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Q8N162

- OR8H2_HUMAN

UniProt

Q8N162 - OR8H2_HUMAN

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Protein
Olfactory receptor 8H2
Gene
OR8H2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 8H2
    Alternative name(s):
    Olfactory receptor OR11-171
    Gene namesi
    Name:OR8H2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15308. OR8H2.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei27 – 4721Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini48 – 558Cytoplasmic Reviewed prediction
    Transmembranei56 – 7621Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini77 – 9923Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei100 – 12021Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini121 – 13919Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei140 – 16021Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini161 – 19737Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei198 – 21720Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini218 – 23720Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei238 – 25821Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini259 – 27113Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei272 – 29221Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini293 – 31220Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32768.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 8H2
    PRO_0000150666Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi97 ↔ 189 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8N162.
    PRIDEiQ8N162.

    PTM databases

    PhosphoSiteiQ8N162.

    Expressioni

    Gene expression databases

    CleanExiHS_OR8H2.
    GenevestigatoriQ8N162.

    Interactioni

    Protein-protein interaction databases

    BioGridi133421. 1 interaction.
    STRINGi9606.ENSP00000323982.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N162.
    SMRiQ8N162. Positions 34-169.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45310.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8N162.
    KOiK04257.
    OMAiFIIVGST.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8N162.
    TreeFamiTF352753.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N162-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMGRRNNTNV ADFILMGLTL SEEIQMALFM LFLLIYLITM LGNVGMILII    50
    RLDLQLHTPM YFFLTHLSFI DLSYSTVVTP KTLANLLTSN YISFTGCFAQ 100
    MFFFAFLGTA ECYLLSSMAH DRYAAICSPL HYTVIMSKRL CLALITGPYV 150
    IGFIDSFVNV VSMSRLHFYD SNVIHHFFCD TSPILALSCT DTYNTEILIF 200
    IIVGSTLMVS LFTISASYVF ILFTILKINS TSGKQKAFST CVSHLLGVTI 250
    FYSTLIFTYL KPRKSYSLGR DQVASVFYTI VIPVLNPLIY SLRNKEVKNA 300
    VIRVMQRRQD SR 312
    Length:312
    Mass (Da):35,422
    Last modified:October 1, 2002 - v1
    Checksum:i0D5112EF980EC13E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti120 – 1201H → Y.
    Corresponds to variant rs2512961 [ dbSNP | Ensembl ].
    VAR_034262
    Natural varianti169 – 1691Y → C.
    Corresponds to variant rs2449148 [ dbSNP | Ensembl ].
    VAR_034263
    Natural varianti284 – 2841V → M.
    Corresponds to variant rs1842696 [ dbSNP | Ensembl ].
    VAR_062060

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065657 Genomic DNA. Translation: BAC05883.1.
    AB065845 Genomic DNA. Translation: BAC06063.1.
    BK004341 Genomic DNA. Translation: DAA04739.1.
    CCDSiCCDS31518.1.
    RefSeqiNP_001005200.1. NM_001005200.1.
    UniGeneiHs.553744.

    Genome annotation databases

    EnsembliENST00000313503; ENSP00000323982; ENSG00000181767.
    GeneIDi390151.
    KEGGihsa:390151.
    UCSCiuc010riy.2. human.

    Polymorphism databases

    DMDMi38372643.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065657 Genomic DNA. Translation: BAC05883.1 .
    AB065845 Genomic DNA. Translation: BAC06063.1 .
    BK004341 Genomic DNA. Translation: DAA04739.1 .
    CCDSi CCDS31518.1.
    RefSeqi NP_001005200.1. NM_001005200.1.
    UniGenei Hs.553744.

    3D structure databases

    ProteinModelPortali Q8N162.
    SMRi Q8N162. Positions 34-169.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 133421. 1 interaction.
    STRINGi 9606.ENSP00000323982.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8N162.

    Polymorphism databases

    DMDMi 38372643.

    Proteomic databases

    PaxDbi Q8N162.
    PRIDEi Q8N162.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313503 ; ENSP00000323982 ; ENSG00000181767 .
    GeneIDi 390151.
    KEGGi hsa:390151.
    UCSCi uc010riy.2. human.

    Organism-specific databases

    CTDi 390151.
    GeneCardsi GC11P055872.
    HGNCi HGNC:15308. OR8H2.
    neXtProti NX_Q8N162.
    PharmGKBi PA32768.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45310.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8N162.
    KOi K04257.
    OMAi FIIVGST.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8N162.
    TreeFami TF352753.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR8H2.
    NextBioi 103445.
    PROi Q8N162.

    Gene expression databases

    CleanExi HS_OR8H2.
    Genevestigatori Q8N162.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR8H2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N162
    Secondary accession number(s): Q6IFC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: September 3, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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