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Protein

Dynein assembly factor with WDR repeat domains 1

Gene

DAW1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in axonemal outer row dynein assembly.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8N136.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein assembly factor with WDR repeat domains 1
Alternative name(s):
Outer row dynein assembly protein 16 homolog
WD repeat-containing protein 69
Gene namesi
Name:DAW1
Synonyms:WDR69
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26383. DAW1.

Subcellular locationi

GO - Cellular componenti

  • cilium Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670602.

Polymorphism and mutation databases

BioMutaiDAW1.
DMDMi74759762.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Dynein assembly factor with WDR repeat domains 1PRO_0000242654Add
BLAST

Proteomic databases

PaxDbiQ8N136.
PRIDEiQ8N136.

PTM databases

PhosphoSiteiQ8N136.

Expressioni

Gene expression databases

BgeeiQ8N136.
CleanExiHS_WDR69.
ExpressionAtlasiQ8N136. baseline and differential.
GenevisibleiQ8N136. HS.

Organism-specific databases

HPAiHPA046118.

Interactioni

Subunit structurei

Interacts with IFT46.1 Publication

Protein-protein interaction databases

BioGridi127902. 2 interactions.
IntActiQ8N136. 2 interactions.
STRINGi9606.ENSP00000311899.

Structurei

3D structure databases

ProteinModelPortaliQ8N136.
SMRiQ8N136. Positions 41-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati90 – 12940WD 1Add
BLAST
Repeati132 – 17443WD 2Add
BLAST
Repeati175 – 21440WD 3Add
BLAST
Repeati217 – 25640WD 4Add
BLAST
Repeati259 – 29840WD 5Add
BLAST
Repeati301 – 34040WD 6Add
BLAST
Repeati343 – 38442WD 7Add
BLAST
Repeati386 – 41530WD 8Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat WDR69 family.Curated
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0272. Eukaryota.
ENOG410XNP8. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000253909.
HOVERGENiHBG103651.
InParanoidiQ8N136.
KOiK19760.
OMAiLCTFYGH.
PhylomeDBiQ8N136.
TreeFamiTF323481.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 8 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 8 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N136-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLKSLLLRY YPPGIMLEYE KHGELKTKSI DLLDLGPSTD VSALVEEIQK
60 70 80 90 100
AEPLLTASRT EQVKLLIQRL QEKLGQNSNH TFYLFKVLKA HILPLTNVAL
110 120 130 140 150
NKSGSCFITG SYDRTCKLWD TASGEELNTL EGHRNVVYAI AFNNPYGDKI
160 170 180 190 200
ATGSFDKTCK LWSVETGKCY HTFRGHTAEI VCLSFNPQST LVATGSMDTT
210 220 230 240 250
AKLWDIQNGE EVYTLRGHSA EIISLSFNTS GDRIITGSFD HTVVVWDADT
260 270 280 290 300
GRKVNILIGH CAEISSASFN WDCSLILTGS MDKTCKLWDA TNGKCVATLT
310 320 330 340 350
GHDDEILDSC FDYTGKLIAT ASADGTARIF SAATRKCIAK LEGHEGEISK
360 370 380 390 400
ISFNPQGNHL LTGSSDKTAR IWDAQTGQCL QVLEGHTDEI FSCAFNYKGN
410
IVITGSKDNT CRIWR
Length:415
Mass (Da):45,777
Last modified:October 1, 2002 - v1
Checksum:i457B11B1DAD4E321
GO
Isoform 2 (identifier: Q8N136-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-369: GTARIFSAAT...LLTGSSDKTA → DGVSLCRPGR...ELCHVLGNHV
     370-415: Missing.

