UniProtKB - Q8N140 (EID3_HUMAN)
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Protein
EP300-interacting inhibitor of differentiation 3
Gene
EID3
Organism
Homo sapiens (Human)
Status
Functioni
Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.1 Publication
Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.1 Publication
GO - Biological processi
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- regulation of transcription, DNA-templated Source: UniProtKB-KW
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Repressor |
Biological process | DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-HSA-3108214 SUMOylation of DNA damage response and repair proteins |
Names & Taxonomyi
Protein namesi | Recommended name: EP300-interacting inhibitor of differentiation 3Short name: EID-3 Alternative name(s): E1A-like inhibitor of differentiation 3 EID-1-like inhibitor of differentiation 3 Non-structural maintenance of chromosomes element 4 homolog B Short name: NS4EB Short name: Non-SMC element 4 homolog B |
Gene namesi | Name:EID3Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000255150.1 |
HGNCi | HGNC:32961 EID3 |
MIMi | 612986 gene |
neXtProti | NX_Q8N140 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000255150 |
PharmGKBi | PA162384552 |
Polymorphism and mutation databases
BioMutai | EID3 |
DMDMi | 74728487 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315905 | 1 – 333 | EP300-interacting inhibitor of differentiation 3Add BLAST | 333 |
Proteomic databases
EPDi | Q8N140 |
MaxQBi | Q8N140 |
PaxDbi | Q8N140 |
PeptideAtlasi | Q8N140 |
PRIDEi | Q8N140 |
PTM databases
iPTMneti | Q8N140 |
PhosphoSitePlusi | Q8N140 |
Expressioni
Tissue specificityi
Highly expressed in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000255150 |
CleanExi | HS_EID3 |
ExpressionAtlasi | Q8N140 baseline and differential |
Genevisiblei | Q8N140 HS |
Organism-specific databases
HPAi | HPA059367 |
Interactioni
Subunit structurei
Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3; EID3 seems to be a testis-specific subunit. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Homodimer, and heterodimer with EID2 (By similarity). Interacts with the C-terminal region of CREBBP.By similarity3 Publications
Binary interactionsi
Protein-protein interaction databases
BioGridi | 13892430 interactors. |
IntActi | Q8N140 8 interactors. |
STRINGi | 9606.ENSP00000435619 |
Family & Domainsi
Sequence similaritiesi
Belongs to the NSE4 family.Sequence analysis
Phylogenomic databases
eggNOGi | KOG2866 Eukaryota COG5125 LUCA |
GeneTreei | ENSGT00390000011476 |
HOVERGENi | HBG107841 |
InParanoidi | Q8N140 |
OMAi | ADEEKCR |
OrthoDBi | EOG091G0GO8 |
PhylomeDBi | Q8N140 |
TreeFami | TF313999 |
Family and domain databases
InterProi | View protein in InterPro IPR027786 Nse4/EID IPR014854 Nse4_C IPR029225 Nse4_Nse3-bd |
PANTHERi | PTHR16140 PTHR16140, 1 hit |
Pfami | View protein in Pfam PF15412 Nse4-Nse3_bdg, 1 hit PF08743 Nse4_C, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8N140-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKMDVSVRAA GCSDDLSSGE ADVDPKLLEL TADEEKCRSI RRQYRQLMYC
60 70 80 90 100
VRQNREDIVS SANNSLTEAL EEANVLFDGV SRTREAALDA RFLVMASDLG
110 120 130 140 150
KEKAKQLNSD MNFFNQLAFC DFLFLFVGLN WMEGDPDKLS DCDDSIALSF
160 170 180 190 200
WKAIEKEATS WMVKAETFHF VFGSFKLERS APKPRLEHQK KVRKMEENGN
210 220 230 240 250
MPTKLQKLDL SSYPEATEKN VERILGLLQT YFRKYPDTPV SYFEFVIDPN
260 270 280 290 300
SFSRTVENIF YVSFIVRDGF ARIRLDEDRL PILEPMNVNQ MGEGNDSSCH
310 320 330
GRKQGVISLT LQEWKNIVAA FEISEAMITY SSY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK098698 mRNA Translation: BAC05385.1 CH471054 Genomic DNA Translation: EAW97747.1 BC027612 mRNA Translation: AAH27612.1 |
CCDSi | CCDS53822.1 |
RefSeqi | NP_001008395.1, NM_001008394.2 |
UniGenei | Hs.659857 |
Genome annotation databases
Ensembli | ENST00000527879; ENSP00000435619; ENSG00000255150 |
GeneIDi | 493861 |
KEGGi | hsa:493861 |
UCSCi | uc001tkw.4 human |
Similar proteinsi
Entry informationi
Entry namei | EID3_HUMAN | |
Accessioni | Q8N140Primary (citable) accession number: Q8N140 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 28, 2018 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |