EID3

Functionⁱ

Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.1 Publication

Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.1 Publication

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 15970276

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.

Reactomeⁱ

R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: EP300-interacting inhibitor of differentiation 3 Short name: EID-3 Alternative name(s): E1A-like inhibitor of differentiation 3 EID-1-like inhibitor of differentiation 3 Non-structural maintenance of chromosomes element 4 homolog B Short name: NS4EB Short name: Non-SMC element 4 homolog B
Gene namesⁱ	Name:EID3Imported Manual assertion inferred from database entriesⁱ EMBL:AAH27612.1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

HGNCⁱ	HGNC:32961. EID3.

HGNCⁱ

HGNC:32961. EID3.

Subcellular locationⁱ

Nucleus
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation."
  Bavner A., Matthews J., Sanyal S., Gustafsson J.-A., Treuter E.
  Nucleic Acids Res. 33:3561-3569(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CREBBP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Cytoplasm
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation."
  Bavner A., Matthews J., Sanyal S., Gustafsson J.-A., Treuter E.
  Nucleic Acids Res. 33:3561-3569(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CREBBP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Chromosome › telomere
1 Publication
Manual assertion inferred by curator fromⁱ
- Ref.1
  "EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation."
  Bavner A., Matthews J., Sanyal S., Gustafsson J.-A., Treuter E.
  Nucleic Acids Res. 33:3561-3569(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CREBBP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Note:

May shuttle between nucleus and cytoplasm.1 Publication

GO - Cellular componentⁱ

chromosome, telomeric region Source: UniProtKB-SubCell
cytoplasm Source: UniProtKB-SubCell
nucleoplasm Source: Reactome
Smc5-Smc6 complex
Source: UniProtKB
Inferred from direct assayⁱ
- 18086888

Complete GO annotation...

Keywords - Cellular componentⁱ

Chromosome, Cytoplasm, Nucleus, Telomere

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA162384552.

PharmGKBⁱ

PA162384552.

Polymorphism and mutation databases

BioMutaⁱ	EID3.
DMDMⁱ	74728487.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 333	333	EP300-interacting inhibitor of differentiation 3		PRO_0000315905	Add BLAST

Proteomic databases

EPDⁱ	Q8N140.
PaxDbⁱ	Q8N140.
PeptideAtlasⁱ	Q8N140.
PRIDEⁱ	Q8N140.

PTM databases

iPTMnetⁱ	Q8N140.
PhosphoSiteⁱ	Q8N140.

Expressionⁱ

Tissue specificityⁱ

Highly expressed in testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000255150.
CleanExⁱ	HS_EID3.
Genevisibleⁱ	Q8N140. HS.

Organism-specific databases

HPAⁱ	HPA059367.

Interactionⁱ

Subunit structureⁱ

Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3; EID3 seems to be a testis-specific subunit. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Homodimer, and heterodimer with EID2 (By similarity). Interacts with the C-terminal region of CREBBP.By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		2	EBI-744483,EBI-744483
EID2	Q8N6I1	3	EBI-744483,EBI-5525894
HDAC1	Q13547	2	EBI-744483,EBI-301834
MAGEA1	P43355	3	EBI-744483,EBI-740978
NSMCE3	Q96MG7	4	EBI-744483,EBI-2557356

With

Entry

#Exp.

IntAct

Notes

itself

2

EBI-744483,EBI-744483

EID2

Q8N6I1

3

EBI-744483,EBI-5525894

HDAC1

Q13547

2

EBI-744483,EBI-301834

MAGEA1

P43355

3

EBI-744483,EBI-740978

NSMCE3

Q96MG7

4

EBI-744483,EBI-2557356

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 15970276

Protein-protein interaction databases

BioGridⁱ	138924. 30 interactions.
IntActⁱ	Q8N140. 9 interactions.
MINTⁱ	MINT-1443977.
STRINGⁱ	9606.ENSP00000435619.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N140.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NSE4 family.Sequence analysis

Phylogenomic databases

eggNOGⁱ	KOG2866. Eukaryota. COG5125. LUCA.
GeneTreeⁱ	ENSGT00390000011476.
HOVERGENⁱ	HBG107841.
InParanoidⁱ	Q8N140.
OMAⁱ	WMEDECD.
OrthoDBⁱ	EOG091G0GO8.
PhylomeDBⁱ	Q8N140.
TreeFamⁱ	TF313999.

