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Protein

Vacuolar protein sorting-associated protein 52 homolog

Gene

VPS52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).3 Publications

GO - Molecular functioni

  • syntaxin binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 52 homolog
Alternative name(s):
SAC2 suppressor of actin mutations 2-like protein
Gene namesi
Name:VPS52
Synonyms:SACM2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 6, Unplaced

Organism-specific databases

HGNCiHGNC:10518. VPS52.

Subcellular locationi

GO - Cellular componenti

  • endosome membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34926.

Polymorphism and mutation databases

BioMutaiVPS52.
DMDMi74750887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 723722Vacuolar protein sorting-associated protein 52 homologPRO_0000213315Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8N1B4.
PaxDbiQ8N1B4.
PRIDEiQ8N1B4.

PTM databases

PhosphoSiteiQ8N1B4.

Expressioni

Gene expression databases

BgeeiQ8N1B4.
CleanExiHS_VPS52.
ExpressionAtlasiQ8N1B4. baseline and differential.
GenevisibleiQ8N1B4. HS.

Organism-specific databases

HPAiHPA042667.
HPA048128.

Interactioni

Subunit structurei

Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (PubMed:15878329, PubMed:20685960). Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and CCDC132/Syndetin (PubMed:25799061). Interacts with RAB6A and STX10 (PubMed:15878329, PubMed:20685960).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9WMX22EBI-2799833,EBI-6863748From a different organism.
AAMPC9JG973EBI-2799833,EBI-10176499
ATP6V1DQ6PJ053EBI-2799833,EBI-10253919
ATP6V1DQ8N5Z93EBI-2799833,EBI-10266952
ATP6V1DQ9Y5K83EBI-2799833,EBI-2684998
C1orf109Q9NX043EBI-2799833,EBI-8643161
CCDC146Q8IYE0-23EBI-2799833,EBI-10247802
DDX6P261963EBI-2799833,EBI-351257
EPM2AIP1Q7L7753EBI-2799833,EBI-6255981
FAM184AQ6P9G83EBI-2799833,EBI-10253239
GFM2Q969S93EBI-2799833,EBI-2371750
GOLGA1Q928053EBI-2799833,EBI-6164177
HAUS1Q96CS23EBI-2799833,EBI-2514791
HEATR1Q96ES53EBI-2799833,EBI-10285245
HEL-S-61V9HW293EBI-2799833,EBI-10330057
KANK2Q63ZY33EBI-2799833,EBI-2556193
KIAA1217Q5T5P2-63EBI-2799833,EBI-10188326
KLC3Q6P5973EBI-2799833,EBI-1643885
LMO4P619683EBI-2799833,EBI-2798728
METTL13Q8N6R03EBI-2799833,EBI-1053295
MFAP1P550813EBI-2799833,EBI-1048159
MRPL11Q9Y3B73EBI-2799833,EBI-5453723
NFKBIBQ156533EBI-2799833,EBI-352889
NOP2P460873EBI-2799833,EBI-356811
PPP1R18Q6NYC83EBI-2799833,EBI-2557469
PRKAA1Q131313EBI-2799833,EBI-1181405
PRKAA2P546463EBI-2799833,EBI-1383852
RAB4AP203383EBI-2799833,EBI-722284
RNF41Q9H4P43EBI-2799833,EBI-2130266
SH2D4AQ9H7883EBI-2799833,EBI-747035
STX11O755583EBI-2799833,EBI-714135
TBC1D22BQ9NU193EBI-2799833,EBI-8787464
TCEANCQ8N8B73EBI-2799833,EBI-954696
TEAD4D3DUQ63EBI-2799833,EBI-10176734
THAP11Q96EK43EBI-2799833,EBI-1790529
TPM3P067533EBI-2799833,EBI-355607
TPM3Q5VU623EBI-2799833,EBI-10184033
TRAF6Q9Y4K33EBI-2799833,EBI-359276
TSSK3Q96PN83EBI-2799833,EBI-3918381
TSTD2Q5T7W73EBI-2799833,EBI-8994397
TXLNAP402223EBI-2799833,EBI-359793
TXN2Q997573EBI-2799833,EBI-2932492
USP2O756043EBI-2799833,EBI-743272
VPS28Q548N13EBI-2799833,EBI-10243107
WTAPQ150073EBI-2799833,EBI-751647
ZMAT2Q96NC03EBI-2799833,EBI-2682299

Protein-protein interaction databases

BioGridi112200. 62 interactions.
DIPiDIP-57843N.
IntActiQ8N1B4. 50 interactions.
MINTiMINT-3039108.
STRINGi9606.ENSP00000409952.

