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Q8N162 (OR8H2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 8H2
Alternative name(s):
Olfactory receptor OR11-171
Gene names
Name:OR8H2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Olfactory receptor 8H2
PRO_0000150666

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 4721Helical; Name=1; Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 9923Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21720Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31220Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant1201H → Y.
Corresponds to variant rs2512961 [ dbSNP | Ensembl ].
VAR_034262
Natural variant1691Y → C.
Corresponds to variant rs2449148 [ dbSNP | Ensembl ].
VAR_034263
Natural variant2841V → M.
Corresponds to variant rs1842696 [ dbSNP | Ensembl ].
VAR_062060

Sequences

Sequence LengthMass (Da)Tools
Q8N162 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 0D5112EF980EC13E

FASTA31235,422
        10         20         30         40         50         60 
MMGRRNNTNV ADFILMGLTL SEEIQMALFM LFLLIYLITM LGNVGMILII RLDLQLHTPM 

        70         80         90        100        110        120 
YFFLTHLSFI DLSYSTVVTP KTLANLLTSN YISFTGCFAQ MFFFAFLGTA ECYLLSSMAH 

       130        140        150        160        170        180 
DRYAAICSPL HYTVIMSKRL CLALITGPYV IGFIDSFVNV VSMSRLHFYD SNVIHHFFCD 

       190        200        210        220        230        240 
TSPILALSCT DTYNTEILIF IIVGSTLMVS LFTISASYVF ILFTILKINS TSGKQKAFST 

       250        260        270        280        290        300 
CVSHLLGVTI FYSTLIFTYL KPRKSYSLGR DQVASVFYTI VIPVLNPLIY SLRNKEVKNA 

       310 
VIRVMQRRQD SR 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065657 Genomic DNA. Translation: BAC05883.1.
AB065845 Genomic DNA. Translation: BAC06063.1.
BK004341 Genomic DNA. Translation: DAA04739.1.
RefSeqNP_001005200.1. NM_001005200.1.
UniGeneHs.553744.

3D structure databases

ProteinModelPortalQ8N162.
SMRQ8N162. Positions 34-169, 278-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid133421. 1 interaction.
STRING9606.ENSP00000323982.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8N162.

Polymorphism databases

DMDM38372643.

Proteomic databases

PaxDbQ8N162.
PRIDEQ8N162.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000313503; ENSP00000323982; ENSG00000181767.
GeneID390151.
KEGGhsa:390151.
UCSCuc010riy.2. human.

Organism-specific databases

CTD390151.
GeneCardsGC11P055872.
HGNCHGNC:15308. OR8H2.
neXtProtNX_Q8N162.
PharmGKBPA32768.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45310.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8N162.
KOK04257.
OMAFIIVGST.
OrthoDBEOG71K63J.
PhylomeDBQ8N162.
TreeFamTF352753.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR8H2.
GenevestigatorQ8N162.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR8H2.
NextBio103445.
PROQ8N162.

Entry information

Entry nameOR8H2_HUMAN
AccessionPrimary (citable) accession number: Q8N162
Secondary accession number(s): Q6IFC1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries