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Protein

RNA exonuclease 1 homolog

Gene

REXO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to have no detectable effect on transcription elongation in vitro.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
RNA exonuclease 1 homolog (EC:3.1.-.-)
Alternative name(s):
Elongin-A-binding protein 1
Short name:
EloA-BP1
Transcription elongation factor B polypeptide 3-binding protein 1
Gene namesi
Name:REXO1
Synonyms:ELOABP1, KIAA1138, TCEB3BP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24616. REXO1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671077.

Polymorphism and mutation databases

BioMutaiREXO1.
DMDMi296452990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12211221RNA exonuclease 1 homologPRO_0000239232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei287 – 2871PhosphoserineBy similarity
Modified residuei289 – 2891PhosphoserineBy similarity
Modified residuei358 – 3581PhosphoserineCombined sources
Modified residuei459 – 4591PhosphoserineCombined sources
Modified residuei499 – 4991PhosphoserineCombined sources
Modified residuei526 – 5261PhosphoserineBy similarity
Modified residuei610 – 6101PhosphoserineCombined sources
Modified residuei914 – 9141PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N1G1.
MaxQBiQ8N1G1.
PaxDbiQ8N1G1.
PeptideAtlasiQ8N1G1.
PRIDEiQ8N1G1.

PTM databases

iPTMnetiQ8N1G1.
PhosphoSiteiQ8N1G1.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000079313.
CleanExiHS_REXO1.
ExpressionAtlasiQ8N1G1. baseline and differential.
GenevisibleiQ8N1G1. HS.

Organism-specific databases

HPAiHPA042155.
HPA042552.

Interactioni

Subunit structurei

Interacts with TCEA2 and TCEB3.1 Publication

Protein-protein interaction databases

BioGridi121526. 7 interactions.
IntActiQ8N1G1. 2 interactions.
MINTiMINT-1401484.
STRINGi9606.ENSP00000170168.

Structurei

3D structure databases

ProteinModelPortaliQ8N1G1.
SMRiQ8N1G1. Positions 1060-1221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1060 – 1209150ExonucleaseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni498 – 57780Interacts with TCEB3Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili86 – 11530Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi188 – 19710Poly-Gly
Compositional biasi375 – 3806Poly-Lys
Compositional biasi537 – 59256Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the REXO1/REXO3 family.Curated
Contains 1 exonuclease domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2248. Eukaryota.
COG0847. LUCA.
GeneTreeiENSGT00840000129821.
HOGENOMiHOG000039979.
HOVERGENiHBG090644.
InParanoidiQ8N1G1.
KOiK14570.
OMAiFRAIDCP.
OrthoDBiEOG091G08EX.
PhylomeDBiQ8N1G1.
TreeFamiTF350172.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR031736. EloA-BP1.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF15870. EloA-BP1. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N1G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSTGFFRA IDCPYWSGAP GGPCRRPYCH FRHRGARGSG APGDGGEAPP
60 70 80 90 100
AAGLGYDPYN PELPKPPAQR ENGTLGLGEE PRPDVLELEL VNQAIEAVRS
110 120 130 140 150
EVELEQRRYR ELLETTREHR SAEAPALAPR GPNASPTVGP DEDAFPLAFD
160 170 180 190 200
YSPGSHGLLS PDAGYQPTPL AAPAEPGSKY SLASLDRGQG RGGGGGGALE
210 220 230 240 250
YVPKAVSQPR RHSRPVPSGK YVVDNSRPPT DLEYDPLSNY SARHLSRASS
260 270 280 290 300
RDERAAKRPR GSRGSEPYTP APKKLCDPFG SCDARFSDSE DEAATVPGNE
310 320 330 340 350
PTTASTPKAR ADPEIKATGQ PPSKEGLEAE GGGLRETKET AVQCDVGDLQ
360 370 380 390 400
PPPAKPASPA QVQSSQDGGC PKEGKPKKKK TGAPPAPSCK DGAQGKDKTK
410 420 430 440 450
DKGRGRPVEK PRADKKGPQA SSPRRKAERP EGTKKKPSSA TPVATSGKGR
460 470 480 490 500
PDRPARRPSP TSGDSRPAAG RGPPRPLQLP DRKSTKAPSG KLVERKARSL
510 520 530 540 550
DEGASQDAPK LKKRALSHAD LFGDESEDEA AGPGVPSVWP SALPSLSSDS
560 570 580 590 600
DSDSDSSLGF PEAQGPPKRL KASPPPSPAP SSSSSSSSST SSAGADVDYS
610 620 630 640 650
ALEKEVDFDS DPMEECLRIF NESTSVKTED RGRLARQPPK EEKSEEKGLS
660 670 680 690 700
GLTTLFPGQK RRISHLSKQG QEVEPPRRGP AVPPARPPTA QEVCYLRAQQ
710 720 730 740 750
AQRASASLLQ APARLAEKSP SVHISAPGEK RRIAHIPNPR LAAAPTGAKR
760 770 780 790 800
TLAASGSQSS NGPEPGGQQL KTRTLSGMAS KTTTTIIPKR IAHSPSLQSL
810 820 830 840 850
KKPIIPKEFG GKVPTVIRQR YLNLFIEECL KFCTSNQEAI EKALNEEKVA
860 870 880 890 900
YDRSPSKNIY LNVAVNTLKK LRGLAPSAVP GLSKTSGRRV VSHEVVLGGR
910 920 930 940 950
LAAKTSFSLS RPSSPRVEDL KGAALYSRLR EYLLTQDQLK ENGYPFPHPE
960 970 980 990 1000
RPGGAIIFTA EEKRPKDSSC RTCCRCGTEY LVSSSGRCIR DEECYYHWGR
1010 1020 1030 1040 1050
LRRNRVAGGW ETQYMCCSAA AGSVGCQVAK QHVQDGRKER LEGFVKTFEK
1060 1070 1080 1090 1100
ELSGDTHPGI YALDCEMSYT TYGLELTRVT VVDTDVHVVY DTFVKPDNEI
1110 1120 1130 1140 1150
VDYNTRFSGV TEADLADTSV TLRDVQAVLL SMFSADTILI GHSLESDLLA
1160 1170 1180 1190 1200
LKVIHSTVVD TSVLFPHRLG LPYKRSLRNL MADYLRQIIQ DNVDGHSSSE
1210 1220
DAGACMHLVI WKVREDAKTK R
Length:1,221
Mass (Da):131,510
Last modified:May 18, 2010 - v3
Checksum:i4165C5394664B021
GO

