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Protein

F-box/LRR-repeat protein 14

Gene

FBXL14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.1 Publication

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 14
Alternative name(s):
F-box and leucine-rich repeat protein 14
Gene namesi
Name:FBXL14
Synonyms:FBL14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28624. FBXL14.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • Golgi apparatus Source: HPA
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134979350.

Polymorphism and mutation databases

BioMutaiFBXL14.
DMDMi48428083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418F-box/LRR-repeat protein 14PRO_0000119861Add
BLAST

Proteomic databases

MaxQBiQ8N1E6.
PaxDbiQ8N1E6.
PRIDEiQ8N1E6.

PTM databases

iPTMnetiQ8N1E6.
PhosphoSiteiQ8N1E6.

Expressioni

Inductioni

Down-regulated by hypoxia.1 Publication

Gene expression databases

BgeeiQ8N1E6.
CleanExiHS_FBXL14.
GenevisibleiQ8N1E6. HS.

Organism-specific databases

HPAiHPA053889.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase complex. Interacts with SKP1 and CUL1 (By similarity). Interacts with SNAI1; the interaction requires the phosphorylation of the two serine residues in the substrate destruction motif D-S-G-X(2,3,4)-S.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SNAI1O958632EBI-6425532,EBI-1045459

Protein-protein interaction databases

BioGridi126870. 24 interactions.
IntActiQ8N1E6. 8 interactions.
STRINGi9606.ENSP00000344855.

Structurei

3D structure databases

ProteinModelPortaliQ8N1E6.
SMRiQ8N1E6. Positions 85-153, 190-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 4847F-boxAdd
BLAST
Repeati144 – 16320LRR 1Add
BLAST
Repeati170 – 19122LRR 2Add
BLAST
Repeati203 – 22523LRR 3Add
BLAST
Repeati229 – 25022LRR 4Add
BLAST
Repeati254 – 27522LRR 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 4847Required for down-regulation of SNAI1Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT1Z. Eukaryota.
ENOG410YK3H. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000007617.
HOVERGENiHBG051674.
InParanoidiQ8N1E6.
KOiK10280.
OMAiKHLARMP.
OrthoDBiEOG7RJPR7.
PhylomeDBiQ8N1E6.
TreeFamiTF313434.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 11 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N1E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METHISCLFP ELLAMIFGYL DVRDKGRAAQ VCTAWRDAAY HKSVWRGVEA
60 70 80 90 100
KLHLRRANPS LFPSLQARGI RRVQILSLRR SLSYVIQGMA NIESLNLSGC
110 120 130 140 150
YNLTDNGLGH AFVQEIGSLR ALNLSLCKQI TDSSLGRIAQ YLKGLEVLEL
160 170 180 190 200
GGCSNITNTG LLLIAWGLQR LKSLNLRSCR HLSDVGIGHL AGMTRSAAEG
210 220 230 240 250
CLGLEQLTLQ DCQKLTDLSL KHISRGLTGL RLLNLSFCGG ISDAGLLHLS
260 270 280 290 300
HMGSLRSLNL RSCDNISDTG IMHLAMGSLR LSGLDVSFCD KVGDQSLAYI
310 320 330 340 350
AQGLDGLKSL SLCSCHISDD GINRMVRQMH GLRTLNIGQC VRITDKGLEL
360 370 380 390 400
IAEHLSQLTG IDLYGCTRIT KRGLERITQL PCLKVLNLGL WQMTDSEKEA
410
RGDFSPLFTV RTRGSSRR
Length:418
Mass (Da):45,886
Last modified:October 1, 2002 - v1
Checksum:i5779961C8177779F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti220 – 2201L → V.
Corresponds to variant rs35571553 [ dbSNP | Ensembl ].
VAR_049033

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028132 mRNA. Translation: AAH28132.1.
CCDSiCCDS8509.1.
RefSeqiNP_689654.1. NM_152441.2.
UniGeneiHs.367956.

Genome annotation databases

EnsembliENST00000339235; ENSP00000344855; ENSG00000171823.
GeneIDi144699.
KEGGihsa:144699.
UCSCiuc001qjh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028132 mRNA. Translation: AAH28132.1.
CCDSiCCDS8509.1.
RefSeqiNP_689654.1. NM_152441.2.
UniGeneiHs.367956.

3D structure databases

ProteinModelPortaliQ8N1E6.
SMRiQ8N1E6. Positions 85-153, 190-388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126870. 24 interactions.
IntActiQ8N1E6. 8 interactions.
STRINGi9606.ENSP00000344855.

PTM databases

iPTMnetiQ8N1E6.
PhosphoSiteiQ8N1E6.

Polymorphism and mutation databases

BioMutaiFBXL14.
DMDMi48428083.

Proteomic databases

MaxQBiQ8N1E6.
PaxDbiQ8N1E6.
PRIDEiQ8N1E6.

Protocols and materials databases

DNASUi144699.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339235; ENSP00000344855; ENSG00000171823.
GeneIDi144699.
KEGGihsa:144699.
UCSCiuc001qjh.3. human.

Organism-specific databases

CTDi144699.
GeneCardsiFBXL14.
HGNCiHGNC:28624. FBXL14.
HPAiHPA053889.
MIMi609081. gene.
neXtProtiNX_Q8N1E6.
PharmGKBiPA134979350.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT1Z. Eukaryota.
ENOG410YK3H. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000007617.
HOVERGENiHBG051674.
InParanoidiQ8N1E6.
KOiK10280.
OMAiKHLARMP.
OrthoDBiEOG7RJPR7.
PhylomeDBiQ8N1E6.
TreeFamiTF313434.

Miscellaneous databases

GenomeRNAii144699.
PROiQ8N1E6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N1E6.
CleanExiHS_FBXL14.
GenevisibleiQ8N1E6. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 11 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. "The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation."
    Vinas-Castells R., Beltran M., Valls G., Gomez I., Garcia J.M., Montserrat-Sentis B., Baulida J., Bonilla F., de Herreros A.G., Diaz V.M.
    J. Biol. Chem. 285:3794-3805(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SNAI1, SUBCELLULAR LOCATION, INDUCTION BY HYPOXIA.

Entry informationi

Entry nameiFXL14_HUMAN
AccessioniPrimary (citable) accession number: Q8N1E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.