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Protein

Keratin-like protein KRT222

Gene

KRT222

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-like protein KRT222
Alternative name(s):
Keratin-222
Keratin-222 pseudogene
Gene namesi
Name:KRT222
Synonyms:KA21, KRT222P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28695. KRT222.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165432008.

Polymorphism and mutation databases

BioMutaiKRT222.
DMDMi74750885.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Keratin-like protein KRT222PRO_0000344215Add
BLAST

Proteomic databases

EPDiQ8N1A0.
MaxQBiQ8N1A0.
PaxDbiQ8N1A0.
PRIDEiQ8N1A0.

PTM databases

PhosphoSiteiQ8N1A0.

Expressioni

Gene expression databases

BgeeiQ8N1A0.
ExpressionAtlasiQ8N1A0. baseline and differential.
GenevisibleiQ8N1A0. HS.

Organism-specific databases

HPAiHPA043708.
HPA054586.

Interactioni

Protein-protein interaction databases

BioGridi125916. 1 interaction.
IntActiQ8N1A0. 1 interaction.
MINTiMINT-8417683.
STRINGi9606.ENSP00000463483.

Structurei

3D structure databases

ProteinModelPortaliQ8N1A0.
SMRiQ8N1A0. Positions 57-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2 – 150149Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEQR. Eukaryota.
ENOG410YA01. LUCA.
GeneTreeiENSGT00770000120671.
HOGENOMiHOG000113187.
InParanoidiQ8N1A0.
OMAiDEGCLQT.
PhylomeDBiQ8N1A0.
TreeFamiTF332442.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N1A0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELSQLLNEI RANYEKILTR NQIETVLSTR IQLEEDISKK MDKDEEALKA
60 70 80 90 100
AQAELKEARR QWHHLQVEIE SLHAVERGLE NSLHASEQHY QMQLQDLETV
110 120 130 140 150
IEGLEKELQE VRRGIEKQLQ EHEMLLNTKM RLEQEIATYR HLLEKEEIRY
160 170 180 190 200
YGCIQGGKKD KKPTTSRVGF VLPSAIINEI SFTTKVPQKY ENENVETVTK
210 220 230 240 250
QAILNGSIVK ESTEAHGTIQ TEKVDEVIKE WEGSFFKDNP RLRKKSVSLR
260 270 280 290
FDLHLAATDE GCLETKQDNL PDIEVRLIMR RSCSIPSIKP PSTAN
Length:295
Mass (Da):34,158
Last modified:October 1, 2002 - v1
Checksum:i5A8A90215BA56563
GO
Isoform 2 (identifier: Q8N1A0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: Missing.

Show »
Length:255
Mass (Da):29,414
Checksum:i48D88ECA974C5A3B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4040Missing in isoform 2. 1 PublicationVSP_034744Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538083 mRNA. Translation: CAD98007.1.
CH471152 Genomic DNA. Translation: EAW60672.1.
CH471152 Genomic DNA. Translation: EAW60673.1.
BC032815 mRNA. Translation: AAH32815.1.
CCDSiCCDS11371.1. [Q8N1A0-1]
RefSeqiNP_689562.1. NM_152349.2. [Q8N1A0-1]
UniGeneiHs.6920.

Genome annotation databases

EnsembliENST00000394052; ENSP00000377616; ENSG00000213424. [Q8N1A0-1]
GeneIDi125113.
KEGGihsa:125113.
UCSCiuc002hvc.3. human. [Q8N1A0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538083 mRNA. Translation: CAD98007.1.
CH471152 Genomic DNA. Translation: EAW60672.1.
CH471152 Genomic DNA. Translation: EAW60673.1.
BC032815 mRNA. Translation: AAH32815.1.
CCDSiCCDS11371.1. [Q8N1A0-1]
RefSeqiNP_689562.1. NM_152349.2. [Q8N1A0-1]
UniGeneiHs.6920.

3D structure databases

ProteinModelPortaliQ8N1A0.
SMRiQ8N1A0. Positions 57-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125916. 1 interaction.
IntActiQ8N1A0. 1 interaction.
MINTiMINT-8417683.
STRINGi9606.ENSP00000463483.

PTM databases

PhosphoSiteiQ8N1A0.

Polymorphism and mutation databases

BioMutaiKRT222.
DMDMi74750885.

Proteomic databases

EPDiQ8N1A0.
MaxQBiQ8N1A0.
PaxDbiQ8N1A0.
PRIDEiQ8N1A0.

Protocols and materials databases

DNASUi125113.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394052; ENSP00000377616; ENSG00000213424. [Q8N1A0-1]
GeneIDi125113.
KEGGihsa:125113.
UCSCiuc002hvc.3. human. [Q8N1A0-1]

Organism-specific databases

CTDi125113.
GeneCardsiKRT222.
H-InvDBHIX0079852.
HGNCiHGNC:28695. KRT222.
HPAiHPA043708.
HPA054586.
neXtProtiNX_Q8N1A0.
PharmGKBiPA165432008.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEQR. Eukaryota.
ENOG410YA01. LUCA.
GeneTreeiENSGT00770000120671.
HOGENOMiHOG000113187.
InParanoidiQ8N1A0.
OMAiDEGCLQT.
PhylomeDBiQ8N1A0.
TreeFamiTF332442.

Miscellaneous databases

ChiTaRSiKRT222. human.
GenomeRNAii125113.
NextBioi81485.
PROiQ8N1A0.

Gene expression databases

BgeeiQ8N1A0.
ExpressionAtlasiQ8N1A0. baseline and differential.
GenevisibleiQ8N1A0. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Adrenal cortex.
  4. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiKT222_HUMAN
AccessioniPrimary (citable) accession number: Q8N1A0
Secondary accession number(s): Q7Z368
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

According to PubMed:16831889, it is a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.