Q8N1I0 (DOCK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dedicator of cytokinesis protein 4

Gene names

Name:	DOCK4
Synonyms:	KIAA0716

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1966 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. Ref.1 Ref.10
Subunit structure	Interacts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1. Interacts with FASLG. Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2. Ref.1 Ref.8 Ref.10
Subcellular location	Endomembrane system; Peripheral membrane protein. Cytoplasm › cytosol Ref.1 Ref.10.
Tissue specificity	Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary. Ref.1
Domain	The DHR-2 domain probably mediates the GEF activity By similarity.
Miscellaneous	Injection of wild-type protein suppresses tumor invasion in osteosarcoma mouse cell lines while it is not the case with the Leu-1718 variant.
Sequence similarities	Belongs to the DOCK family. Contains 1 DHR-1 domain. Contains 1 DHR-2 domain. Contains 1 SH3 domain.
Sequence caution	The sequence BAC03696.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Proto-oncogene
Domain	SH3 domain SH3-binding
Molecular function	Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell chemotaxis Inferred from mutant phenotype Ref.10. Source: UniProtKB small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytosol Inferred from direct assay Ref.10. Source: UniProtKB endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from direct assay Ref.10. Source: UniProtKB stereocilium Inferred from sequence or structural similarity PubMed 16464467. Source: HGNC
Molecular_function	Rac GTPase activator activity Inferred from direct assay PubMed 16464467. Source: HGNC Rac GTPase binding Inferred from direct assay PubMed 16464467. Source: HGNC guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N1I0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N1I0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1134-1134: I → IIPLFGPYPS
     1760-1797: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8N1I0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1134-1134: I → IIPLFGPYPS

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8N1I0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1687: Missing.
     1688-1698: NVTSSAPSSAR → MLMILSLLLFP

