Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8N162

- OR8H2_HUMAN

UniProt

Q8N162 - OR8H2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Olfactory receptor 8H2

Gene

OR8H2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8H2
Alternative name(s):
Olfactory receptor OR11-171
Gene namesi
Name:OR8H2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15308. OR8H2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32768.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 8H2PRO_0000150666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N162.
PRIDEiQ8N162.

PTM databases

PhosphoSiteiQ8N162.

Expressioni

Gene expression databases

CleanExiHS_OR8H2.
GenevestigatoriQ8N162.

Interactioni

Protein-protein interaction databases

BioGridi133421. 1 interaction.
STRINGi9606.ENSP00000323982.

Structurei

3D structure databases

ProteinModelPortaliQ8N162.
SMRiQ8N162. Positions 34-169.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Topological domaini77 – 9923ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini293 – 31220CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45310.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8N162.
KOiK04257.
OMAiFIIVGST.
OrthoDBiEOG71K63J.
PhylomeDBiQ8N162.
TreeFamiTF352753.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N162-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMGRRNNTNV ADFILMGLTL SEEIQMALFM LFLLIYLITM LGNVGMILII
60 70 80 90 100
RLDLQLHTPM YFFLTHLSFI DLSYSTVVTP KTLANLLTSN YISFTGCFAQ
110 120 130 140 150
MFFFAFLGTA ECYLLSSMAH DRYAAICSPL HYTVIMSKRL CLALITGPYV
160 170 180 190 200
IGFIDSFVNV VSMSRLHFYD SNVIHHFFCD TSPILALSCT DTYNTEILIF
210 220 230 240 250
IIVGSTLMVS LFTISASYVF ILFTILKINS TSGKQKAFST CVSHLLGVTI
260 270 280 290 300
FYSTLIFTYL KPRKSYSLGR DQVASVFYTI VIPVLNPLIY SLRNKEVKNA
310
VIRVMQRRQD SR
Length:312
Mass (Da):35,422
Last modified:October 1, 2002 - v1
Checksum:i0D5112EF980EC13E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201H → Y.
Corresponds to variant rs2512961 [ dbSNP | Ensembl ].
VAR_034262
Natural varianti169 – 1691Y → C.
Corresponds to variant rs2449148 [ dbSNP | Ensembl ].
VAR_034263
Natural varianti284 – 2841V → M.
Corresponds to variant rs1842696 [ dbSNP | Ensembl ].
VAR_062060

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065657 Genomic DNA. Translation: BAC05883.1.
AB065845 Genomic DNA. Translation: BAC06063.1.
BK004341 Genomic DNA. Translation: DAA04739.1.
CCDSiCCDS31518.1.
RefSeqiNP_001005200.1. NM_001005200.1.
UniGeneiHs.553744.

Genome annotation databases

EnsembliENST00000313503; ENSP00000323982; ENSG00000181767.
GeneIDi390151.
KEGGihsa:390151.
UCSCiuc010riy.2. human.

Polymorphism databases

DMDMi38372643.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065657 Genomic DNA. Translation: BAC05883.1 .
AB065845 Genomic DNA. Translation: BAC06063.1 .
BK004341 Genomic DNA. Translation: DAA04739.1 .
CCDSi CCDS31518.1.
RefSeqi NP_001005200.1. NM_001005200.1.
UniGenei Hs.553744.

3D structure databases

ProteinModelPortali Q8N162.
SMRi Q8N162. Positions 34-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 133421. 1 interaction.
STRINGi 9606.ENSP00000323982.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8N162.

Polymorphism databases

DMDMi 38372643.

Proteomic databases

PaxDbi Q8N162.
PRIDEi Q8N162.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313503 ; ENSP00000323982 ; ENSG00000181767 .
GeneIDi 390151.
KEGGi hsa:390151.
UCSCi uc010riy.2. human.

Organism-specific databases

CTDi 390151.
GeneCardsi GC11P055872.
HGNCi HGNC:15308. OR8H2.
neXtProti NX_Q8N162.
PharmGKBi PA32768.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45310.
GeneTreei ENSGT00760000118941.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8N162.
KOi K04257.
OMAi FIIVGST.
OrthoDBi EOG71K63J.
PhylomeDBi Q8N162.
TreeFami TF352753.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR8H2.
GenomeRNAii 390151.
NextBioi 103445.
PROi Q8N162.

Gene expression databases

CleanExi HS_OR8H2.
Genevestigatori Q8N162.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR8H2_HUMAN
AccessioniPrimary (citable) accession number: Q8N162
Secondary accession number(s): Q6IFC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3