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Protein

B-cell CLL/lymphoma 6 member B protein

Gene

BCL6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri328 – 35023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46324C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 6 member B protein
Alternative name(s):
Bcl6-associated zinc finger protein
Zinc finger protein 62
Gene namesi
Name:BCL6B
Synonyms:BAZF, ZNF62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:1002. BCL6B.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25313.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479B-cell CLL/lymphoma 6 member B proteinPRO_0000047100Add
BLAST

Proteomic databases

PaxDbiQ8N143.
PRIDEiQ8N143.

PTM databases

PhosphoSiteiQ8N143.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression found in heart and placenta.1 Publication

Gene expression databases

BgeeiQ8N143.
CleanExiHS_BCL6B.
ExpressionAtlasiQ8N143. baseline and differential.
GenevestigatoriQ8N143.

Organism-specific databases

HPAiHPA059147.

Interactioni

Subunit structurei

Associates with BCL6 through the BTB domain.By similarity

Protein-protein interaction databases

BioGridi129125. 19 interactions.
STRINGi9606.ENSP00000293805.

Structurei

3D structure databases

ProteinModelPortaliQ8N143.
SMRiQ8N143. Positions 16-134, 325-460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 10568BTBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi144 – 18946Pro-richAdd
BLAST
Compositional biasi234 – 24411Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri328 – 35023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46324C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121934.
HOVERGENiHBG004831.
InParanoidiQ8N143.
OMAiELDKMAC.
OrthoDBiEOG7KQ22S.
PhylomeDBiQ8N143.
TreeFamiTF330912.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N143-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR
60 70 80 90 100
AHKAVLIACS GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR
110 120 130 140 150
LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPLEAEPP
160 170 180 190 200
TPPTAPPPGS PRRSEGHPDP PTESRSCSQG PPSPASPDPK ACNWKKYKYI
210 220 230 240 250
VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS SSSSEEGPIP
260 270 280 290 300
GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF
310 320 330 340 350
FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH
360 370 380 390 400
TGEKPYHCSI CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR
410 420 430 440 450
AHVLIHTGEK PYPCPTCGTR FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR
460 470
HKSQLRLHLR QKHGAATNTK VHYHILGGP
Length:479
Mass (Da):51,531
Last modified:May 18, 2010 - v2
Checksum:iAB04E3331A7DB8E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti244 – 2441S → SS in BAC00962. (PubMed:11855826)Curated
Sequence conflicti244 – 2441S → SS in BAC00963. (PubMed:11855826)Curated
Sequence conflicti244 – 2441S → SS in AAH59404. (PubMed:15489334)Curated
Sequence conflicti306 – 3061C → S in AAH59404. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076580 mRNA. Translation: BAC00962.1.
AB076581 Genomic DNA. Translation: BAC00963.1.
AC040977 Genomic DNA. No translation available.
BC059404 mRNA. Translation: AAH59404.1.
PIRiJC7812.
RefSeqiNP_862827.1. NM_181844.3.
UniGeneiHs.22575.

Genome annotation databases

EnsembliENST00000293805; ENSP00000293805; ENSG00000161940.
GeneIDi255877.
KEGGihsa:255877.
UCSCiuc002geg.2. human.

Polymorphism databases

DMDMi296434409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076580 mRNA. Translation: BAC00962.1.
AB076581 Genomic DNA. Translation: BAC00963.1.
AC040977 Genomic DNA. No translation available.
BC059404 mRNA. Translation: AAH59404.1.
PIRiJC7812.
RefSeqiNP_862827.1. NM_181844.3.
UniGeneiHs.22575.

3D structure databases

ProteinModelPortaliQ8N143.
SMRiQ8N143. Positions 16-134, 325-460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129125. 19 interactions.
STRINGi9606.ENSP00000293805.

PTM databases

PhosphoSiteiQ8N143.

Polymorphism databases

DMDMi296434409.

Proteomic databases

PaxDbiQ8N143.
PRIDEiQ8N143.

Protocols and materials databases

DNASUi255877.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293805; ENSP00000293805; ENSG00000161940.
GeneIDi255877.
KEGGihsa:255877.
UCSCiuc002geg.2. human.

Organism-specific databases

CTDi255877.
GeneCardsiGC17P006926.
HGNCiHGNC:1002. BCL6B.
HPAiHPA059147.
MIMi608992. gene.
neXtProtiNX_Q8N143.
PharmGKBiPA25313.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121934.
HOVERGENiHBG004831.
InParanoidiQ8N143.
OMAiELDKMAC.
OrthoDBiEOG7KQ22S.
PhylomeDBiQ8N143.
TreeFamiTF330912.

Miscellaneous databases

GenomeRNAii255877.
NextBioi92672.
PROiQ8N143.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N143.
CleanExiHS_BCL6B.
ExpressionAtlasiQ8N143. baseline and differential.
GenevestigatoriQ8N143.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene."
    Sakashita C., Fukuda T., Okabe S., Kobayashi H., Hirosawa S., Tokuhisa T., Miyasaka N., Miura O., Miki T.
    Biochem. Biophys. Res. Commun. 291:567-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiBCL6B_HUMAN
AccessioniPrimary (citable) accession number: Q8N143
Secondary accession number(s): Q6PCB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 18, 2010
Last modified: February 4, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.