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Q8N1I0

- DOCK4_HUMAN

UniProt

Q8N1I0 - DOCK4_HUMAN

Protein

Dedicator of cytokinesis protein 4

Gene

DOCK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.2 Publications

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
    2. PDZ domain binding Source: HGNC
    3. protein binding Source: UniProtKB
    4. Rac GTPase activator activity Source: HGNC
    5. Rac GTPase binding Source: HGNC
    6. receptor tyrosine kinase binding Source: UniProtKB

    GO - Biological processi

    1. cell chemotaxis Source: UniProtKB
    2. positive regulation of Rac GTPase activity Source: GOC
    3. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dedicator of cytokinesis protein 4
    Gene namesi
    Name:DOCK4
    Synonyms:KIAA0716
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:19192. DOCK4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. endomembrane system Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB
    4. stereocilium Source: HGNC
    5. stereocilium bundle Source: HGNC

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA134939318.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19661966Dedicator of cytokinesis protein 4PRO_0000189990Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei167 – 1671PhosphotyrosineBy similarity
    Modified residuei1614 – 16141Phosphoserine2 Publications
    Modified residuei1618 – 16181Phosphoserine2 Publications
    Modified residuei1620 – 16201Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8N1I0.
    PaxDbiQ8N1I0.
    PRIDEiQ8N1I0.

    PTM databases

    PhosphoSiteiQ8N1I0.

    Expressioni

    Tissue specificityi

    Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.1 Publication

    Gene expression databases

    ArrayExpressiQ8N1I0.
    BgeeiQ8N1I0.
    CleanExiHS_DOCK4.
    GenevestigatoriQ8N1I0.

    Interactioni

    Subunit structurei

    Interacts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1. Interacts with FASLG. Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2.3 Publications

    Protein-protein interaction databases

    BioGridi115081. 11 interactions.
    IntActiQ8N1I0. 2 interactions.
    MINTiMINT-1632264.
    STRINGi9606.ENSP00000404179.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N1I0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 6762SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini401 – 574174DHR-1Add
    BLAST
    Domaini1190 – 1596407DHR-2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1788 – 17947SH3-bindingSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1642 – 1863222Ser-richAdd
    BLAST
    Compositional biasi1875 – 196086Pro-richAdd
    BLAST

    Domaini

    The DHR-2 domain probably mediates the GEF activity.By similarity

    Sequence similaritiesi

    Belongs to the DOCK family.Curated
    Contains 1 DHR-1 domain.Curated
    Contains 1 DHR-2 domain.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain, SH3-binding

    Phylogenomic databases

    eggNOGiNOG289808.
    HOGENOMiHOG000006631.
    HOVERGENiHBG051389.
    KOiK17697.
    PhylomeDBiQ8N1I0.
    TreeFamiTF300423.

