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Protein

Olfactory receptor 6V1

Gene

OR6V1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6V1
Alternative name(s):
Olfactory receptor OR7-3
Gene namesi
Name:OR6V1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000225781.1.
HGNCiHGNC:15090. OR6V1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 215Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 269ExtracellularSequence analysisAdd BLAST13
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 313CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32607.

Polymorphism and mutation databases

BioMutaiOR6V1.
DMDMi38372642.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506391 – 313Olfactory receptor 6V1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N148.
PRIDEiQ8N148.

PTM databases

iPTMnetiQ8N148.
PhosphoSitePlusiQ8N148.

Expressioni

Gene expression databases

BgeeiENSG00000225781.
CleanExiHS_OR6V1.
ExpressionAtlasiQ8N148. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000396085.

Structurei

3D structure databases

ProteinModelPortaliQ8N148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG0S. Eukaryota.
ENOG41117GC. LUCA.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8N148.
KOiK04257.
OMAiRLLEFWD.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8N148.
TreeFamiTF336833.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N148-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLSQPSEF VLLGFSSFGE LQALLYGPFL MLYLLAFMGN TIIIVMVIAD
60 70 80 90 100
THLHTPMYFF LGNFSLLEIL VTMTAVPRML SDLLVPHKVI TFTGCMVQFY
110 120 130 140 150
FHFSLGSTSF LILTDMALDR FVAICHPLRY GTLMSRAMCV QLAGAAWAAP
160 170 180 190 200
FLAMVPTVLS RAHLDYCHGD VINHFFCDNE PLLQLSCSDT RLLEFWDFLM
210 220 230 240 250
ALTFVLSSFL VTLISYGYIV TTVLRIPSAS SCQKAFSTCG SHLTLVFIGY
260 270 280 290 300
SSTIFLYVRP GKAHSVQVRK VVALVTSVLT PFLNPFILTF CNQTVKTVLQ
310
GQMQRLKGLC KAQ
Length:313
Mass (Da):34,902
Last modified:October 1, 2002 - v1
Checksum:i2BA8B7A3A74048EF
GO

Sequence cautioni

The sequence DAA04790 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034251237S → F. Corresponds to variant dbSNP:rs10245778Ensembl.1
Natural variantiVAR_034252269R → K. Corresponds to variant dbSNP:rs7791886Ensembl.1
Natural variantiVAR_034253295V → A. Corresponds to variant dbSNP:rs7779316Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065697 Genomic DNA. Translation: BAC05920.1.
AB065873 Genomic DNA. Translation: BAC06091.1.
AC099652 Genomic DNA. No translation available.
CH236959 Genomic DNA. Translation: EAL23780.1.
CH471198 Genomic DNA. Translation: EAW51889.1.
BC137044 mRNA. Translation: AAI37045.1.
BK004392 Genomic DNA. Translation: DAA04790.1. Different initiation.
CCDSiCCDS47728.1.
RefSeqiNP_001001667.1. NM_001001667.1.
UniGeneiHs.554721.

Genome annotation databases

EnsembliENST00000418316; ENSP00000396085; ENSG00000225781.
ENST00000615548; ENSP00000483439; ENSG00000277378.
GeneIDi346517.
KEGGihsa:346517.
UCSCiuc011ksv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR6V1_HUMAN
AccessioniPrimary (citable) accession number: Q8N148
Secondary accession number(s): A4D2I0, B9EH48, Q6IF70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families