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Protein

Serine/threonine-protein kinase PDIK1L

Gene

PDIK1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATPPROSITE-ProRule annotation
Active sitei164 – 1641Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8N165.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PDIK1L (EC:2.7.11.1)
Alternative name(s):
PDLIM1-interacting kinase 1-like
Gene namesi
Name:PDIK1L
Synonyms:CLIK1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18981. PDIK1L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134959839.

Polymorphism and mutation databases

BioMutaiPDIK1L.
DMDMi74762512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Serine/threonine-protein kinase PDIK1LPRO_0000086494Add
BLAST

Proteomic databases

MaxQBiQ8N165.
PaxDbiQ8N165.
PRIDEiQ8N165.

PTM databases

iPTMnetiQ8N165.
PhosphoSiteiQ8N165.

Expressioni

Tissue specificityi

Expressed in liver, kidney, pancreas, spleen, thymus and prostate.1 Publication

Gene expression databases

BgeeiQ8N165.
CleanExiHS_PDIK1L.
ExpressionAtlasiQ8N165. baseline and differential.
GenevisibleiQ8N165. HS.

Organism-specific databases

HPAiHPA064157.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
C1orf174Q8IYL35EBI-6423298,EBI-715898

Protein-protein interaction databases

BioGridi127209. 9 interactions.
IntActiQ8N165. 3 interactions.
STRINGi9606.ENSP00000363387.

Structurei

3D structure databases

ProteinModelPortaliQ8N165.
SMRiQ8N165. Positions 17-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 334327Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0595. Eukaryota.
ENOG410XR01. LUCA.
GeneTreeiENSGT00820000126991.
HOGENOMiHOG000231155.
HOVERGENiHBG056829.
InParanoidiQ8N165.
KOiK17539.
OMAiHRNQIIH.
OrthoDBiEOG76DTSN.
PhylomeDBiQ8N165.
TreeFamiTF105336.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSQPKYDL IREVGRGSYG VVYEAVIRKT SARVAVKKIR CHAPENVELA
60 70 80 90 100
LREFWALSSI KSQHPNVIHL EECILQKDGM VQKMSHGSNS SLYLQLVETS
110 120 130 140 150
LKGEIAFDPR SAYYLWFVMD FCDGGDMNEY LLSRKPNRKT NTSFMLQLSS
160 170 180 190 200
ALAFLHKNQI IHRDLKPDNI LISQTRLDTS DLEPTLKVAD FGLSKVCSAS
210 220 230 240 250
GQNPEEPVSV NKCFLSTACG TDFYMAPEVW EGHYTAKADI FALGIIIWAM
260 270 280 290 300
LERITFIDTE TKKELLGSYV KQGTEIVPVG EALLENPKME LLIPVKKKSM
310 320 330 340
NGRMKQLIKE MLAANPQDRP DAFELELRLV QIAFKDSSWE T
Length:341
Mass (Da):38,546
Last modified:October 1, 2002 - v1
Checksum:i0676FA66CCCA1364
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411102 mRNA. Translation: AAN03661.1.
AK312872 mRNA. Translation: BAG35724.1.
AL391650 Genomic DNA. Translation: CAI17134.1.
AL391650 Genomic DNA. Translation: CAI17135.1.
CH471059 Genomic DNA. Translation: EAX07845.1.
CH471059 Genomic DNA. Translation: EAX07846.1.
CH471059 Genomic DNA. Translation: EAX07847.1.
BC028713 mRNA. Translation: AAH28713.1.
AL834290 mRNA. Translation: CAD38964.1.
CCDSiCCDS274.1.
RefSeqiNP_001230461.1. NM_001243532.1.
NP_001230462.1. NM_001243533.1.
NP_690048.1. NM_152835.4.
XP_005245800.1. XM_005245743.3.
UniGeneiHs.468801.
Hs.736837.

Genome annotation databases

EnsembliENST00000374269; ENSP00000363387; ENSG00000175087.
ENST00000374271; ENSP00000363389; ENSG00000175087.
ENST00000619836; ENSP00000480635; ENSG00000175087.
GeneIDi149420.
KEGGihsa:149420.
UCSCiuc001blj.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411102 mRNA. Translation: AAN03661.1.
AK312872 mRNA. Translation: BAG35724.1.
AL391650 Genomic DNA. Translation: CAI17134.1.
AL391650 Genomic DNA. Translation: CAI17135.1.
CH471059 Genomic DNA. Translation: EAX07845.1.
CH471059 Genomic DNA. Translation: EAX07846.1.
CH471059 Genomic DNA. Translation: EAX07847.1.
BC028713 mRNA. Translation: AAH28713.1.
AL834290 mRNA. Translation: CAD38964.1.
CCDSiCCDS274.1.
RefSeqiNP_001230461.1. NM_001243532.1.
NP_001230462.1. NM_001243533.1.
NP_690048.1. NM_152835.4.
XP_005245800.1. XM_005245743.3.
UniGeneiHs.468801.
Hs.736837.

3D structure databases

ProteinModelPortaliQ8N165.
SMRiQ8N165. Positions 17-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127209. 9 interactions.
IntActiQ8N165. 3 interactions.
STRINGi9606.ENSP00000363387.

PTM databases

iPTMnetiQ8N165.
PhosphoSiteiQ8N165.

Polymorphism and mutation databases

BioMutaiPDIK1L.
DMDMi74762512.

Proteomic databases

MaxQBiQ8N165.
PaxDbiQ8N165.
PRIDEiQ8N165.

Protocols and materials databases

DNASUi149420.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374269; ENSP00000363387; ENSG00000175087.
ENST00000374271; ENSP00000363389; ENSG00000175087.
ENST00000619836; ENSP00000480635; ENSG00000175087.
GeneIDi149420.
KEGGihsa:149420.
UCSCiuc001blj.5. human.

Organism-specific databases

CTDi149420.
GeneCardsiPDIK1L.
HGNCiHGNC:18981. PDIK1L.
HPAiHPA064157.
MIMi610785. gene.
neXtProtiNX_Q8N165.
PharmGKBiPA134959839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0595. Eukaryota.
ENOG410XR01. LUCA.
GeneTreeiENSGT00820000126991.
HOGENOMiHOG000231155.
HOVERGENiHBG056829.
InParanoidiQ8N165.
KOiK17539.
OMAiHRNQIIH.
OrthoDBiEOG76DTSN.
PhylomeDBiQ8N165.
TreeFamiTF105336.

Enzyme and pathway databases

SignaLinkiQ8N165.

Miscellaneous databases

GenomeRNAii149420.
PROiQ8N165.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N165.
CleanExiHS_PDIK1L.
ExpressionAtlasiQ8N165. baseline and differential.
GenevisibleiQ8N165. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human kinase gene, PDIK1L."
    Guo L., Ji C., Gu S., Ying K., Cheng H., Ni X., Liu J., Xie Y., Mao Y.
    J. Genet. 82:27-32(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 134-341.
    Tissue: Lymph node.

Entry informationi

Entry nameiPDK1L_HUMAN
AccessioniPrimary (citable) accession number: Q8N165
Secondary accession number(s): B2R777
, D3DPK2, Q5T2I0, Q8NDB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.