Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat LGI family member 3

Gene

LGI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May participate in the regulation of neuronal exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis

Enzyme and pathway databases

ReactomeiR-HSA-5682910. LGI-ADAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat LGI family member 3
Alternative name(s):
LGI1-like protein 4
Leucine-rich glioma-inactivated protein 3
Gene namesi
Name:LGI3
Synonyms:LGIL4
ORF Names:UNQ8190/PRO23199
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18711. LGI3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Secreted, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38655.

Polymorphism and mutation databases

BioMutaiLGI3.
DMDMi32469742.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 548518Leucine-rich repeat LGI family member 3PRO_0000017710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis
Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N145.
PRIDEiQ8N145.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in brain and lung.1 Publication

Gene expression databases

BgeeiQ8N145.
CleanExiHS_LGI3.
ExpressionAtlasiQ8N145. baseline and differential.
GenevisibleiQ8N145. HS.

Organism-specific databases

HPAiHPA024826.

Interactioni

Subunit structurei

Interacts with STX1A.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000302297.

Structurei

3D structure databases

ProteinModelPortaliQ8N145.
SMRiQ8N145. Positions 39-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 6434LRRNTAdd
BLAST
Repeati89 – 11022LRR 1Add
BLAST
Repeati113 – 13422LRR 2Add
BLAST
Repeati137 – 15822LRR 3Add
BLAST
Domaini170 – 22051LRRCTAdd
BLAST
Repeati221 – 26444EAR 1Add
BLAST
Repeati267 – 31044EAR 2Add
BLAST
Repeati313 – 36149EAR 3Add
BLAST
Repeati362 – 40645EAR 4Add
BLAST
Repeati409 – 45345EAR 5Add
BLAST
Repeati454 – 49744EAR 6Add
BLAST
Repeati500 – 54344EAR 7Add
BLAST

Sequence similaritiesi

Contains 7 EAR repeats.PROSITE-ProRule annotation
Contains 3 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJD3. Eukaryota.
ENOG4110HT0. LUCA.
GeneTreeiENSGT00840000129728.
HOGENOMiHOG000286015.
HOVERGENiHBG036744.
InParanoidiQ8N145.
KOiK19999.
OMAiTLGFCLM.
OrthoDBiEOG78SQHH.
PhylomeDBiQ8N145.
TreeFamiTF333155.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view]
PfamiPF03736. EPTP. 7 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50912. EAR. 7 hits.
PS51450. LRR. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N145-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGLRARGGP GPGLLALSAL GFCLMLQVSA KRPPKTPPCP PSCSCTRDTA
60 70 80 90 100
FCVDSKAVPR NLPSEVISLT LVNAAFSEIQ DGAFSHLPLL QFLLLNSNKF
110 120 130 140 150
TLIGDNAFTG LSHLQYLFIE NNDIWALSKF TFRGLKSLTH LSLANNNLQT
160 170 180 190 200
LPRDIFRPLD ILNDLDLRGN SLNCDCKVKW LVEWLAHTNT TVAPIYCASP
210 220 230 240 250
PRFQEHKVQD LPLREFDCIT TDFVLYQTLA FPAVSAEPFL YSSDLYLALA
260 270 280 290 300
QPGVSACTIL KWDYVERQLR DYDRIPAPSA VHCKPMVVDS QLYVVVAQLF
310 320 330 340 350
GGSYIYHWDP NTTRFTRLQD IDPQRVRKPN DLEAFRIDGD WYFAVADSSK
360 370 380 390 400
AGATSLYRWH QNGFYSHQAL HPWHRDTDLE FVDGEGKPRL IVSSSSQAPV
410 420 430 440 450
IYQWSRTQKQ FVAQGEVTQV PDAQAVKHFR AGRDSYLCLS RYIGDSKILR
460 470 480 490 500
WEGTRFSEVQ ALPSRGSLAL QPFLVGGRRY LALGSDFSFT QIYQWDEGRQ
510 520 530 540
KFVRFQELAV QAPRAFCYMP AGDAQLLLAP SFKGQTLVYR HIVVDLSA
Length:548
Mass (Da):61,704
Last modified:October 1, 2002 - v1
Checksum:i32FE6EABA184E47B
GO
Isoform 2 (identifier: Q8N145-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-140: Missing.

Note: No experimental confirmation available.
Show »
Length:524
Mass (Da):58,871
Checksum:iA7526C577252D8E6
GO

Sequence cautioni

The sequence BAC03553.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti509 – 5091A → V in AAQ88483 (PubMed:12975309).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti524 – 5241A → T.
Corresponds to variant rs34112456 [ dbSNP | Ensembl ].
VAR_053488

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei117 – 14024Missing in isoform 2. 1 PublicationVSP_056297Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467956 mRNA. Translation: AAM49554.1.
AJ487961 mRNA. Translation: CAD32308.1.
AJ487518 mRNA. Translation: CAD31786.1.
AY358116 mRNA. Translation: AAQ88483.1.
AK090946 mRNA. Translation: BAC03553.1. Different initiation.
AC105206 Genomic DNA. No translation available.
BC042542 mRNA. Translation: AAH42542.1.
BC142997 mRNA. Translation: AAI42998.1.
CCDSiCCDS6025.1. [Q8N145-1]
RefSeqiNP_644807.1. NM_139278.2. [Q8N145-1]
UniGeneiHs.33470.

Genome annotation databases

EnsembliENST00000306317; ENSP00000302297; ENSG00000168481. [Q8N145-1]
ENST00000424267; ENSP00000399121; ENSG00000168481. [Q8N145-2]
GeneIDi203190.
KEGGihsa:203190.
UCSCiuc003xav.4. human. [Q8N145-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467956 mRNA. Translation: AAM49554.1.
AJ487961 mRNA. Translation: CAD32308.1.
AJ487518 mRNA. Translation: CAD31786.1.
AY358116 mRNA. Translation: AAQ88483.1.
AK090946 mRNA. Translation: BAC03553.1. Different initiation.
AC105206 Genomic DNA. No translation available.
BC042542 mRNA. Translation: AAH42542.1.
BC142997 mRNA. Translation: AAI42998.1.
CCDSiCCDS6025.1. [Q8N145-1]
RefSeqiNP_644807.1. NM_139278.2. [Q8N145-1]
UniGeneiHs.33470.

3D structure databases

ProteinModelPortaliQ8N145.
SMRiQ8N145. Positions 39-274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302297.

Polymorphism and mutation databases

BioMutaiLGI3.
DMDMi32469742.

Proteomic databases

PaxDbiQ8N145.
PRIDEiQ8N145.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306317; ENSP00000302297; ENSG00000168481. [Q8N145-1]
ENST00000424267; ENSP00000399121; ENSG00000168481. [Q8N145-2]
GeneIDi203190.
KEGGihsa:203190.
UCSCiuc003xav.4. human. [Q8N145-1]

Organism-specific databases

CTDi203190.
GeneCardsiLGI3.
HGNCiHGNC:18711. LGI3.
HPAiHPA024826.
MIMi608302. gene.
neXtProtiNX_Q8N145.
PharmGKBiPA38655.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJD3. Eukaryota.
ENOG4110HT0. LUCA.
GeneTreeiENSGT00840000129728.
HOGENOMiHOG000286015.
HOVERGENiHBG036744.
InParanoidiQ8N145.
KOiK19999.
OMAiTLGFCLM.
OrthoDBiEOG78SQHH.
PhylomeDBiQ8N145.
TreeFamiTF333155.

Enzyme and pathway databases

ReactomeiR-HSA-5682910. LGI-ADAM interactions.

Miscellaneous databases

ChiTaRSiLGI3. human.
GenomeRNAii203190.
NextBioi35462273.
PROiQ8N145.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N145.
CleanExiHS_LGI3.
ExpressionAtlasiQ8N145. baseline and differential.
GenevisibleiQ8N145. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR011041. Quinoprot_gluc/sorb_DH.
[Graphical view]
PfamiPF03736. EPTP. 7 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50912. EAR. 7 hits.
PS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins."
    Gu W., Wevers A., Schroder H., Grzeschik K.H., Derst C., Brodtkorb E., de Vos R., Steinlein O.K.
    FEBS Lett. 519:71-76(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "A common protein interaction domain links two recently identified epilepsy genes."
    Scheel H., Tomiuk S., Hofmann K.
    Hum. Mol. Genet. 11:1757-1762(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders."
    Staub E., Perez-Tur J., Siebert R., Nobile C., Moschonas N.K., Deloukas P., Hinzmann B.
    Trends Biochem. Sci. 27:441-444(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 131-548 (ISOFORM 1).
    Tissue: Amygdala.
  6. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiLGI3_HUMAN
AccessioniPrimary (citable) accession number: Q8N145
Secondary accession number(s): A5PLP2, Q86TL4, Q8N296
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.