ID   CF107_HUMAN             Reviewed;         194 AA.
AC   Q8N1D5; Q5VUY4;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 3.
DT   27-MAR-2024, entry version 125.
DE   RecName: Full=Cilia- and flagella-associated protein 107 {ECO:0000312|HGNC:HGNC:28567};
GN   Name=CFAP107 {ECO:0000312|HGNC:HGNC:28567};
GN   Synonyms=C1orf158 {ECO:0000312|HGNC:HGNC:28567};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3] {ECO:0007744|PDB:7UNG}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS), FUNCTION, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=36191189; DOI=10.1073/pnas.2207605119;
RA   Gui M., Croft J.T., Zabeo D., Acharya V., Kollman J.M., Burgoyne T.,
RA   Hoog J.L., Brown A.;
RT   "SPACA9 is a lumenal protein of human ciliary singlet and doublet
RT   microtubules.";
RL   Proc. Natl. Acad. Sci. U.S.A. 119:e2207605119-e2207605119(2022).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. {ECO:0000269|PubMed:36191189}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:36191189}.
CC   -!- TISSUE SPECIFICITY: Expressed in airway epithelial cells.
CC       {ECO:0000269|PubMed:36191189}.
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DR   EMBL; AL513016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC029894; AAH29894.1; -; mRNA.
DR   CCDS; CCDS147.1; -.
DR   RefSeq; NP_689503.3; NM_152290.3.
DR   PDB; 7UNG; EM; 3.60 A; 8/9=1-194.
DR   PDB; 8J07; EM; 4.10 A; 1Y/1Z=1-194.
DR   PDBsum; 7UNG; -.
DR   PDBsum; 8J07; -.
DR   AlphaFoldDB; Q8N1D5; -.
DR   EMDB; EMD-26624; -.
DR   EMDB; EMD-35888; -.
DR   SMR; Q8N1D5; -.
DR   BioGRID; 125012; 15.
DR   STRING; 9606.ENSP00000477802; -.
DR   iPTMnet; Q8N1D5; -.
DR   PhosphoSitePlus; Q8N1D5; -.
DR   BioMuta; C1orf158; -.
DR   MassIVE; Q8N1D5; -.
DR   PaxDb; 9606-ENSP00000477802; -.
DR   PeptideAtlas; Q8N1D5; -.
DR   ProteomicsDB; 71588; -.
DR   Antibodypedia; 28545; 60 antibodies from 12 providers.
DR   DNASU; 93190; -.
DR   Ensembl; ENST00000614859.5; ENSP00000477802.1; ENSG00000157330.10.
DR   GeneID; 93190; -.
DR   KEGG; hsa:93190; -.
DR   MANE-Select; ENST00000614859.5; ENSP00000477802.1; NM_152290.4; NP_689503.3.
DR   UCSC; uc001auh.4; human.
DR   AGR; HGNC:28567; -.
DR   CTD; 93190; -.
DR   GeneCards; CFAP107; -.
DR   HGNC; HGNC:28567; CFAP107.
DR   HPA; ENSG00000157330; Group enriched (choroid plexus, fallopian tube, testis).
DR   neXtProt; NX_Q8N1D5; -.
DR   OpenTargets; ENSG00000157330; -.
DR   VEuPathDB; HostDB:ENSG00000157330; -.
DR   eggNOG; ENOG502RZRC; Eukaryota.
DR   GeneTree; ENSGT00390000014553; -.
DR   InParanoid; Q8N1D5; -.
DR   OMA; EKTPQCI; -.
DR   OrthoDB; 2919077at2759; -.
DR   PhylomeDB; Q8N1D5; -.
DR   TreeFam; TF328903; -.
DR   PathwayCommons; Q8N1D5; -.
DR   BioGRID-ORCS; 93190; 12 hits in 1118 CRISPR screens.
DR   GenomeRNAi; 93190; -.
DR   Pharos; Q8N1D5; Tdark.
DR   PRO; PR:Q8N1D5; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8N1D5; Protein.
DR   Bgee; ENSG00000157330; Expressed in right uterine tube and 78 other cell types or tissues.
DR   ExpressionAtlas; Q8N1D5; baseline and differential.
DR   GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR   InterPro; IPR037662; CFAP68/107.
DR   PANTHER; PTHR31180:SF2; PROTEIN CFAP107; 1.
DR   PANTHER; PTHR31180; UNCHARACTERIZED; 1.
DR   Genevisible; Q8N1D5; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..194
FT                   /note="Cilia- and flagella-associated protein 107"
FT                   /id="PRO_0000247260"
SQ   SEQUENCE   194 AA;  23033 MW;  234715695C85238F CRC64;
     MFLTAVNPQP LSTPSWQIET KYSTKVLTGN WMEERRKFTR DTDKTPQSIY RKEYIPFPDH
     RPDQISRWYG KRKVEGLPYK HLITHHQEPP HRYLISTYDD HYNRHGYNPG LPPLRTWNGQ
     KLLWLPEKSD FPLLAPPTNY GLYEQLKQRQ LTPKAGLKQS TYTSSYPRPP LCAMSWREHA
     VPVPPHRLHP LPHF
//