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Protein

Serine/threonine-protein kinase 11-interacting protein

Gene

STK11IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate STK11/LKB1 function by controlling its subcellular localization.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

GO - Biological processi

  • neutrophil degranulation Source: Reactome
  • protein localization Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 11-interacting protein
Alternative name(s):
LKB1-interacting protein 1
Gene namesi
Name:STK11IP
Synonyms:KIAA1898, LIP1, LKB1IP, STK11IP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000144589.20
HGNCiHGNC:19184 STK11IP
MIMi607172 gene
neXtProtiNX_Q8N1F8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi114790
OpenTargetsiENSG00000144589
PharmGKBiPA38822

Polymorphism and mutation databases

BioMutaiSTK11IP
DMDMi296452972

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174621 – 1088Serine/threonine-protein kinase 11-interacting proteinAdd BLAST1088

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei387PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1
Modified residuei392PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei761PhosphoserineCombined sources1
Modified residuei773PhosphoserineCombined sources1
Modified residuei777PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N1F8
MaxQBiQ8N1F8
PaxDbiQ8N1F8
PeptideAtlasiQ8N1F8
PRIDEiQ8N1F8

PTM databases

iPTMnetiQ8N1F8
PhosphoSitePlusiQ8N1F8

Expressioni

Gene expression databases

BgeeiENSG00000144589
CleanExiHS_STK11IP
GenevisibleiQ8N1F8 HS

Organism-specific databases

HPAiHPA036837
HPA036838
HPA053192

Interactioni

Subunit structurei

Found in a ternary complex composed of STK11/LKB1, STK11IP and SMAD4. Interacts with STK11/LKB1 and SMAD4.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125352, 23 interactors
IntActiQ8N1F8, 10 interactors
STRINGi9606.ENSP00000295641

Structurei

3D structure databases

ProteinModelPortaliQ8N1F8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati109 – 130LRR 1Add BLAST22
Repeati132 – 152LRR 2Add BLAST21
Repeati164 – 185LRR 3Add BLAST22
Repeati187 – 209LRR 4Add BLAST23
Repeati210 – 231LRR 5Add BLAST22
Repeati233 – 254LRR 6Add BLAST22
Repeati255 – 276LRR 7Add BLAST22
Repeati280 – 301LRR 8Add BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi474 – 593Glu-richAdd BLAST120

Sequence similaritiesi

Belongs to the STK11IP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1859 Eukaryota
ENOG410XRFD LUCA
GeneTreeiENSGT00530000063625
HOGENOMiHOG000070454
HOVERGENiHBG108429
InParanoidiQ8N1F8
OrthoDBiEOG091G0FVG
PhylomeDBiQ8N1F8
TreeFamiTF326448

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR031782 LIP1_N
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF15904 LIP1, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits

Sequencei

Sequence statusi: Complete.

Q8N1F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTAQRDSLL WKLAGLLRES GDVVLSGCST LSLLTPTLQQ LNHVFELHLG
60 70 80 90 100
PWGPGQTGFV ALPSHPADSP VILQLQFLFD VLQKTLSLKL VHVAGPGPTG
110 120 130 140 150
PIKIFPFKSL RHLELRGVPL HCLHGLRGIY SQLETLICSR SLQALEELLS
160 170 180 190 200
ACGGDFCSAL PWLALLSANF SYNALTALDS SLRLLSALRF LNLSHNQVQD
210 220 230 240 250
CQGFLMDLCE LHHLDISYNR LHLVPRMGPS GAALGVLILR GNELRSLHGL
260 270 280 290 300
EQLRNLRHLD LAYNLLEGHR ELSPLWLLAE LRKLYLEGNP LWFHPEHRAA
310 320 330 340 350
TAQYLSPRAR DAATGFLLDG KVLSLTDFQT HTSLGLSPMG PPLPWPVGST
360 370 380 390 400
PETSGGPDLS DSLSSGGVVT QPLLHKVKSR VRVRRASISE PSDTDPEPRT
410 420 430 440 450
LNPSPAGWFV QQHPELELMS SFRERFGRNW LQYRSHLEPS GNPLPATPTT
460 470 480 490 500
SAPSAPPASS QGPDTAPRPS PPQEEARGPQ ESPQKMSEEV RAEPQEEEEE
510 520 530 540 550
KEGKEEKEEG EMVEQGEEEA GEEEEEEQDQ KEVEAELCRP LLVCPLEGPE
560 570 580 590 600
GVRGRECFLR VTSAHLFEVE LQAARTLERL ELQSLEAAEI EPEAQAQRSP
610 620 630 640 650
RPTGSDLLPG APILSLRFSY ICPDRQLRRY LVLEPDAHAA VQELLAVLTP
660 670 680 690 700
VTNVAREQLG EARDLLLGRF QCLRCGHEFK PEEPRMGLDS EEGWRPLFQK
710 720 730 740 750
TESPAVCPNC GSDHVVLLAV SRGTPNRERK QGEQSLAPSP SASPVCHPPG
760 770 780 790 800
HGDHLDRAKN SPPQAPSTRD HGSWSLSPPP ERCGLRSVDH RLRLFLDVEV
810 820 830 840 850
FSDAQEEFQC CLKVPVALAG HTGEFMCLVV VSDRRLYLLK VTGEMREPPA
860 870 880 890 900
SWLQLTLAVP LQDLSGIELG LAGQSLRLEW AAGAGRCVLL PRDARHCRAF
910 920 930 940 950
LEELLDVLQS LPPAWRNCVS ATEEEVTPQH RLWPLLEKDS SLEARQFFYL
960 970 980 990 1000
RAFLVEGPST CLVSLLLTPS TLFLLDEDAA GSPAEPSPPA ASGEASEKVP
1010 1020 1030 1040 1050
PSGPGPAVRV REQQPLSSLS SVLLYRSAPE DLRLLFYDEV SRLESFWALR
1060 1070 1080
VVCQEQLTAL LAWIREPWEE LFSIGLRTVI QEALALDR
Length:1,088
Mass (Da):120,259
Last modified:March 28, 2018 - v4
Checksum:iB5EA45D6C1B7BEF8
GO

Sequence cautioni

The sequence AAH34051 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAL49726 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti337S → N in AAL49726 (PubMed:11741830).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038529382R → H1 PublicationCorresponds to variant dbSNP:rs17855575Ensembl.1
Natural variantiVAR_038530399R → G1 PublicationCorresponds to variant dbSNP:rs17855576Ensembl.1
Natural variantiVAR_038531552V → I2 PublicationsCorresponds to variant dbSNP:rs673951Ensembl.1
Natural variantiVAR_038532741S → F3 PublicationsCorresponds to variant dbSNP:rs627530Ensembl.1
Natural variantiVAR_0385331074I → V1 PublicationCorresponds to variant dbSNP:rs17853279Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450267 mRNA Translation: AAL49726.1 Different initiation.
AC009955 Genomic DNA No translation available.
BC014114 mRNA Translation: AAH14114.2
BC034051 mRNA Translation: AAH34051.1 Different initiation.
AB067485 mRNA Translation: BAB67791.1
CCDSiCCDS46521.2
RefSeqiNP_443134.3, NM_052902.3
UniGeneiHs.22410

Genome annotation databases

EnsembliENST00000456909; ENSP00000389383; ENSG00000144589
GeneIDi114790
KEGGihsa:114790
UCSCiuc002vml.3 human

Keywords - Coding sequence diversityi

Polymorphism

Entry informationi

Entry nameiS11IP_HUMAN
AccessioniPrimary (citable) accession number: Q8N1F8
Secondary accession number(s): C9JQV3
, Q8NAW9, Q8WXE4, Q96CN3, Q96PY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 127 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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