Q8N1L4 (CP4Z2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative inactive cytochrome P450 family member 4Z2

Gene names

Name:

CYP4Z2P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Cofactor	Heme group By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein Potential.
Tissue specificity	Detected at low levels in mammary gland and mammary carcinoma. Ref.1
Sequence similarities	Belongs to the cytochrome P450 family.
Caution	Could be the product of a pseudogene. In contrast to other members of the family, it is shorter at the C-terminus and lacks the heme-binding sites.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal-anchor Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N1L4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N1L4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     293-340: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Putative inactive cytochrome P450 family member 4Z2		PRO_0000330732
Regions
	Topological domain	1 – 9	9	Cytoplasmic Potential
	Transmembrane	10 – 30	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	31 – 340	310	Lumenal Potential
Natural variations
	Alternative sequence	293 – 340	48	Missing in isoform 2.		VSP_033072
Experimental info
	Sequence conflict	8	1	E → G in AAU10524. Ref.2
	Sequence conflict	34	1	Q → R in BAC05026. Ref.3
	Sequence conflict	107	1	D → N in AAU10524. Ref.2
	Sequence conflict	173	1	Q → H in AAU10524. Ref.2
	Sequence conflict	189	1	D → H in AAU10524. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 29, 2008. Version 2. Checksum: 2E6F7C0AACC02EF4	FASTA	340	40,159
	10 20 30 40 50 60 MEPSWLQELM AHPFLLLILL CMSLLLFQVI RLYQRRRWTI RAMHLFPAPP AHWFYGHKES 70 80 90 100 110 120 YPVKEFEVYP ELMEKYPCAV PLWVGPFTMF FNIHDPDYVK ILLKRQDPKS AVSHKILESW 130 140 150 160 170 180 VGRGLVTLDG SKWKKHRQIV KPGFNISILK IFITMMSKSV RMMLNKWEEH IAQNSRLELF 190 200 210 220 230 240 QHVSLMTLDS IMKCAFSHQG SIQLDSTLDS YLKAVFNLSK ISNQRMNNFL HHNDLVFKFS 250 260 270 280 290 300 SQGQIFSKFN QELHQFTEKV IQDRKESLKD KLKQDTTQKR RQDFLDILLS AKSENTKDFS 310 320 330 340 EADLQAEVKT FMFAGHDTTT TAISWIFYCL AKYPEHQQRC
	Isoform 2 [UniParc]. Checksum: 30B160CFD7AB03AB	FASTA	292	34,616
	10 20 30 40 50 60 MEPSWLQELM AHPFLLLILL CMSLLLFQVI RLYQRRRWTI RAMHLFPAPP AHWFYGHKES 70 80 90 100 110 120 YPVKEFEVYP ELMEKYPCAV PLWVGPFTMF FNIHDPDYVK ILLKRQDPKS AVSHKILESW 130 140 150 160 170 180 VGRGLVTLDG SKWKKHRQIV KPGFNISILK IFITMMSKSV RMMLNKWEEH IAQNSRLELF 190 200 210 220 230 240 QHVSLMTLDS IMKCAFSHQG SIQLDSTLDS YLKAVFNLSK ISNQRMNNFL HHNDLVFKFS 250 260 270 280 290 SQGQIFSKFN QELHQFTEKV IQDRKESLKD KLKQDTTQKR RQDFLDILLS AK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma." Rieger M.A., Ebner R., Bell D.R., Kiessling A., Rohayem J., Schmitz M., Temme A., Rieber E.P., Weigle B. Cancer Res. 64:2357-2364(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Mammary carcinoma.
[2]	Lin L., Zheng G., Ke R., Li H., Zhou G., Shen C., Yang S. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Mammary gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY262057 mRNA. No translation available. AY696295 mRNA. Translation: AAU10524.1. AK097373 mRNA. Translation: BAC05026.1.
IPI	IPI00295854. IPI00890692.
UniGene	Hs.591431.
3D structure databases
ProteinModelPortal	Q8N1L4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N1L4. 1 interaction.
Polymorphism databases
DMDM	187470849.
Proteomic databases
PRIDE	Q8N1L4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC01M047309.
HGNC	HGNC:24426. CYP4Z2P.
HPA	HPA043005.
neXtProt	NX_Q8N1L4.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG000182.
InParanoid	Q8N1L4.
PhylomeDB	Q8N1L4.
Gene expression databases
Genevestigator	Q8N1L4.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP4Z2_HUMAN

Accession

Primary (citable) accession number: Q8N1L4
Secondary accession number(s): Q66ZJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.