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Protein

Centrobin

Gene

CNTROB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB

GO - Biological processi

  • centriole replication Source: HGNC
  • centrosome separation Source: HGNC
  • mitotic cytokinetic process Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Centrobin
Alternative name(s):
Centrosomal BRCA2-interacting protein
LYST-interacting protein 8
Gene namesi
Name:CNTROB
Synonyms:LIP8
ORF Names:PP1221
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29616. CNTROB.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: HGNC
  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485436.

Polymorphism and mutation databases

BioMutaiCNTROB.
DMDMi74728485.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 903903CentrobinPRO_0000076240Add
BLAST

Proteomic databases

EPDiQ8N137.
MaxQBiQ8N137.
PaxDbiQ8N137.
PRIDEiQ8N137.

PTM databases

iPTMnetiQ8N137.
PhosphoSiteiQ8N137.

Expressioni

Tissue specificityi

Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.1 Publication

Developmental stagei

Preferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases.1 Publication

Gene expression databases

BgeeiQ8N137.
CleanExiHS_CNTROB.
ExpressionAtlasiQ8N137. baseline and differential.
GenevisibleiQ8N137. HS.

Organism-specific databases

HPAiHPA023319.
HPA023320.
HPA023321.
HPA023325.

Interactioni

Subunit structurei

Interacts with LYST.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
COASYQ13057-23EBI-947360,EBI-10227704
TTC23Q5W5X93EBI-947360,EBI-6447954

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125533. 120 interactions.
IntActiQ8N137. 119 interactions.
MINTiMINT-2878302.
STRINGi9606.ENSP00000369614.

Structurei

3D structure databases

ProteinModelPortaliQ8N137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni365 – 903539Required for centrosome localizationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili196 – 560365Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi573 – 777205Pro-richAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410ISM1. Eukaryota.
ENOG4111JSV. LUCA.
GeneTreeiENSGT00610000086191.
HOVERGENiHBG081290.
InParanoidiQ8N137.
KOiK16468.
OMAiFQSQHSF.
OrthoDBiEOG7KH9J6.
PhylomeDBiQ8N137.
TreeFamiTF337444.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N137-1) [UniParc]FASTAAdd to basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSADSPSS PLGAEDLLSD SSEPPGLNQV SSEVTSQLYA SLRLSRQAEA
60 70 80 90 100
TARAQLYLPS TSPPHEGLDG FAQELSRSLS VGLEKNLKKK DGSKHIFEME
110 120 130 140 150
SVRGQLQTML QTSRDTAYRD PLIPGAGSER REEDSFDSDS TATLLNTRPL
160 170 180 190 200
QDLSPSSSAQ ALEELFPRYT SLRPGPPLNP PDFQGLRDAL DSEHTRRKHC
210 220 230 240 250
ERHIQSLQTR VLELQQQLAV AVAADRKKDT MIEQLDKTLA RVVEGWNRHE
260 270 280 290 300
AERTEVLRGL QEEHQAAELT RSKQQETVTR LEQSLSEAME ALNREQESAR
310 320 330 340 350
LQQRERETLE EERQALTLRL EAEQQRCCVL QEERDAARAG QLSEHRELET
360 370 380 390 400
LRAALEEERQ TWAQQEHQLK EHYQALQEES QAQLEREKEK SQREAQAAWE
410 420 430 440 450
TQHQLALVQS EVRRLEGELD TARRERDALQ LEMSLVQARY ESQRIQLESE
460 470 480 490 500
LAVQLEQRVT ERLAQAQESS LRQAASLREH HRKQLQDLSG QHQQELASQL
510 520 530 540 550
AQFKVEMAER EERQQQVAED YELRLAREQA RVCELQSGNQ QLEEQRVELV
560 570 580 590 600
ERLQAMLQAH WDEANQLLST TLPPPNPPAP PAGPSSPGPQ EPEKEERRVW
610 620 630 640 650
TMPPMAVALK PVLQQSREAR DELPGAPPVL CSSSSDLSLL LGPSFQSQHS
660 670 680 690 700
FQPLEPKPDL TSSTAGAFSA LGAFHPDHRA ERPFPEEDPG PDGEGLLKQG
710 720 730 740 750
LPPAQLEGLK NFLHQLLETV PQNNENPSVD LLPPKSGPLT VPSWEEAPQV
760 770 780 790 800
PRIPPPVHKT KVPLAMASSL FRVPEPPSSH SQGSGPSSGS PERGGDGLTF
810 820 830 840 850
PRQLMEVSQL LRLYQARGWG ALPAEDLLLY LKRLEHSGTD GRGDNVPRRN
860 870 880 890 900
TDSRLGEIPR KEIPSQAVPR RLATAPKTEK PPARKKSGHP APSSMRSRGG

VWR
Length:903
Mass (Da):101,253
Last modified:October 1, 2002 - v1
Checksum:i3F8E6DE4CEF51851
GO
Isoform 2 (identifier: Q8N137-2) [UniParc]FASTAAdd to basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     838-838: G → GYKPGRKEEGFSGWKLDYGEWSG

Show »
Length:925
Mass (Da):103,812
Checksum:i996115AF2E10061C
GO
Isoform 3 (identifier: Q8N137-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     838-838: G → GR

Note: No experimental confirmation available.
Show »
Length:904
Mass (Da):101,409
Checksum:i10601C3ADA721982
GO
Isoform 4 (identifier: Q8N137-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     526-554: AREQARVCELQSGNQQLEEQRVELVERLQ → LLLDPPAPGLRSPRRRRGGSGLCLPWPWP
     555-903: Missing.

Note: No experimental confirmation available.
Show »
Length:554
Mass (Da):63,334
Checksum:i41E04379767F8EF7
GO
Isoform 5 (identifier: Q8N137-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     839-864: TDGRGDNVPRRNTDSRLGEIPRKEIP → YKPGRKEEGFSGWKLDYGEWSGCVLH
     865-903: Missing.

Note: No experimental confirmation available.
Show »
Length:864
Mass (Da):97,113
Checksum:i83F2A5096710E8FB
GO

Sequence cautioni

The sequence AAG49447.1 differs from that shown. Reason: Frameshift at position 609. Curated
The sequence AAG49447.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAC11241.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti582 – 5821A → D in AAG49447 (PubMed:11984006).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti439 – 4391R → Q.
Corresponds to variant rs35421969 [ dbSNP | Ensembl ].
VAR_050877
Natural varianti578 – 5781P → Q.2 Publications
Corresponds to variant rs11650083 [ dbSNP | Ensembl ].
VAR_024787

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei526 – 55429AREQA…VERLQ → LLLDPPAPGLRSPRRRRGGS GLCLPWPWP in isoform 4. 1 PublicationVSP_016836Add
BLAST
Alternative sequencei555 – 903349Missing in isoform 4. 1 PublicationVSP_016837Add
BLAST
Alternative sequencei838 – 8381G → GYKPGRKEEGFSGWKLDYGE WSG in isoform 2. 1 PublicationVSP_016838
Alternative sequencei838 – 8381G → GR in isoform 3. 1 PublicationVSP_016839
Alternative sequencei839 – 86426TDGRG…RKEIP → YKPGRKEEGFSGWKLDYGEW SGCVLH in isoform 5. 1 PublicationVSP_016840Add
BLAST
Alternative sequencei865 – 90339Missing in isoform 5. 1 PublicationVSP_016841Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY160226 mRNA. Translation: AAO22135.1.
AY160227 mRNA. Translation: AAO22136.1.
AF331638 mRNA. Translation: AAL56068.2.
AL137669 mRNA. Translation: CAH10698.1.
AL833907 mRNA. Translation: CAD38763.1.
AC104581 Genomic DNA. No translation available.
BC014055 mRNA. Translation: AAH14055.3.
BC021134 mRNA. Translation: AAH21134.1.
AK074847 mRNA. Translation: BAC11241.1. Different initiation.
AF141344 mRNA. Translation: AAG49447.1. Sequence problems.
CCDSiCCDS11126.1. [Q8N137-1]
CCDS32557.1. [Q8N137-2]
RefSeqiNP_001032221.1. NM_001037144.5. [Q8N137-2]
NP_444279.2. NM_053051.3. [Q8N137-1]
XP_005256494.1. XM_005256437.1. [Q8N137-3]
UniGeneiHs.348012.

Genome annotation databases

EnsembliENST00000380262; ENSP00000369614; ENSG00000170037. [Q8N137-2]
ENST00000563694; ENSP00000456335; ENSG00000170037. [Q8N137-1]
ENST00000565740; ENSP00000454840; ENSG00000170037. [Q8N137-3]
GeneIDi116840.
KEGGihsa:116840.
UCSCiuc060axe.1. human. [Q8N137-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY160226 mRNA. Translation: AAO22135.1.
AY160227 mRNA. Translation: AAO22136.1.
AF331638 mRNA. Translation: AAL56068.2.
AL137669 mRNA. Translation: CAH10698.1.
AL833907 mRNA. Translation: CAD38763.1.
AC104581 Genomic DNA. No translation available.
BC014055 mRNA. Translation: AAH14055.3.
BC021134 mRNA. Translation: AAH21134.1.
AK074847 mRNA. Translation: BAC11241.1. Different initiation.
AF141344 mRNA. Translation: AAG49447.1. Sequence problems.
CCDSiCCDS11126.1. [Q8N137-1]
CCDS32557.1. [Q8N137-2]
RefSeqiNP_001032221.1. NM_001037144.5. [Q8N137-2]
NP_444279.2. NM_053051.3. [Q8N137-1]
XP_005256494.1. XM_005256437.1. [Q8N137-3]
UniGeneiHs.348012.

3D structure databases

ProteinModelPortaliQ8N137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125533. 120 interactions.
IntActiQ8N137. 119 interactions.
MINTiMINT-2878302.
STRINGi9606.ENSP00000369614.

PTM databases

iPTMnetiQ8N137.
PhosphoSiteiQ8N137.

Polymorphism and mutation databases

BioMutaiCNTROB.
DMDMi74728485.

Proteomic databases

EPDiQ8N137.
MaxQBiQ8N137.
PaxDbiQ8N137.
PRIDEiQ8N137.

Protocols and materials databases

DNASUi116840.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380262; ENSP00000369614; ENSG00000170037. [Q8N137-2]
ENST00000563694; ENSP00000456335; ENSG00000170037. [Q8N137-1]
ENST00000565740; ENSP00000454840; ENSG00000170037. [Q8N137-3]
GeneIDi116840.
KEGGihsa:116840.
UCSCiuc060axe.1. human. [Q8N137-1]

Organism-specific databases

CTDi116840.
GeneCardsiCNTROB.
HGNCiHGNC:29616. CNTROB.
HPAiHPA023319.
HPA023320.
HPA023321.
HPA023325.
MIMi611425. gene.
neXtProtiNX_Q8N137.
PharmGKBiPA143485436.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISM1. Eukaryota.
ENOG4111JSV. LUCA.
GeneTreeiENSGT00610000086191.
HOVERGENiHBG081290.
InParanoidiQ8N137.
KOiK16468.
OMAiFQSQHSF.
OrthoDBiEOG7KH9J6.
PhylomeDBiQ8N137.
TreeFamiTF337444.

Miscellaneous databases

ChiTaRSiCNTROB. human.
GeneWikiiCNTROB.
GenomeRNAii116840.
PROiQ8N137.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N137.
CleanExiHS_CNTROB.
ExpressionAtlasiQ8N137. baseline and differential.
GenevisibleiQ8N137. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication."
    Zou C., Li J., Bai Y., Gunning W.T., Wazer D.E., Band V., Gao Q.
    J. Cell Biol. 171:437-445(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 147-903 (ISOFORM 4).
    Tissue: Testis.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 100-903 (ISOFORM 3).
    Tissue: Brain and Skin.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 369-903 (ISOFORM 5), VARIANT GLN-578.
    Tissue: Teratocarcinoma.
  7. "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins."
    Tchernev V.T., Mansfield T.A., Giot L., Kumar A.M., Nandabalan K., Li Y., Mishra V.S., Detter J.C., Rothberg J.M., Wallace M.R., Southwick F.S., Kingsmore S.F.
    Mol. Med. 8:56-64(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 524-646, INTERACTION WITH LYST, VARIANT GLN-578.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCNTRB_HUMAN
AccessioniPrimary (citable) accession number: Q8N137
Secondary accession number(s): A6NHQ1
, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.