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Q8N1K8

- Q8N1K8_HUMAN

UniProt

Q8N1K8 - Q8N1K8_HUMAN

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Protein
Submitted name:

cDNA FLJ40556 fis, clone THYMU2002583, highly similar to DYNAMIN 2

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: InterPro

GO - Biological processi

  1. endocytosis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ40556 fis, clone THYMU2002583, highly similar to DYNAMIN 2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. microtubule Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27442.

PTM / Processingi

Proteomic databases

PRIDEiQ8N1K8.

Expressioni

Gene expression databases

BgeeiQ8N1K8.
ExpressionAtlasiQ8N1K8. baseline and differential.

Interactioni

Protein-protein interaction databases

MINTiMINT-1379377.

Structurei

3D structure databases

ProteinModelPortaliQ8N1K8.
SMRiQ8N1K8. Positions 114-219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation
Contains GED domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000161069.
HOVERGENiHBG107833.
KOiK01528.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR027188. DNM2.
IPR000375. Dynamin_central.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF23. PTHR11566:SF23. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N1K8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFEAIVKKQ IVKLKEPSLK CVDLVVSELA TVIKKCAEKL SSYPRLREET
60 70 80 90 100
ERIVTTYIRE REGRTKDQIL LLIDIEQSYI NTNHEDFIGF ANAQQRSTQL
110 120 130 140 150
NKKRAIPNQG EILVIRRGWL TINNISLMKG GSKEYWFVLT AESLSWYKDE
160 170 180 190 200
EEKEKKYMLP LDNLKIRDVE KGFMSNKHVF AIFNTEQRNV YKDLRQIELA
210 220 230 240 250
CDSQEDVDSW KASFLRAGVY PEKDQAENED GAQENTFSMD PQLERQVETI
260 270 280 290 300
RNLVDSYVAI INKSIRDLMP KTIMHLMINN TKAFIHHELL AYLYSSADQS
310 320 330 340 350
SLMEESADQA QRRDDMLRMY HALKEALNII GDISTSTVST PVPPPVDDTW
360 370 380 390 400
LQSASSHSPT PQRRPVSSIH PPGRPPAVRG PTPGPPLIPV PVGAAASFSA
410 420 430 440 450
PPIPSRPGPQ SVFANSDLFP APPQIPSRPV RIPPGIPPGV PSRRPPAAPS
460
RPTIIRPAEP SLLD
Length:464
Mass (Da):52,199
Last modified:October 1, 2002 - v1
Checksum:iA56592DDAD9B7368
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097875 mRNA. Translation: BAC05190.1.
RefSeqiNP_001005361.1. NM_001005361.2.
UniGeneiHs.211463.

Genome annotation databases

GeneIDi1785.
KEGGihsa:1785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097875 mRNA. Translation: BAC05190.1 .
RefSeqi NP_001005361.1. NM_001005361.2.
UniGenei Hs.211463.

3D structure databases

ProteinModelPortali Q8N1K8.
SMRi Q8N1K8. Positions 114-219.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1379377.

Proteomic databases

PRIDEi Q8N1K8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1785.
KEGGi hsa:1785.

Organism-specific databases

CTDi 1785.
PharmGKBi PA27442.

Phylogenomic databases

HOGENOMi HOG000161069.
HOVERGENi HBG107833.
KOi K01528.

Miscellaneous databases

GenomeRNAii 1785.
NextBioi 7257.

Gene expression databases

Bgeei Q8N1K8.
ExpressionAtlasi Q8N1K8. baseline and differential.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR027188. DNM2.
IPR000375. Dynamin_central.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
PANTHERi PTHR11566. PTHR11566. 1 hit.
PTHR11566:SF23. PTHR11566:SF23. 1 hit.
Pfami PF01031. Dynamin_M. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view ]
PROSITEi PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ThymusImported.

Entry informationi

Entry nameiQ8N1K8_HUMAN
AccessioniPrimary (citable) accession number: Q8N1K8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.