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1966	1966	Dedicator of cytokinesis protein 4		PRO_0000189990
Regions
	Domain	6 – 67	62	SH3
	Domain	401 – 574	174	DHR-1
	Domain	1190 – 1596	407	DHR-2
	Motif	1788 – 1794	7	SH3-binding Potential
	Compositional bias	1642 – 1863	222	Ser-rich
	Compositional bias	1875 – 1960	86	Pro-rich
Amino acid modifications
	Modified residue	167	1	Phosphotyrosine By similarity
	Modified residue	1614	1	Phosphoserine Ref.7 Ref.9
	Modified residue	1618	1	Phosphoserine Ref.7 Ref.9
	Modified residue	1620	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	1 – 1687	1687	Missing in isoform 4.		VSP_007701
	Alternative sequence	1134	1	I → IIPLFGPYPS in isoform 2 and isoform 3.		VSP_007703
	Alternative sequence	1688 – 1698	11	NVTSSAPSSAR → MLMILSLLLFP in isoform 4.		VSP_007705
	Alternative sequence	1760 – 1797	38	Missing in isoform 2.		VSP_007706
	Natural variant	87	1	T → I in a CNS cancer cell line. Ref.1		VAR_015823
	Natural variant	535	1	N → D. Corresponds to variant rs12705801 [ dbSNP | Ensembl ].		VAR_057517
	Natural variant	606	1	E → Q. Ref.1		VAR_015824
	Natural variant	853	1	R → H. Corresponds to variant rs2074130 [ dbSNP | Ensembl ].		VAR_057518
	Natural variant	1059	1	K → T in a CNS cancer cell line. Ref.1		VAR_015825
	Natural variant	1570	1	R → K. Corresponds to variant rs3757650 [ dbSNP | Ensembl ].		VAR_057519
	Natural variant	1580	1	F → L. Corresponds to variant rs3757651 [ dbSNP | Ensembl ].		VAR_057520
	Natural variant	1718	1	P → L in prostate and ovarian cancer cell lines; abolishes ability to interact with CRK and to activate Rap1. Ref.1		VAR_015826
	Natural variant	1733	1	P → A. Ref.1		VAR_015827
	Natural variant	1755	1	S → P in colorectal cancer cell line. Ref.1		VAR_015828
	Natural variant	1822	1	Q → K. Corresponds to variant rs10281942 [ dbSNP | Ensembl ].		VAR_057521
	Natural variant	1884	1	V → M in a prostate cancer cell line. Ref.1		VAR_015829
	Natural variant	1914	1	V → I. Ref.1 Corresponds to variant rs12705795 [ dbSNP | Ensembl ].		VAR_015830
	Natural variant	1917	1	P → L. Ref.1		VAR_015831
	Natural variant	1926	1	S → L. Ref.1 Corresponds to variant rs34597439 [ dbSNP | Ensembl ].		VAR_015832
Experimental info
	Sequence conflict	945	1	R → K in AAB83946. Ref.3
	Sequence conflict	1080	1	D → G in AAO73565. Ref.1
	Sequence conflict	1122	1	K → E in BAC03696. Ref.2
	Sequence conflict	1379 – 1381	3	YLQ → CIRTYKGWTQFGTAVITDVG RLGTQIITQIN in BAC05221. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 9CFB6299F7730AA9	FASTA	1,966	225,206
	10 20 30 40 50 60 MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN PNIKGIFPSS 70 80 90 100 110 120 YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW KQLYVRNEGD LFHRLWHIMN 130 140 150 160 170 180 EILDLRRQVL VGHLTHDRMK DVKRHITARL DWGNEQLGLD LVPRKEYAMV DPEDISITEL 190 200 210 220 230 240 YRLMEHRHRK KDTPVQASSH HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR 250 260 270 280 290 300 LNRNGLPKAP DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP 310 320 330 340 350 360 FGCAVLSIAD LLTGETKDDL ILKVYMCNTE SEWYQIHENI IKKLNARYNL TGSNAGLAVS 370 380 390 400 410 420 LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSNIIMPGEM RNDLYITIER GEFEKGGKSV 430 440 450 460 470 480 ARNVEVTMFI VDSSGQTLKD FISFGSGEPP ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF 490 500 510 520 530 