Unreviewed, UniProtKB/TrEMBL Q8N1A4 (Q8N1A4_HUMAN)

Names and origin

Protein names	Submitted name:     Similar to phospholipase C, beta 3 (Phosphatidylinositol-specific) EMBL AAH32659.1
Organism	Homo sapiens (Human) EMBL AAH32659.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1191 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain.

Ontologies

Keywords
Molecular function	Transducer Spearmint SPM001192
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro lipid catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro phosphoinositide phospholipase C activity Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAH32659.1

Sequences

	Sequence		Length	Mass (Da)
	Q8N1A4-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 3A61A8B93CA39C92	FASTA	1,191	133,503
	10 20 30 40 50 60 TRPSSGAVGP RQGSVGPRPA PGRAMAGAQP GVHALQLEPP TVVETLRRGS KFIKWDEEKL 70 80 90 100 110 120 MTVVSGPDPV NTVFLNFMAV QDDTAKVWSE ELFKLAMNIL AQNASRNTFL RKAYTKLKLQ 130 140 150 160 170 180 VNQDGRIPVK NILKMFSADK KRVETALESC GLKFNRSESI RPDEFSLEIF ERFLNKLCLR 190 200 210 220 230 240 PDIDKILLEI GAKGKPYLTL EQLMDFINQK QRDPRLNEVL YPPLRPSQAR LLIEKYEPNQ 250 260 270 280 290 300 QFLERDQMSM EGFSRYLGGE ENGILPLEAL DLSTDMTQPL SAYFINSSHN TYLTAGQLAG 310 320 330 340 350 360 TSSVEMYRQA LLWGCRCVEL DVWKGRPPEE EPFITHGFTM TTEVPLRDVL EAIAETAFKT 370 380 390 400 410 420 SPYPVILSFE NHVDSAKQQA KMAEYCRSIF GDALLIEPLD KYPLAPGVPL PSPQDLMGRI 430 440 450 460 470 480 LVKNKKRHRP SAGGPDSAGR KRPLEQSNSA LSESSAATEP SSPQLGSPSS DSCPGLSNGE 490 500 510 520 530 540 EVGLEKPSLE PQKSLGDEGL NRGPYVLGPA DREDEEEDEE EEEQTDPKKP TTDEGTASSE 550 560 570 580 590 600 VNATEEMSTL VNYIEPVKFK SFEAARKRNK CFEMSSFVET KAMEQLTKSP MEFVEYNKQQ 610 620 630 640 650 660 LSRIYPKGTR VDSSNYMPQL FWNVGCQLVA LNFQTLDVAM QLNAGVFEYN GRSGYLLKPE 670 680 690 700 710 720 FMRRPDKSFD PFTEVIVDGI VANALRVKVI SGQFLSDRKV GIYVEVDMFG LPVDTRRKYR 730 740 750 760 770 780 TRTSQGNSFN PVWDEEPFDF PKVVLPTLAS LRIAAFEEGG KFVGHRILPV SAIRSGYHYV 790 800 810 820 830 840 CLRNEANQPL CLPALLIYTE ASDYIPDDHQ DYAEALINPI KHVSLMDQRA RQLAALIGES 850 860 870 880 890 900 EAQAGQETCQ DTQSQQLGSQ PSSNPTPSPL DASPRRPPGP TTSPASTSLS SPGQRDDLIA 910 920 930 940 950 960 SILSEVAPTP LDELRGHKAL VKLRSRQERD LRELRKKHQR KAVTLTRRLL DGLAQAQAEG 970 980 990 1000 1010 1020 RCRLRPGALG GAADVEDTKE GEDEAKRYQE FQNRQVQSLL ELREAQVDAE AQRRLEHLRQ 1030 1040 1050 1060 1070 1080 ALQRLREVVL DANTTQFKRL KEMNEREKKE LQKILDRKRH NSISEAKMRD KHKKEAELTE 1090 1100 1110 1120 1130 1140 INRRHITESV NSIRRLEEAQ KQRHDRLVAG QQQVLQQLAE EEPKLLAQLA QECQEQRARL 1150 1160 1170 1180 1190 PQEIRRSLLG EMPEGLGDGP LVACASNGHA PGSSGHLSGA DSESQEENTQ L

References

[1]	Strausberg R. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Uterus EMBL AAH32659.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC032659 mRNA. Translation: AAH32659.1.
IPI	IPI00181283.
UniGene	Hs.591953
3D structure databases
HSSP	HSSP built from PDB template 1DJX based on UniProtKB P10688.
SMR	Q8N1A4. Positions 56-803, 903-1155.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8N1A4.
Proteomic databases
PRIDE	Q8N1A4.
Genome annotation databases
Ensembl	ENST00000325234; ENSP00000324660; ENSG00000149782; Homo sapiens. [Genome view]
UCSC	uc009yph.1. human.
Organism-specific databases
HGNC	HGNC:9056. PLCB3.
Phylogenomic databases
HOVERGEN	Q8N1A4.
PhylomeDB	Q8N1A4.
Gene expression databases
ArrayExpress	Q8N1A4.
Bgee	Q8N1A4.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR011992. EF-hand-like_dom. IPR015359. Phospholipase_C_EF-hand-like. IPR001192. Phospholipase_C_Pinositol-sp_C. IPR001711. Phospholipase_C_Pinositol-sp_Y. IPR016280. PLC-beta. IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR000909. PLipase_C_PInositol-sp_X_dom. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit. G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 1 hit.
Pfam	PF00168. C2. 1 hit. PF09279. efhand_like. 1 hit. PF00388. PI-PLC-X. 1 hit. PF00387. PI-PLC-Y. 1 hit. [Graphical view]
PIRSF	PIRSF000956. PLC-beta. 1 hit.
PRINTS	PR00390. PHPHLIPASEC.
SMART	SM00239. C2. 1 hit. SM00148. PLCXc. 1 hit. SM00149. PLCYc. 1 hit. [Graphical view]
PROSITE	PS50004. C2. 1 hit. PS50007. PIPLC_X_DOMAIN. 1 hit. PS50008. PIPLC_Y_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8N1A4_HUMAN

Accession

Primary (citable) accession number: Q8N1A4

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	February 9, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.