Structurei

3D structure databases

ProteinModelPortaliQ8N1B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili107 – 12721Sequence AnalysisAdd
BLAST
Coiled coili194 – 21522Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the VPS52 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG296730.
GeneTreeiENSGT00390000008815.
HOVERGENiHBG052966.
InParanoidiQ8N1B4.
OMAiTHYLEVP.
OrthoDBiEOG7HTHGH.
PhylomeDBiQ8N1B4.
TreeFamiTF314937.

Family and domain databases

InterProiIPR007258. Vps52.
[Graphical view]
PANTHERiPTHR14190. PTHR14190. 1 hit.
PfamiPF04129. Vps52. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N1B4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAATMAAA ARELVLRAGT SDMEEEEGPL AGGPGLQEPL QLGELDITSD
60 70 80 90 100
EFILDEVDVH IQANLEDELV KEALKTGVDL RHYSKQVELE LQQIEQKSIR
110 120 130 140 150
DYIQESENIA SLHNQITACD AVLERMEQML GAFQSDLSSI SSEIRTLQEQ
160 170 180 190 200
SGAMNIRLRN RQAVRGKLGE LVDGLVVPSA LVTAILEAPV TEPRFLEQLQ
210 220 230 240 250
ELDAKAAAVR EQEARGTAAC ADVRGVLDRL RVKAVTKIRE FILQKIYSFR
260 270 280 290 300
KPMTNYQIPQ TALLKYRFFY QFLLGNERAT AKEIRDEYVE TLSKIYLSYY
310 320 330 340 350
RSYLGRLMKV QYEEVAEKDD LMGVEDTAKK GFFSKPSLRS RNTIFTLGTR
360 370 380 390 400
GSVISPTELE APILVPHTAQ RGEQRYPFEA LFRSQHYALL DNSCREYLFI
410 420 430 440 450
CEFFVVSGPA AHDLFHAVMG RTLSMTLKHL DSYLADCYDA IAVFLCIHIV
460 470 480 490 500
LRFRNIAAKR DVPALDRYWE QVLALLWPRF ELILEMNVQS VRSTDPQRLG
510 520 530 540 550
GLDTRPHYIT RRYAEFSSAL VSINQTIPNE RTMQLLGQLQ VEVENFVLRV
560 570 580 590 600
AAEFSSRKEQ LVFLINNYDM MLGVLMERAA DDSKEVESFQ QLLNARTQEF
610 620 630 640 650
IEELLSPPFG GLVAFVKEAE ALIERGQAER LRGEEARVTQ LIRGFGSSWK
660 670 680 690 700
SSVESLSQDV MRSFTNFRNG TSIIQGALTQ LIQLYHRFHR VLSQPQLRAL
710 720
PARAELINIH HLMVELKKHK PNF
Length:723
Mass (Da):82,221
Last modified:October 1, 2002 - v1
Checksum:iC0961E2BE50B24DF
GO
Isoform 2 (identifier: Q8N1B4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.

Note: No experimental confirmation available.
Show »
Length:598
Mass (Da):68,496
Checksum:iA5901265E5EEDBC7
GO

Sequence cautioni

The sequence CAI95619.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti710 – 7101H → P in BAD96587 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 125125Missing in isoform 2. 1 PublicationVSP_056476Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297935 mRNA. Translation: BAG60251.1.
AK222867 mRNA. Translation: BAD96587.1.
AL645940 Genomic DNA. No translation available.
AL031228 Genomic DNA. Translation: CAI95619.1. Sequence problems.
BX248408 Genomic DNA. Translation: CAM26258.1.
CR762434, CR759817 Genomic DNA. Translation: CAQ06872.1.
CR759817, CR762434 Genomic DNA. Translation: CAQ08020.1.
CR759786 Genomic DNA. Translation: CAQ08250.1.
CH471081 Genomic DNA. Translation: EAX03688.1.
BC032108 mRNA. Translation: AAH32108.1.
BC040114 mRNA. Translation: AAH40114.2.
AL390171 mRNA. Translation: CAB99099.1.
CCDSiCCDS4770.2. [Q8N1B4-1]
PIRiT51882.
RefSeqiNP_001276104.1. NM_001289175.1. [Q8N1B4-2]
NP_001276105.1. NM_001289176.1.
NP_072047.4. NM_022553.5. [Q8N1B4-1]
UniGeneiHs.480356.

