EID3

Functionⁱ

Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.1 Publication

Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.1 Publication

GO - Biological processⁱ

DNA recombination Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor
Biological process	DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3108214 SUMOylation of DNA damage response and repair proteins

Reactomeⁱ

R-HSA-3108214 SUMOylation of DNA damage response and repair proteins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: EP300-interacting inhibitor of differentiation 3 Short name: EID-3 Alternative name(s): E1A-like inhibitor of differentiation 3 EID-1-like inhibitor of differentiation 3 Non-structural maintenance of chromosomes element 4 homolog B Short name: NS4EB Short name: Non-SMC element 4 homolog B
Gene namesⁱ	Name:EID3Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000255150.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:32961 EID3
MIMⁱ	612986 gene
neXtProtⁱ	NX_Q8N140

Keywords - Cellular componentⁱ

Chromosome, Cytoplasm, Nucleus, Telomere

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000255150
PharmGKBⁱ	PA162384552

Polymorphism and mutation databases

BioMutaⁱ	EID3
DMDMⁱ	74728487

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000315905	1 – 333	EP300-interacting inhibitor of differentiation 3Add BLAST		333

Proteomic databases

EPDⁱ	Q8N140
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N140
PaxDbⁱ	Q8N140
PeptideAtlas More...PeptideAtlasⁱ	Q8N140
PRIDEⁱ	Q8N140

PTM databases

iPTMnetⁱ	Q8N140
PhosphoSitePlusⁱ	Q8N140

Expressionⁱ

Tissue specificityⁱ

Highly expressed in testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000255150
CleanExⁱ	HS_EID3
ExpressionAtlasⁱ	Q8N140 baseline and differential
Genevisibleⁱ	Q8N140 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA059367

HPAⁱ

HPA059367

Interactionⁱ

Subunit structureⁱ

Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3; EID3 seems to be a testis-specific subunit. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Homodimer, and heterodimer with EID2 (By similarity). Interacts with the C-terminal region of CREBBP.By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MAGEA1	P43355	3	EBI-744483,EBI-740978
NSMCE3	Q96MG7	4	EBI-744483,EBI-2557356

Show more details

Protein-protein interaction databases

BioGridⁱ	13892430 interactors.
IntActⁱ	Q8N140 8 interactors.
STRINGⁱ	9606.ENSP00000435619

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N140
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NSE4 family.Sequence analysis

Phylogenomic databases

eggNOGⁱ	KOG2866 Eukaryota COG5125 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011476
HOVERGENⁱ	HBG107841
InParanoidⁱ	Q8N140
OMAⁱ	ADEEKCR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GO8
PhylomeDBⁱ	Q8N140
TreeFamⁱ	TF313999

Family and domain databases

InterProⁱ	View protein in InterPro IPR027786 Nse4/EID IPR014854 Nse4_C IPR029225 Nse4_Nse3-bd
PANTHERⁱ	PTHR16140 PTHR16140, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15412 Nse4-Nse3_bdg, 1 hit PF08743 Nse4_C, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8N140-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKMDVSVRAA GCSDDLSSGE ADVDPKLLEL TADEEKCRSI RRQYRQLMYC 
        60         70         80         90        100
VRQNREDIVS SANNSLTEAL EEANVLFDGV SRTREAALDA RFLVMASDLG 
       110        120        130        140        150
KEKAKQLNSD MNFFNQLAFC DFLFLFVGLN WMEGDPDKLS DCDDSIALSF 
       160        170        180        190        200
WKAIEKEATS WMVKAETFHF VFGSFKLERS APKPRLEHQK KVRKMEENGN 
       210        220        230        240        250
MPTKLQKLDL SSYPEATEKN VERILGLLQT YFRKYPDTPV SYFEFVIDPN 
       260        270        280        290        300
SFSRTVENIF YVSFIVRDGF ARIRLDEDRL PILEPMNVNQ MGEGNDSSCH 
       310        320        330 
GRKQGVISLT LQEWKNIVAA FEISEAMITY SSY

Length:333

Mass (Da):38,168

Last modified:October 1, 2002 - v1

Checksum:ⁱ3B35D08977C47C5A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098698 mRNA Translation: BAC05385.1 CH471054 Genomic DNA Translation: EAW97747.1 BC027612 mRNA Translation: AAH27612.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53822.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001008395.1, NM_001008394.2
UniGeneⁱ	Hs.659857

Genome annotation databases

Ensemblⁱ	ENST00000527879; ENSP00000435619; ENSG00000255150
GeneIDⁱ	493861
KEGGⁱ	hsa:493861
UCSC genome browser More...UCSCⁱ	uc001tkw.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8N140	A0A140VJI9	Homo sapiens (Human)	333	UniRef100_Q8N140	Cluster: EP300-interacting inhibitor of differentiation 3	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8N140	A0A140VJI9 UPI00045DFB7A UPI0005F3E3CA UPI0005F38C94 UPI00027F4A0B UPI000C2ACA38 A5LFW4 UPI0005F3C4D8 UPI00020AD038 UPI000533496C +8	Homo sapiens (Human) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Colobus angolensis palliatus (Peters' Angolan colobus) Papio anubis (Olive baboon) Piliocolobus tephrosceles (Ugandan red Colobus) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) And more	333	UniRef90_Q8N140	Cluster: EP300-interacting inhibitor of differentiation 3	19

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8N140	A0A140VJI9 UPI00045DFB7A UPI0005F3E3CA UPI0005F38C94 UPI00027F4A0B UPI0005F3C4D8 UPI000C2ACA38 A5LFW4 UPI000533496C UPI00020AD038 +28	Homo sapiens (Human) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Colobus angolensis palliatus (Peters' Angolan colobus) Papio anubis (Olive baboon) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Piliocolobus tephrosceles (Ugandan red Colobus) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) And more	333	UniRef50_Q8N140	Cluster: EP300-interacting inhibitor of differentiation 3	39

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098698 mRNA Translation: BAC05385.1 CH471054 Genomic DNA Translation: EAW97747.1 BC027612 mRNA Translation: AAH27612.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53822.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001008395.1, NM_001008394.2
UniGeneⁱ	Hs.659857

3D structure databases

ProteinModelPortalⁱ	Q8N140
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	13892430 interactors.
IntActⁱ	Q8N140 8 interactors.
STRINGⁱ	9606.ENSP00000435619

PTM databases

iPTMnetⁱ	Q8N140
PhosphoSitePlusⁱ	Q8N140

Polymorphism and mutation databases

BioMutaⁱ	EID3
DMDMⁱ	74728487

Proteomic databases

EPDⁱ	Q8N140
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N140
PaxDbⁱ	Q8N140
PeptideAtlas More...PeptideAtlasⁱ	Q8N140
PRIDEⁱ	Q8N140

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	493861
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000527879; ENSP00000435619; ENSG00000255150
GeneIDⁱ	493861
KEGGⁱ	hsa:493861
UCSC genome browser More...UCSCⁱ	uc001tkw.4 human

Organism-specific databases

CTDⁱ	493861
EuPathDBⁱ	HostDB:ENSG00000255150.1
GeneCardsⁱ	EID3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:32961 EID3
Human Protein Atlas More...HPAⁱ	HPA059367
MIMⁱ	612986 gene
neXtProtⁱ	NX_Q8N140
Open Targets More...OpenTargetsⁱ	ENSG00000255150
PharmGKBⁱ	PA162384552
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2866 Eukaryota COG5125 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011476
HOVERGENⁱ	HBG107841
InParanoidⁱ	Q8N140
OMAⁱ	ADEEKCR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GO8
PhylomeDBⁱ	Q8N140
TreeFamⁱ	TF313999

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3108214 SUMOylation of DNA damage response and repair proteins

Reactomeⁱ

R-HSA-3108214 SUMOylation of DNA damage response and repair proteins

Miscellaneous databases

GenomeRNAiⁱ	493861
Protein Ontology More...PROⁱ	PR:Q8N140
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000255150
CleanExⁱ	HS_EID3
ExpressionAtlasⁱ	Q8N140 baseline and differential
Genevisibleⁱ	Q8N140 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027786 Nse4/EID IPR014854 Nse4_C IPR029225 Nse4_Nse3-bd
PANTHERⁱ	PTHR16140 PTHR16140, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15412 Nse4-Nse3_bdg, 1 hit PF08743 Nse4_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EID3_HUMAN
Accessionⁱ	Q8N140Primary (citable) accession number: Q8N140
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	October 1, 2002
	Last modified:	February 28, 2018
	This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniProtKB - Q8N140 (EID3_HUMAN)

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EP300-interacting inhibitor of differentiation 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

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Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