Reviewed, UniProtKB/Swiss-Prot Q8N1F7 (NUP93_HUMAN)

Names and origin

Protein names

Recommended name:
    Nuclear pore complex protein Nup93
Alternative name(s):
    Nucleoporin Nup93
    93 kDa nucleoporin

Gene names

Name:	NUP93
Synonyms:	KIAA0095

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	819 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Part of the nucleoporin complex; required for correct nuclear pore assembly.
Subunit structure	Component of the p62 complex, a complex composed of NUP62, NUP54. Interacts also with NUP205.
Subcellular location	Nucleus › nuclear pore complex. Note: Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.
Sequence similarities	Belongs to the nucleoporin interacting component (NIC) family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Nuclear pore complex Nucleus
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	intracellular protein transmembrane transport Inferred from electronic annotation. Source: UniProtKB-KW mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nuclear pore Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BRF2	Q9HAW0	1	EBI-1042703,EBI-1055224
CASP4	P49662	1	EBI-1042703,EBI-1057327
GIPC1	O14908	1	EBI-1042703,EBI-373132
NEK6	Q9HC98	1	EBI-1042703,EBI-740364
PHB2	Q99623	1	EBI-1042703,EBI-358348
PHLDA3	Q9Y5J5	1	EBI-1042703,EBI-1055859
PNKP	Q96T60	1	EBI-1042703,EBI-1045072
TSC22D1	Q15714	1	EBI-1042703,EBI-712609

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 819	819	Nuclear pore complex protein Nup93		PRO_0000124782
Amino acid modifications
	Modified residue	52	1	Phosphoserine Ref.6
	Modified residue	72	1	Phosphoserine Ref.6
	Modified residue	430	1	Phosphoserine Ref.5
	Modified residue	767	1	Phosphoserine Ref.4
Natural variations
	Natural variant	509	1	S → R: dbSNP rs17853288. Ref.2		VAR_028160

Sequences

	Sequence		Length	Mass (Da)
	Q8N1F7-1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 7A611FABE964FE98	FASTA	819	93,488
	10 20 30 40 50 60 MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA 70 80 90 100 110 120 SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG FLKNEKDNAL LSAIEESRKR 130 140 150 160 170 180 TFGMAEEYHR ESMLVEWEQV KQRILHTLLA SGEDALDFTQ ESEPSYISDV GPPGRSSLDN 190 200 210 220 230 240 IEMAYARQIY IYNEKIVNGH LQPNLVDLCA SVAELDDKSI SDMWTMVKQM TDVLLTPATD 250 260 270 280 290 300 ALKNRSSVEV RMEFVRQALA YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK 310 320 330 340 350 360 LPAPLPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVNR AQHQLGEFKT WFQEYMNSKD 370 380 390 400 410 420 RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDVT DNQSEVADKT EDYLWLKLNQ 430 440 450 460 470 480 VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE SHFTVNQQPF LYFQVLFLTA QFEAAVAFLF 490 500 510 520 530 540 RMERLRCHAV HVALVLFELK LLLKSSGQSA QLLSHEPGDP PCLRRLNFVR LLMLYTRKFE 550 560 570 580 590 600 STDPREALQY FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK 610 620 630 640 650 660 FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV PQISAPQSNK 670 680 690 700 710 720 ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD EYHSGHIDRA FDIIERLKLV 730 740 750 760 770 780 PLNQESVEER VAAFRNFSDE IRHNLSEVLL ATMNILFTQF KRLKGTSPSS SSRPQRVIED 790 800 810 RDSQLRSQAR TLITFAGMIP YRTSGDTNAR LVQMEVLMN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N. DNA Res. 2:37-43(1995) [PubMed: 7788527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-509. Tissue: Skin.
[3]	"Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly." Grandi P., Dang T., Pane N., Shevchenko A., Mann M., Forbes D., Hurt E. Mol. Biol. Cell 8:2017-2038(1997) [PubMed: 9348540] [Abstract] Cited for: CHARACTERIZATION.
[4]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-767, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, MASS SPECTROMETRY.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52 AND SER-72, MASS SPECTROMETRY.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D42085 mRNA. Translation: BAA07680.2. Different initiation. BC034346 mRNA. Translation: AAH34346.1.
IPI	IPI00397904.
RefSeq	NP_055484.3.
UniGene	Hs.276878
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N1F7. 17 interactions.
PTM databases
PhosphoSite	Q8N1F7.
Proteomic databases
PRIDE	Q8N1F7.
Genome annotation databases
Ensembl	ENSG00000102900. Homo sapiens. [Contig view]
GeneID	9688.
KEGG	hsa:9688.
Organism-specific databases
GeneCards	GC16P055322.
H-InvDB	HIX0013063.
HGNC	HGNC:28958. NUP93.
HPA	HPA017937.
PharmGKB	PA134912759.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8N1F7.
HOVERGEN	Q8N1F7.
OMA	Q8N1F7. LTAQFEA.
Enzyme and pathway databases
Reactome	REACT_6185. HIV Infection.
Gene expression databases
ArrayExpress	Q8N1F7.
Bgee	Q8N1F7.
CleanEx	HS_NUP93.
GermOnline	ENSG00000102900. Homo sapiens.
Family and domain databases
InterPro	IPR007231. Nucleoporin_int_Nup93/Nic96. [Graphical view]
PANTHER	PTHR11225. NIC. 1 hit.
Pfam	PF04097. Nic96. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	36387.

Entry information

Entry name

NUP93_HUMAN

Accession

Primary (citable) accession number: Q8N1F7
Secondary accession number(s): Q14705

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)