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Q8N1I0 (DOCK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dedicator of cytokinesis protein 4
Gene names
Name:DOCK4
Synonyms:KIAA0716
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1966 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. Ref.1 Ref.10

Subunit structure

Interacts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1. Interacts with FASLG. Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2. Ref.1 Ref.8 Ref.10

Subcellular location

Endomembrane system; Peripheral membrane protein. Cytoplasmcytosol Ref.1 Ref.10.

Tissue specificity

Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary. Ref.1

Domain

The DHR-2 domain probably mediates the GEF activity By similarity.

Miscellaneous

Injection of wild-type protein suppresses tumor invasion in osteosarcoma mouse cell lines while it is not the case with the Leu-1718 variant.

Sequence similarities

Belongs to the DOCK family.

Contains 1 DHR-1 domain.

Contains 1 DHR-2 domain.

Contains 1 SH3 domain.

Sequence caution

The sequence BAC03696.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseProto-oncogene
   DomainSH3 domain
SH3-binding
   Molecular functionGuanine-nucleotide releasing factor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from mutant phenotype Ref.10. Source: UniProtKB

positive regulation of Rac GTPase activity

Inferred from direct assay PubMed 16464467. Source: GOC

small GTPase mediated signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytosol

Inferred from direct assay Ref.10. Source: UniProtKB

endomembrane system

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from direct assay Ref.10. Source: UniProtKB

stereocilium

Inferred from sequence or structural similarity PubMed 16464467. Source: HGNC

stereocilium bundle

Inferred from sequence or structural similarity PubMed 16464467. Source: HGNC

   Molecular_functionPDZ domain binding

Inferred from physical interaction PubMed 16464467. Source: HGNC

Rac GTPase activator activity

Inferred from direct assay PubMed 16464467. Source: HGNC

Rac GTPase binding

Inferred from direct assay PubMed 16464467. Source: HGNC

guanyl-nucleotide exchange factor activity

Inferred from electronic annotation. Source: UniProtKB-KW

receptor tyrosine kinase binding

Inferred from physical interaction Ref.10. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N1I0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N1I0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1134-1134: I → IIPLFGPYPS
     1760-1797: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8N1I0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1134-1134: I → IIPLFGPYPS
Note: No experimental confirmation available.
Isoform 4 (identifier: Q8N1I0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1687: Missing.
     1688-1698: NVTSSAPSSAR → MLMILSLLLFP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19661966Dedicator of cytokinesis protein 4
PRO_0000189990

Regions

Domain6 – 6762SH3
Domain401 – 574174DHR-1
Domain1190 – 1596407DHR-2
Motif1788 – 17947SH3-binding Potential
Compositional bias1642 – 1863222Ser-rich
Compositional bias1875 – 196086Pro-rich

Amino acid modifications

Modified residue1671Phosphotyrosine By similarity
Modified residue16141Phosphoserine Ref.7 Ref.9
Modified residue16181Phosphoserine Ref.7 Ref.9
Modified residue16201Phosphoserine Ref.9

Natural variations

Alternative sequence1 – 16871687Missing in isoform 4.
VSP_007701
Alternative sequence11341I → IIPLFGPYPS in isoform 2 and isoform 3.
VSP_007703
Alternative sequence1688 – 169811NVTSSAPSSAR → MLMILSLLLFP in isoform 4.
VSP_007705
Alternative sequence1760 – 179738Missing in isoform 2.
VSP_007706
Natural variant871T → I in a CNS cancer cell line. Ref.1
VAR_015823
Natural variant5351N → D.
Corresponds to variant rs12705801 [ dbSNP | Ensembl ].
VAR_057517
Natural variant6061E → Q. Ref.1
VAR_015824
Natural variant8531R → H.
Corresponds to variant rs2074130 [ dbSNP | Ensembl ].
VAR_057518
Natural variant10591K → T in a CNS cancer cell line. Ref.1
VAR_015825
Natural variant15701R → K.
Corresponds to variant rs3757650 [ dbSNP | Ensembl ].
VAR_057519
Natural variant15801F → L.
Corresponds to variant rs3757651 [ dbSNP | Ensembl ].
VAR_057520
Natural variant17181P → L in prostate and ovarian cancer cell lines; abolishes ability to interact with CRK and to activate Rap1. Ref.1
VAR_015826
Natural variant17331P → A. Ref.1
Corresponds to variant rs150569245 [ dbSNP | Ensembl ].
VAR_015827
Natural variant17551S → P in colorectal cancer cell line. Ref.1
VAR_015828
Natural variant18221Q → K.
Corresponds to variant rs10281942 [ dbSNP | Ensembl ].
VAR_057521
Natural variant18841V → M in a prostate cancer cell line. Ref.1
VAR_015829
Natural variant19141V → I. Ref.1
Corresponds to variant rs12705795 [ dbSNP | Ensembl ].
VAR_015830
Natural variant19171P → L. Ref.1
Corresponds to variant rs199706346 [ dbSNP | Ensembl ].
VAR_015831
Natural variant19261S → L. Ref.1
Corresponds to variant rs34597439 [ dbSNP | Ensembl ].
VAR_015832

Experimental info

Sequence conflict9451R → K in AAB83946. Ref.3
Sequence conflict10801D → G in AAO73565. Ref.1
Sequence conflict11221K → E in BAC03696. Ref.2
Sequence conflict1379 – 13813YLQ → CIRTYKGWTQFGTAVITDVG RLGTQIITQIN in BAC05221. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 9CFB6299F7730AA9

FASTA1,966225,206
        10         20         30         40         50         60 
MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN PNIKGIFPSS 

        70         80         90        100        110        120 
YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW KQLYVRNEGD LFHRLWHIMN 

       130        140        150        160        170        180 
EILDLRRQVL VGHLTHDRMK DVKRHITARL DWGNEQLGLD LVPRKEYAMV DPEDISITEL 

       190        200        210        220        230        240 
YRLMEHRHRK KDTPVQASSH HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR 

       250        260        270        280        290        300 
LNRNGLPKAP DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP 

       310        320        330        340        350        360 
FGCAVLSIAD LLTGETKDDL ILKVYMCNTE SEWYQIHENI IKKLNARYNL TGSNAGLAVS 

       370        380        390        400        410        420 
LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSNIIMPGEM RNDLYITIER GEFEKGGKSV 

       430        440        450        460        470        480 
ARNVEVTMFI VDSSGQTLKD FISFGSGEPP ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF 

       490        500        510        520        530        540 
RGAHIRFEFR HCSTKEKGEK KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT 

       550        560        570        580        590        600 
RYLKLPFSKG IFLGNNNQAM KATKESFCIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC 

       610        620        630        640        650        660 
LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ DSKFHHFKPV 

       670        680        690        700        710        720 
MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE VLKAQEYIFK YIVQSRRLFS 

       730        740        750        760        770        780 
LATGGQNEEE FRCCIQELLM SVRFFLSQES KGSGALSQSQ AVFLSSFPAV YSELLKLFDV 

       790        800        810        820        830        840 
REVANLVQDT LGSLPTILHV DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI 

       850        860        870        880        890        900 
HLQEQKDLIM CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQPS 

       910        920        930        940        950        960 
SSAMRFQFQD VTGEFVACLL SLLRQMTDRH YQQLLDSFNT KEELRDFLLQ IFTVFRILIR 

       970        980        990       1000       1010       1020 
PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD YKIWDSYFYL AVIFINQLCL 

      1030       1040       1050       1060       1070       1080 
QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS MWQNLGEHKL HFIPALIGPF LEVTLIPQPD 

      1090       1100       1110       1120       1130       1140 
LRNVMIPIFH DMMDWEQRRS GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSILLKKIE 

      1150       1160       1170       1180       1190       1200 
RETWRESGVS LIATVTRLME RLLDYRDCMK MGEVDGKKIG CTVSLLNFYK TELNKEEMYI 

      1210       1220       1230       1240       1250       1260 
RYIHKLYDLH LKAQNFTEAA YTLLLYDELL EWSDRPLREF LTYPMQTEWQ RKEHLHLTII 

      1270       1280       1290       1300       1310       1320 
QNFDRGKCWE NGIILCRKIA EQYESYYDYR NLSKMRMMEA SLYDKIMDQQ RLEPEFFRVG 

      1330       1340       1350       1360       1370       1380 
FYGKKFPFFL RNKEFVCRGH DYERLEAFQQ RMLNEFPHAI AMQHANQPDE TIFQAEAQYL 

      1390       1400       1410       1420       1430       1440 
QIYAVTPIPE SQEVLQREGV PDNIKSFYKV NHIWKFRYDR PFHKGTKDKE NEFKSLWVER 

      1450       1460       1470       1480       1490       1500 
TSLYLVQSLP GISRWFEVEK REVVEMSPLE NAIEVLENKN QQLKTLISQC QTRQMQNINP 

      1510       1520       1530       1540       1550       1560 
LTMCLNGVID AAVNGGVSRY QEAFFVKEYI LSHPEDGEKI ARLRELMLEQ AQILEFGLAV 

      1570       1580       1590       1600       1610       1620 
HEKFVPQDMR PLHKKLVDQF FVMKSSLGIQ EFSACMQASP VHFPNGSPRV CRNSAPASVS 

      1630       1640       1650       1660       1670       1680 
PDGTRVIPRR SPLSYPAVNR YSSSSLSSQA SAEVSNITGQ SESSDEVFNM QPSPSTSSLS 

      1690       1700       1710       1720       1730       1740 
STHSASPNVT SSAPSSARAS PLLSDKHKHS RENSCLSPRE RPCSAIYPTP VEPSQRMLFN 

