENSG00000168062.
PharmGKBiPA143485315.

Polymorphism and mutation databases

BioMutaiBATF2.
DMDMi74750901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002886811 – 274Basic leucine zipper transcriptional factor ATF-like 2Add BLAST274

Proteomic databases

PaxDbiQ8N1L9.
PeptideAtlasiQ8N1L9.
PRIDEiQ8N1L9.

PTM databases

iPTMnetiQ8N1L9.
PhosphoSitePlusiQ8N1L9.

Expressioni

Inductioni

By type I interferon. Down-regulated in most hepatocellular carcinoma tumorous tissues (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000168062.
CleanExiHS_BATF2.
ExpressionAtlasiQ8N1L9. baseline and differential.
GenevisibleiQ8N1L9. HS.

Organism-specific databases

HPAiHPA062496.

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DAZAP2Q150383EBI-742695,EBI-724310
JUNBP172753EBI-742695,EBI-748062

Protein-protein interaction databases

BioGridi125470. 17 interactors.
DIPiDIP-48662N.
IntActiQ8N1L9. 8 interactors.
MINTiMINT-1447095.
STRINGi9606.ENSP00000301887.

Structurei

3D structure databases

ProteinModelPortaliQ8N1L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 80bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 41Basic motifPROSITE-ProRule annotationAdd BLAST22
Regioni45 – 66Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00390000016869.
HOGENOMiHOG000070120.
HOVERGENiHBG103463.
InParanoidiQ8N1L9.
KOiK09034.
OMAiSSAQVHF.
OrthoDBiEOG091G0YSM.
PhylomeDBiQ8N1L9.
TreeFamiTF332340.

Family and domain databases

InterProiIPR000837. AP-1.
IPR029857. BATF2.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF11. PTHR23351:SF11. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N1L9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHLCGGNGLL TQTDPKEQQR QLKKQKNRAA AQRSRQKHTD KADALHQQHE
60 70 80 90 100
SLEKDNLALR KEIQSLQAEL AWWSRTLHVH ERLCPMDCAS CSAPGLLGCW
110 120 130 140 150
DQAEGLLGPG PQGQHGCREQ LELFQTPGSC YPAQPLSPGP QPHDSPSLLQ
160 170 180 190 200
CPLPSLSLGP AVVAEPPVQL SPSPLLFASH TGSSLQGSSS KLSALQPSLT
210 220 230 240 250
AQTAPPQPLE LEHPTRGKLG SSPDNPSSAL GLARLQSREH KPALSAATWQ
260 270
GLVVDPSPHP LLAFPLLSSA QVHF
Length:274
Mass (Da):29,398
Last modified:October 1, 2002 - v1
Checksum:iCC4BDAA61A681B14
GO
Isoform 2 (identifier: Q8N1L9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:189
Mass (Da):19,503
Checksum:iBC1D0F5B688D62E7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0484436G → S.Corresponds to variant rs12419103dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0257521 – 85Missing in isoform 2. 2 PublicationsAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM134154 mRNA. Translation: ADJ55304.1.
AK092453 mRNA. Translation: BAC03894.2.
AK092761 mRNA. Translation: BAC03968.2.
AK096702 mRNA. Translation: BAC04846.1.
CH471076 Genomic DNA. Translation: EAW74330.1.
BC012330 mRNA. Translation: AAH12330.1.
CCDSiCCDS73317.1. [Q8N1L9-2]
CCDS8087.1. [Q8N1L9-1]
RefSeqiNP_001287736.1. NM_001300807.1.
NP_001287737.1. NM_001300808.1. [Q8N1L9-2]
NP_612465.3. NM_138456.3. [Q8N1L9-1]
UniGeneiHs.124840.

Genome annotation databases

EnsembliENST00000301887; ENSP00000301887; ENSG00000168062. [Q8N1L9-1]
ENST00000435842; ENSP00000398911; ENSG00000168062. [Q8N1L9-2]
GeneIDi116071.
KEGGihsa:116071.
UCSCiuc001oce.1. human. [Q8N1L9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM134154 mRNA. Translation: ADJ55304.1.
AK092453 mRNA. Translation: BAC03894.2.
AK092761 mRNA. Translation: BAC03968.2.
AK096702 mRNA. Translation: BAC04846.1.
CH471076 Genomic DNA. Translation: EAW74330.1.
BC012330 mRNA. Translation: AAH12330.1.
CCDSiCCDS73317.1. [Q8N1L9-2]
CCDS8087.1. [Q8N1L9-1]
RefSeqiNP_001287736.1. NM_001300807.1.
NP_001287737.1. NM_001300808.1. [Q8N1L9-2]
NP_612465.3. NM_138456.3. [Q8N1L9-1]
UniGeneiHs.124840.

3D structure databases

ProteinModelPortaliQ8N1L9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125470. 17 interactors.
DIPiDIP-48662N.
IntActiQ8N1L9. 8 interactors.
MINTiMINT-1447095.
STRINGi9606.ENSP00000301887.

PTM databases

iPTMnetiQ8N1L9.
PhosphoSitePlusiQ8N1L9.

Polymorphism and mutation databases

BioMutaiBATF2.
DMDMi74750901.

Proteomic databases

PaxDbiQ8N1L9.
PeptideAtlasiQ8N1L9.
PRIDEiQ8N1L9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301887; ENSP00000301887; ENSG00000168062. [Q8N1L9-1]
ENST00000435842; ENSP00000398911; ENSG00000168062. [Q8N1L9-2]
GeneIDi116071.
KEGGihsa:116071.
UCSCiuc001oce.1. human. [Q8N1L9-1]

Organism-specific databases

CTDi116071.
DisGeNETi116071.
GeneCardsiBATF2.
HGNCiHGNC:25163. BATF2.
HPAiHPA062496.
MIMi614983. gene.
neXtProtiNX_Q8N1L9.
OpenTargetsiENSG00000168062.
PharmGKBiPA143485315.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00390000016869.
HOGENOMiHOG000070120.
HOVERGENiHBG103463.
InParanoidiQ8N1L9.
KOiK09034.
OMAiSSAQVHF.
OrthoDBiEOG091G0YSM.
PhylomeDBiQ8N1L9.
TreeFamiTF332340.

Miscellaneous databases

ChiTaRSiBATF2. human.
GenomeRNAii116071.
PROiQ8N1L9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168062.
CleanExiHS_BATF2.
ExpressionAtlasiQ8N1L9. baseline and differential.
GenevisibleiQ8N1L9. HS.

Family and domain databases

InterProiIPR000837. AP-1.
IPR029857. BATF2.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF11. PTHR23351:SF11. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBATF2_HUMAN
AccessioniPrimary (citable) accession number: Q8N1L9
Secondary accession number(s): D9IC56
, Q8NAF4, Q8NAL8, Q96EH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.