540 RGAHIRFEFR HCSTKEKGEK KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT 550 560 570 580 590 600 RYLKLPFSKG IFLGNNNQAM KATKESFCIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC 610 620 630 640 650 660 LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ DSKFHHFKPV 670 680 690 700 710 720 MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE VLKAQEYIFK YIVQSRRLFS 730 740 750 760 770 780 LATGGQNEEE FRCCIQELLM SVRFFLSQES KGSGALSQSQ AVFLSSFPAV YSELLKLFDV 790 800 810 820 830 840 REVANLVQDT LGSLPTILHV DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI 850 860 870 880 890 900 HLQEQKDLIM CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQPS 910 920 930 940 950 960 SSAMRFQFQD VTGEFVACLL SLLRQMTDRH YQQLLDSFNT KEELRDFLLQ IFTVFRILIR 970 980 990 1000 1010 1020 PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD YKIWDSYFYL AVIFINQLCL 1030 1040 1050 1060 1070 1080 QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS MWQNLGEHKL HFIPALIGPF LEVTLIPQPD 1090 1100 1110 1120 1130 1140 LRNVMIPIFH DMMDWEQRRS GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSILLKKIE 1150 1160 1170 1180 1190 1200 RETWRESGVS LIATVTRLME RLLDYRDCMK MGEVDGKKIG CTVSLLNFYK TELNKEEMYI 1210 1220 1230 1240 1250 1260 RYIHKLYDLH LKAQNFTEAA YTLLLYDELL EWSDRPLREF LTYPMQTEWQ RKEHLHLTII 1270 1280 1290 1300 1310 1320 QNFDRGKCWE NGIILCRKIA EQYESYYDYR NLSKMRMMEA SLYDKIMDQQ RLEPEFFRVG 1330 1340 1350 1360 1370 1380 FYGKKFPFFL RNKEFVCRGH DYERLEAFQQ RMLNEFPHAI AMQHANQPDE TIFQAEAQYL 1390 1400 1410 1420 1430 1440 QIYAVTPIPE SQEVLQREGV PDNIKSFYKV NHIWKFRYDR PFHKGTKDKE NEFKSLWVER 1450 1460 1470 1480 1490 1500 TSLYLVQSLP GISRWFEVEK REVVEMSPLE NAIEVLENKN QQLKTLISQC QTRQMQNINP 1510 1520 1530 1540 1550 1560 LTMCLNGVID AAVNGGVSRY QEAFFVKEYI LSHPEDGEKI ARLRELMLEQ AQILEFGLAV 1570 1580 1590 1600 1610 1620 HEKFVPQDMR PLHKKLVDQF FVMKSSLGIQ EFSACMQASP VHFPNGSPRV CRNSAPASVS 1630 1640 1650 1660 1670 1680 PDGTRVIPRR SPLSYPAVNR YSSSSLSSQA SAEVSNITGQ SESSDEVFNM QPSPSTSSLS 1690 1700 1710 1720 1730 1740 STHSASPNVT SSAPSSARAS PLLSDKHKHS RENSCLSPRE RPCSAIYPTP VEPSQRMLFN 1750 1760 1770 1780 1790 1800 HIGDGALPRS DPNLSAPEKA VNPTPSSWSL DSGKEAKNMS DSGKLISPPV PPRPTQTASP 1810 1820 1830 1840 1850 1860 ARHTTSVSPS PAGRSPLKGS VQSFTPSPVE YHSPGLISNS PVLSGSYSSG ISSLSRCSTS 1870 1880 1890 1900 1910 1920 ETSGFENQVN EQSAPLPVPV PVPVPSYGGE EPVRKESKTP PPYSVYERTL RRPVPLPHSL 1930 1940 1950 1960 SIPVTSEPPA LPPKPLAARS SHLENGARRT DPGPRPRPLP RKVSQL
	Isoform 2 [UniParc]. Checksum: 544451D8A8B23F09	FASTA	1,937	222,218
	10 20 30 40 50 60 MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN PNIKGIFPSS 70 80 90 100 110 120 YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW KQLYVRNEGD LFHRLWHIMN 130 140 150 160 170 180 EILDLRRQVL VGHLTHDRMK DVKRHITARL DWGNEQLGLD LVPRKEYAMV DPEDISITEL 190 200 210 220 230 240 YRLMEHRHRK KDTPVQASSH HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR 250 260 270 280 290 300 LNRNGLPKAP DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP 310 320 330 340 350 360 FGCAVLSIAD LLTGETKDDL ILKVYMCNTE SEWYQIHENI IKKLNARYNL TGSNAGLAVS 370 380 390 400 410 420 LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSNIIMPGEM RNDLYITIER GEFEKGGKSV 430 440 450 460 470 480 ARNVEVTMFI VDSSGQTLKD FISFGSGEPP ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF 490 500 510 520 530 540 RGAHIRFEFR HCSTKEKGEK KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT 550 560 570 580 590 600 RYLKLPFSKG IFLGNNNQAM KATKESFCIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC 610 620 630 640 650 660 LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ DSKFHHFKPV 670 680 690 700 710 720 MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE VLKAQEYIFK YIVQSRRLFS 730 740 750 760 770 780 LATGGQNEEE FRCCIQELLM SVRFFLSQES KGSGALSQSQ AVFLSSFPAV YSELLKLFDV 790 800 810 820 830 840 REVANLVQDT LGSLPTILHV DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI 850 860 870 880 890 900 HLQEQKDLIM CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQPS 910 920 930 940 950 960 SSAMRFQFQD VTGEFVACLL SLLRQMTDRH YQQLLDSFNT KEELRDFLLQ IFTVFRILIR 970 980 990 1000 1010 1020 PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD YKIWDSYFYL AVIFINQLCL 1030 1040 1050 1060 1070 1080 QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS MWQNLGEHKL HFIPALIGPF LEVTLIPQPD 1090 1100 1110 1120 1130 1140 LRNVMIPIFH DMMDWEQRRS GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSIIPLFGP 1150 1160 1170 1180 1190 1200 YPSLLKKIER ETWRESGVSL IATVTRLMER LLDYRDCMKM GEVDGKKIGC TVSLLNFYKT 1210 1220 1230 1240 1250 1260 ELNKEEMYIR YIHKLYDLHL KAQNFTEAAY TLLLYDELLE WSDRPLREFL TYPMQTEWQR 1270 1280 1290 1300 1310 1320 KEHLHLTIIQ NFDRGKCWEN GIILCRKIAE QYESYYDYRN LSKMRMMEAS LYDKIMDQQR 1330 1340 1350 1360 1370 1380 LEPEFFRVGF YGKKFPFFLR NKEFVCRGHD YERLEAFQQR MLNEFPHAIA MQHANQPDET 1390 1400 1410 1420 1430 1440 IFQAEAQYLQ IYAVTPIPES QEVLQREGVP DNIKSFYKVN HIWKFRYDRP FHKGTKDKEN 1450 1460 1470 1480 1490 1500 EFKSLWVERT SLYLVQSLPG ISRWFEVEKR EVVEMSPLEN AIEVLENKNQ QLKTLISQCQ 1510 1520 1530 1540 1550 1560 TRQMQNINPL TMCLNGVIDA AVNGGVSRYQ EAFFVKEYIL SHPEDGEKIA RLRELMLEQA 1570 1580 1590 1600 1610 1620 QILEFGLAVH EKFVPQDMRP LHKKLVDQFF VMKSSLGIQE FSACMQASPV HFPNGSPRVC 1630 1640 1650 1660 1670 1680 RNSAPASVSP DGTRVIPRRS PLSYPAVNRY SSSSLSSQAS AEVSNITGQS ESSDEVFNMQ 1690 1700 1710 1720 1730 1740 PSPSTSSLSS THSASPNVTS SAPSSARASP LLSDKHKHSR ENSCLSPRER PCSAIYPTPV 1750 1760 1770 1780 1790 1800 EPSQRMLFNH IGDGALPRSD PNLSAPEKAS PARHTTSVSP SPAGRSPLKG SVQSFTPSPV 1810 1820 1830 1840 1850 1860 EYHSPGLISN SPVLSGSYSS GISSLSRCST SETSGFENQV NEQSAPLPVP VPVPVPSYGG 1870 1880 1890 1900 1910 1920 EEPVRKESKT PPPYSVYERT LRRPVPLPHS LSIPVTSEPP ALPPKPLAAR SSHLENGARR 1930 TDPGPRPRPL PRKVSQL
	Isoform 3 [UniParc]. Checksum: 535C971462E903DB	FASTA	1,975	226,178
	10 20 30 40 50 60 MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN PNIKGIFPSS 70 80 90 100 110 120 YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW KQLYVRNEGD LFHRLWHIMN 130 140 150 160 170 180 EILDLRRQVL VGHLTHDRMK DVKRHITARL DWGNEQLGLD LVPRKEYAMV DPEDISITEL 190 200 210 220 230 240 YRLMEHRHRK KDTPVQASSH HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR 250 260 270 280 290 300 LNRNGLPKAP DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP 310 320 330 340 350 360 FGCAVLSIAD LLTGETKDDL ILKVYMCNTE SEWYQIHENI IKKLNARYNL TGSNAGLAVS 370 380 390 400 410 420 LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSNIIMPGEM RNDLYITIER GEFEKGGKSV 430 440 450 460 470 480 ARNVEVTMFI VDSSGQTLKD FISFGSGEPP ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF 490 500 510 520 530 540 RGAHIRFEFR HCSTKEKGEK KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT 550 560 570 580 590 600 RYLKLPFSKG IFLGNNNQAM KATKESFCIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC 610 620 630 640 650 660 LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ DSKFHHFKPV 670 680 690 700 710 720 MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE VLKAQEYIFK YIVQSRRLFS 730 740 750 760 770 780 LATGGQNEEE FRCCIQELLM SVRFFLSQES KGSGALSQSQ AVFLSSFPAV YSELLKLFDV 790 800 810 820 830 840 REVANLVQDT LGSLPTILHV DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI 850 860 870 880 890 900 HLQEQKDLIM CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQPS 910 920 930 940 950 960 SSAMRFQFQD VTGEFVACLL SLLRQMTDRH YQQLLDSFNT KEELRDFLLQ IFTVFRILIR 970 980 990 1000 1010 1020 PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD YKIWDSYFYL AVIFINQLCL 1030 1040 1050 1060 1070 1080 QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS MWQNLGEHKL HFIPALIGPF LEVTLIPQPD 1090 1100 1110 1120 1130 1140 LRNVMIPIFH DMMDWEQRRS GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSIIPLFGP 1150 1160 1170 1180 1190 1200 YPSLLKKIER ETWRESGVSL IATVTRLMER LLDYRDCMKM GEVDGKKIGC TVSLLNFYKT 1210 1220 1230 1240 1250 1260 ELNKEEMYIR YIHKLYDLHL KAQNFTEAAY TLLLYDELLE WSDRPLREFL TYPMQTEWQR 1270 1280 1290 1300 1310 1320 KEHLHLTIIQ NFDRGKCWEN GIILCRKIAE QYESYYDYRN LSKMRMMEAS LYDKIMDQQR 1330 1340 1350 1360 1370 1380 LEPEFFRVGF YGKKFPFFLR NKEFVCRGHD YERLEAFQQR MLNEFPHAIA MQHANQPDET 1390 1400 1410 1420 1430 1440 IFQAEAQYLQ IYAVTPIPES QEVLQREGVP DNIKSFYKVN HIWKFRYDRP FHKGTKDKEN 1450 1460 1470 1480 1490 1500 EFKSLWVERT SLYLVQSLPG ISRWFEVEKR EVVEMSPLEN AIEVLENKNQ QLKTLISQCQ 1510 1520 1530 1540 1550 1560 TRQMQNINPL TMCLNGVIDA AVNGGVSRYQ EAFFVKEYIL SHPEDGEKIA RLRELMLEQA 1570 1580 1590 1600 1610 1620 QILEFGLAVH EKFVPQDMRP LHKKLVDQFF VMKSSLGIQE FSACMQASPV HFPNGSPRVC 1630 1640 1650 1660 1670 1680 RNSAPASVSP DGTRVIPRRS PLSYPAVNRY SSSSLSSQAS AEVSNITGQS ESSDEVFNMQ 1690 1700 1710 1720 1730 1740 PSPSTSSLSS THSASPNVTS SAPSSARASP LLSDKHKHSR ENSCLSPRER PCSAIYPTPV 1750 1760 1770 1780 1790 1800 EPSQRMLFNH IGDGALPRSD PNLSAPEKAV NPTPSSWSLD SGKEAKNMSD SGKLISPPVP 1810 1820 1830 1840 1850 1860 PRPTQTASPA RHTTSVSPSP AGRSPLKGSV QSFTPSPVEY HSPGLISNSP VLSGSYSSGI 1870 1880 1890 1900 1910 1920 SSLSRCSTSE TSGFENQVNE QSAPLPVPVP VPVPSYGGEE PVRKESKTPP PYSVYERTLR 1930 1940 1950 1960 1970 RPVPLPHSLS IPVTSEPPAL PPKPLAARSS HLENGARRTD PGPRPRPLPR KVSQL
	Isoform 4 [UniParc]. Checksum: 52A4E7E9F1738323	FASTA	279	29,833
	10 20 30 40 50 60 MLMILSLLLF PASPLLSDKH KHSRENSCLS PRERPCSAIY PTPVEPSQRM LFNHIGDGAL 70 80 90 100 110 120 PRSDPNLSAP EKAVNPTPSS WSLDSGKEAK NMSDSGKLIS PPVPPRPTQT ASPARHTTSV 130 140 150 160 170 180 SPSPAGRSPL KGSVQSFTPS PVEYHSPGLI SNSPVLSGSY SSGISSLSRC STSETSGFEN 190 200 210 220 230 240 QVNEQSAPLP VPVPVPVPSY GGEEPVRKES KTPPPYSVYE RTLRRPVPLP HSLSIPVTSE 250 260 270 PPALPPKPLA ARSSHLENGA RRTDPGPRPR PLPRKVSQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DOCK4, a GTPase activator, is disrupted during tumorigenesis." Yajnik V., Paulding C., Sordella R., McClatchey A.I., Saito M., Wahrer D.C.R., Reynolds P., Bell D.W., Lake R., van den Heuvel S., Settleman J., Haber D.A. Cell 112:673-684(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CRK, RAP1 ACTIVATION, VARIANTS ILE-87; GLN-606; THR-1059; LEU-1718; ALA-1733; PRO-1755; MET-1884; ILE-1914; LEU-1917 AND LEU-1926.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 645-1426 (ISOFORM 3). Tissue: Fetal brain and Kidney.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 550-1966 (ISOFORM 2). Tissue: Brain.
