##gff-version 3
Q8N138	UniProtKB	Chain	1	153	.	.	.	ID=PRO_0000215639;Note=ORM1-like protein 3	
Q8N138	UniProtKB	Topological domain	1	21	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8N138	UniProtKB	Transmembrane	22	44	.	.	.	Note=Helical;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:33558762,ECO:0007744|PDB:6M4N,ECO:0007744|PDB:6M4O,ECO:0007744|PDB:7CQI,ECO:0007744|PDB:7CQK;Dbxref=PMID:33558762	
Q8N138	UniProtKB	Transmembrane	45	63	.	.	.	Note=Helical;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:33558762,ECO:0007744|PDB:6M4N,ECO:0007744|PDB:6M4O,ECO:0007744|PDB:7CQI,ECO:0007744|PDB:7CQK;Dbxref=PMID:33558762	
Q8N138	UniProtKB	Topological domain	64	100	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8N138	UniProtKB	Transmembrane	101	117	.	.	.	Note=Helical;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:33558762,ECO:0007744|PDB:6M4N,ECO:0007744|PDB:6M4O,ECO:0007744|PDB:7CQI,ECO:0007744|PDB:7CQK;Dbxref=PMID:33558762	
Q8N138	UniProtKB	Topological domain	118	121	.	.	.	Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8N138	UniProtKB	Transmembrane	122	139	.	.	.	Note=Helical;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:33558762,ECO:0007744|PDB:6M4N,ECO:0007744|PDB:6M4O,ECO:0007744|PDB:7CQI,ECO:0007744|PDB:7CQK;Dbxref=PMID:33558762	
Q8N138	UniProtKB	Topological domain	140	153	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8N138	UniProtKB	Region	1	17	.	.	.	Note=Important for ceramide level-sensing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37308477;Dbxref=PMID:37308477	
Q8N138	UniProtKB	Modified residue	137	137	.	.	.	Note=Hydroxyproline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:36408842;Dbxref=PMID:36408842	
Q8N138	UniProtKB	Alternative sequence	43	58	.	.	.	ID=VSP_016052;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3	
Q8N138	UniProtKB	Mutagenesis	2	17	.	.	.	Note=Impaired negative regulation of SPT complex activity in the presence of ceramides. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37308477;Dbxref=PMID:37308477	
Q8N138	UniProtKB	Mutagenesis	2	8	.	.	.	Note=Impaired negative regulation of SPT complex activity in the presence of ceramides. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37308477;Dbxref=PMID:37308477	
Q8N138	UniProtKB	Mutagenesis	2	2	.	.	.	Note=Impaired negative regulation of SPT complex activity in the presence of ceramides. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37308477;Dbxref=PMID:37308477	
Q8N138	UniProtKB	Mutagenesis	13	13	.	.	.	Note=Disrupted ceramide binding%3B impaired negative regulation of SPT complex activity in the presence of ceramides%3B in the absence of ceramides%2C reduced affinity of SPT complex towards palmitoyl-CoA. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37308477;Dbxref=PMID:37308477	
Q8N138	UniProtKB	Mutagenesis	16	16	.	.	.	Note=Impaired negative regulation of SPT complex activity in the presence of ceramides. V->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37308477;Dbxref=PMID:37308477	
Q8N138	UniProtKB	Mutagenesis	22	22	.	.	.	Note=Impaired negative regulation of SPT complex activity in the presence of ceramides. I->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37308477;Dbxref=PMID:37308477	
Q8N138	UniProtKB	Mutagenesis	63	63	.	.	.	Note=Impaired negative regulation of SPT complex activity in the presence of ceramides. F->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37308477;Dbxref=PMID:37308477	
Q8N138	UniProtKB	Mutagenesis	63	63	.	.	.	Note=Impaired negative regulation of SPT complex activity in the presence of ceramides. F->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37308477;Dbxref=PMID:37308477	
Q8N138	UniProtKB	Mutagenesis	85	85	.	.	.	Note=No effect on the negative regulation of SPT complex activity in the presence of ceramides. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37308477;Dbxref=PMID:37308477	
Q8N138	UniProtKB	Mutagenesis	137	137	.	.	.	Note=Increased protein levels%3B decreased ubiquitination%3B increased negative regulation of SPT complex activity. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:36408842;Dbxref=PMID:36408842	
Q8N138	UniProtKB	Helix	12	14	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0M	
Q8N138	UniProtKB	Helix	16	18	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0M	
Q8N138	UniProtKB	Helix	22	38	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0M	
Q8N138	UniProtKB	Beta strand	40	42	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0Q	
Q8N138	UniProtKB	Helix	45	65	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0M	
Q8N138	UniProtKB	Beta strand	67	69	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0Q	
Q8N138	UniProtKB	Beta strand	71	73	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7CQI	
Q8N138	UniProtKB	Turn	75	77	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0P	
Q8N138	UniProtKB	Turn	79	82	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0N	
Q8N138	UniProtKB	Helix	85	88	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0M	
Q8N138	UniProtKB	Helix	89	92	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0M	
Q8N138	UniProtKB	Helix	97	116	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0M	
Q8N138	UniProtKB	Turn	117	119	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0M	
Q8N138	UniProtKB	Helix	121	135	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0M	
Q8N138	UniProtKB	Turn	136	138	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0M	
Q8N138	UniProtKB	Beta strand	142	144	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0M	
Q8N138	UniProtKB	Helix	147	149	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7K0M