      1750       1760       1770       1780       1790       1800 
HIGDGALPRS DPNLSAPEKA VNPTPSSWSL DSGKEAKNMS DSGKLISPPV PPRPTQTASP 

      1810       1820       1830       1840       1850       1860 
ARHTTSVSPS PAGRSPLKGS VQSFTPSPVE YHSPGLISNS PVLSGSYSSG ISSLSRCSTS 

      1870       1880       1890       1900       1910       1920 
ETSGFENQVN EQSAPLPVPV PVPVPSYGGE EPVRKESKTP PPYSVYERTL RRPVPLPHSL 

      1930       1940       1950       1960 
SIPVTSEPPA LPPKPLAARS SHLENGARRT DPGPRPRPLP RKVSQL 

« Hide

Isoform 2 [UniParc].

Checksum: 544451D8A8B23F09
Show »

FASTA1,937222,218
Isoform 3 [UniParc].

Checksum: 535C971462E903DB
Show »

FASTA1,975226,178
Isoform 4 [UniParc].

Checksum: 52A4E7E9F1738323
Show »

FASTA27929,833

References

« Hide 'large scale' references
[1]"DOCK4, a GTPase activator, is disrupted during tumorigenesis."
Yajnik V., Paulding C., Sordella R., McClatchey A.I., Saito M., Wahrer D.C.R., Reynolds P., Bell D.W., Lake R., van den Heuvel S., Settleman J., Haber D.A.
Cell 112:673-684(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CRK, RAP1 ACTIVATION, VARIANTS ILE-87; GLN-606; THR-1059; LEU-1718; ALA-1733; PRO-1755; MET-1884; ILE-1914; LEU-1917 AND LEU-1926.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 645-1426 (ISOFORM 3).
Tissue: Fetal brain and Kidney.
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 550-1966 (ISOFORM 2).
Tissue: Brain.
[5]Ohara O., Nagase T., Kikuno R., Ishikawa K., Suyama M.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[6]"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."
Cote J.-F., Vuori K.
J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1614 AND SER-1618, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
Voss M., Lettau M., Janssen O.
BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FASLG.
[9]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1614; SER-1618 AND SER-1620, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[10]"Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism."
Hiramoto-Yamaki N., Takeuchi S., Ueda S., Harada K., Fujimoto S., Negishi M., Katoh H.
J. Cell Biol. 190:461-477(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ELMO2 AND EPHA2, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY233380 mRNA. Translation: AAO73565.1.
AK091557 mRNA. Translation: BAC03696.1. Different initiation.
AK098050 mRNA. Translation: BAC05221.1.
AC003077 Genomic DNA. Translation: AAB83946.1.
AC003080 Genomic DNA. No translation available.
AC004111 Genomic DNA. No translation available.
AC005047 Genomic DNA. No translation available.
AB018259 mRNA. Translation: BAA34436.3.
PIRT01438.
RefSeqNP_055520.3. NM_014705.3.
UniGeneHs.654652.

3D structure databases

ProteinModelPortalQ8N1I0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115081. 11 interactions.
IntActQ8N1I0. 2 interactions.
MINTMINT-1632264.
STRING9606.ENSP00000404179.

PTM databases

PhosphoSiteQ8N1I0.

Polymorphism databases

DMDM296439369.

Proteomic databases

PaxDbQ8N1I0.
PRIDEQ8N1I0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000428084; ENSP00000410746; ENSG00000128512. [Q8N1I0-3]
ENST00000437633; ENSP00000404179; ENSG00000128512. [Q8N1I0-1]
GeneID9732.
KEGGhsa:9732.
UCSCuc003vfv.3. human. [Q8N1I0-4]
uc003vfx.3. human. [Q8N1I0-1]

Organism-specific databases

CTD9732.
GeneCardsGC07M111366.
H-InvDBHIX0007003.
HGNCHGNC:19192. DOCK4.
MIM607679. gene.
neXtProtNX_Q8N1I0.
PharmGKBPA134939318.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG289808.
HOGENOMHOG000006631.
HOVERGENHBG051389.
KOK17697.
PhylomeDBQ8N1I0.
TreeFamTF300423.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.

Gene expression databases

ArrayExpressQ8N1I0.
BgeeQ8N1I0.
CleanExHS_DOCK4.
GenevestigatorQ8N1I0.

Family and domain databases

InterProIPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR026800. DOCK_B.
IPR010703. DOCK_C.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERPTHR23317. PTHR23317. 1 hit.
PTHR23317:SF28. PTHR23317:SF28. 1 hit.
PfamPF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDOCK4. human.
GeneWikiDock4.
GenomeRNAi9732.
NextBio36612.
PROQ8N1I0.
SOURCESearch...

Entry information

Entry nameDOCK4_HUMAN
AccessionPrimary (citable) accession number: Q8N1I0
Secondary accession number(s): O14584, O94824, Q8NB45
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM