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Protein

Glypican-2

Gene

GPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-HSA-2022928. HS-GAG biosynthesis.
R-HSA-2024096. HS-GAG degradation.
R-HSA-3560783. Defective B4GALT7 causes EDS, progeroid type.
R-HSA-3560801. Defective B3GAT3 causes JDSSDHD.
R-HSA-3656237. Defective EXT2 causes exostoses 2.
R-HSA-3656253. Defective EXT1 causes exostoses 1, TRPS2 and CHDS.
R-HSA-4420332. Defective B3GALT6 causes EDSP2 and SEMDJL1.
R-HSA-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-2
Cleaved into the following chain:
Gene namesi
Name:GPC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:4450. GPC2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28831.

Polymorphism and mutation databases

BioMutaiGPC2.
DMDMi60390116.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 554531Glypican-2PRO_0000012303Add
BLAST
Chaini24 – ?Secreted glypican-2PRO_0000333841
Propeptidei555 – 57925Removed in mature formSequence analysisPRO_0000012304Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551O-linked (Xyl...) (heparan sulfate)Sequence analysis
Glycosylationi92 – 921O-linked (Xyl...) (heparan sulfate)Sequence analysis
Glycosylationi155 – 1551O-linked (Xyl...) (heparan sulfate)Sequence analysis
Glycosylationi500 – 5001O-linked (Xyl...) (heparan sulfate)Sequence analysis
Glycosylationi502 – 5021O-linked (Xyl...) (heparan sulfate)Sequence analysis
Lipidationi554 – 5541GPI-anchor amidated glycineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

Proteomic databases

EPDiQ8N158.
PaxDbiQ8N158.
PeptideAtlasiQ8N158.
PRIDEiQ8N158.

PTM databases

iPTMnetiQ8N158.
PhosphoSiteiQ8N158.

Expressioni

Gene expression databases

BgeeiENSG00000213420.
CleanExiHS_GPC2.
ExpressionAtlasiQ8N158. baseline and differential.
GenevisibleiQ8N158. HS.

Organism-specific databases

HPAiCAB025423.

Interactioni

Protein-protein interaction databases

MINTiMINT-4721926.
STRINGi9606.ENSP00000292377.

Structurei

3D structure databases

ProteinModelPortaliQ8N158.
SMRiQ8N158. Positions 29-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000253003.
HOVERGENiHBG003464.
InParanoidiQ8N158.
KOiK08108.
OMAiAAPCWTG.
OrthoDBiEOG091G06T6.
PhylomeDBiQ8N158.
TreeFamiTF105317.

Family and domain databases

InterProiIPR001863. Glypican.
IPR031181. Glypican-2.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF24. PTHR10822:SF24. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALRPLLLL LLPLCPGPGP GPGSEAKVTR SCAETRQVLG ARGYSLNLIP
60 70 80 90 100
PALISGEHLR VCPQEYTCCS SETEQRLIRE TEATFRGLVE DSGSFLVHTL
110 120 130 140 150
AARHRKFDEF FLEMLSVAQH SLTQLFSHSY GRLYAQHALI FNGLFSRLRD
160 170 180 190 200
FYGESGEGLD DTLADFWAQL LERVFPLLHP QYSFPPDYLL CLSRLASSTD
210 220 230 240 250
GSLQPFGDSP RRLRLQITRT LVAARAFVQG LETGRNVVSE ALKVPVSEGC
260 270 280 290 300
SQALMRLIGC PLCRGVPSLM PCQGFCLNVV RGCLSSRGLE PDWGNYLDGL
310 320 330 340 350
LILADKLQGP FSFELTAESI GVKISEGLMY LQENSAKVSA QVFQECGPPD
360 370 380 390 400
PVPARNRRAP PPREEAGRLW SMVTEEERPT TAAGTNLHRL VWELRERLAR
410 420 430 440 450
MRGFWARLSL TVCGDSRMAA DASLEAAPCW TGAGRGRYLP PVVGGSPAEQ
460 470 480 490 500
VNNPELKVDA SGPDVPTRRR RLQLRAATAR MKTAALGHDL DGQDADEDAS
510 520 530 540 550
GSGGGQQYAD DWMAGAVAPP ARPPRPPYPP RRDGSGGKGG GGSARYNQGR
560 570
SRSGGASIGF HTQTILILSL SALALLGPR
Length:579
Mass (Da):62,830
Last modified:October 1, 2002 - v1
Checksum:i1630E3A22BB83DFA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti200 – 2001D → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_036045

