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Q8N143 (BCL6B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
B-cell CLL/lymphoma 6 member B protein
Alternative name(s):
Bcl6-associated zinc finger protein
Zinc finger protein 62
Gene names
Name:BCL6B
Synonyms:BAZF, ZNF62
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development. Ref.1

Subunit structure

Associates with BCL6 through the BTB domain By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Ubiquitously expressed with higher expression found in heart and placenta. Ref.1

Sequence similarities

Contains 1 BTB (POZ) domain.

Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: Ensembl

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479B-cell CLL/lymphoma 6 member B protein
PRO_0000047100

Regions

Domain38 – 10568BTB
Zinc finger328 – 35023C2H2-type 1
Zinc finger356 – 37823C2H2-type 2
Zinc finger384 – 40623C2H2-type 3
Zinc finger412 – 43423C2H2-type 4
Zinc finger440 – 46324C2H2-type 5
Compositional bias144 – 18946Pro-rich
Compositional bias234 – 24411Ser-rich

Experimental info

Sequence conflict2441S → SS in BAC00962. Ref.1
Sequence conflict2441S → SS in BAC00963. Ref.1
Sequence conflict2441S → SS in AAH59404. Ref.3
Sequence conflict3061C → S in AAH59404. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8N143 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: AB04E3331A7DB8E6

FASTA47951,531
        10         20         30         40         50         60 
MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR AHKAVLIACS 

        70         80         90        100        110        120 
GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR LRLSPATAPA VLAAATYLQM 

       130        140        150        160        170        180 
EHVVQACHRF IQASYEPLGI SLRPLEAEPP TPPTAPPPGS PRRSEGHPDP PTESRSCSQG 

       190        200        210        220        230        240 
PPSPASPDPK ACNWKKYKYI VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS 

       250        260        270        280        290        300 
SSSSEEGPIP GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF 

       310        320        330        340        350        360 
FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH TGEKPYHCSI 

       370        380        390        400        410        420 
CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR AHVLIHTGEK PYPCPTCGTR 

       430        440        450        460        470 
FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR HKSQLRLHLR QKHGAATNTK VHYHILGGP 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene."
Sakashita C., Fukuda T., Okabe S., Kobayashi H., Hirosawa S., Tokuhisa T., Miyasaka N., Miura O., Miki T.
Biochem. Biophys. Res. Commun. 291:567-573(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB076580 mRNA. Translation: BAC00962.1.
AB076581 Genomic DNA. Translation: BAC00963.1.
AC040977 Genomic DNA. No translation available.
BC059404 mRNA. Translation: AAH59404.1.
PIRJC7812.
RefSeqNP_862827.1. NM_181844.3.
UniGeneHs.22575.

3D structure databases

ProteinModelPortalQ8N143.
SMRQ8N143. Positions 16-134, 298-463.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129125. 6 interactions.
STRING9606.ENSP00000293805.

PTM databases

PhosphoSiteQ8N143.

Polymorphism databases

DMDM296434409.

Proteomic databases

PaxDbQ8N143.
PRIDEQ8N143.

Protocols and materials databases

DNASU255877.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293805; ENSP00000293805; ENSG00000161940.
GeneID255877.
KEGGhsa:255877.
UCSCuc002geg.2. human.

Organism-specific databases

CTD255877.
GeneCardsGC17P006926.
HGNCHGNC:1002. BCL6B.
HPAHPA059147.
MIM608992. gene.
neXtProtNX_Q8N143.
PharmGKBPA25313.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOVERGENHBG004831.
InParanoidQ8N143.
OMAELDKMAC.
OrthoDBEOG7KQ22S.
PhylomeDBQ8N143.
TreeFamTF330912.

Gene expression databases

ArrayExpressQ8N143.
BgeeQ8N143.
CleanExHS_BCL6B.
GenevestigatorQ8N143.

Family and domain databases

Gene3D3.30.160.60. 5 hits.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00651. BTB. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi255877.
NextBio92672.
PROQ8N143.
SOURCESearch...

Entry information

Entry nameBCL6B_HUMAN
AccessionPrimary (citable) accession number: Q8N143
Secondary accession number(s): Q6PCB4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM