Q8N1F7 (NUP93_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear pore complex protein Nup93

Alternative name(s):
93 kDa nucleoporin
Nucleoporin Nup93

Gene names

Name:	NUP93
Synonyms:	KIAA0095

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	819 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. Ref.7 Ref.8
Subunit structure	Part of the nuclear pore complex (NPC). Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP53, NUP155, NUP205 and lamin B; the interaction with NUP53 is direct. Does not interact with TPR. Ref.7 Ref.8
Subcellular location	Nucleus membrane; Peripheral membrane protein. Nucleus › nuclear pore complex. Nucleus membrane; Peripheral membrane protein By similarity. Note: Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore. Ref.6 Ref.7
Sequence similarities	Belongs to the nucleoporin interacting component (NIC) family.
Sequence caution	The sequence BAA07680.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Membrane Nuclear pore complex Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Traceable author statement. Source: Reactome cytokine-mediated signaling pathway Traceable author statement. Source: Reactome glucose transport Traceable author statement. Source: Reactome mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW nuclear pore complex assembly Inferred from mutant phenotype Ref.7. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of glucose transport Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome viral reproduction Traceable author statement. Source: Reactome
Cellular_component	nuclear membrane Inferred from direct assay Ref.7. Source: UniProtKB nuclear periphery Inferred from direct assay Ref.7. Source: UniProtKB nuclear pore Inferred from direct assay Ref.6Ref.7. Source: UniProtKB
Molecular_function	structural constituent of nuclear pore Inferred from mutant phenotype Ref.7. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N1F7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N1F7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 819	819	Nuclear pore complex protein Nup93		PRO_0000124782
Amino acid modifications
	Modified residue	52	1	Phosphoserine Ref.10 Ref.12
	Modified residue	72	1	Phosphoserine Ref.10 Ref.12 Ref.14
	Modified residue	75	1	Phosphoserine Ref.14
Natural variations
	Alternative sequence	1 – 123	123	Missing in isoform 2.		VSP_043117
	Natural variant	509	1	S → R. Ref.4 Corresponds to variant rs17853288 [ dbSNP | Ensembl ].		VAR_028160

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 7A611FABE964FE98	FASTA	819	93,488
	10 20 30 40 50 60 MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA 70 80 90 100 110 120 SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG FLKNEKDNAL LSAIEESRKR 130 140 150 160 170 180 TFGMAEEYHR ESMLVEWEQV KQRILHTLLA SGEDALDFTQ ESEPSYISDV GPPGRSSLDN 190 200 210 220 230 240 IEMAYARQIY IYNEKIVNGH LQPNLVDLCA SVAELDDKSI SDMWTMVKQM TDVLLTPATD 250 260 270 280 290 300 ALKNRSSVEV RMEFVRQALA YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK 310 320 330 340 350 360 LPAPLPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVNR AQHQLGEFKT WFQEYMNSKD 370 380 390 400 410 420 RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDVT DNQSEVADKT EDYLWLKLNQ 430 440 450 460 470 480 VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE SHFTVNQQPF LYFQVLFLTA QFEAAVAFLF 490 500 510 520 530 540 RMERLRCHAV HVALVLFELK LLLKSSGQSA QLLSHEPGDP PCLRRLNFVR LLMLYTRKFE 550 560 570 580 590 600 STDPREALQY FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK 610 620 630 640 650 660 FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV PQISAPQSNK 670 680 690 700 710 720 ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD EYHSGHIDRA FDIIERLKLV 730 740 750 760 770 780 PLNQESVEER VAAFRNFSDE IRHNLSEVLL ATMNILFTQF KRLKGTSPSS SSRPQRVIED 790 800 810 RDSQLRSQAR TLITFAGMIP YRTSGDTNAR LVQMEVLMN
	Isoform 2 [UniParc]. Checksum: 8B232CEE9284D4B1	FASTA	696	79,882
	10 20 30 40 50 60 MAEEYHRESM LVEWEQVKQR ILHTLLASGE DALDFTQESE PSYISDVGPP GRSSLDNIEM 70 80 90 100 110 120 AYARQIYIYN EKIVNGHLQP NLVDLCASVA ELDDKSISDM WTMVKQMTDV LLTPATDALK 130 140 150 160 170 180 NRSSVEVRME FVRQALAYLE QSYKNYTLVT VFGNLHQAQL GGVPGTYQLV RSFLNIKLPA 190 200 210 220 230 240 PLPGLQDGEV EGHPVWALIY YCMRCGDLLA ASQVVNRAQH QLGEFKTWFQ EYMNSKDRRL 250 260 270 280 290 300 SPATENKLRL HYRRALRNNT DPYKRAVYCI IGRCDVTDNQ SEVADKTEDY LWLKLNQVCF 310 320 330 340 350 360 DDDGTSSPQD RLTLSQFQKQ LLEDYGESHF TVNQQPFLYF QVLFLTAQFE AAVAFLFRME 370 380 390 400 410 420 RLRCHAVHVA LVLFELKLLL KSSGQSAQLL SHEPGDPPCL RRLNFVRLLM LYTRKFESTD 430 440 450 460 470 480 PREALQYFYF LRDEKDSQGE NMFLRCVSEL VIESREFDMI LGKLENDGSR KPGVIDKFTS 490 500 510 520 530 540 DTKPIINKVA SVAENKGLFE EAAKLYDLAK NADKVLELMN KLLSPVVPQI SAPQSNKERL 550 560 570 580 590 600 KNMALSIAER YRAQGISANK FVDSTFYLLL DLITFFDEYH SGHIDRAFDI IERLKLVPLN 610 620 630 640 650 660 QESVEERVAA FRNFSDEIRH NLSEVLLATM NILFTQFKRL KGTSPSSSSR PQRVIEDRDS 670 680 690 QLRSQARTLI TFAGMIPYRT SGDTNARLVQ MEVLMN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N. DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Amygdala and Brain.
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-509. Tissue: Skin.
[5]	"Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly." Grandi P., Dang T., Pane N., Shevchenko A., Mann M., Forbes D., Hurt E. Mol. Biol. Cell 8:2017-2038(1997) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[6]	"Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex." Hase M.E., Cordes V.C. Mol. Biol. Cell 14:1923-1940(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ABSENCE OF INTERACTION WITH TPR, SUBCELLULAR LOCATION.
[7]	"Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket." Krull S., Thyberg J., Bjorkroth B., Rackwitz H.R., Cordes V.C. Mol. Biol. Cell 15:4261-4277(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN THE NUCLEAR PORE COMPLEX, SUBCELLULAR LOCATION.
[8]	"Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex." Hawryluk-Gara L.A., Shibuya E.K., Wozniak R.W. Mol. Biol. Cell 16:2382-2394(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH NUP53, IDENTIFICATION IN A COMPLEX WITH NUP155; NUP205 AND LAMIN B.
[9]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52 AND SER-72, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52 AND SER-72, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72 AND SER-75, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D42085 mRNA. Translation: BAA07680.2. Different initiation. AK294176 mRNA. Translation: BAH11689.1. BC034346 mRNA. Translation: AAH34346.1. AC012181 Genomic DNA. No translation available. AC106779 Genomic DNA. No translation available. AC127456 Genomic DNA. No translation available. AK056637 mRNA. Translation: BAG51770.1.
IPI	IPI00397904. IPI00644506.
RefSeq	NP_001229724.1. NM_001242795.1. NP_001229725.1. NM_001242796.1. NP_055484.3. NM_014669.4.
UniGene	Hs.276878.
3D structure databases
ProteinModelPortal	Q8N1F7.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-44020N.
IntAct	Q8N1F7. 12 interactions.
MINT	MINT-3039167.
STRING	9606.ENSP00000310668.
PTM databases
PhosphoSite	Q8N1F7.
Polymorphism databases
DMDM	116242684.
Proteomic databases
PaxDb	Q8N1F7.
PRIDE	Q8N1F7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308159; ENSP00000310668; ENSG00000102900. ENST00000542526; ENSP00000440235; ENSG00000102900. ENST00000564887; ENSP00000458039; ENSG00000102900.
GeneID	9688.
KEGG	hsa:9688.
UCSC	uc002eka.3. human.
Organism-specific databases
CTD	9688.
GeneCards	GC16P056764.
HGNC	HGNC:28958. NUP93.
HPA	HPA017937.
MIM	614351. gene.
neXtProt	NX_Q8N1F7.
PharmGKB	PA134912759.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG312233.
HOGENOM	HOG000007350.
HOVERGEN	HBG052701.
InParanoid	Q8N1F7.
KO	K14309.
OMA	IAFLFRM.
OrthoDB	EOG4BRWK4.
PhylomeDB	Q8N1F7.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_116125. Disease. REACT_15518. Transmembrane transport of small molecules. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q8N1F7.
Bgee	Q8N1F7.
CleanEx	HS_NUP93.
Genevestigator	Q8N1F7.
GermOnline	ENSG00000102900. Homo sapiens.
Family and domain databases
InterPro	IPR007231. Nucleoporin_int_Nup93/Nic96. [Graphical view]
PANTHER	PTHR11225. PTHR11225. 1 hit.
Pfam	PF04097. Nic96. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NUP93. human.
GenomeRNAi	9688.
NextBio	36387.
SOURCE	Search...

Entry information

Entry name

NUP93_HUMAN

Accession

Primary (citable) accession number: Q8N1F7
Secondary accession number(s): B3KPQ8, Q14705

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.