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Protein

F-box/LRR-repeat protein 14

Gene

FBXL14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.1 Publication

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 14
Alternative name(s):
F-box and leucine-rich repeat protein 14
Gene namesi
Name:FBXL14
Synonyms:FBL14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000171823.6
HGNCiHGNC:28624 FBXL14
MIMi609081 gene
neXtProtiNX_Q8N1E6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171823
PharmGKBiPA134979350

Polymorphism and mutation databases

BioMutaiFBXL14
DMDMi48428083

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198611 – 418F-box/LRR-repeat protein 14Add BLAST418

Proteomic databases

EPDiQ8N1E6
MaxQBiQ8N1E6
PaxDbiQ8N1E6
PeptideAtlasiQ8N1E6
PRIDEiQ8N1E6

PTM databases

iPTMnetiQ8N1E6
PhosphoSitePlusiQ8N1E6

Expressioni

Inductioni

Down-regulated by hypoxia.1 Publication

Gene expression databases

BgeeiENSG00000171823
CleanExiHS_FBXL14
GenevisibleiQ8N1E6 HS

Organism-specific databases

HPAiHPA053889

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase complex. Interacts with SKP1 and CUL1 (By similarity). Interacts with SNAI1; the interaction requires the phosphorylation of the two serine residues in the substrate destruction motif D-S-G-X(2,3,4)-S.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SNAI1O958632EBI-6425532,EBI-1045459

Protein-protein interaction databases

BioGridi126870, 28 interactors
IntActiQ8N1E6, 9 interactors
STRINGi9606.ENSP00000344855

Structurei

3D structure databases

ProteinModelPortaliQ8N1E6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 48F-boxAdd BLAST47
Repeati144 – 163LRR 1Add BLAST20
Repeati170 – 191LRR 2Add BLAST22
Repeati203 – 225LRR 3Add BLAST23
Repeati229 – 250LRR 4Add BLAST22
Repeati254 – 275LRR 5Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 48Required for down-regulation of SNAI1Add BLAST47

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT1Z Eukaryota
ENOG410YK3H LUCA
GeneTreeiENSGT00760000119059
HOGENOMiHOG000007617
HOVERGENiHBG051674
InParanoidiQ8N1E6
KOiK10280
OMAiSCWHVSD
OrthoDBiEOG091G08CA
PhylomeDBiQ8N1E6
TreeFamiTF313434

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF13516 LRR_6, 5 hits
SMARTiView protein in SMART
SM00367 LRR_CC, 11 hits
SUPFAMiSSF81383 SSF81383, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N1E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METHISCLFP ELLAMIFGYL DVRDKGRAAQ VCTAWRDAAY HKSVWRGVEA
60 70 80 90 100
KLHLRRANPS LFPSLQARGI RRVQILSLRR SLSYVIQGMA NIESLNLSGC
110 120 130 140 150
YNLTDNGLGH AFVQEIGSLR ALNLSLCKQI TDSSLGRIAQ YLKGLEVLEL
160 170 180 190 200
GGCSNITNTG LLLIAWGLQR LKSLNLRSCR HLSDVGIGHL AGMTRSAAEG
210 220 230 240 250
CLGLEQLTLQ DCQKLTDLSL KHISRGLTGL RLLNLSFCGG ISDAGLLHLS
260 270 280 290 300
HMGSLRSLNL RSCDNISDTG IMHLAMGSLR LSGLDVSFCD KVGDQSLAYI
310 320 330 340 350
AQGLDGLKSL SLCSCHISDD GINRMVRQMH GLRTLNIGQC VRITDKGLEL
360 370 380 390 400
IAEHLSQLTG IDLYGCTRIT KRGLERITQL PCLKVLNLGL WQMTDSEKEA
410
RGDFSPLFTV RTRGSSRR
Length:418
Mass (Da):45,886
Last modified:October 1, 2002 - v1
Checksum:i5779961C8177779F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049033220L → V. Corresponds to variant dbSNP:rs35571553Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028132 mRNA Translation: AAH28132.1
CCDSiCCDS8509.1
RefSeqiNP_689654.1, NM_152441.2
UniGeneiHs.367956

Genome annotation databases

EnsembliENST00000339235; ENSP00000344855; ENSG00000171823
GeneIDi144699
KEGGihsa:144699
UCSCiuc001qjh.3 human

Keywords - Coding sequence diversityi

Polymorphism

Entry informationi

Entry nameiFXL14_HUMAN
AccessioniPrimary (citable) accession number: Q8N1E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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