Note: No experimental confirmation available.
Show »
Length:369
Mass (Da):40,515
Checksum:i9FC1B6C16FDA8E96
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti408 – 4081D → G in BAC05425 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271T → I.
Corresponds to variant rs11894733 [ dbSNP | Ensembl ].
VAR_026853
Natural varianti121 – 1211T → S.1 Publication
Corresponds to variant rs1715828 [ dbSNP | Ensembl ].
VAR_026854
Natural varianti129 – 1291T → M in a breast cancer sample; somatic mutation. 1 Publication
VAR_035891
Natural varianti259 – 2591G → S.
Corresponds to variant rs35027781 [ dbSNP | Ensembl ].
VAR_033811
Natural varianti317 – 3171L → F.
Corresponds to variant rs35395984 [ dbSNP | Ensembl ].
VAR_033812

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei325 – 36945GTARI…SDKTA → DGVSLCRPGRSAVARSWLTA TCASQVQAILLPQPPELCHV LGNHV in isoform 2. 1 PublicationVSP_019460Add
BLAST
Alternative sequencei370 – 41546Missing in isoform 2. 1 PublicationVSP_019461Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097409 mRNA. Translation: BAC05039.1.
AK098821 mRNA. Translation: BAC05425.1.
AK127882 mRNA. Translation: BAC87175.1.
AC073065 Genomic DNA. Translation: AAX93215.1.
BC036377 mRNA. Translation: AAH36377.1.
CCDSiCCDS2470.1. [Q8N136-1]
RefSeqiNP_849143.1. NM_178821.1. [Q8N136-1]
UniGeneiHs.424594.

Genome annotation databases

EnsembliENST00000309931; ENSP00000311899; ENSG00000123977. [Q8N136-1]
GeneIDi164781.
KEGGihsa:164781.
UCSCiuc002vpn.2. human. [Q8N136-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097409 mRNA. Translation: BAC05039.1.
AK098821 mRNA. Translation: BAC05425.1.
AK127882 mRNA. Translation: BAC87175.1.
AC073065 Genomic DNA. Translation: AAX93215.1.
BC036377 mRNA. Translation: AAH36377.1.
CCDSiCCDS2470.1. [Q8N136-1]
RefSeqiNP_849143.1. NM_178821.1. [Q8N136-1]
UniGeneiHs.424594.

3D structure databases

ProteinModelPortaliQ8N136.
SMRiQ8N136. Positions 41-415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127902. 2 interactions.
IntActiQ8N136. 2 interactions.
STRINGi9606.ENSP00000311899.

PTM databases

PhosphoSiteiQ8N136.

Polymorphism and mutation databases

BioMutaiDAW1.
DMDMi74759762.

Proteomic databases

PaxDbiQ8N136.
PRIDEiQ8N136.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309931; ENSP00000311899; ENSG00000123977. [Q8N136-1]
GeneIDi164781.
KEGGihsa:164781.
UCSCiuc002vpn.2. human. [Q8N136-1]

Organism-specific databases

CTDi164781.
GeneCardsiDAW1.
HGNCiHGNC:26383. DAW1.
HPAiHPA046118.
neXtProtiNX_Q8N136.
PharmGKBiPA142670602.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0272. Eukaryota.
ENOG410XNP8. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000253909.
HOVERGENiHBG103651.
InParanoidiQ8N136.
KOiK19760.
OMAiLCTFYGH.
PhylomeDBiQ8N136.
TreeFamiTF323481.

Enzyme and pathway databases

SignaLinkiQ8N136.

Miscellaneous databases

GenomeRNAii164781.
NextBioi88498.
PROiQ8N136.

Gene expression databases

BgeeiQ8N136.
CleanExiHS_WDR69.
ExpressionAtlasiQ8N136. baseline and differential.
GenevisibleiQ8N136. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 8 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 8 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-121.
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery."
    Ahmed N.T., Gao C., Lucker B.F., Cole D.G., Mitchell D.R.
    J. Cell Biol. 183:313-322(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IFT46.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-129.

Entry informationi

Entry nameiDAW1_HUMAN
AccessioniPrimary (citable) accession number: Q8N136
Secondary accession number(s): Q6ZRY1, Q8N776
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.