    Family and domain databases

    InterProiIPR027007. DHR-1_domain.
    IPR027357. DHR-2.
    IPR026791. DOCK.
    IPR010703. DOCK_C.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR23317. PTHR23317. 1 hit.
    PfamiPF06920. Ded_cyto. 1 hit.
    PF14429. DOCK-C2. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS51650. DHR_1. 1 hit.
    PS51651. DHR_2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N1I0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN     50
    PNIKGIFPSS YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW 100
    KQLYVRNEGD LFHRLWHIMN EILDLRRQVL VGHLTHDRMK DVKRHITARL 150
    DWGNEQLGLD LVPRKEYAMV DPEDISITEL YRLMEHRHRK KDTPVQASSH 200
    HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR LNRNGLPKAP 250
    DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP 300
    FGCAVLSIAD LLTGETKDDL ILKVYMCNTE SEWYQIHENI IKKLNARYNL 350
    TGSNAGLAVS LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSNIIMPGEM 400
    RNDLYITIER GEFEKGGKSV ARNVEVTMFI VDSSGQTLKD FISFGSGEPP 450
    ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF RGAHIRFEFR HCSTKEKGEK 500
    KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT RYLKLPFSKG 550
    IFLGNNNQAM KATKESFCIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC 600
    LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ 650
    DSKFHHFKPV MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE 700
    VLKAQEYIFK YIVQSRRLFS LATGGQNEEE FRCCIQELLM SVRFFLSQES 750
    KGSGALSQSQ AVFLSSFPAV YSELLKLFDV REVANLVQDT LGSLPTILHV 800
    DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI HLQEQKDLIM 850
    CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQPS 900
    SSAMRFQFQD VTGEFVACLL SLLRQMTDRH YQQLLDSFNT KEELRDFLLQ 950
    IFTVFRILIR PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD 1000
    YKIWDSYFYL AVIFINQLCL QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS 1050
    MWQNLGEHKL HFIPALIGPF LEVTLIPQPD LRNVMIPIFH DMMDWEQRRS 1100
    GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSILLKKIE RETWRESGVS 1150
    LIATVTRLME RLLDYRDCMK MGEVDGKKIG CTVSLLNFYK TELNKEEMYI 1200
    RYIHKLYDLH LKAQNFTEAA YTLLLYDELL EWSDRPLREF LTYPMQTEWQ 1250
    RKEHLHLTII QNFDRGKCWE NGIILCRKIA EQYESYYDYR NLSKMRMMEA 1300
    SLYDKIMDQQ RLEPEFFRVG FYGKKFPFFL RNKEFVCRGH DYERLEAFQQ 1350
    RMLNEFPHAI AMQHANQPDE TIFQAEAQYL QIYAVTPIPE SQEVLQREGV 1400
    PDNIKSFYKV NHIWKFRYDR PFHKGTKDKE NEFKSLWVER TSLYLVQSLP 1450
    GISRWFEVEK REVVEMSPLE NAIEVLENKN QQLKTLISQC QTRQMQNINP 1500
    LTMCLNGVID AAVNGGVSRY QEAFFVKEYI LSHPEDGEKI ARLRELMLEQ 1550
    AQILEFGLAV HEKFVPQDMR PLHKKLVDQF FVMKSSLGIQ EFSACMQASP 1600
    VHFPNGSPRV CRNSAPASVS PDGTRVIPRR SPLSYPAVNR YSSSSLSSQA 1650
    SAEVSNITGQ SESSDEVFNM QPSPSTSSLS STHSASPNVT SSAPSSARAS 1700
    PLLSDKHKHS RENSCLSPRE RPCSAIYPTP VEPSQRMLFN HIGDGALPRS 1750
    DPNLSAPEKA VNPTPSSWSL DSGKEAKNMS DSGKLISPPV PPRPTQTASP 1800
    ARHTTSVSPS PAGRSPLKGS VQSFTPSPVE YHSPGLISNS PVLSGSYSSG 1850
    ISSLSRCSTS ETSGFENQVN EQSAPLPVPV PVPVPSYGGE EPVRKESKTP 1900
    PPYSVYERTL RRPVPLPHSL SIPVTSEPPA LPPKPLAARS SHLENGARRT 1950
    DPGPRPRPLP RKVSQL 1966
    Length:1,966
    Mass (Da):225,206
    Last modified:May 18, 2010 - v3
    Checksum:i9CFB6299F7730AA9
    GO
    Isoform 2 (identifier: Q8N1I0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1134-1134: I → IIPLFGPYPS
         1760-1797: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,937
    Mass (Da):222,218
    Checksum:i544451D8A8B23F09
    GO
    Isoform 3 (identifier: Q8N1I0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1134-1134: I → IIPLFGPYPS

    Note: No experimental confirmation available.

    Show »
    Length:1,975
    Mass (Da):226,178
    Checksum:i535C971462E903DB
    GO
    Isoform 4 (identifier: Q8N1I0-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1687: Missing.
         1688-1698: NVTSSAPSSAR → MLMILSLLLFP

    Note: No experimental confirmation available.