[5]	Ohara O., Nagase T., Kikuno R., Ishikawa K., Suyama M. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[6]	"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity." Cote J.-F., Vuori K. J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1614 AND SER-1618, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening." Voss M., Lettau M., Janssen O. BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FASLG.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1614; SER-1618 AND SER-1620, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism." Hiramoto-Yamaki N., Takeuchi S., Ueda S., Harada K., Fujimoto S., Negishi M., Katoh H. J. Cell Biol. 190:461-477(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH ELMO2 AND EPHA2, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY233380 mRNA. Translation: AAO73565.1. AK091557 mRNA. Translation: BAC03696.1. Different initiation. AK098050 mRNA. Translation: BAC05221.1. AC003077 Genomic DNA. Translation: AAB83946.1. AC003080 Genomic DNA. No translation available. AC004111 Genomic DNA. No translation available. AC005047 Genomic DNA. No translation available. AB018259 mRNA. Translation: BAA34436.3.
IPI	IPI00006024. IPI00166163. IPI00297415. IPI00334728.
PIR	T01438.
RefSeq	NP_055520.3. NM_014705.3.
UniGene	Hs.654652.
3D structure databases
ProteinModelPortal	Q8N1I0.
SMR	Q8N1I0. Positions 2-164, 401-576, 1178-1584.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N1I0. 2 interactions.
MINT	MINT-1632264.
STRING	9606.ENSP00000404179.
PTM databases
PhosphoSite	Q8N1I0.
Polymorphism databases
DMDM	296439369.
Proteomic databases
PaxDb	Q8N1I0.
PRIDE	Q8N1I0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000428084; ENSP00000410746; ENSG00000128512. ENST00000437633; ENSP00000404179; ENSG00000128512.
GeneID	9732.
KEGG	hsa:9732.
UCSC	uc003vfv.3. human. uc003vfw.3. human. uc003vfx.3. human.
Organism-specific databases
CTD	9732.
GeneCards	GC07M111366.
H-InvDB	HIX0007003.
HGNC	HGNC:19192. DOCK4.
MIM	607679. gene.
neXtProt	NX_Q8N1I0.
PharmGKB	PA134939318.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG289808.
HOGENOM	HOG000006631.
HOVERGEN	HBG051389.
KO	K05727.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q8N1I0.
Bgee	Q8N1I0.
CleanEx	HS_DOCK4.
Genevestigator	Q8N1I0.
GermOnline	ENSG00000128512. Homo sapiens.
Family and domain databases
InterPro	IPR027007. DHR-1_domain. IPR027357. DHR-2. IPR026791. DOCK. IPR026800. DOCK_B. IPR010703. DOCK_C. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
PANTHER	PTHR23317. PTHR23317. 1 hit. PTHR23317:SF28. PTHR23317:SF28. 1 hit.
Pfam	PF06920. Ded_cyto. 1 hit. PF14429. DOCK-C2. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
SMART	SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS51650. DHR_1. 1 hit. PS51651. DHR_2. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DOCK4. human.
GenomeRNAi	9732.
NextBio	36612.
SOURCE	Search...

Entry information

Entry name

DOCK4_HUMAN

Accession

Primary (citable) accession number: Q8N1I0
Secondary accession number(s): O14584, O94824, Q8NB45

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 3, 2003
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 104 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.