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Protein

Leucine-rich repeat-containing protein 47

Gene

LRRC47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130764-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 47
Gene namesi
Name:LRRC47
Synonyms:KIAA1185
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29207. LRRC47.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130764.
PharmGKBiPA142671507.

Polymorphism and mutation databases

BioMutaiLRRC47.
DMDMi74750895.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002239262 – 583Leucine-rich repeat-containing protein 47Add BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei315PhosphoserineCombined sources1
Modified residuei431PhosphoserineCombined sources1
Modified residuei509PhosphotyrosineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei520PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8N1G4.
MaxQBiQ8N1G4.
PaxDbiQ8N1G4.
PeptideAtlasiQ8N1G4.
PRIDEiQ8N1G4.

PTM databases

iPTMnetiQ8N1G4.
PhosphoSitePlusiQ8N1G4.
SwissPalmiQ8N1G4.

Miscellaneous databases

PMAP-CutDBQ8N1G4.

Expressioni

Gene expression databases

BgeeiENSG00000130764.
CleanExiHS_LRRC47.
ExpressionAtlasiQ8N1G4. baseline and differential.
GenevisibleiQ8N1G4. HS.

Organism-specific databases

HPAiHPA008512.
HPA012018.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
gagP045912EBI-2509921,EBI-6179727From a different organism.

Protein-protein interaction databases

BioGridi121540. 36 interactors.
IntActiQ8N1G4. 12 interactors.
MINTiMINT-3039182.
STRINGi9606.ENSP00000367498.

Structurei

3D structure databases

ProteinModelPortaliQ8N1G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati76 – 95LRR 1Add BLAST20
Repeati100 – 121LRR 2Add BLAST22
Repeati130 – 152LRR 3Add BLAST23
Repeati154 – 175LRR 4Add BLAST22
Repeati180 – 202LRR 5Add BLAST23
Repeati203 – 225LRR 6Add BLAST23
Repeati226 – 246LRR 7Add BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili402 – 437Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 5Poly-Ala4

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2472. Eukaryota.
COG0072. LUCA.
COG4886. LUCA.
GeneTreeiENSGT00530000063489.
HOGENOMiHOG000007166.
HOVERGENiHBG066309.
InParanoidiQ8N1G4.
OMAiVRPYLVC.
OrthoDBiEOG091G07VP.
PhylomeDBiQ8N1G4.
TreeFamiTF315742.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR005146. B3/B4_tRNA-bd.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF03483. B3_4. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00873. B3_4. 1 hit.
SM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N1G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAVSESW PELELAERER RRELLLTGPG LEERVRAAGG QLPPRLFTLP
60 70 80 90 100
LLHYLEVSGC GSLRAPGPGL AQGLPQLHSL VLRRNALGPG LSPELGPLPA
110 120 130 140 150
LRVLDLSGNA LEALPPGQGL GPAEPPGLPQ LQSLNLSGNR LRELPADLAR
160 170 180 190 200
CAPRLQSLNL TGNCLDSFPA ELFRPGALPL LSELAAADNC LRELSPDIAH
210 220 230 240 250
LASLKTLDLS NNQLSEIPAE LADCPKLKEI NFRGNKLRDK RLEKMVSGCQ
260 270 280 290 300
TRSILEYLRV GGRGGGKGKG RAEGSEKEES RRKRRERKQR REGGDGEEQD
310 320 330 340 350
VGDAGRLLLR VLHVSENPVP LTVRVSPEVR DVRPYIVGAV VRGMDLQPGN
360 370 380 390 400
ALKRFLTSQT KLHEDLCEKR TAATLATHEL RAVKGPLLYC ARPPQDLKIV
410 420 430 440 450
PLGRKEAKAK ELVRQLQLEA EEQRKQKKRQ SVSGLHRYLH LLDGNENYPC
460 470 480 490 500
LVDADGDVIS FPPITNSEKT KVKKTTSDLF LEVTSATSLQ ICKDVMDALI
510 520 530 540 550
LKMAEMKKYT LENKEEGSLS DTEADAVSGQ LPDPTTNPSA GKDGPSLLVV
560 570 580
EQVRVVDLEG SLKVVYPSKA DLATAPPHVT VVR
Length:583
Mass (Da):63,473
Last modified:October 1, 2002 - v1
Checksum:iBCCFAE89BCD46031
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035471193E → D in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_051118545P → L.Corresponds to variant rs11547614dbSNPEnsembl.1
Natural variantiVAR_051119581V → I.Corresponds to variant rs11547615dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365330 Genomic DNA. Translation: CAI42528.1.
BC031301 mRNA. Translation: AAH31301.1.
AB033011 mRNA. Translation: BAA86499.1.
CCDSiCCDS51.1.
RefSeqiNP_065761.1. NM_020710.2.
UniGeneiHs.268488.

Genome annotation databases

EnsembliENST00000378251; ENSP00000367498; ENSG00000130764.
GeneIDi57470.
KEGGihsa:57470.
UCSCiuc001akx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365330 Genomic DNA. Translation: CAI42528.1.
BC031301 mRNA. Translation: AAH31301.1.
AB033011 mRNA. Translation: BAA86499.1.
CCDSiCCDS51.1.
RefSeqiNP_065761.1. NM_020710.2.
UniGeneiHs.268488.

3D structure databases

ProteinModelPortaliQ8N1G4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121540. 36 interactors.
IntActiQ8N1G4. 12 interactors.
MINTiMINT-3039182.
STRINGi9606.ENSP00000367498.

PTM databases

iPTMnetiQ8N1G4.
PhosphoSitePlusiQ8N1G4.
SwissPalmiQ8N1G4.

Polymorphism and mutation databases

BioMutaiLRRC47.
DMDMi74750895.

Proteomic databases

EPDiQ8N1G4.
MaxQBiQ8N1G4.
PaxDbiQ8N1G4.
PeptideAtlasiQ8N1G4.
PRIDEiQ8N1G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378251; ENSP00000367498; ENSG00000130764.
GeneIDi57470.
KEGGihsa:57470.
UCSCiuc001akx.2. human.

Organism-specific databases

CTDi57470.
GeneCardsiLRRC47.
HGNCiHGNC:29207. LRRC47.
HPAiHPA008512.
HPA012018.
neXtProtiNX_Q8N1G4.
OpenTargetsiENSG00000130764.
PharmGKBiPA142671507.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2472. Eukaryota.
COG0072. LUCA.
COG4886. LUCA.
GeneTreeiENSGT00530000063489.
HOGENOMiHOG000007166.
HOVERGENiHBG066309.
InParanoidiQ8N1G4.
OMAiVRPYLVC.
OrthoDBiEOG091G07VP.
PhylomeDBiQ8N1G4.
TreeFamiTF315742.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130764-MONOMER.

Miscellaneous databases

ChiTaRSiLRRC47. human.
GenomeRNAii57470.
PMAP-CutDBQ8N1G4.
PROiQ8N1G4.

Gene expression databases

BgeeiENSG00000130764.
CleanExiHS_LRRC47.
ExpressionAtlasiQ8N1G4. baseline and differential.
GenevisibleiQ8N1G4. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR005146. B3/B4_tRNA-bd.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF03483. B3_4. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00873. B3_4. 1 hit.
SM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC47_HUMAN
AccessioniPrimary (citable) accession number: Q8N1G4
Secondary accession number(s): Q9ULN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.