Q8N143 (BCL6B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
B-cell CLL/lymphoma 6 member B protein

Alternative name(s):
Bcl6-associated zinc finger protein
Zinc finger protein 62

Gene names

Name:	BCL6B
Synonyms:	BAZF, ZNF62

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development. Ref.1
Subunit structure	Associates with BCL6 through the BTB domain By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Ubiquitously expressed with higher expression found in heart and placenta. Ref.1
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	B-cell CLL/lymphoma 6 member B protein		PRO_0000047100
Regions
	Domain	38 – 105	68	BTB
	Zinc finger	328 – 350	23	C2H2-type 1
	Zinc finger	356 – 378	23	C2H2-type 2
	Zinc finger	384 – 406	23	C2H2-type 3
	Zinc finger	412 – 434	23	C2H2-type 4
	Zinc finger	440 – 463	24	C2H2-type 5
	Compositional bias	144 – 189	46	Pro-rich
	Compositional bias	234 – 244	11	Ser-rich
Experimental info
	Sequence conflict	244	1	S → SS in BAC00962. Ref.1
	Sequence conflict	244	1	S → SS in BAC00963. Ref.1
	Sequence conflict	244	1	S → SS in AAH59404. Ref.3
	Sequence conflict	306	1	C → S in AAH59404. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8N143 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: AB04E3331A7DB8E6	FASTA	479	51,531
	10 20 30 40 50 60 MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR AHKAVLIACS 70 80 90 100 110 120 GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR LRLSPATAPA VLAAATYLQM 130 140 150 160 170 180 EHVVQACHRF IQASYEPLGI SLRPLEAEPP TPPTAPPPGS PRRSEGHPDP PTESRSCSQG 190 200 210 220 230 240 PPSPASPDPK ACNWKKYKYI VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS 250 260 270 280 290 300 SSSSEEGPIP GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF 310 320 330 340 350 360 FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH TGEKPYHCSI 370 380 390 400 410 420 CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR AHVLIHTGEK PYPCPTCGTR 430 440 450 460 470 FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR HKSQLRLHLR QKHGAATNTK VHYHILGGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene." Sakashita C., Fukuda T., Okabe S., Kobayashi H., Hirosawa S., Tokuhisa T., Miyasaka N., Miura O., Miki T. Biochem. Biophys. Res. Commun. 291:567-573(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB076580 mRNA. Translation: BAC00962.1. AB076581 Genomic DNA. Translation: BAC00963.1. AC040977 Genomic DNA. No translation available. BC059404 mRNA. Translation: AAH59404.1.
IPI	IPI00166071.
PIR	JC7812.
RefSeq	NP_862827.1. NM_181844.3.
UniGene	Hs.22575.
3D structure databases
ProteinModelPortal	Q8N143.
SMR	Q8N143. Positions 16-134, 325-460.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000293805.
PTM databases
PhosphoSite	Q8N143.
Polymorphism databases
DMDM	296434409.
Proteomic databases
PaxDb	Q8N143.
PRIDE	Q8N143.
Protocols and materials databases
DNASU	255877.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000293805; ENSP00000293805; ENSG00000161940.
GeneID	255877.
KEGG	hsa:255877.
UCSC	uc002geg.2. human.
Organism-specific databases
CTD	255877.
GeneCards	GC17P006926.
HGNC	HGNC:1002. BCL6B.
MIM	608992. gene.
neXtProt	NX_Q8N143.
PharmGKB	PA25313.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOVERGEN	HBG004831.
InParanoid	Q8N143.
OMA	DEDKPYK.
OrthoDB	EOG41RPTV.
PhylomeDB	Q8N143.
Gene expression databases
ArrayExpress	Q8N143.
Bgee	Q8N143.
CleanEx	HS_BCL6B.
Genevestigator	Q8N143.
GermOnline	ENSG00000161940. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 5 hits. 3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00651. BTB. 1 hit. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 5 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 5 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	255877.
NextBio	92672.
SOURCE	Search...

Entry information

Entry name

BCL6B_HUMAN

Accession

Primary (citable) accession number: Q8N143
Secondary accession number(s): Q6PCB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.