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Protein

Zinc finger protein 567

Gene

ZNF567

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri210 – 232C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173514-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 567
Gene namesi
Name:ZNF567
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28696. ZNF567.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189042.
PharmGKBiPA134986394.

Polymorphism and mutation databases

BioMutaiZNF567.
DMDMi150387826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476581 – 647Zinc finger protein 567Add BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8N184.
PeptideAtlasiQ8N184.
PRIDEiQ8N184.

PTM databases

iPTMnetiQ8N184.
PhosphoSitePlusiQ8N184.

Expressioni

Gene expression databases

BgeeiENSG00000189042.
CleanExiHS_ZNF567.
ExpressionAtlasiQ8N184. baseline and differential.
GenevisibleiQ8N184. HS.

Organism-specific databases

HPAiHPA023937.
HPA061812.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-749400,EBI-10175124
ZAKQ9NYL2-23EBI-749400,EBI-10255081

Protein-protein interaction databases

BioGridi127848. 3 interactors.
IntActiQ8N184. 3 interactors.
MINTiMINT-1465607.
STRINGi9606.ENSP00000353957.

Structurei

3D structure databases

ProteinModelPortaliQ8N184.
SMRiQ8N184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri210 – 232C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N184.
KOiK09228.
OMAiQKSYECP.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N184.
TreeFamiTF337898.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q8N184-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQGSVSFND VTVDFTQEEW QHLDHAQKTL YMDVMLENYC HLISVGCHMT
60 70 80 90 100
KPDVILKLER GEEPWTSFAG HTCLEENWKA EDFLVKFKEH QEKYSRSVVS
110 120 130 140 150
INHKKLVKEK SKIYEKTFTL GKNPVNSKNL PPEYDTHGRI LKNVSELIIS
160 170 180 190 200
NLNPARKRLS EYNGYGKSLL STKQETTHPE VKSHNQSARA FSHNEVLMQY
210 220 230 240 250
QKTETPAQSF GYNDCEKSFL QRGGLITHSR PYKGENPSVY NKKRRATNIE
260 270 280 290 300
KKHTCNECGK SFCRKSVLIL HQGIHSEEKP YQCHQCGNAF RRKSYLIDHQ
310 320 330 340 350
RTHTGEKPFV CNECGKSFRL KTALTDHQRT HTGEKSYECL QCRNAFRLKS
360 370 380 390 400
HLIRHQRTHT GEKPYECNDC GKSFRQKTTL SLHQRIHTGE KPYICKECGK
410 420 430 440 450
SFHQKANLTV HQRTHTGEKP YICNECGKSF SQKTTLALHE KTHNEEKPYI
460 470 480 490 500
CSECGKSFRQ KTTLVAHQRT HTGEKSYECP HCGKAFRMKS YLIDHHRTHT
510 520 530 540 550
GEKPYECNEC GKSFSQKTNL NLHQRIHTGE KPYVCNECGK SFRQKATLTV
560 570 580 590 600
HQKIHTGQKS YECPQCGKAF SRKSYLIHHQ RTHTGEKPYK CSECGKCFRQ
610 620 630 640
KTNLIVHQRT HTGEKPYVCN ECGKSFSYKR NLIVHQRTHK GENIEMQ
Note: No experimental confirmation available.
Length:647
Mass (Da):75,164
Last modified:June 26, 2007 - v3
Checksum:i0A384AF156FA2B78
GO
Isoform 1 (identifier: Q8N184-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:616
Mass (Da):71,556
Checksum:i9BA3B3DE2711462C
GO
Isoform 2 (identifier: Q8N184-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     579-634: Missing.

Note: No experimental confirmation available.
Show »
Length:591
Mass (Da):68,612
Checksum:i6B8E5D830BF75775
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59E → G in CAE45826 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0163831 – 31Missing in isoform 1. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_016384579 – 634Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126691 mRNA. Translation: BAG54361.1.
BX640706 mRNA. Translation: CAE45826.1.
BC033849 mRNA. Translation: AAH33849.2.
CCDSiCCDS12495.1. [Q8N184-1]
CCDS74349.1. [Q8N184-3]
RefSeqiNP_001287908.1. NM_001300979.1. [Q8N184-3]
NP_001309840.1. NM_001322911.1. [Q8N184-1]
NP_001309841.1. NM_001322912.1. [Q8N184-1]
NP_001309842.1. NM_001322913.1. [Q8N184-3]
NP_001309843.1. NM_001322914.1. [Q8N184-3]
NP_001309844.1. NM_001322915.1. [Q8N184-3]
NP_001309845.1. NM_001322916.1. [Q8N184-3]
NP_001309846.1. NM_001322917.1. [Q8N184-3]
NP_001309847.1. NM_001322918.1. [Q8N184-3]
NP_001309848.1. NM_001322919.1. [Q8N184-3]
NP_001309849.1. NM_001322920.1. [Q8N184-3]
NP_689816.2. NM_152603.4. [Q8N184-1]
XP_011524886.1. XM_011526584.2. [Q8N184-1]
XP_016881906.1. XM_017026417.1. [Q8N184-3]
XP_016881907.1. XM_017026418.1. [Q8N184-3]
XP_016881909.1. XM_017026420.1. [Q8N184-1]
XP_016881910.1. XM_017026421.1. [Q8N184-1]
UniGeneiHs.412517.
Hs.654967.
Hs.714002.