Family and domain databases

InterProⁱ	IPR027786. Nse4/EID. IPR014854. Nse4_C. IPR029225. Nse4_Nse3-bd. [Graphical view]
PANTHERⁱ	PTHR16140. PTHR16140. 1 hit.
Pfamⁱ	PF15412. Nse4-Nse3_bdg. 1 hit. PF08743. Nse4_C. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8N140-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKMDVSVRAA GCSDDLSSGE ADVDPKLLEL TADEEKCRSI RRQYRQLMYC 
        60         70         80         90        100
VRQNREDIVS SANNSLTEAL EEANVLFDGV SRTREAALDA RFLVMASDLG 
       110        120        130        140        150
KEKAKQLNSD MNFFNQLAFC DFLFLFVGLN WMEGDPDKLS DCDDSIALSF 
       160        170        180        190        200
WKAIEKEATS WMVKAETFHF VFGSFKLERS APKPRLEHQK KVRKMEENGN 
       210        220        230        240        250
MPTKLQKLDL SSYPEATEKN VERILGLLQT YFRKYPDTPV SYFEFVIDPN 
       260        270        280        290        300
SFSRTVENIF YVSFIVRDGF ARIRLDEDRL PILEPMNVNQ MGEGNDSSCH 
       310        320        330 
GRKQGVISLT LQEWKNIVAA FEISEAMITY SSY

Length:333

Mass (Da):38,168

Last modified:October 1, 2002 - v1

Checksum:ⁱ3B35D08977C47C5A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098698 mRNA. Translation: BAC05385.1. CH471054 Genomic DNA. Translation: EAW97747.1. BC027612 mRNA. Translation: AAH27612.1.
CCDSⁱ	CCDS53822.1.
RefSeqⁱ	NP_001008395.1. NM_001008394.2.
UniGeneⁱ	Hs.659857.

Genome annotation databases

Ensemblⁱ	ENST00000527879; ENSP00000435619; ENSG00000255150.
GeneIDⁱ	493861.
KEGGⁱ	hsa:493861.
UCSCⁱ	uc001tkw.4. human.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098698 mRNA. Translation: BAC05385.1. CH471054 Genomic DNA. Translation: EAW97747.1. BC027612 mRNA. Translation: AAH27612.1.
CCDSⁱ	CCDS53822.1.
RefSeqⁱ	NP_001008395.1. NM_001008394.2.
UniGeneⁱ	Hs.659857.

3D structure databases

ProteinModelPortalⁱ	Q8N140.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	138924. 30 interactions.
IntActⁱ	Q8N140. 9 interactions.
MINTⁱ	MINT-1443977.
STRINGⁱ	9606.ENSP00000435619.

PTM databases

iPTMnetⁱ	Q8N140.
PhosphoSiteⁱ	Q8N140.

Polymorphism and mutation databases

BioMutaⁱ	EID3.
DMDMⁱ	74728487.

Proteomic databases

EPDⁱ	Q8N140.
PaxDbⁱ	Q8N140.
PeptideAtlasⁱ	Q8N140.
PRIDEⁱ	Q8N140.

Protocols and materials databases

DNASUⁱ	493861.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000527879; ENSP00000435619; ENSG00000255150.
GeneIDⁱ	493861.
KEGGⁱ	hsa:493861.
UCSCⁱ	uc001tkw.4. human.

Organism-specific databases

CTDⁱ	493861.
GeneCardsⁱ	EID3.
HGNCⁱ	HGNC:32961. EID3.
HPAⁱ	HPA059367.
MIMⁱ	612986. gene.
neXtProtⁱ	NX_Q8N140.
PharmGKBⁱ	PA162384552.
GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2866. Eukaryota. COG5125. LUCA.
GeneTreeⁱ	ENSGT00390000011476.
HOVERGENⁱ	HBG107841.
InParanoidⁱ	Q8N140.
OMAⁱ	WMEDECD.
OrthoDBⁱ	EOG091G0GO8.
PhylomeDBⁱ	Q8N140.
TreeFamⁱ	TF313999.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.

Reactomeⁱ

R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.

Miscellaneous databases

GenomeRNAiⁱ	493861.
PROⁱ	Q8N140.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000255150.
CleanExⁱ	HS_EID3.
Genevisibleⁱ	Q8N140. HS.

Family and domain databases

InterProⁱ	IPR027786. Nse4/EID. IPR014854. Nse4_C. IPR029225. Nse4_Nse3-bd. [Graphical view]
PANTHERⁱ	PTHR16140. PTHR16140. 1 hit.
Pfamⁱ	PF15412. Nse4-Nse3_bdg. 1 hit. PF08743. Nse4_C. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

EID3_HUMAN

Accessionⁱ

Primary (citable) accession number: Q8N140

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 1, 2002
Last modified:	September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N140 (EID3_HUMAN)

UniProt

Q8N140 - EID3_HUMAN

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EP300-interacting inhibitor of differentiation 3

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