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Protein

Amino acid transporter

Gene

SLC1A3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processSymportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amino acid transporterUniRule annotation
Gene namesi
Name:SLC1A3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 71HelicalUniRule annotationAdd BLAST23
Transmembranei91 – 111HelicalUniRule annotationAdd BLAST21
Transmembranei123 – 145HelicalUniRule annotationAdd BLAST23
Transmembranei241 – 260HelicalUniRule annotationAdd BLAST20
Transmembranei281 – 302HelicalUniRule annotationAdd BLAST22
Transmembranei314 – 339HelicalUniRule annotationAdd BLAST26
Transmembranei346 – 365HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35828

PTM / Processingi

Proteomic databases

PRIDEiQ8N169

Expressioni

Gene expression databases

GenevisibleiQ8N169 HS

Structurei

3D structure databases

ProteinModelPortaliQ8N169
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
HOVERGENiHBG000080
KOiK05614

Family and domain databases

Gene3Di1.10.3860.10, 2 hits
InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 2 hits
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSNGEEPK MGGRMERFQQ GVSKRTLLAK KKVQNITKED VKSYLFRNAF
60 70 80 90 100
VLLTVTAVIV GTILGFTLRP YRMSYREVKY FSFPGELLMR MLQMLVLPLI
110 120 130 140 150
ISSLVTGMAA LDSKASGKMG MRAVVYYMTT TIIAVVIGII IVIIIHPGKG
160 170 180 190 200
TKENMHREGK IVRVTAADAF LDLIRNMFPP NLVEACFKQF KTNYEKRSFK
210 220 230 240 250
VPIQANETLV GAVINNVSEA METLTRITEE LVPVPGSVNG VNALGLVVFS
260 270 280 290 300
MCFGFVIGNM KEQGQALREF FDSLNEAIMR LVAVIMWYAP VGILFLIAGK
310 320 330 340 350
IVEMEDMGVI GGQLAMYTVT VIVGLLIHAV IVLPLLYFLV TRKNPWVFIG
360 370 380 390 400
GLLQALITAL GTSSSSATLP ITFKCLEENN GVDKRVTRFV LPVGATINMD
410 420 430 440 450
GTALYEALAA IFIAQVNNFE LNFGQIITIS ITATAASIGA AGIPQAGLVT
460 470 480 490 500
MVIVLTSVGL PTDDITLIIA VDWFLDRLRT TTNVLGDSLG AGIVEHLSRH
510 520 530 540
ELKNRDVEMG NSVIEENEMK KPYQLIAQDN ETEKPIDSET KM
Length:542
Mass (Da):59,503
Last modified:October 1, 2002 - v1
Checksum:i0AB0C7D35A3A5A29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC037310 mRNA Translation: AAH37310.1
RefSeqiNP_001160167.1, NM_001166695.2
NP_001276868.1, NM_001289939.1
NP_001276869.1, NM_001289940.1
NP_004163.3, NM_004172.4
UniGeneiHs.481918

Genome annotation databases

GeneIDi6507
KEGGihsa:6507

Similar proteinsi

Entry informationi

Entry nameiQ8N169_HUMAN
AccessioniPrimary (citable) accession number: Q8N169
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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Main funding by: National Institutes of Health