Genome annotation databases

EnsembliENST00000360729; ENSP00000353957; ENSG00000189042. [Q8N184-1]
ENST00000536254; ENSP00000441838; ENSG00000189042. [Q8N184-3]
ENST00000585696; ENSP00000467379; ENSG00000189042. [Q8N184-1]
GeneIDi163081.
KEGGihsa:163081.
UCSCiuc002oep.5. human. [Q8N184-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126691 mRNA. Translation: BAG54361.1.
BX640706 mRNA. Translation: CAE45826.1.
BC033849 mRNA. Translation: AAH33849.2.
CCDSiCCDS12495.1. [Q8N184-1]
CCDS74349.1. [Q8N184-3]
RefSeqiNP_001287908.1. NM_001300979.1. [Q8N184-3]
NP_001309840.1. NM_001322911.1. [Q8N184-1]
NP_001309841.1. NM_001322912.1. [Q8N184-1]
NP_001309842.1. NM_001322913.1. [Q8N184-3]
NP_001309843.1. NM_001322914.1. [Q8N184-3]
NP_001309844.1. NM_001322915.1. [Q8N184-3]
NP_001309845.1. NM_001322916.1. [Q8N184-3]
NP_001309846.1. NM_001322917.1. [Q8N184-3]
NP_001309847.1. NM_001322918.1. [Q8N184-3]
NP_001309848.1. NM_001322919.1. [Q8N184-3]
NP_001309849.1. NM_001322920.1. [Q8N184-3]
NP_689816.2. NM_152603.4. [Q8N184-1]
XP_011524886.1. XM_011526584.2. [Q8N184-1]
XP_016881906.1. XM_017026417.1. [Q8N184-3]
XP_016881907.1. XM_017026418.1. [Q8N184-3]
XP_016881909.1. XM_017026420.1. [Q8N184-1]
XP_016881910.1. XM_017026421.1. [Q8N184-1]
UniGeneiHs.412517.
Hs.654967.
Hs.714002.

3D structure databases

ProteinModelPortaliQ8N184.
SMRiQ8N184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127848. 3 interactors.
IntActiQ8N184. 3 interactors.
MINTiMINT-1465607.
STRINGi9606.ENSP00000353957.

PTM databases

iPTMnetiQ8N184.
PhosphoSitePlusiQ8N184.

Polymorphism and mutation databases

BioMutaiZNF567.
DMDMi150387826.

Proteomic databases

PaxDbiQ8N184.
PeptideAtlasiQ8N184.
PRIDEiQ8N184.

Protocols and materials databases

DNASUi163081.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360729; ENSP00000353957; ENSG00000189042. [Q8N184-1]
ENST00000536254; ENSP00000441838; ENSG00000189042. [Q8N184-3]
ENST00000585696; ENSP00000467379; ENSG00000189042. [Q8N184-1]
GeneIDi163081.
KEGGihsa:163081.
UCSCiuc002oep.5. human. [Q8N184-3]

Organism-specific databases

CTDi163081.
GeneCardsiZNF567.
HGNCiHGNC:28696. ZNF567.
HPAiHPA023937.
HPA061812.
neXtProtiNX_Q8N184.
OpenTargetsiENSG00000189042.
PharmGKBiPA134986394.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N184.
KOiK09228.
OMAiQKSYECP.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N184.
TreeFamiTF337898.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173514-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii163081.
PROiQ8N184.

Gene expression databases

BgeeiENSG00000189042.
CleanExiHS_ZNF567.
ExpressionAtlasiQ8N184. baseline and differential.
GenevisibleiQ8N184. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 8 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN567_HUMAN
AccessioniPrimary (citable) accession number: Q8N184
Secondary accession number(s): B3KX49, Q6N044
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 26, 2007
Last modified: November 30, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.