ID   BCL6B_HUMAN             Reviewed;         479 AA.
AC   Q8N143; Q6PCB4;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   27-MAR-2024, entry version 160.
DE   RecName: Full=B-cell CLL/lymphoma 6 member B protein;
DE   AltName: Full=Bcl6-associated zinc finger protein;
DE   AltName: Full=Zinc finger protein 62;
GN   Name=BCL6B; Synonyms=BAZF, ZNF62;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=11855826; DOI=10.1006/bbrc.2002.6481;
RA   Sakashita C., Fukuda T., Okabe S., Kobayashi H., Hirosawa S., Tokuhisa T.,
RA   Miyasaka N., Miura O., Miki T.;
RT   "Cloning and characterization of the human BAZF gene, a homologue of the
RT   BCL6 oncogene.";
RL   Biochem. Biophys. Res. Commun. 291:567-573(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Acts as a sequence-specific transcriptional repressor in
CC       association with BCL6. May function in a narrow stage or be related to
CC       some events in the early B-cell development.
CC       {ECO:0000269|PubMed:11855826}.
CC   -!- SUBUNIT: Associates with BCL6 through the BTB domain. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed with higher expression found
CC       in heart and placenta. {ECO:0000269|PubMed:11855826}.
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DR   EMBL; AB076580; BAC00962.1; -; mRNA.
DR   EMBL; AB076581; BAC00963.1; -; Genomic_DNA.
DR   EMBL; AC040977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC059404; AAH59404.1; -; mRNA.
DR   CCDS; CCDS42248.1; -.
DR   PIR; JC7812; JC7812.
DR   RefSeq; NP_862827.1; NM_181844.3.
DR   AlphaFoldDB; Q8N143; -.
DR   SMR; Q8N143; -.
DR   BioGRID; 129125; 33.
DR   IntAct; Q8N143; 2.
DR   STRING; 9606.ENSP00000293805; -.
DR   iPTMnet; Q8N143; -.
DR   PhosphoSitePlus; Q8N143; -.
DR   BioMuta; BCL6B; -.
DR   DMDM; 296434409; -.
DR   jPOST; Q8N143; -.
DR   MassIVE; Q8N143; -.
DR   PaxDb; 9606-ENSP00000293805; -.
DR   PeptideAtlas; Q8N143; -.
DR   ProteomicsDB; 71552; -.
DR   TopDownProteomics; Q8N143; -.
DR   Antibodypedia; 23875; 97 antibodies from 23 providers.
DR   DNASU; 255877; -.
DR   Ensembl; ENST00000293805.10; ENSP00000293805.5; ENSG00000161940.11.
DR   GeneID; 255877; -.
DR   KEGG; hsa:255877; -.
DR   MANE-Select; ENST00000293805.10; ENSP00000293805.5; NM_181844.4; NP_862827.2.
DR   UCSC; uc010clt.2; human.
DR   AGR; HGNC:1002; -.
DR   CTD; 255877; -.
DR   DisGeNET; 255877; -.
DR   GeneCards; BCL6B; -.
DR   HGNC; HGNC:1002; BCL6B.
DR   HPA; ENSG00000161940; Low tissue specificity.
DR   MIM; 608992; gene.
DR   neXtProt; NX_Q8N143; -.
DR   OpenTargets; ENSG00000161940; -.
DR   PharmGKB; PA25313; -.
DR   VEuPathDB; HostDB:ENSG00000161940; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000159844; -.
DR   HOGENOM; CLU_024196_2_0_1; -.
DR   InParanoid; Q8N143; -.
DR   OMA; VCGARFN; -.
DR   OrthoDB; 5352496at2759; -.
DR   PhylomeDB; Q8N143; -.
DR   TreeFam; TF330912; -.
DR   PathwayCommons; Q8N143; -.
DR   SignaLink; Q8N143; -.
DR   BioGRID-ORCS; 255877; 10 hits in 1213 CRISPR screens.
DR   GenomeRNAi; 255877; -.
DR   Pharos; Q8N143; Tbio.
DR   PRO; PR:Q8N143; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q8N143; Protein.
DR   Bgee; ENSG00000161940; Expressed in upper lobe of left lung and 148 other cell types or tissues.
DR   ExpressionAtlas; Q8N143; baseline and differential.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR   GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR46105; AGAP004733-PA; 1.
DR   PANTHER; PTHR46105:SF16; BCL6B TRANSCRIPTION REPRESSOR; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
DR   Genevisible; Q8N143; HS.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..479
FT                   /note="B-cell CLL/lymphoma 6 member B protein"
FT                   /id="PRO_0000047100"
FT   DOMAIN          38..105
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   ZN_FING         328..350
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         356..378
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         384..406
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         412..434
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         440..463
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          143..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..165
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        244
FT                   /note="S -> SS (in Ref. 1; BAC00962/BAC00963 and 3;
FT                   AAH59404)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        306
FT                   /note="C -> S (in Ref. 3; AAH59404)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   479 AA;  51531 MW;  AB04E3331A7DB8E6 CRC64;
     MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR AHKAVLIACS
     GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR LRLSPATAPA VLAAATYLQM
     EHVVQACHRF IQASYEPLGI SLRPLEAEPP TPPTAPPPGS PRRSEGHPDP PTESRSCSQG
     PPSPASPDPK ACNWKKYKYI VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS
     SSSSEEGPIP GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF
     FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH TGEKPYHCSI
     CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR AHVLIHTGEK PYPCPTCGTR
     FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR HKSQLRLHLR QKHGAATNTK VHYHILGGP
//