Unreviewed, UniProtKB/TrEMBL Q8N1F0 (Q8N1F0_HUMAN)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein phosphatase RuleBase RU004273V0
    EC=3.1.3.16 RuleBase RU004273V0

Gene names

Name:	PPP3CB EMBL AAH28049.1
ORF Names:	hCG_18332 EMBL EAW54497.1

Organism

Homo sapiens (Human) EMBL AAH28049.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	525 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate. RuleBase RU004273V0
Sequence similarities	Belongs to the PPP phosphatase family.

Ontologies

Keywords
Ligand	Iron RuleBase RU004273V0
Molecular function	Hydrolase Spearmint SPM006186 RuleBase RU004273V0
Gene Ontology (GO)
Biological process	T cell differentiation Inferred from electronic annotation. Source: Compara T cell homeostasis Inferred from electronic annotation. Source: Compara heart development Inferred from electronic annotation. Source: Compara muscle homeostasis Inferred from electronic annotation. Source: Compara negative regulation of T cell mediated cytotoxicity Inferred from electronic annotation. Source: Compara protein amino acid dephosphorylation Inferred from electronic annotation. Source: Compara regulation of gene expression Inferred from electronic annotation. Source: Compara response to amphetamine Inferred from electronic annotation. Source: Compara response to cytokine stimulus Inferred from electronic annotation. Source: Compara
Cellular component	insoluble fraction Inferred from electronic annotation. Source: Compara soluble fraction Inferred from electronic annotation. Source: Compara
Molecular function	calcium-dependent protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: Compara iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein heterodimerization activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8N1F0-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: ADB0ECB75371B574	FASTA	525	59,123
	10 20 30 40 50 60 MAAPEPARAA PPPPPPPPPP PGADRVVKAV PFPPTHRLTS EEVFDLDGIP RVDVLKNHLV 70 80 90 100 110 120 KEGRVDEEIA LRIINEGAAI LRREKTMIEV EAPITVCGDI HGQFFDLMKL FEVGGSPANT 130 140 150 160 170 180 RYLFLGDYVD RGYFSIECVL YLWVLKILYP STLFLLRGNH ECRHLTEYFT FKQECKIKYS 190 200 210 220 230 240 ERVYEACMEA FDSLPLAALL NQQFLCVHGG LSPEIHTLDD IRRLDRFKEP PAFGPMCDLL 250 260 270 280 290 300 WSDPSEDFGN EKSQEHFSHN TVRGCSYFYN YPAVCEFLQN NNLLSIIRAH EAQDAGYRMY 310 320 330 340 350 360 RKSQTTGFPS LITIFSAPNY LDVYNNKAAV LKYENNVMNI RQFNCSPHPY WLPNFMDVFT 370 380 390 400 410 420 WSLPFVGEKV TEMLVNVLSI CSDDELMTEG EDQFDVGSAA ARKEIIRNKI RAIGKMARVF 430 440 450 460 470 480 SVLREESESV LTLKGLTPTG MLPSGVLAGG RQTLQSATVE AIEAEKAIRG FSPPHRICSF 490 500 510 520 EEAKGLDRIN ERMPPRKDAV QQDGFNSLNT AHATENHGTG NHTAQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis EMBL AAH28049.1.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC028049 mRNA. Translation: AAH28049.1. CH471083 Genomic DNA. Translation: EAW54497.1.
IPI	IPI00027809.
RefSeq	NP_001135825.1.
UniGene	Hs.500067
3D structure databases
HSSP	HSSP built from PDB template 1AUI based on UniProtKB Q08209.
SMR	Q8N1F0. Positions 24-381.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8N1F0.
Proteomic databases
PRIDE	Q8N1F0.
Genome annotation databases
Ensembl	ENST00000394829; ENSP00000378306; ENSG00000107758; Homo sapiens. [Genome view]
GeneID	5532.
KEGG	hsa:5532.
UCSC	uc001juf.1. human.
Organism-specific databases
CTD	5532.
HGNC	HGNC:9315. PPP3CB.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG716770.
HOVERGEN	Q8N1F0.
OrthoDB	EOG976NK6.
PhylomeDB	Q8N1F0.
Gene expression databases
ArrayExpress	Q8N1F0.
Bgee	Q8N1F0.
Family and domain databases
InterPro	IPR004843. M-pesterase. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
PANTHER	PTHR11668. T_phtase_apaH. 1 hit.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8N1F0_HUMAN

Accession

Primary (citable) accession number: Q8N1F0

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	February 9, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.