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Protein

Putative inactive cytochrome P450 family member 4Z2

Gene

CYP4Z2P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Cofactori

hemeBy similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inactive cytochrome P450 family member 4Z2
Gene namesi
Name:CYP4Z2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:24426. CYP4Z2P.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence Analysis
Transmembranei10 – 3021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini31 – 340310LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Putative inactive cytochrome P450 family member 4Z2PRO_0000330732Add
BLAST

Proteomic databases

PRIDEiQ8N1L4.

Expressioni

Tissue specificityi

Detected at low levels in mammary gland and mammary carcinoma.1 Publication

Gene expression databases

GenevestigatoriQ8N1L4.

Organism-specific databases

HPAiHPA043005.

Interactioni

Protein-protein interaction databases

IntActiQ8N1L4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8N1L4.
SMRiQ8N1L4. Positions 105-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000182.
InParanoidiQ8N1L4.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N1L4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPSWLQELM AHPFLLLILL CMSLLLFQVI RLYQRRRWTI RAMHLFPAPP
60 70 80 90 100
AHWFYGHKES YPVKEFEVYP ELMEKYPCAV PLWVGPFTMF FNIHDPDYVK
110 120 130 140 150
ILLKRQDPKS AVSHKILESW VGRGLVTLDG SKWKKHRQIV KPGFNISILK
160 170 180 190 200
IFITMMSKSV RMMLNKWEEH IAQNSRLELF QHVSLMTLDS IMKCAFSHQG
210 220 230 240 250
SIQLDSTLDS YLKAVFNLSK ISNQRMNNFL HHNDLVFKFS SQGQIFSKFN
260 270 280 290 300
QELHQFTEKV IQDRKESLKD KLKQDTTQKR RQDFLDILLS AKSENTKDFS
310 320 330 340
EADLQAEVKT FMFAGHDTTT TAISWIFYCL AKYPEHQQRC
Length:340
Mass (Da):40,159
Last modified:April 29, 2008 - v2
Checksum:i2E6F7C0AACC02EF4
GO
Isoform 2 (identifier: Q8N1L4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-340: Missing.

Show »
Length:292
Mass (Da):34,616
Checksum:i30B160CFD7AB03AB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81E → G in AAU10524. 1 PublicationCurated
Sequence conflicti34 – 341Q → R in BAC05026. (PubMed:14702039)Curated
Sequence conflicti107 – 1071D → N in AAU10524. 1 PublicationCurated
Sequence conflicti173 – 1731Q → H in AAU10524. 1 PublicationCurated
Sequence conflicti189 – 1891D → H in AAU10524. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei293 – 34048Missing in isoform 2. 1 PublicationVSP_033072Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262057 mRNA. No translation available.
AY696295 mRNA. Translation: AAU10524.1.
AK097373 mRNA. Translation: BAC05026.1.
UniGeneiHs.591431.

Polymorphism databases

DMDMi187470849.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262057 mRNA. No translation available.
AY696295 mRNA. Translation: AAU10524.1.
AK097373 mRNA. Translation: BAC05026.1.
UniGeneiHs.591431.

3D structure databases

ProteinModelPortaliQ8N1L4.
SMRiQ8N1L4. Positions 105-339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N1L4. 1 interaction.

Polymorphism databases

DMDMi187470849.

Proteomic databases

PRIDEiQ8N1L4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC01M047309.
HGNCiHGNC:24426. CYP4Z2P.
HPAiHPA043005.
neXtProtiNX_Q8N1L4.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG000182.
InParanoidiQ8N1L4.

Gene expression databases

GenevestigatoriQ8N1L4.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
SUPFAMiSSF48264. SSF48264. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma."
    Rieger M.A., Ebner R., Bell D.R., Kiessling A., Rohayem J., Schmitz M., Temme A., Rieber E.P., Weigle B.
    Cancer Res. 64:2357-2364(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Mammary carcinoma.
  2. Lin L., Zheng G., Ke R., Li H., Zhou G., Shen C., Yang S.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.

Entry informationi

Entry nameiCP4Z2_HUMAN
AccessioniPrimary (citable) accession number: Q8N1L4
Secondary accession number(s): Q66ZJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: January 7, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. In contrast to other members of the family, it is shorter at the C-terminus and lacks the heme-binding sites.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.