SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8N1I0

- DOCK4_HUMAN

UniProt

Q8N1I0 - DOCK4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Dedicator of cytokinesis protein 4
Gene
DOCK4, KIAA0716
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.2 Publications

GO - Molecular functioni

  1. PDZ domain binding Source: HGNC
  2. Rac GTPase activator activity Source: HGNC
  3. Rac GTPase binding Source: HGNC
  4. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
  5. protein binding Source: UniProtKB
  6. receptor tyrosine kinase binding Source: UniProtKB

GO - Biological processi

  1. cell chemotaxis Source: UniProtKB
  2. positive regulation of Rac GTPase activity Source: GOC
  3. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 4
Gene namesi
Name:DOCK4
Synonyms:KIAA0716
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:19192. DOCK4.

Subcellular locationi

Endomembrane system; Peripheral membrane protein. Cytoplasmcytosol 2 Publications

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. endomembrane system Source: UniProtKB-SubCell
  3. membrane Source: UniProtKB
  4. stereocilium Source: HGNC
  5. stereocilium bundle Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA134939318.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19661966Dedicator of cytokinesis protein 4
PRO_0000189990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei167 – 1671Phosphotyrosine By similarity
Modified residuei1614 – 16141Phosphoserine2 Publications
Modified residuei1618 – 16181Phosphoserine2 Publications
Modified residuei1620 – 16201Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N1I0.
PaxDbiQ8N1I0.
PRIDEiQ8N1I0.

PTM databases

PhosphoSiteiQ8N1I0.

Expressioni

Tissue specificityi

Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.1 Publication

Gene expression databases

ArrayExpressiQ8N1I0.
BgeeiQ8N1I0.
CleanExiHS_DOCK4.
GenevestigatoriQ8N1I0.

Interactioni

Subunit structurei

Interacts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1. Interacts with FASLG. Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2.3 Publications

Protein-protein interaction databases

BioGridi115081. 11 interactions.
IntActiQ8N1I0. 2 interactions.
MINTiMINT-1632264.
STRINGi9606.ENSP00000404179.

Structurei

3D structure databases

ProteinModelPortaliQ8N1I0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6762SH3
Add
BLAST
Domaini401 – 574174DHR-1
Add
BLAST
Domaini1190 – 1596407DHR-2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1788 – 17947SH3-binding Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1642 – 1863222Ser-rich
Add
BLAST
Compositional biasi1875 – 196086Pro-rich
Add
BLAST

Domaini

The DHR-2 domain probably mediates the GEF activity By similarity.

Sequence similaritiesi

Belongs to the DOCK family.
Contains 1 DHR-1 domain.
Contains 1 DHR-2 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain, SH3-binding

Phylogenomic databases

eggNOGiNOG289808.
HOGENOMiHOG000006631.
HOVERGENiHBG051389.
KOiK17697.
PhylomeDBiQ8N1I0.
TreeFamiTF300423.

Family and domain databases

InterProiIPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PfamiPF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N1I0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN     50
PNIKGIFPSS YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW 100
KQLYVRNEGD LFHRLWHIMN EILDLRRQVL VGHLTHDRMK DVKRHITARL 150
DWGNEQLGLD LVPRKEYAMV DPEDISITEL YRLMEHRHRK KDTPVQASSH 200
HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR LNRNGLPKAP 250
DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP 300
FGCAVLSIAD LLTGETKDDL ILKVYMCNTE SEWYQIHENI IKKLNARYNL 350
TGSNAGLAVS LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSNIIMPGEM 400
RNDLYITIER GEFEKGGKSV ARNVEVTMFI VDSSGQTLKD FISFGSGEPP 450
ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF RGAHIRFEFR HCSTKEKGEK 500
KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT RYLKLPFSKG 550
IFLGNNNQAM KATKESFCIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC 600
LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ 650
DSKFHHFKPV MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE 700
VLKAQEYIFK YIVQSRRLFS LATGGQNEEE FRCCIQELLM SVRFFLSQES 750
KGSGALSQSQ AVFLSSFPAV YSELLKLFDV REVANLVQDT LGSLPTILHV 800
DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI HLQEQKDLIM 850
CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQPS 900
SSAMRFQFQD VTGEFVACLL SLLRQMTDRH YQQLLDSFNT KEELRDFLLQ 950
IFTVFRILIR PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD 1000
YKIWDSYFYL AVIFINQLCL QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS 1050
MWQNLGEHKL HFIPALIGPF LEVTLIPQPD LRNVMIPIFH DMMDWEQRRS 1100
GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSILLKKIE RETWRESGVS 1150
LIATVTRLME RLLDYRDCMK MGEVDGKKIG CTVSLLNFYK TELNKEEMYI 1200
RYIHKLYDLH LKAQNFTEAA YTLLLYDELL EWSDRPLREF LTYPMQTEWQ 1250
RKEHLHLTII QNFDRGKCWE NGIILCRKIA EQYESYYDYR NLSKMRMMEA 1300
SLYDKIMDQQ RLEPEFFRVG FYGKKFPFFL RNKEFVCRGH DYERLEAFQQ 1350
RMLNEFPHAI AMQHANQPDE TIFQAEAQYL QIYAVTPIPE SQEVLQREGV 1400
PDNIKSFYKV NHIWKFRYDR PFHKGTKDKE NEFKSLWVER TSLYLVQSLP 1450
GISRWFEVEK REVVEMSPLE NAIEVLENKN QQLKTLISQC QTRQMQNINP 1500
LTMCLNGVID AAVNGGVSRY QEAFFVKEYI LSHPEDGEKI ARLRELMLEQ 1550
AQILEFGLAV HEKFVPQDMR PLHKKLVDQF FVMKSSLGIQ EFSACMQASP 1600
VHFPNGSPRV CRNSAPASVS PDGTRVIPRR SPLSYPAVNR YSSSSLSSQA 1650
SAEVSNITGQ SESSDEVFNM QPSPSTSSLS STHSASPNVT SSAPSSARAS 1700
PLLSDKHKHS RENSCLSPRE RPCSAIYPTP VEPSQRMLFN HIGDGALPRS 1750
DPNLSAPEKA VNPTPSSWSL DSGKEAKNMS DSGKLISPPV PPRPTQTASP 1800
ARHTTSVSPS PAGRSPLKGS VQSFTPSPVE YHSPGLISNS PVLSGSYSSG 1850
ISSLSRCSTS ETSGFENQVN EQSAPLPVPV PVPVPSYGGE EPVRKESKTP 1900
PPYSVYERTL RRPVPLPHSL SIPVTSEPPA LPPKPLAARS SHLENGARRT 1950
DPGPRPRPLP RKVSQL 1966
Length:1,966
Mass (Da):225,206
Last modified:May 18, 2010 - v3
Checksum:i9CFB6299F7730AA9
GO
Isoform 2 (identifier: Q8N1I0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1134-1134: I → IIPLFGPYPS
     1760-1797: Missing.

Note: No experimental confirmation available.

Show »
Length:1,937
Mass (Da):222,218
Checksum:i544451D8A8B23F09
GO
Isoform 3 (identifier: Q8N1I0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1134-1134: I → IIPLFGPYPS

Note: No experimental confirmation available.

Show »
Length:1,975
Mass (Da):226,178
Checksum:i535C971462E903DB
GO
Isoform 4 (identifier: Q8N1I0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1687: Missing.
     1688-1698: NVTSSAPSSAR → MLMILSLLLFP

Note: No experimental confirmation available.

