Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8N1L4

- CP4Z2_HUMAN

UniProt

Q8N1L4 - CP4Z2_HUMAN

Protein

Putative inactive cytochrome P450 family member 4Z2

Gene

CYP4Z2P

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (29 Apr 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cofactori

    Heme group.By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative inactive cytochrome P450 family member 4Z2
    Gene namesi
    Name:CYP4Z2P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:24426. CYP4Z2P.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Putative inactive cytochrome P450 family member 4Z2PRO_0000330732Add
    BLAST

    Proteomic databases

    PRIDEiQ8N1L4.

    Expressioni

    Tissue specificityi

    Detected at low levels in mammary gland and mammary carcinoma.1 Publication

    Gene expression databases

    GenevestigatoriQ8N1L4.

    Organism-specific databases

    HPAiHPA043005.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8N1L4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N1L4.
    SMRiQ8N1L4. Positions 105-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini31 – 340310LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG000182.
    InParanoidiQ8N1L4.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    SUPFAMiSSF48264. SSF48264. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N1L4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPSWLQELM AHPFLLLILL CMSLLLFQVI RLYQRRRWTI RAMHLFPAPP    50
    AHWFYGHKES YPVKEFEVYP ELMEKYPCAV PLWVGPFTMF FNIHDPDYVK 100
    ILLKRQDPKS AVSHKILESW VGRGLVTLDG SKWKKHRQIV KPGFNISILK 150
    IFITMMSKSV RMMLNKWEEH IAQNSRLELF QHVSLMTLDS IMKCAFSHQG 200
    SIQLDSTLDS YLKAVFNLSK ISNQRMNNFL HHNDLVFKFS SQGQIFSKFN 250
    QELHQFTEKV IQDRKESLKD KLKQDTTQKR RQDFLDILLS AKSENTKDFS 300
    EADLQAEVKT FMFAGHDTTT TAISWIFYCL AKYPEHQQRC 340
    Length:340
    Mass (Da):40,159
    Last modified:April 29, 2008 - v2
    Checksum:i2E6F7C0AACC02EF4
    GO
    Isoform 2 (identifier: Q8N1L4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         293-340: Missing.

    Show »
    Length:292
    Mass (Da):34,616
    Checksum:i30B160CFD7AB03AB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81E → G in AAU10524. 1 PublicationCurated
    Sequence conflicti34 – 341Q → R in BAC05026. (PubMed:14702039)Curated
    Sequence conflicti107 – 1071D → N in AAU10524. 1 PublicationCurated
    Sequence conflicti173 – 1731Q → H in AAU10524. 1 PublicationCurated
    Sequence conflicti189 – 1891D → H in AAU10524. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei293 – 34048Missing in isoform 2. 1 PublicationVSP_033072Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY262057 mRNA. No translation available.
    AY696295 mRNA. Translation: AAU10524.1.
    AK097373 mRNA. Translation: BAC05026.1.
    UniGeneiHs.591431.

    Polymorphism databases

    DMDMi187470849.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY262057 mRNA. No translation available.
    AY696295 mRNA. Translation: AAU10524.1 .
    AK097373 mRNA. Translation: BAC05026.1 .
    UniGenei Hs.591431.

    3D structure databases

    ProteinModelPortali Q8N1L4.
    SMRi Q8N1L4. Positions 105-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8N1L4. 1 interaction.

    Polymorphism databases

    DMDMi 187470849.

    Proteomic databases

    PRIDEi Q8N1L4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC01M047309.
    HGNCi HGNC:24426. CYP4Z2P.
    HPAi HPA043005.
    neXtProti NX_Q8N1L4.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG000182.
    InParanoidi Q8N1L4.

    Gene expression databases

    Genevestigatori Q8N1L4.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48264. SSF48264. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma."
      Rieger M.A., Ebner R., Bell D.R., Kiessling A., Rohayem J., Schmitz M., Temme A., Rieber E.P., Weigle B.
      Cancer Res. 64:2357-2364(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Mammary carcinoma.
    2. Lin L., Zheng G., Ke R., Li H., Zhou G., Shen C., Yang S.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCP4Z2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N1L4
    Secondary accession number(s): Q66ZJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene. In contrast to other members of the family, it is shorter at the C-terminus and lacks the heme-binding sites.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3