    Show »
    Length:279
    Mass (Da):29,833
    Checksum:i52A4E7E9F1738323
    GO

    Sequence cautioni

    The sequence BAC03696.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti945 – 9451R → K in AAB83946. (PubMed:12853948)Curated
    Sequence conflicti1080 – 10801D → G in AAO73565. (PubMed:12628187)Curated
    Sequence conflicti1122 – 11221K → E in BAC03696. (PubMed:14702039)Curated
    Sequence conflicti1379 – 13813YLQ → CIRTYKGWTQFGTAVITDVG RLGTQIITQIN in BAC05221. (PubMed:12853948)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti87 – 871T → I in a CNS cancer cell line. 1 Publication
    VAR_015823
    Natural varianti535 – 5351N → D.
    Corresponds to variant rs12705801 [ dbSNP | Ensembl ].
    VAR_057517
    Natural varianti606 – 6061E → Q.1 Publication
    VAR_015824
    Natural varianti853 – 8531R → H.
    Corresponds to variant rs2074130 [ dbSNP | Ensembl ].
    VAR_057518
    Natural varianti1059 – 10591K → T in a CNS cancer cell line. 1 Publication
    VAR_015825
    Natural varianti1570 – 15701R → K.
    Corresponds to variant rs3757650 [ dbSNP | Ensembl ].
    VAR_057519
    Natural varianti1580 – 15801F → L.
    Corresponds to variant rs3757651 [ dbSNP | Ensembl ].
    VAR_057520
    Natural varianti1718 – 17181P → L in prostate and ovarian cancer cell lines; abolishes ability to interact with CRK and to activate Rap1. 1 Publication
    VAR_015826
    Natural varianti1733 – 17331P → A.1 Publication
    Corresponds to variant rs150569245 [ dbSNP | Ensembl ].
    VAR_015827
    Natural varianti1755 – 17551S → P in colorectal cancer cell line. 1 Publication
    VAR_015828
    Natural varianti1822 – 18221Q → K.
    Corresponds to variant rs10281942 [ dbSNP | Ensembl ].
    VAR_057521
    Natural varianti1884 – 18841V → M in a prostate cancer cell line. 1 Publication
    VAR_015829
    Natural varianti1914 – 19141V → I.1 Publication
    Corresponds to variant rs12705795 [ dbSNP | Ensembl ].
    VAR_015830
    Natural varianti1917 – 19171P → L.1 Publication
    Corresponds to variant rs199706346 [ dbSNP | Ensembl ].
    VAR_015831
    Natural varianti1926 – 19261S → L.1 Publication
    Corresponds to variant rs34597439 [ dbSNP | Ensembl ].
    VAR_015832

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 16871687Missing in isoform 4. 1 PublicationVSP_007701Add
    BLAST
    Alternative sequencei1134 – 11341I → IIPLFGPYPS in isoform 2 and isoform 3. 2 PublicationsVSP_007703
    Alternative sequencei1688 – 169811NVTSSAPSSAR → MLMILSLLLFP in isoform 4. 1 PublicationVSP_007705Add
    BLAST
    Alternative sequencei1760 – 179738Missing in isoform 2. 1 PublicationVSP_007706Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY233380 mRNA. Translation: AAO73565.1.
    AK091557 mRNA. Translation: BAC03696.1. Different initiation.
    AK098050 mRNA. Translation: BAC05221.1.
    AC003077 Genomic DNA. Translation: AAB83946.1.
    AC003080 Genomic DNA. No translation available.
    AC004111 Genomic DNA. No translation available.
    AC005047 Genomic DNA. No translation available.
    AB018259 mRNA. Translation: BAA34436.3.
    CCDSiCCDS47688.1. [Q8N1I0-1]
    PIRiT01438.
    RefSeqiNP_055520.3. NM_014705.3. [Q8N1I0-1]
    XP_006716251.1. XM_006716188.1. [Q8N1I0-3]
    XP_006716252.1. XM_006716189.1. [Q8N1I0-2]
    UniGeneiHs.654652.

    Genome annotation databases

    EnsembliENST00000428084; ENSP00000410746; ENSG00000128512. [Q8N1I0-3]
    ENST00000437633; ENSP00000404179; ENSG00000128512. [Q8N1I0-1]
    GeneIDi9732.
    KEGGihsa:9732.
    UCSCiuc003vfv.3. human. [Q8N1I0-4]
    uc003vfx.3. human. [Q8N1I0-1]

    Polymorphism databases

    DMDMi296439369.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY233380 mRNA. Translation: AAO73565.1 .
    AK091557 mRNA. Translation: BAC03696.1 . Different initiation.
    AK098050 mRNA. Translation: BAC05221.1 .
    AC003077 Genomic DNA. Translation: AAB83946.1 .
    AC003080 Genomic DNA. No translation available.
    AC004111 Genomic DNA. No translation available.
    AC005047 Genomic DNA. No translation available.
    AB018259 mRNA. Translation: BAA34436.3 .
    CCDSi CCDS47688.1. [Q8N1I0-1 ]
    PIRi T01438.
    RefSeqi NP_055520.3. NM_014705.3. [Q8N1I0-1 ]
    XP_006716251.1. XM_006716188.1. [Q8N1I0-3 ]
    XP_006716252.1. XM_006716189.1. [Q8N1I0-2 ]
    UniGenei Hs.654652.

    3D structure databases

    ProteinModelPortali Q8N1I0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115081. 11 interactions.
    IntActi Q8N1I0. 2 interactions.
    MINTi MINT-1632264.
    STRINGi 9606.ENSP00000404179.

    PTM databases

    PhosphoSitei Q8N1I0.

    Polymorphism databases

    DMDMi 296439369.

    Proteomic databases

    MaxQBi Q8N1I0.
    PaxDbi Q8N1I0.
    PRIDEi Q8N1I0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000428084 ; ENSP00000410746 ; ENSG00000128512 . [Q8N1I0-3 ]
    ENST00000437633 ; ENSP00000404179 ; ENSG00000128512 . [Q8N1I0-1 ]
    GeneIDi 9732.
    KEGGi hsa:9732.
    UCSCi uc003vfv.3. human. [Q8N1I0-4 ]
    uc003vfx.3. human. [Q8N1I0-1 ]

    Organism-specific databases

    CTDi 9732.
    GeneCardsi GC07M111366.
    H-InvDB HIX0007003.
    HGNCi HGNC:19192. DOCK4.
    MIMi 607679. gene.
    neXtProti NX_Q8N1I0.
    PharmGKBi PA134939318.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289808.
    HOGENOMi HOG000006631.
    HOVERGENi HBG051389.
    KOi K17697.
    PhylomeDBi Q8N1I0.
    TreeFami TF300423.

    Enzyme and pathway databases

    Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    ChiTaRSi DOCK4. human.
    GeneWikii Dock4.
    GenomeRNAii 9732.
    NextBioi 36612.
    PROi Q8N1I0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N1I0.
    Bgeei Q8N1I0.
    CleanExi HS_DOCK4.
    Genevestigatori Q8N1I0.

    Family and domain databases

    InterProi IPR027007. DHR-1_domain.
    IPR027357. DHR-2.
    IPR026791. DOCK.
    IPR010703. DOCK_C.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR23317. PTHR23317. 1 hit.
    Pfami PF06920. Ded_cyto. 1 hit.
    PF14429. DOCK-C2. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS51650. DHR_1. 1 hit.
    PS51651. DHR_2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CRK, RAP1 ACTIVATION, VARIANTS ILE-87; GLN-606; THR-1059; LEU-1718; ALA-1733; PRO-1755; MET-1884; ILE-1914; LEU-1917 AND LEU-1926.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 645-1426 (ISOFORM 3).
      Tissue: Fetal brain and Kidney.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 550-1966 (ISOFORM 2).
      Tissue: Brain.
    5. Ohara O., Nagase T., Kikuno R., Ishikawa K., Suyama M.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    6. "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."
      Cote J.-F., Vuori K.
      J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1614 AND SER-1618, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
      Voss M., Lettau M., Janssen O.
      BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FASLG.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1614; SER-1618 AND SER-1620, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism."
      Hiramoto-Yamaki N., Takeuchi S., Ueda S., Harada K., Fujimoto S., Negishi M., Katoh H.
      J. Cell Biol. 190:461-477(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ELMO2 AND EPHA2, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiDOCK4_HUMAN
    AccessioniPrimary (citable) accession number: Q8N1I0
    Secondary accession number(s): O14584, O94824, Q8NB45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 3, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 117 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Injection of wild-type protein suppresses tumor invasion in osteosarcoma mouse cell lines while it is not the case with the Leu-1718 variant.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3