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Protein

Olfactory receptor 8H3

Gene

OR8H3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8H3
Alternative name(s):
Olfactory receptor OR11-172
Gene namesi
Name:OR8H3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15309. OR8H3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence analysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence analysis
Transmembranei56 – 7621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini77 – 9923ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31220CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32769.

Polymorphism and mutation databases

BioMutaiOR8H3.
DMDMi38372641.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 8H3PRO_0000150667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N146.
PRIDEiQ8N146.

Expressioni

Gene expression databases

CleanExiHS_OR8H3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323928.

Structurei

3D structure databases

ProteinModelPortaliQ8N146.
SMRiQ8N146. Positions 34-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIPE. Eukaryota.
ENOG4111C57. LUCA.
GeneTreeiENSGT00840000129818.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8N146.
KOiK04257.
OMAiDTHDIEX.
OrthoDBiEOG71K63J.
PhylomeDBiQ8N146.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N146-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGRRNDTNV ADFILTGLSD SEEVQMALFM LFLLIYLITM LGNVGMLLII
60 70 80 90 100
RLDLQLHTPM YFFLTHLSFI DLSYSTVVTP KTLANLLTSN YISFTGCFAQ
110 120 130 140 150
MFCFVFLGTA ECYLLSSMAY DRYAAICSPL HYTVIMPKRL CLALITGPYV
160 170 180 190 200
IGFMDSFVNV VSMSRLHFCD SNIIHHFFCD TSPILALSCT DTDNTEMLIF
210 220 230 240 250
IIAGSTLMVS LITISASYVS ILSTILKINS TSGKQKAFST CVSHLLGVTI
260 270 280 290 300
FYGTMIFTYL KPRKSYSLGR DQVAPVFYTI VIPMLNPLIY SLRNREVKNA
310
LIRVMQRRQD SR
Length:312
Mass (Da):35,219
Last modified:October 1, 2002 - v1
Checksum:i328AC0E2BC8DCDD1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471L → I.
Corresponds to variant rs7107077 [ dbSNP | Ensembl ].
VAR_060012
Natural varianti137 – 1371P → S.
Corresponds to variant rs1842691 [ dbSNP | Ensembl ].
VAR_034264
Natural varianti201 – 2011I → V.
Corresponds to variant rs17531522 [ dbSNP | Ensembl ].
VAR_024122
Natural varianti295 – 2951R → K.
Corresponds to variant rs11606538 [ dbSNP | Ensembl ].
VAR_034265

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065658 Genomic DNA. Translation: BAC05884.1.
AB065840 Genomic DNA. Translation: BAC06059.1.
BK004345 Genomic DNA. Translation: DAA04743.1.
CCDSiCCDS31519.1.
RefSeqiNP_001005201.1. NM_001005201.1.
UniGeneiHs.553745.

Genome annotation databases

EnsembliENST00000313472; ENSP00000323928; ENSG00000181761.
GeneIDi390152.
KEGGihsa:390152.
UCSCiuc001nii.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065658 Genomic DNA. Translation: BAC05884.1.
AB065840 Genomic DNA. Translation: BAC06059.1.
BK004345 Genomic DNA. Translation: DAA04743.1.
CCDSiCCDS31519.1.
RefSeqiNP_001005201.1. NM_001005201.1.
UniGeneiHs.553745.

3D structure databases

ProteinModelPortaliQ8N146.
SMRiQ8N146. Positions 34-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323928.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR8H3.
DMDMi38372641.

Proteomic databases

PaxDbiQ8N146.
PRIDEiQ8N146.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313472; ENSP00000323928; ENSG00000181761.
GeneIDi390152.
KEGGihsa:390152.
UCSCiuc001nii.1. human.

Organism-specific databases

CTDi390152.
GeneCardsiOR8H3.
HGNCiHGNC:15309. OR8H3.
neXtProtiNX_Q8N146.
PharmGKBiPA32769.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIPE. Eukaryota.
ENOG4111C57. LUCA.
GeneTreeiENSGT00840000129818.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8N146.
KOiK04257.
OMAiDTHDIEX.
OrthoDBiEOG71K63J.
PhylomeDBiQ8N146.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8H3.
GenomeRNAii390152.
NextBioi103449.
PROiQ8N146.

Gene expression databases

CleanExiHS_OR8H3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR8H3_HUMAN
AccessioniPrimary (citable) accession number: Q8N146
Secondary accession number(s): Q6IFB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.