Show »
Length:279
Mass (Da):29,833
Checksum:i52A4E7E9F1738323
GO

Sequence cautioni

The sequence BAC03696.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871T → I in a CNS cancer cell line. 1 Publication
VAR_015823
Natural varianti535 – 5351N → D.
Corresponds to variant rs12705801 [ dbSNP | Ensembl ].
VAR_057517
Natural varianti606 – 6061E → Q.1 Publication
VAR_015824
Natural varianti853 – 8531R → H.
Corresponds to variant rs2074130 [ dbSNP | Ensembl ].
VAR_057518
Natural varianti1059 – 10591K → T in a CNS cancer cell line. 1 Publication
VAR_015825
Natural varianti1570 – 15701R → K.
Corresponds to variant rs3757650 [ dbSNP | Ensembl ].
VAR_057519
Natural varianti1580 – 15801F → L.
Corresponds to variant rs3757651 [ dbSNP | Ensembl ].
VAR_057520
Natural varianti1718 – 17181P → L in prostate and ovarian cancer cell lines; abolishes ability to interact with CRK and to activate Rap1. 1 Publication
VAR_015826
Natural varianti1733 – 17331P → A.1 Publication
Corresponds to variant rs150569245 [ dbSNP | Ensembl ].
VAR_015827
Natural varianti1755 – 17551S → P in colorectal cancer cell line. 1 Publication
VAR_015828
Natural varianti1822 – 18221Q → K.
Corresponds to variant rs10281942 [ dbSNP | Ensembl ].
VAR_057521
Natural varianti1884 – 18841V → M in a prostate cancer cell line. 1 Publication
VAR_015829
Natural varianti1914 – 19141V → I.1 Publication
Corresponds to variant rs12705795 [ dbSNP | Ensembl ].
VAR_015830
Natural varianti1917 – 19171P → L.1 Publication
Corresponds to variant rs199706346 [ dbSNP | Ensembl ].
VAR_015831
Natural varianti1926 – 19261S → L.1 Publication
Corresponds to variant rs34597439 [ dbSNP | Ensembl ].
VAR_015832

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 16871687Missing in isoform 4.
VSP_007701Add
BLAST
Alternative sequencei1134 – 11341I → IIPLFGPYPS in isoform 2 and isoform 3.
VSP_007703
Alternative sequencei1688 – 169811NVTSSAPSSAR → MLMILSLLLFP in isoform 4.
VSP_007705Add
BLAST
Alternative sequencei1760 – 179738Missing in isoform 2.
VSP_007706Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti945 – 9451R → K in AAB83946. 1 Publication
Sequence conflicti1080 – 10801D → G in AAO73565. 1 Publication
Sequence conflicti1122 – 11221K → E in BAC03696. 1 Publication
Sequence conflicti1379 – 13813YLQ → CIRTYKGWTQFGTAVITDVG RLGTQIITQIN in BAC05221. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY233380 mRNA. Translation: AAO73565.1.
AK091557 mRNA. Translation: BAC03696.1. Different initiation.
AK098050 mRNA. Translation: BAC05221.1.
AC003077 Genomic DNA. Translation: AAB83946.1.
AC003080 Genomic DNA. No translation available.
AC004111 Genomic DNA. No translation available.
AC005047 Genomic DNA. No translation available.
AB018259 mRNA. Translation: BAA34436.3.
CCDSiCCDS47688.1. [Q8N1I0-1]
PIRiT01438.
RefSeqiNP_055520.3. NM_014705.3. [Q8N1I0-1]
XP_006716251.1. XM_006716188.1. [Q8N1I0-3]
XP_006716252.1. XM_006716189.1. [Q8N1I0-2]
UniGeneiHs.654652.

Genome annotation databases

EnsembliENST00000428084; ENSP00000410746; ENSG00000128512. [Q8N1I0-3]
ENST00000437633; ENSP00000404179; ENSG00000128512. [Q8N1I0-1]
GeneIDi9732.
KEGGihsa:9732.
UCSCiuc003vfv.3. human. [Q8N1I0-4]
uc003vfx.3. human. [Q8N1I0-1]

Polymorphism databases

DMDMi296439369.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY233380 mRNA. Translation: AAO73565.1 .
AK091557 mRNA. Translation: BAC03696.1 . Different initiation.
AK098050 mRNA. Translation: BAC05221.1 .
AC003077 Genomic DNA. Translation: AAB83946.1 .
AC003080 Genomic DNA. No translation available.
AC004111 Genomic DNA. No translation available.
AC005047 Genomic DNA. No translation available.
AB018259 mRNA. Translation: BAA34436.3 .
CCDSi CCDS47688.1. [Q8N1I0-1 ]
PIRi T01438.
RefSeqi NP_055520.3. NM_014705.3. [Q8N1I0-1 ]
XP_006716251.1. XM_006716188.1. [Q8N1I0-3 ]
XP_006716252.1. XM_006716189.1. [Q8N1I0-2 ]
UniGenei Hs.654652.

3D structure databases

ProteinModelPortali Q8N1I0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115081. 11 interactions.
IntActi Q8N1I0. 2 interactions.
MINTi MINT-1632264.
STRINGi 9606.ENSP00000404179.

PTM databases

PhosphoSitei Q8N1I0.

Polymorphism databases

DMDMi 296439369.

Proteomic databases

MaxQBi Q8N1I0.
PaxDbi Q8N1I0.
PRIDEi Q8N1I0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000428084 ; ENSP00000410746 ; ENSG00000128512 . [Q8N1I0-3 ]
ENST00000437633 ; ENSP00000404179 ; ENSG00000128512 . [Q8N1I0-1 ]
GeneIDi 9732.
KEGGi hsa:9732.
UCSCi uc003vfv.3. human. [Q8N1I0-4 ]
uc003vfx.3. human. [Q8N1I0-1 ]

Organism-specific databases

CTDi 9732.
GeneCardsi GC07M111366.
H-InvDB HIX0007003.
HGNCi HGNC:19192. DOCK4.
MIMi 607679. gene.
neXtProti NX_Q8N1I0.
PharmGKBi PA134939318.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289808.
HOGENOMi HOG000006631.
HOVERGENi HBG051389.
KOi K17697.
PhylomeDBi Q8N1I0.
TreeFami TF300423.

Enzyme and pathway databases

Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSi DOCK4. human.
GeneWikii Dock4.
GenomeRNAii 9732.
NextBioi 36612.
PROi Q8N1I0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8N1I0.
Bgeei Q8N1I0.
CleanExi HS_DOCK4.
Genevestigatori Q8N1I0.

Family and domain databases

InterProi IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR23317. PTHR23317. 1 hit.
Pfami PF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CRK, RAP1 ACTIVATION, VARIANTS ILE-87; GLN-606; THR-1059; LEU-1718; ALA-1733; PRO-1755; MET-1884; ILE-1914; LEU-1917 AND LEU-1926.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 645-1426 (ISOFORM 3).
    Tissue: Fetal brain and Kidney.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 550-1966 (ISOFORM 2).
    Tissue: Brain.
  5. Ohara O., Nagase T., Kikuno R., Ishikawa K., Suyama M.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  6. "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."
    Cote J.-F., Vuori K.
    J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1614 AND SER-1618, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
    Voss M., Lettau M., Janssen O.
    BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FASLG.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1614; SER-1618 AND SER-1620, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism."
    Hiramoto-Yamaki N., Takeuchi S., Ueda S., Harada K., Fujimoto S., Negishi M., Katoh H.
    J. Cell Biol. 190:461-477(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ELMO2 AND EPHA2, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiDOCK4_HUMAN
AccessioniPrimary (citable) accession number: Q8N1I0
Secondary accession number(s): O14584, O94824, Q8NB45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Injection of wild-type protein suppresses tumor invasion in osteosarcoma mouse cell lines while it is not the case with the Leu-1718 variant.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi