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Protein

EP300-interacting inhibitor of differentiation 3

Gene

EID3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.1 Publication
Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3108214. SUMOylation of DNA damage response and repair proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
EP300-interacting inhibitor of differentiation 3
Short name:
EID-3
Alternative name(s):
E1A-like inhibitor of differentiation 3
EID-1-like inhibitor of differentiation 3
Non-structural maintenance of chromosomes element 4 homolog B
Short name:
NS4EB
Short name:
Non-SMC element 4 homolog B
Gene namesi
Name:EID3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:32961. EID3.

Subcellular locationi

GO - Cellular componenti

  • chromosome, telomeric region Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB-SubCell
  • nucleoplasm Source: Reactome
  • Smc5-Smc6 complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus, Telomere

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000255150.
PharmGKBiPA162384552.

Polymorphism and mutation databases

BioMutaiEID3.
DMDMi74728487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003159051 – 333EP300-interacting inhibitor of differentiation 3Add BLAST333

Proteomic databases

EPDiQ8N140.
MaxQBiQ8N140.
PaxDbiQ8N140.
PeptideAtlasiQ8N140.
PRIDEiQ8N140.

PTM databases

iPTMnetiQ8N140.
PhosphoSitePlusiQ8N140.

Expressioni

Tissue specificityi

Highly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000255150.
CleanExiHS_EID3.
ExpressionAtlasiQ8N140. baseline and differential.
GenevisibleiQ8N140. HS.

Organism-specific databases

HPAiHPA059367.

Interactioni

Subunit structurei

Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3; EID3 seems to be a testis-specific subunit. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Homodimer, and heterodimer with EID2 (By similarity). Interacts with the C-terminal region of CREBBP.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-744483,EBI-744483
EID2Q8N6I13EBI-744483,EBI-5525894
HDAC1Q135472EBI-744483,EBI-301834
MAGEA1P433553EBI-744483,EBI-740978
NSMCE3Q96MG74EBI-744483,EBI-2557356

Protein-protein interaction databases

BioGridi138924. 30 interactors.
IntActiQ8N140. 9 interactors.
MINTiMINT-1443977.
STRINGi9606.ENSP00000435619.

Structurei

3D structure databases

ProteinModelPortaliQ8N140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NSE4 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG2866. Eukaryota.
COG5125. LUCA.
GeneTreeiENSGT00390000011476.
HOVERGENiHBG107841.
InParanoidiQ8N140.
OMAiWMEDECD.
OrthoDBiEOG091G0GO8.
PhylomeDBiQ8N140.
TreeFamiTF313999.

Family and domain databases

InterProiIPR027786. Nse4/EID.
IPR014854. Nse4_C.
IPR029225. Nse4_Nse3-bd.
[Graphical view]
PANTHERiPTHR16140. PTHR16140. 1 hit.
PfamiPF15412. Nse4-Nse3_bdg. 1 hit.
PF08743. Nse4_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMDVSVRAA GCSDDLSSGE ADVDPKLLEL TADEEKCRSI RRQYRQLMYC
60 70 80 90 100
VRQNREDIVS SANNSLTEAL EEANVLFDGV SRTREAALDA RFLVMASDLG
110 120 130 140 150
KEKAKQLNSD MNFFNQLAFC DFLFLFVGLN WMEGDPDKLS DCDDSIALSF
160 170 180 190 200
WKAIEKEATS WMVKAETFHF VFGSFKLERS APKPRLEHQK KVRKMEENGN
210 220 230 240 250
MPTKLQKLDL SSYPEATEKN VERILGLLQT YFRKYPDTPV SYFEFVIDPN
260 270 280 290 300
SFSRTVENIF YVSFIVRDGF ARIRLDEDRL PILEPMNVNQ MGEGNDSSCH
310 320 330
GRKQGVISLT LQEWKNIVAA FEISEAMITY SSY
Length:333
Mass (Da):38,168
Last modified:October 1, 2002 - v1
Checksum:i3B35D08977C47C5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098698 mRNA. Translation: BAC05385.1.
CH471054 Genomic DNA. Translation: EAW97747.1.
BC027612 mRNA. Translation: AAH27612.1.
CCDSiCCDS53822.1.
RefSeqiNP_001008395.1. NM_001008394.2.
UniGeneiHs.659857.

Genome annotation databases

EnsembliENST00000527879; ENSP00000435619; ENSG00000255150.
GeneIDi493861.
KEGGihsa:493861.
UCSCiuc001tkw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098698 mRNA. Translation: BAC05385.1.
CH471054 Genomic DNA. Translation: EAW97747.1.
BC027612 mRNA. Translation: AAH27612.1.
CCDSiCCDS53822.1.
RefSeqiNP_001008395.1. NM_001008394.2.
UniGeneiHs.659857.

3D structure databases

ProteinModelPortaliQ8N140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138924. 30 interactors.
IntActiQ8N140. 9 interactors.
MINTiMINT-1443977.
STRINGi9606.ENSP00000435619.

PTM databases

iPTMnetiQ8N140.
PhosphoSitePlusiQ8N140.

Polymorphism and mutation databases

BioMutaiEID3.
DMDMi74728487.

Proteomic databases

EPDiQ8N140.
MaxQBiQ8N140.
PaxDbiQ8N140.
PeptideAtlasiQ8N140.
PRIDEiQ8N140.

Protocols and materials databases

DNASUi493861.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000527879; ENSP00000435619; ENSG00000255150.
GeneIDi493861.
KEGGihsa:493861.
UCSCiuc001tkw.4. human.

Organism-specific databases

CTDi493861.
GeneCardsiEID3.
HGNCiHGNC:32961. EID3.
HPAiHPA059367.
MIMi612986. gene.
neXtProtiNX_Q8N140.
OpenTargetsiENSG00000255150.
PharmGKBiPA162384552.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2866. Eukaryota.
COG5125. LUCA.
GeneTreeiENSGT00390000011476.
HOVERGENiHBG107841.
InParanoidiQ8N140.
OMAiWMEDECD.
OrthoDBiEOG091G0GO8.
PhylomeDBiQ8N140.
TreeFamiTF313999.

Enzyme and pathway databases

ReactomeiR-HSA-3108214. SUMOylation of DNA damage response and repair proteins.

Miscellaneous databases

GenomeRNAii493861.
PROiQ8N140.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000255150.
CleanExiHS_EID3.
ExpressionAtlasiQ8N140. baseline and differential.
GenevisibleiQ8N140. HS.

Family and domain databases

InterProiIPR027786. Nse4/EID.
IPR014854. Nse4_C.
IPR029225. Nse4_Nse3-bd.
[Graphical view]
PANTHERiPTHR16140. PTHR16140. 1 hit.
PfamiPF15412. Nse4-Nse3_bdg. 1 hit.
PF08743. Nse4_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEID3_HUMAN
AccessioniPrimary (citable) accession number: Q8N140
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.