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Protein

Zinc finger protein 82 homolog

Gene

ZFP82

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri170 – 19223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 22023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri226 – 24823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 82 homolog
Short name:
Zfp-82
Alternative name(s):
Zinc finger protein 545
Gene namesi
Name:ZFP82
Synonyms:KIAA1948, ZNF545
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28682. ZFP82.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409714.

Polymorphism and mutation databases

BioMutaiZFP82.
DMDMi74762511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Zinc finger protein 82 homologPRO_0000233164Add
BLAST

Proteomic databases

PaxDbiQ8N141.
PeptideAtlasiQ8N141.
PRIDEiQ8N141.

PTM databases

iPTMnetiQ8N141.
PhosphoSiteiQ8N141.

Expressioni

Gene expression databases

BgeeiQ8N141.
CleanExiHS_ZFP82.
ExpressionAtlasiQ8N141. baseline and differential.
GenevisibleiQ8N141. HS.

Organism-specific databases

HPAiHPA060470.

Interactioni

Protein-protein interaction databases

BioGridi129864. 1 interaction.
IntActiQ8N141. 1 interaction.
MINTiMINT-4719110.
STRINGi9606.ENSP00000431265.

Structurei

3D structure databases

ProteinModelPortaliQ8N141.
SMRiQ8N141. Positions 6-46, 167-528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7772KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri170 – 19223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 22023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri226 – 24823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N141.
KOiK09228.
OMAiHQRIHFV.
PhylomeDBiQ8N141.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRSVMFSD VSIDFSPEEW EYLDLEQKDL YRDVMLENYS NLVSLGCFIS
60 70 80 90 100
KPDVISSLEQ GKEPWKVVRK GRRQYPDLET KYETKKLSLE NDIYEINLSQ
110 120 130 140 150
WKIMERIENH GLKGLILKND WESTGKIEGQ ERPQEGYFSS VKMPSEKVSS
160 170 180 190 200
YQKRTSVTPH QRLHFVDKPY ECKECGKAFR VRQQLTFHHR IHTGEKPYEC
210 220 230 240 250
KECGMAFRQT AHLTRHQRLH SGEKLYECKE CGEAFICGAD LRVHQKMHIG
260 270 280 290 300
EKPYECKECG KAFRVRGQLT LHQRIHTGEK PYVCKECGKA FRQYAHLTRH
310 320 330 340 350
QKLNSADRLY ECKECGKAFL CGSGLRVHHK LHTGEKPYEC KECGKAFRVR
360 370 380 390 400
QQLTLHQRIH TGEKPYECKE CGKTFSRGYH LILHHRIHTG EKPYECKECW
410 420 430 440 450
KAFSRYSQLI SHQSIHIGVK PYDCKECGKA FRLLSQLTQH QSIHIGEKPY
460 470 480 490 500
KCKECGKAFR LRQKLTLHQS IHTGEKPFEC KECRKAFRLN SSLIQHLRIH
510 520 530
SGEKPYECKE CKKAFRQHSH LTHHLKIHNV KI
Length:532
Mass (Da):62,578
Last modified:October 1, 2002 - v1
Checksum:i39B18CE288A82DDC
GO

Sequence cautioni

The sequence BAB85534.1 differs from that shown.Probable cloning artifact.Curated
The sequence BAB85534.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281E → G in BAC11308 (PubMed:14702039).Curated
Sequence conflicti158 – 1581T → A in BAC11308 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074942 mRNA. Translation: BAC11308.1.
AL834267 mRNA. Translation: CAD38942.1.
BC032577 mRNA. Translation: AAH32577.1.
AB075828 mRNA. Translation: BAB85534.1. Sequence problems.
CCDSiCCDS12493.1.
RefSeqiNP_597723.1. NM_133466.3.
UniGeneiHs.558734.

Genome annotation databases

EnsembliENST00000392161; ENSP00000431265; ENSG00000181007.
GeneIDi284406.
KEGGihsa:284406.
UCSCiuc002ody.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074942 mRNA. Translation: BAC11308.1.
AL834267 mRNA. Translation: CAD38942.1.
BC032577 mRNA. Translation: AAH32577.1.
AB075828 mRNA. Translation: BAB85534.1. Sequence problems.
CCDSiCCDS12493.1.
RefSeqiNP_597723.1. NM_133466.3.
UniGeneiHs.558734.

3D structure databases

ProteinModelPortaliQ8N141.
SMRiQ8N141. Positions 6-46, 167-528.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129864. 1 interaction.
IntActiQ8N141. 1 interaction.
MINTiMINT-4719110.
STRINGi9606.ENSP00000431265.

PTM databases

iPTMnetiQ8N141.
PhosphoSiteiQ8N141.

Polymorphism and mutation databases

BioMutaiZFP82.
DMDMi74762511.

Proteomic databases

PaxDbiQ8N141.
PeptideAtlasiQ8N141.
PRIDEiQ8N141.

Protocols and materials databases

DNASUi284406.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392161; ENSP00000431265; ENSG00000181007.
GeneIDi284406.
KEGGihsa:284406.
UCSCiuc002ody.2. human.

Organism-specific databases

CTDi284406.
GeneCardsiZFP82.
HGNCiHGNC:28682. ZFP82.
HPAiHPA060470.
neXtProtiNX_Q8N141.
PharmGKBiPA162409714.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N141.
KOiK09228.
OMAiHQRIHFV.
PhylomeDBiQ8N141.
TreeFamiTF341817.

Miscellaneous databases

GenomeRNAii284406.
PROiQ8N141.

Gene expression databases

BgeeiQ8N141.
CleanExiHS_ZFP82.
ExpressionAtlasiQ8N141. baseline and differential.
GenevisibleiQ8N141. HS.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 77-532.
    Tissue: Brain.

Entry informationi

Entry nameiZFP82_HUMAN
AccessioniPrimary (citable) accession number: Q8N141
Secondary accession number(s): Q8NC63, Q8TF53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.