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Q8N1F7 (NUP93_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Nuclear pore complex protein Nup93
Alternative name(s):
93 kDa nucleoporin
Nucleoporin Nup93
Gene names
Name:NUP93
Synonyms:KIAA0095
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length819 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of the nucleoporin complex; required for correct nuclear pore assembly.

Subunit structure

Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP53, NUP155, NUP205 and lamin B; the interaction with NUP53 is direct.

Subcellular location

Nucleusnuclear pore complex. Nucleus membrane; Peripheral membrane protein By similarity. Note: Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.

Sequence similarities

Belongs to the nucleoporin interacting component (NIC) family.

Sequence caution

The sequence BAA07680.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 819819Nuclear pore complex protein Nup93
PRO_0000124782

Amino acid modifications

Modified residue11N-acetylmethionine Ref.8
Modified residue521Phosphoserine Ref.7
Modified residue721Phosphoserine Ref.7
Modified residue4301Phosphoserine Ref.6
Modified residue7671Phosphoserine Ref.5

Natural variations

Natural variant5091S → R. Ref.2
Corresponds to variant rs17853288 [ dbSNP | Ensembl ].
VAR_028160

Sequences

Sequence LengthMass (Da)Tools
Q8N1F7 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 7A611FABE964FE98

FASTA81993,488
        10         20         30         40         50         60 
MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA 

        70         80         90        100        110        120 
SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG FLKNEKDNAL LSAIEESRKR 

       130        140        150        160        170        180 
TFGMAEEYHR ESMLVEWEQV KQRILHTLLA SGEDALDFTQ ESEPSYISDV GPPGRSSLDN 

       190        200        210        220        230        240 
IEMAYARQIY IYNEKIVNGH LQPNLVDLCA SVAELDDKSI SDMWTMVKQM TDVLLTPATD 

       250        260        270        280        290        300 
ALKNRSSVEV RMEFVRQALA YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK 

       310        320        330        340        350        360 
LPAPLPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVNR AQHQLGEFKT WFQEYMNSKD 

       370        380        390        400        410        420 
RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDVT DNQSEVADKT EDYLWLKLNQ 

       430        440        450        460        470        480 
VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE SHFTVNQQPF LYFQVLFLTA QFEAAVAFLF 

       490        500        510        520        530        540 
RMERLRCHAV HVALVLFELK LLLKSSGQSA QLLSHEPGDP PCLRRLNFVR LLMLYTRKFE 

       550        560        570        580        590        600 
STDPREALQY FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK 

       610        620        630        640        650        660 
FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV PQISAPQSNK 

       670        680        690        700        710        720 
ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD EYHSGHIDRA FDIIERLKLV 

       730        740        750        760        770        780 
PLNQESVEER VAAFRNFSDE IRHNLSEVLL ATMNILFTQF KRLKGTSPSS SSRPQRVIED 

       790        800        810 
RDSQLRSQAR TLITFAGMIP YRTSGDTNAR LVQMEVLMN 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
DNA Res. 2:37-43(1995) [PubMed: 7788527] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-509.
Tissue: Skin.
[3]"Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly."
Grandi P., Dang T., Pane N., Shevchenko A., Mann M., Forbes D., Hurt E.
Mol. Biol. Cell 8:2017-2038(1997) [PubMed: 9348540] [Abstract]
Cited for: CHARACTERIZATION.
[4]"Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex."
Hawryluk-Gara L.A., Shibuya E.K., Wozniak R.W.
Mol. Biol. Cell 16:2382-2394(2005) [PubMed: 15703211] [Abstract]
Cited for: FUNCTION, INTERACTION WITH NUP53, IDENTIFICATION IN A COMPLEX WITH NUP155; NUP205 AND LAMIN B.
[5]"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-767, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[6]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52 AND SER-72, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[8]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, MASS SPECTROMETRY.
Tissue: Embryonic kidney.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D42085 mRNA. Translation: BAA07680.2. Different initiation.
BC034346 mRNA. Translation: AAH34346.1.
IPIIPI00397904.
RefSeqNP_055484.3. NM_014669.4.
UniGeneHs.276878.

3D structure databases

ProteinModelPortalQ8N1F7.
SMRQ8N1F7. Positions 177-814.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-44020N.
IntActQ8N1F7. 9 interactions.
MINTMINT-3039167.
STRINGQ8N1F7.

PTM databases

PhosphoSiteQ8N1F7.

Polymorphism databases

DMDM116242684.

Proteomic databases

PRIDEQ8N1F7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308159; ENSP00000310668; ENSG00000102900.
GeneID9688.
KEGGhsa:9688.
UCSCuc002eka.1. human.

Organism-specific databases

CTD9688.
GeneCardsGC16P056764.
H-InvDBHIX0202270.
HGNCHGNC:28958. NUP93.
HPAHPA017937.
MIM614351. gene.
neXtProtNX_Q8N1F7.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG06164.
GeneTreeENSGT00390000016353.
HOGENOMHBG314379.
HOVERGENHBG052701.
InParanoidQ8N1F7.
OMAFQVLFLT.
OrthoDBEOG4BRWK4.
PhylomeDBQ8N1F7.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_474. Metabolism of carbohydrates.
REACT_6185. HIV Infection.

Gene expression databases

ArrayExpressQ8N1F7.
BgeeQ8N1F7.
CleanExHS_NUP93.
GenevestigatorQ8N1F7.
GermOnlineENSG00000102900. Homo sapiens.

Family and domain databases

InterProIPR007231. Nucleoporin_int_Nup93/Nic96.
[Graphical view]
KOK14309.
PANTHERPTHR11225. NIC. 1 hit.
PfamPF04097. Nic96. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio36387.
SOURCESearch...

Entry information

Entry nameNUP93_HUMAN
AccessionPrimary (citable) accession number: Q8N1F7
Secondary accession number(s): Q14705
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families