Sequence cautioni

The sequence BAA86452 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391S → P in BAA86452 (PubMed:10574461).Curated
Sequence conflicti39 – 391S → P in AAH32244 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti408 – 4081V → A.
Corresponds to variant rs10415018 [ dbSNP | Ensembl ].
VAR_057148
Natural varianti759 – 7591S → P.3 Publications
Corresponds to variant rs4807145 [ dbSNP | Ensembl ].
VAR_060444
Natural varianti804 – 8041I → V.
Corresponds to variant rs34831403 [ dbSNP | Ensembl ].
VAR_057149
Natural varianti886 – 8861S → G.1 Publication
Corresponds to variant rs2396359 [ dbSNP | Ensembl ].
VAR_026587

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032964 mRNA. Translation: BAA86452.1. Different initiation.
AC012615 Genomic DNA. No translation available.
BC032244 mRNA. Translation: AAH32244.1.
CCDSiCCDS32866.1.
RefSeqiNP_065746.3. NM_020695.3.
UniGeneiHs.192477.

Genome annotation databases

EnsembliENST00000170168; ENSP00000170168; ENSG00000079313.
GeneIDi57455.
KEGGihsa:57455.
UCSCiuc002lua.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032964 mRNA. Translation: BAA86452.1. Different initiation.
AC012615 Genomic DNA. No translation available.
BC032244 mRNA. Translation: AAH32244.1.
CCDSiCCDS32866.1.
RefSeqiNP_065746.3. NM_020695.3.
UniGeneiHs.192477.

3D structure databases

ProteinModelPortaliQ8N1G1.
SMRiQ8N1G1. Positions 1060-1221.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121526. 7 interactions.
IntActiQ8N1G1. 2 interactions.
MINTiMINT-1401484.
STRINGi9606.ENSP00000170168.

PTM databases

iPTMnetiQ8N1G1.
PhosphoSiteiQ8N1G1.

Polymorphism and mutation databases

BioMutaiREXO1.
DMDMi296452990.

Proteomic databases

EPDiQ8N1G1.
MaxQBiQ8N1G1.
PaxDbiQ8N1G1.
PeptideAtlasiQ8N1G1.
PRIDEiQ8N1G1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000170168; ENSP00000170168; ENSG00000079313.
GeneIDi57455.
KEGGihsa:57455.
UCSCiuc002lua.5. human.

Organism-specific databases

CTDi57455.
GeneCardsiREXO1.
H-InvDBHIX0014594.
HIX0027481.
HGNCiHGNC:24616. REXO1.
HPAiHPA042155.
HPA042552.
MIMi609614. gene.
neXtProtiNX_Q8N1G1.
PharmGKBiPA142671077.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2248. Eukaryota.
COG0847. LUCA.
GeneTreeiENSGT00840000129821.
HOGENOMiHOG000039979.
HOVERGENiHBG090644.
InParanoidiQ8N1G1.
KOiK14570.
OMAiFRAIDCP.
OrthoDBiEOG091G08EX.
PhylomeDBiQ8N1G1.
TreeFamiTF350172.

Miscellaneous databases

ChiTaRSiREXO1. human.
GenomeRNAii57455.
PROiQ8N1G1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079313.
CleanExiHS_REXO1.
ExpressionAtlasiQ8N1G1. baseline and differential.
GenevisibleiQ8N1G1. HS.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR031736. EloA-BP1.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF15870. EloA-BP1. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiREXO1_HUMAN
AccessioniPrimary (citable) accession number: Q8N1G1
Secondary accession number(s): Q9ULT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.