Genome annotation databases

EnsembliENST00000383210; ENSP00000372697; ENSG00000206286. [Q8N1B4-1]
ENST00000428608; ENSP00000406988; ENSG00000236014. [Q8N1B4-1]
ENST00000441058; ENSP00000390831; ENSG00000228425. [Q8N1B4-1]
ENST00000443860; ENSP00000404016; ENSG00000224455. [Q8N1B4-1]
ENST00000445902; ENSP00000409952; ENSG00000223501. [Q8N1B4-1]
ENST00000448042; ENSP00000391197; ENSG00000225590. [Q8N1B4-1]
GeneIDi6293.
KEGGihsa:6293.
UCSCiuc003odm.1. human. [Q8N1B4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297935 mRNA. Translation: BAG60251.1.
AK222867 mRNA. Translation: BAD96587.1.
AL645940 Genomic DNA. No translation available.
AL031228 Genomic DNA. Translation: CAI95619.1. Sequence problems.
BX248408 Genomic DNA. Translation: CAM26258.1.
CR762434, CR759817 Genomic DNA. Translation: CAQ06872.1.
CR759817, CR762434 Genomic DNA. Translation: CAQ08020.1.
CR759786 Genomic DNA. Translation: CAQ08250.1.
CH471081 Genomic DNA. Translation: EAX03688.1.
BC032108 mRNA. Translation: AAH32108.1.
BC040114 mRNA. Translation: AAH40114.2.
AL390171 mRNA. Translation: CAB99099.1.
CCDSiCCDS4770.2. [Q8N1B4-1]
PIRiT51882.
RefSeqiNP_001276104.1. NM_001289175.1. [Q8N1B4-2]
NP_001276105.1. NM_001289176.1.
NP_072047.4. NM_022553.5. [Q8N1B4-1]
UniGeneiHs.480356.

3D structure databases

ProteinModelPortaliQ8N1B4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112200. 62 interactions.
DIPiDIP-57843N.
IntActiQ8N1B4. 50 interactions.
MINTiMINT-3039108.
STRINGi9606.ENSP00000409952.

PTM databases

PhosphoSiteiQ8N1B4.

Polymorphism and mutation databases

BioMutaiVPS52.
DMDMi74750887.

Proteomic databases

MaxQBiQ8N1B4.
PaxDbiQ8N1B4.
PRIDEiQ8N1B4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383210; ENSP00000372697; ENSG00000206286. [Q8N1B4-1]
ENST00000428608; ENSP00000406988; ENSG00000236014. [Q8N1B4-1]
ENST00000441058; ENSP00000390831; ENSG00000228425. [Q8N1B4-1]
ENST00000443860; ENSP00000404016; ENSG00000224455. [Q8N1B4-1]
ENST00000445902; ENSP00000409952; ENSG00000223501. [Q8N1B4-1]
ENST00000448042; ENSP00000391197; ENSG00000225590. [Q8N1B4-1]
GeneIDi6293.
KEGGihsa:6293.
UCSCiuc003odm.1. human. [Q8N1B4-1]

Organism-specific databases

CTDi6293.
GeneCardsiGC06M033218.
GC06Mj33140.
GC06Mk33195.
GC06Mm33388.
GC06Mn33146.
GC06Mo33357.
HGNCiHGNC:10518. VPS52.
HPAiHPA042667.
HPA048128.
MIMi603443. gene.
neXtProtiNX_Q8N1B4.
PharmGKBiPA34926.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG296730.
GeneTreeiENSGT00390000008815.
HOVERGENiHBG052966.
InParanoidiQ8N1B4.
OMAiTHYLEVP.
OrthoDBiEOG7HTHGH.
PhylomeDBiQ8N1B4.
TreeFamiTF314937.

Miscellaneous databases

ChiTaRSiVPS52. human.
GeneWikiiVPS52.
GenomeRNAii6293.
NextBioi24431.
PROiQ8N1B4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N1B4.
CleanExiHS_VPS52.
ExpressionAtlasiQ8N1B4. baseline and differential.
GenevisibleiQ8N1B4. HS.

Family and domain databases

InterProiIPR007258. Vps52.
[Graphical view]
PANTHERiPTHR14190. PTHR14190. 1 hit.
PfamiPF04129. Vps52. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Colon.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 255-723 (ISOFORM 1).
    Tissue: Brain.
  7. Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, INTERACTION WITH RAB6A AND STX10.
  8. "Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes."
    Perez-Victoria F.J., Mardones G.A., Bonifacino J.S.
    Mol. Biol. Cell 19:2350-2362(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. "Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex."
    Perez-Victoria F.J., Schindler C., Magadan J.G., Mardones G.A., Delevoye C., Romao M., Raposo G., Bonifacino J.S.
    Mol. Biol. Cell 21:3386-3395(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VPS51.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  13. "EARP is a multisubunit tethering complex involved in endocytic recycling."
    Schindler C., Chen Y., Pu J., Guo X., Bonifacino J.S.
    Nat. Cell Biol. 0:0-0(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE EARP COMPLEX.

Entry informationi

Entry nameiVPS52_HUMAN
AccessioniPrimary (citable) accession number: Q8N1B4
Secondary accession number(s): A2BF38
, B0UZZ4, B4DNI9, Q53GR4, Q5JPA0, Q5SQW1, Q8IUN6, Q9NPT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.