Q8N1L9 (BATF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Basic leucine zipper transcriptional factor ATF-like 2
Short name=B-ATF-2

Gene names

Name:

BATF2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the bZIP family. Contains 1 bZIP domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DAZAP2	Q15038	3	EBI-742695,EBI-724310
JUNB	P17275	3	EBI-742695,EBI-748062

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N1L9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N1L9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Basic leucine zipper transcriptional factor ATF-like 2		PRO_0000288681
Regions
	Domain	45 – 66	22	Leucine-zipper
	DNA binding	23 – 41	19	Basic motif
Natural variations
	Alternative sequence	1 – 85	85	Missing in isoform 2.		VSP_025752
	Natural variant	6	1	G → S. Corresponds to variant rs12419103 [ dbSNP | Ensembl ].		VAR_048443

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: CC4BDAA61A681B14	FASTA	274	29,398
	10 20 30 40 50 60 MHLCGGNGLL TQTDPKEQQR QLKKQKNRAA AQRSRQKHTD KADALHQQHE SLEKDNLALR 70 80 90 100 110 120 KEIQSLQAEL AWWSRTLHVH ERLCPMDCAS CSAPGLLGCW DQAEGLLGPG PQGQHGCREQ 130 140 150 160 170 180 LELFQTPGSC YPAQPLSPGP QPHDSPSLLQ CPLPSLSLGP AVVAEPPVQL SPSPLLFASH 190 200 210 220 230 240 TGSSLQGSSS KLSALQPSLT AQTAPPQPLE LEHPTRGKLG SSPDNPSSAL GLARLQSREH 250 260 270 KPALSAATWQ GLVVDPSPHP LLAFPLLSSA QVHF
	Isoform 2 [UniParc]. Checksum: BC1D0F5B688D62E7	FASTA	189	19,503
	10 20 30 40 50 60 MDCASCSAPG LLGCWDQAEG LLGPGPQGQH GCREQLELFQ TPGSCYPAQP LSPGPQPHDS 70 80 90 100 110 120 PSLLQCPLPS LSLGPAVVAE PPVQLSPSPL LFASHTGSSL QGSSSKLSAL QPSLTAQTAP 130 140 150 160 170 180 PQPLELEHPT RGKLGSSPDN PSSALGLARL QSREHKPALS AATWQGLVVD PSPHPLLAFP LLSSAQVHF

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Pericardium, Placenta and Small intestine.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK092453 mRNA. Translation: BAC03894.2. AK092761 mRNA. Translation: BAC03968.2. AK096702 mRNA. Translation: BAC04846.1. BC012330 mRNA. Translation: AAH12330.1.
IPI	IPI00409656. IPI00980331.
RefSeq	NP_612465.3. NM_138456.3.
UniGene	Hs.124840.
3D structure databases
ProteinModelPortal	Q8N1L9.
SMR	Q8N1L9. Positions 19-79.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48662N.
IntAct	Q8N1L9. 9 interactions.
MINT	MINT-1447095.
STRING	Q8N1L9.
Polymorphism databases
DMDM	74750901.
Proteomic databases
PRIDE	Q8N1L9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301887; ENSP00000301887; ENSG00000168062.
GeneID	116071.
KEGG	hsa:116071.
UCSC	uc001oce.1. human. uc001ocf.1. human.
Organism-specific databases
CTD	116071.
GeneCards	GC11M064755.
HGNC	HGNC:25163. BATF2.
neXtProt	NX_Q8N1L9.
PharmGKB	PA143485315.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08124.
GeneTree	ENSGT00390000016869.
HOGENOM	HBG125819.
HOVERGEN	HBG103463.
InParanoid	Q8N1L9.
OMA	RSRQKHT.
OrthoDB	EOG42FSJD.
PhylomeDB	Q8N1L9.
Gene expression databases
ArrayExpress	Q8N1L9.
Bgee	Q8N1L9.
CleanEx	HS_BATF2.
Genevestigator	Q8N1L9.
Family and domain databases
InterPro	IPR004827. bZIP. IPR011616. bZIP_1. [Graphical view]
KO	K09034.
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	79747.

Entry information

Entry name

BATF2_HUMAN

Accession

Primary (citable) accession number: Q8N1L9
Secondary accession number(s): Q8NAF4, Q8NAL8, Q96EH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.