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096281 mRNA. Translation: BAC04745.1.
AL834418 mRNA. Translation: CAD39080.1.
CH236956 Genomic DNA. Translation: EAL23846.1.
CH471091 Genomic DNA. Translation: EAW76578.1.
BC027972 mRNA. Translation: AAH27972.1.
CCDSiCCDS5689.1.
RefSeqiNP_689955.1. NM_152742.2.
UniGeneiHs.211701.

Genome annotation databases

EnsembliENST00000292377; ENSP00000292377; ENSG00000213420.
GeneIDi221914.
KEGGihsa:221914.
UCSCiuc003utv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096281 mRNA. Translation: BAC04745.1.
AL834418 mRNA. Translation: CAD39080.1.
CH236956 Genomic DNA. Translation: EAL23846.1.
CH471091 Genomic DNA. Translation: EAW76578.1.
BC027972 mRNA. Translation: AAH27972.1.
CCDSiCCDS5689.1.
RefSeqiNP_689955.1. NM_152742.2.
UniGeneiHs.211701.

3D structure databases

ProteinModelPortaliQ8N158.
SMRiQ8N158. Positions 29-489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4721926.
STRINGi9606.ENSP00000292377.

PTM databases

iPTMnetiQ8N158.
PhosphoSiteiQ8N158.

Polymorphism and mutation databases

BioMutaiGPC2.
DMDMi60390116.

Proteomic databases

EPDiQ8N158.
PaxDbiQ8N158.
PeptideAtlasiQ8N158.
PRIDEiQ8N158.

Protocols and materials databases

DNASUi221914.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292377; ENSP00000292377; ENSG00000213420.
GeneIDi221914.
KEGGihsa:221914.
UCSCiuc003utv.3. human.

Organism-specific databases

CTDi221914.
GeneCardsiGPC2.
H-InvDBHIX0078872.
HGNCiHGNC:4450. GPC2.
HPAiCAB025423.
neXtProtiNX_Q8N158.
PharmGKBiPA28831.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000253003.
HOVERGENiHBG003464.
InParanoidiQ8N158.
KOiK08108.
OMAiAAPCWTG.
OrthoDBiEOG091G06T6.
PhylomeDBiQ8N158.
TreeFamiTF105317.

Enzyme and pathway databases

ReactomeiR-HSA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-HSA-2022928. HS-GAG biosynthesis.
R-HSA-2024096. HS-GAG degradation.
R-HSA-3560783. Defective B4GALT7 causes EDS, progeroid type.
R-HSA-3560801. Defective B3GAT3 causes JDSSDHD.
R-HSA-3656237. Defective EXT2 causes exostoses 2.
R-HSA-3656253. Defective EXT1 causes exostoses 1, TRPS2 and CHDS.
R-HSA-4420332. Defective B3GALT6 causes EDSP2 and SEMDJL1.
R-HSA-975634. Retinoid metabolism and transport.

Miscellaneous databases

GeneWikiiGlypican_2.
GenomeRNAii221914.
PROiQ8N158.

Gene expression databases

BgeeiENSG00000213420.
CleanExiHS_GPC2.
ExpressionAtlasiQ8N158. baseline and differential.
GenevisibleiQ8N158. HS.

Family and domain databases

InterProiIPR001863. Glypican.
IPR031181. Glypican-2.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF24. PTHR10822:SF24. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPC2_HUMAN
AccessioniPrimary (citable) accession number: Q8N158
Secondary accession number(s): A4D2A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.