Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8N1L4 (CP4Z2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative inactive cytochrome P450 family member 4Z2
Gene names
Name:CYP4Z2P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Tissue specificity

Detected at low levels in mammary gland and mammary carcinoma. Ref.1

Sequence similarities

Belongs to the cytochrome P450 family.

Caution

Could be the product of a pseudogene. In contrast to other members of the family, it is shorter at the C-terminus and lacks the heme-binding sites.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N1L4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N1L4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     293-340: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Putative inactive cytochrome P450 family member 4Z2
PRO_0000330732

Regions

Topological domain1 – 99Cytoplasmic Potential
Transmembrane10 – 3021Helical; Signal-anchor for type II membrane protein; Potential
Topological domain31 – 340310Lumenal Potential

Natural variations

Alternative sequence293 – 34048Missing in isoform 2.
VSP_033072

Experimental info

Sequence conflict81E → G in AAU10524. Ref.2
Sequence conflict341Q → R in BAC05026. Ref.3
Sequence conflict1071D → N in AAU10524. Ref.2
Sequence conflict1731Q → H in AAU10524. Ref.2
Sequence conflict1891D → H in AAU10524. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 29, 2008. Version 2.
Checksum: 2E6F7C0AACC02EF4

FASTA34040,159
        10         20         30         40         50         60 
MEPSWLQELM AHPFLLLILL CMSLLLFQVI RLYQRRRWTI RAMHLFPAPP AHWFYGHKES 

        70         80         90        100        110        120 
YPVKEFEVYP ELMEKYPCAV PLWVGPFTMF FNIHDPDYVK ILLKRQDPKS AVSHKILESW 

       130        140        150        160        170        180 
VGRGLVTLDG SKWKKHRQIV KPGFNISILK IFITMMSKSV RMMLNKWEEH IAQNSRLELF 

       190        200        210        220        230        240 
QHVSLMTLDS IMKCAFSHQG SIQLDSTLDS YLKAVFNLSK ISNQRMNNFL HHNDLVFKFS 

       250        260        270        280        290        300 
SQGQIFSKFN QELHQFTEKV IQDRKESLKD KLKQDTTQKR RQDFLDILLS AKSENTKDFS 

       310        320        330        340 
EADLQAEVKT FMFAGHDTTT TAISWIFYCL AKYPEHQQRC 

« Hide

Isoform 2 [UniParc].

Checksum: 30B160CFD7AB03AB
Show »

FASTA29234,616

References

« Hide 'large scale' references
[1]"Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma."
Rieger M.A., Ebner R., Bell D.R., Kiessling A., Rohayem J., Schmitz M., Temme A., Rieber E.P., Weigle B.
Cancer Res. 64:2357-2364(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Mammary carcinoma.
[2]Lin L., Zheng G., Ke R., Li H., Zhou G., Shen C., Yang S.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Mammary gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY262057 mRNA. No translation available.
AY696295 mRNA. Translation: AAU10524.1.
AK097373 mRNA. Translation: BAC05026.1.
UniGeneHs.591431.

3D structure databases

ProteinModelPortalQ8N1L4.
SMRQ8N1L4. Positions 105-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8N1L4. 1 interaction.

Polymorphism databases

DMDM187470849.

Proteomic databases

PRIDEQ8N1L4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC01M047309.
HGNCHGNC:24426. CYP4Z2P.
HPAHPA043005.
neXtProtNX_Q8N1L4.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG000182.
InParanoidQ8N1L4.

Gene expression databases

GenevestigatorQ8N1L4.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
SUPFAMSSF48264. SSF48264. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCP4Z2_HUMAN
AccessionPrimary (citable) accession number: Q8N1L4
Secondary accession number(s): Q66ZJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM