Q8N1K8 (Q8N1K8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ40556 fis, clone THYMU2002583, highly similar to DYNAMIN 2 EMBL BAC05190.1
Organism	Homo sapiens (Human) EMBL BAC05190.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 GED domain. SAAS SAAS020850 Contains 1 PH domain. RuleBase RU003350

Ontologies

Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC receptor-mediated endocytosis Inferred from electronic annotation. Source: Compara
Cellular_component	clathrin-coated endocytic vesicle Inferred from electronic annotation. Source: Compara microtubule Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	GTP binding Inferred from electronic annotation. Source: InterPro GTPase activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8N1K8 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: A56592DDAD9B7368	FASTA	464	52,199
	10 20 30 40 50 60 MAFEAIVKKQ IVKLKEPSLK CVDLVVSELA TVIKKCAEKL SSYPRLREET ERIVTTYIRE 70 80 90 100 110 120 REGRTKDQIL LLIDIEQSYI NTNHEDFIGF ANAQQRSTQL NKKRAIPNQG EILVIRRGWL 130 140 150 160 170 180 TINNISLMKG GSKEYWFVLT AESLSWYKDE EEKEKKYMLP LDNLKIRDVE KGFMSNKHVF 190 200 210 220 230 240 AIFNTEQRNV YKDLRQIELA CDSQEDVDSW KASFLRAGVY PEKDQAENED GAQENTFSMD 250 260 270 280 290 300 PQLERQVETI RNLVDSYVAI INKSIRDLMP KTIMHLMINN TKAFIHHELL AYLYSSADQS 310 320 330 340 350 360 SLMEESADQA QRRDDMLRMY HALKEALNII GDISTSTVST PVPPPVDDTW LQSASSHSPT 370 380 390 400 410 420 PQRRPVSSIH PPGRPPAVRG PTPGPPLIPV PVGAAASFSA PPIPSRPGPQ SVFANSDLFP 430 440 450 460 APPQIPSRPV RIPPGIPPGV PSRRPPAAPS RPTIIRPAEP SLLD

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Thymus EMBL BAC05190.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK097875 mRNA. Translation: BAC05190.1.
IPI	IPI00514550.
RefSeq	NP_001005361.1. NM_001005361.2.
UniGene	Hs.211463.
3D structure databases
HSSP	HSSP built from PDB template 2DYN based on UniProtKB Q05193.
ProteinModelPortal	Q8N1K8.
SMR	Q8N1K8. Positions 114-219.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1379377.
STRING	Q8N1K8.
Proteomic databases
PRIDE	Q8N1K8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1785.
KEGG	hsa:1785.
Organism-specific databases
CTD	1785.
PharmGKB	PA27442.
Phylogenomic databases
HOGENOM	HOG000161069.
HOVERGEN	HBG107833.
KO	K01528.
OrthoDB	EOG49GKG1.
Gene expression databases
ArrayExpress	Q8N1K8.
Bgee	Q8N1K8.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR027188. DNM2. IPR022812. Dynamin. IPR000375. Dynamin_central. IPR003130. GED. IPR020850. GTPase_effector_domain_GED. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
PANTHER	PTHR11566. PTHR11566. 1 hit. PTHR11566:SF23. PTHR11566:SF23. 1 hit.
Pfam	PF01031. Dynamin_M. 1 hit. PF02212. GED. 1 hit. PF00169. PH. 1 hit. [Graphical view]
SMART	SM00302. GED. 1 hit. SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS51388. GED. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1785.
NextBio	7257.

Entry information

Entry name

Q8N1K8_HUMAN

Accession

Primary (citable) accession number: Q8N1K8

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.