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Q8N143

- BCL6B_HUMAN

UniProt

Q8N143 - BCL6B_HUMAN

Protein

B-cell CLL/lymphoma 6 member B protein

Gene

BCL6B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri328 – 35023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri356 – 37823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri384 – 40623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri412 – 43423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri440 – 46324C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B-cell CLL/lymphoma 6 member B protein
    Alternative name(s):
    Bcl6-associated zinc finger protein
    Zinc finger protein 62
    Gene namesi
    Name:BCL6B
    Synonyms:BAZF, ZNF62
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:1002. BCL6B.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25313.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479B-cell CLL/lymphoma 6 member B proteinPRO_0000047100Add
    BLAST

    Proteomic databases

    PaxDbiQ8N143.
    PRIDEiQ8N143.

    PTM databases

    PhosphoSiteiQ8N143.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed with higher expression found in heart and placenta.1 Publication

    Gene expression databases

    ArrayExpressiQ8N143.
    BgeeiQ8N143.
    CleanExiHS_BCL6B.
    GenevestigatoriQ8N143.

    Organism-specific databases

    HPAiHPA059147.

    Interactioni

    Subunit structurei

    Associates with BCL6 through the BTB domain.By similarity

    Protein-protein interaction databases

    BioGridi129125. 6 interactions.
    STRINGi9606.ENSP00000293805.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N143.
    SMRiQ8N143. Positions 16-134, 300-460.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 10568BTBPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi144 – 18946Pro-richAdd
    BLAST
    Compositional biasi234 – 24411Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri328 – 35023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri356 – 37823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri384 – 40623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri412 – 43423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri440 – 46324C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOVERGENiHBG004831.
    InParanoidiQ8N143.
    OMAiELDKMAC.
    OrthoDBiEOG7KQ22S.
    PhylomeDBiQ8N143.
    TreeFamiTF330912.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N143-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR    50
    AHKAVLIACS GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR 100
    LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPLEAEPP 150
    TPPTAPPPGS PRRSEGHPDP PTESRSCSQG PPSPASPDPK ACNWKKYKYI 200
    VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS SSSSEEGPIP 250
    GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF 300
    FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH 350
    TGEKPYHCSI CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR 400
    AHVLIHTGEK PYPCPTCGTR FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR 450
    HKSQLRLHLR QKHGAATNTK VHYHILGGP 479
    Length:479
    Mass (Da):51,531
    Last modified:May 18, 2010 - v2
    Checksum:iAB04E3331A7DB8E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti244 – 2441S → SS in BAC00962. (PubMed:11855826)Curated
    Sequence conflicti244 – 2441S → SS in BAC00963. (PubMed:11855826)Curated
    Sequence conflicti244 – 2441S → SS in AAH59404. (PubMed:15489334)Curated
    Sequence conflicti306 – 3061C → S in AAH59404. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076580 mRNA. Translation: BAC00962.1.
    AB076581 Genomic DNA. Translation: BAC00963.1.
    AC040977 Genomic DNA. No translation available.
    BC059404 mRNA. Translation: AAH59404.1.
    PIRiJC7812.
    RefSeqiNP_862827.1. NM_181844.3.
    UniGeneiHs.22575.

    Genome annotation databases

    EnsembliENST00000293805; ENSP00000293805; ENSG00000161940.
    GeneIDi255877.
    KEGGihsa:255877.
    UCSCiuc002geg.2. human.

    Polymorphism databases

    DMDMi296434409.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076580 mRNA. Translation: BAC00962.1 .
    AB076581 Genomic DNA. Translation: BAC00963.1 .
    AC040977 Genomic DNA. No translation available.
    BC059404 mRNA. Translation: AAH59404.1 .
    PIRi JC7812.
    RefSeqi NP_862827.1. NM_181844.3.
    UniGenei Hs.22575.

    3D structure databases

    ProteinModelPortali Q8N143.
    SMRi Q8N143. Positions 16-134, 300-460.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129125. 6 interactions.
    STRINGi 9606.ENSP00000293805.

    PTM databases

    PhosphoSitei Q8N143.

    Polymorphism databases

    DMDMi 296434409.

    Proteomic databases

    PaxDbi Q8N143.
    PRIDEi Q8N143.

    Protocols and materials databases

    DNASUi 255877.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293805 ; ENSP00000293805 ; ENSG00000161940 .
    GeneIDi 255877.
    KEGGi hsa:255877.
    UCSCi uc002geg.2. human.

    Organism-specific databases

    CTDi 255877.
    GeneCardsi GC17P006926.
    HGNCi HGNC:1002. BCL6B.
    HPAi HPA059147.
    MIMi 608992. gene.
    neXtProti NX_Q8N143.
    PharmGKBi PA25313.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOVERGENi HBG004831.
    InParanoidi Q8N143.
    OMAi ELDKMAC.
    OrthoDBi EOG7KQ22S.
    PhylomeDBi Q8N143.
    TreeFami TF330912.

    Miscellaneous databases

    GenomeRNAii 255877.
    NextBioi 92672.
    PROi Q8N143.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N143.
    Bgeei Q8N143.
    CleanExi HS_BCL6B.
    Genevestigatori Q8N143.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene."
      Sakashita C., Fukuda T., Okabe S., Kobayashi H., Hirosawa S., Tokuhisa T., Miyasaka N., Miura O., Miki T.
      Biochem. Biophys. Res. Commun. 291:567-573(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiBCL6B_HUMAN
    AccessioniPrimary (citable) accession number: Q8N143
    Secondary accession number(s): Q6PCB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3