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Protein

Olfactory receptor 8H2

Gene

OR8H2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181767-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8H2
Alternative name(s):
Olfactory receptor OR11-171
Gene namesi
Name:OR8H2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15308. OR8H2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 99ExtracellularSequence analysisAdd BLAST23
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181767.
PharmGKBiPA32768.

Polymorphism and mutation databases

BioMutaiOR8H2.
DMDMi38372643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506661 – 312Olfactory receptor 8H2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N162.
PeptideAtlasiQ8N162.
PRIDEiQ8N162.

PTM databases

iPTMnetiQ8N162.
PhosphoSitePlusiQ8N162.

Expressioni

Gene expression databases

CleanExiHS_OR8H2.
ExpressionAtlasiQ8N162. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi133421. 1 interactor.
STRINGi9606.ENSP00000323982.

Structurei

3D structure databases

ProteinModelPortaliQ8N162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIPE. Eukaryota.
ENOG4111C57. LUCA.
GeneTreeiENSGT00840000129818.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8N162.
KOiK04257.
OMAiFIIVGST.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8N162.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGRRNNTNV ADFILMGLTL SEEIQMALFM LFLLIYLITM LGNVGMILII
60 70 80 90 100
RLDLQLHTPM YFFLTHLSFI DLSYSTVVTP KTLANLLTSN YISFTGCFAQ
110 120 130 140 150
MFFFAFLGTA ECYLLSSMAH DRYAAICSPL HYTVIMSKRL CLALITGPYV
160 170 180 190 200
IGFIDSFVNV VSMSRLHFYD SNVIHHFFCD TSPILALSCT DTYNTEILIF
210 220 230 240 250
IIVGSTLMVS LFTISASYVF ILFTILKINS TSGKQKAFST CVSHLLGVTI
260 270 280 290 300
FYSTLIFTYL KPRKSYSLGR DQVASVFYTI VIPVLNPLIY SLRNKEVKNA
310
VIRVMQRRQD SR
Length:312
Mass (Da):35,422
Last modified:October 1, 2002 - v1
Checksum:i0D5112EF980EC13E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034262120H → Y.Corresponds to variant rs2512961dbSNPEnsembl.1
Natural variantiVAR_034263169Y → C.Corresponds to variant rs2449148dbSNPEnsembl.1
Natural variantiVAR_062060284V → M.Corresponds to variant rs1842696dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065657 Genomic DNA. Translation: BAC05883.1.
AB065845 Genomic DNA. Translation: BAC06063.1.
BK004341 Genomic DNA. Translation: DAA04739.1.
CCDSiCCDS31518.1.
RefSeqiNP_001005200.1. NM_001005200.1.
UniGeneiHs.553744.

Genome annotation databases

EnsembliENST00000313503; ENSP00000323982; ENSG00000181767.
GeneIDi390151.
KEGGihsa:390151.
UCSCiuc010riy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065657 Genomic DNA. Translation: BAC05883.1.
AB065845 Genomic DNA. Translation: BAC06063.1.
BK004341 Genomic DNA. Translation: DAA04739.1.
CCDSiCCDS31518.1.
RefSeqiNP_001005200.1. NM_001005200.1.
UniGeneiHs.553744.

3D structure databases

ProteinModelPortaliQ8N162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133421. 1 interactor.
STRINGi9606.ENSP00000323982.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8N162.
PhosphoSitePlusiQ8N162.

Polymorphism and mutation databases

BioMutaiOR8H2.
DMDMi38372643.

Proteomic databases

PaxDbiQ8N162.
PeptideAtlasiQ8N162.
PRIDEiQ8N162.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313503; ENSP00000323982; ENSG00000181767.
GeneIDi390151.
KEGGihsa:390151.
UCSCiuc010riy.2. human.

Organism-specific databases

CTDi390151.
GeneCardsiOR8H2.
HGNCiHGNC:15308. OR8H2.
neXtProtiNX_Q8N162.
OpenTargetsiENSG00000181767.
PharmGKBiPA32768.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIPE. Eukaryota.
ENOG4111C57. LUCA.
GeneTreeiENSGT00840000129818.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8N162.
KOiK04257.
OMAiFIIVGST.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8N162.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181767-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8H2.
GenomeRNAii390151.
PROiQ8N162.

Gene expression databases

CleanExiHS_OR8H2.
ExpressionAtlasiQ8N162. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR8H2_HUMAN
AccessioniPrimary (citable) accession number: Q8N162
Secondary accession number(s): Q6IFC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.