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Protein

Dynein assembly factor with WDR repeat domains 1

Gene

DAW1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in axonemal outer row dynein assembly.By similarity

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ8N136.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein assembly factor with WDR repeat domains 1
Alternative name(s):
Outer row dynein assembly protein 16 homolog
WD repeat-containing protein 69
Gene namesi
Name:DAW1
Synonyms:WDR69
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000123977.9.
HGNCiHGNC:26383. DAW1.

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000123977.
PharmGKBiPA142670602.

Polymorphism and mutation databases

BioMutaiDAW1.
DMDMi74759762.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426541 – 415Dynein assembly factor with WDR repeat domains 1Add BLAST415

Proteomic databases

PaxDbiQ8N136.
PeptideAtlasiQ8N136.
PRIDEiQ8N136.

PTM databases

iPTMnetiQ8N136.
PhosphoSitePlusiQ8N136.

Expressioni

Gene expression databases

BgeeiENSG00000123977.
CleanExiHS_WDR69.
ExpressionAtlasiQ8N136. baseline and differential.
GenevisibleiQ8N136. HS.

Organism-specific databases

HPAiHPA046118.

Interactioni

Subunit structurei

Interacts with IFT46.1 Publication

Protein-protein interaction databases

BioGridi127902. 2 interactors.
IntActiQ8N136. 2 interactors.
STRINGi9606.ENSP00000311899.

Structurei

Secondary structure

1415
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi83 – 89Combined sources7
Beta strandi95 – 100Combined sources6
Beta strandi104 – 111Combined sources8
Beta strandi116 – 120Combined sources5
Turni121 – 123Combined sources3
Beta strandi126 – 130Combined sources5
Beta strandi137 – 142Combined sources6
Turni144 – 146Combined sources3
Beta strandi149 – 154Combined sources6
Beta strandi159 – 167Combined sources9
Beta strandi169 – 173Combined sources5
Beta strandi180 – 185Combined sources6
Helixi187 – 189Combined sources3
Beta strandi191 – 196Combined sources6
Beta strandi199 – 208Combined sources10
Beta strandi211 – 216Combined sources6
Beta strandi222 – 227Combined sources6
Beta strandi233 – 238Combined sources6
Beta strandi243 – 247Combined sources5
Turni248 – 250Combined sources3
Beta strandi252 – 257Combined sources6
Beta strandi264 – 269Combined sources6
Beta strandi274 – 283Combined sources10
Beta strandi285 – 289Combined sources5
Turni290 – 292Combined sources3
Beta strandi295 – 299Combined sources5
Beta strandi306 – 311Combined sources6
Beta strandi313 – 315Combined sources3
Beta strandi317 – 322Combined sources6
Beta strandi327 – 331Combined sources5
Turni332 – 334Combined sources3
Beta strandi337 – 341Combined sources5
Beta strandi348 – 353Combined sources6
Beta strandi357 – 364Combined sources8
Beta strandi369 – 373Combined sources5
Turni374 – 376Combined sources3
Beta strandi379 – 383Combined sources5
Beta strandi390 – 395Combined sources6
Beta strandi402 – 406Combined sources5
Beta strandi409 – 415Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NNZX-ray2.65A/B1-415[»]
ProteinModelPortaliQ8N136.
SMRiQ8N136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati90 – 129WD 1Add BLAST40
Repeati132 – 174WD 2Add BLAST43
Repeati175 – 214WD 3Add BLAST40
Repeati217 – 256WD 4Add BLAST40
Repeati259 – 298WD 5Add BLAST40
Repeati301 – 340WD 6Add BLAST40
Repeati343 – 384WD 7Add BLAST42
Repeati386 – 415WD 8Add BLAST30

Sequence similaritiesi

Belongs to the WD repeat WDR69 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0272. Eukaryota.
ENOG410XNP8. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000253909.
HOVERGENiHBG103651.
InParanoidiQ8N136.
KOiK19760.
OMAiSYDRTCH.
OrthoDBiEOG091G07DT.
PhylomeDBiQ8N136.
TreeFamiTF323481.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF00400. WD40. 8 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 8 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 8 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N136-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLKSLLLRY YPPGIMLEYE KHGELKTKSI DLLDLGPSTD VSALVEEIQK
60 70 80 90 100
AEPLLTASRT EQVKLLIQRL QEKLGQNSNH TFYLFKVLKA HILPLTNVAL
110 120 130 140 150
NKSGSCFITG SYDRTCKLWD TASGEELNTL EGHRNVVYAI AFNNPYGDKI
160 170 180 190 200
ATGSFDKTCK LWSVETGKCY HTFRGHTAEI VCLSFNPQST LVATGSMDTT
210 220 230 240 250
AKLWDIQNGE EVYTLRGHSA EIISLSFNTS GDRIITGSFD HTVVVWDADT
260 270 280 290 300
GRKVNILIGH CAEISSASFN WDCSLILTGS MDKTCKLWDA TNGKCVATLT
310 320 330 340 350
GHDDEILDSC FDYTGKLIAT ASADGTARIF SAATRKCIAK LEGHEGEISK
360 370 380 390 400
ISFNPQGNHL LTGSSDKTAR IWDAQTGQCL QVLEGHTDEI FSCAFNYKGN
410
IVITGSKDNT CRIWR
Length:415
Mass (Da):45,777
Last modified:October 1, 2002 - v1
Checksum:i457B11B1DAD4E321
GO
Isoform 2 (identifier: Q8N136-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-369: GTARIFSAAT...LLTGSSDKTA → DGVSLCRPGR...ELCHVLGNHV
     370-415: Missing.

Note: No experimental confirmation available.
Show »
Length:369
Mass (Da):40,515
Checksum:i9FC1B6C16FDA8E96
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti408D → G in BAC05425 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02685327T → I. Corresponds to variant dbSNP:rs11894733Ensembl.1
Natural variantiVAR_026854121T → S1 PublicationCorresponds to variant dbSNP:rs1715828Ensembl.1
Natural variantiVAR_035891129T → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs113776284Ensembl.1
Natural variantiVAR_033811259G → S. Corresponds to variant dbSNP:rs35027781Ensembl.1
Natural variantiVAR_033812317L → F. Corresponds to variant dbSNP:rs35395984Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019460325 – 369GTARI…SDKTA → DGVSLCRPGRSAVARSWLTA TCASQVQAILLPQPPELCHV LGNHV in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_019461370 – 415Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097409 mRNA. Translation: BAC05039.1.
AK098821 mRNA. Translation: BAC05425.1.
AK127882 mRNA. Translation: BAC87175.1.
AC073065 Genomic DNA. Translation: AAX93215.1.
BC036377 mRNA. Translation: AAH36377.1.
CCDSiCCDS2470.1. [Q8N136-1]
RefSeqiNP_001316933.1. NM_001330004.1.
NP_849143.1. NM_178821.2. [Q8N136-1]
UniGeneiHs.424594.

Genome annotation databases

EnsembliENST00000309931; ENSP00000311899; ENSG00000123977. [Q8N136-1]
GeneIDi164781.
KEGGihsa:164781.
UCSCiuc002vpn.2. human. [Q8N136-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDAW1_HUMAN
AccessioniPrimary (citable) accession number: Q8N136
Secondary accession number(s): Q6ZRY1, Q8N776
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families