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Protein

Leucine-rich repeat LGI family member 4

Gene

LGI4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153902-MONOMER.
ReactomeiR-HSA-5682910. LGI-ADAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat LGI family member 4
Alternative name(s):
LGI1-like protein 3
Leucine-rich glioma-inactivated protein 4
Gene namesi
Name:LGI4
Synonyms:LGIL3
ORF Names:UNQ6515/PRO21485
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18712. LGI4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi163175.
OpenTargetsiENSG00000153902.
PharmGKBiPA38656.

Polymorphism and mutation databases

BioMutaiLGI4.
DMDMi32469741.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001771220 – 537Leucine-rich repeat LGI family member 4Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi177N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N135.
PeptideAtlasiQ8N135.
PRIDEiQ8N135.

PTM databases

iPTMnetiQ8N135.
PhosphoSitePlusiQ8N135.

Expressioni

Tissue specificityi

Widely expressed, with highest expression in brain.1 Publication

Gene expression databases

BgeeiENSG00000153902.
CleanExiHS_LGI4.
ExpressionAtlasiQ8N135. baseline and differential.
GenevisibleiQ8N135. HS.

Organism-specific databases

HPAiHPA042116.
HPA043556.

Interactioni

Subunit structurei

Can bind to ADAM11, ADAM22 and ADAM23.By similarity

Protein-protein interaction databases

BioGridi127855. 1 interactor.
STRINGi9606.ENSP00000312273.

Structurei

3D structure databases

ProteinModelPortaliQ8N135.
SMRiQ8N135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 74LRR 1Add BLAST22
Repeati77 – 98LRR 2Add BLAST22
Repeati101 – 122LRR 3Add BLAST22
Repeati125 – 146LRR 4Add BLAST22
Domaini158 – 208LRRCTAdd BLAST51
Repeati209 – 252EAR 1Add BLAST44
Repeati350 – 394EAR 2Add BLAST45
Repeati395 – 439EAR 3Add BLAST45
Repeati440 – 483EAR 4Add BLAST44

Sequence similaritiesi

Contains 4 EAR repeats.PROSITE-ProRule annotation
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJHU. Eukaryota.
ENOG4111DWK. LUCA.
GeneTreeiENSGT00860000133701.
HOGENOMiHOG000286015.
HOVERGENiHBG036744.
InParanoidiQ8N135.
OMAiYQGEPHI.
OrthoDBiEOG091G03ZX.
PhylomeDBiQ8N135.
TreeFamiTF333155.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF03736. EPTP. 3 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS50912. EAR. 4 hits.
PS51450. LRR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N135-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGAGILLLL LAGAGVVVAW RPPKGKCPLR CSCSKDSALC EGSPDLPVSF
60 70 80 90 100
SPTLLSLSLV RTGVTQLKAG SFLRIPSLHL LLFTSNSFSV IEDDAFAGLS
110 120 130 140 150
HLQYLFIEDN EIGSISKNAL RGLRSLTHLS LANNHLETLP RFLFRGLDTL
160 170 180 190 200
THVDLRGNPF QCDCRVLWLL QWMPTVNASV GTGACAGPAS LSHMQLHHLD
210 220 230 240 250
PKTFKCRAIE LSWFQTVGES ALSVEPFSYQ GEPHIVLAQP FAGRCLILSW
260 270 280 290 300
DYSLQRFRPE EELPAASVVS CKPLVLGPSL FVLAARLWGG SQLWARPSPG
310 320 330 340 350
LRLAPTQTLA PRRLLRPNDA ELLWLEGQPC FVVADASKAG STTLLCRDGP
360 370 380 390 400
GFYPHQSLHA WHRDTDAEAL ELDGRPHLLL ASASQRPVLF HWTGGRFERR
410 420 430 440 450
TDIPEAEDVY ATRHFQAGGD VFLCLTRYIG DSMVMRWDGS MFRLLQQLPS
460 470 480 490 500
RGAHVFQPLL IARDQLAILG SDFAFSQVLR LEPDKGLLEP LQELGPPALV
510 520 530
APRAFAHITM AGRRFLFAAC FKGPTQIYQH HEIDLSA
Length:537
Mass (Da):59,141
Last modified:October 1, 2002 - v1
Checksum:i47B920C809679926
GO
Isoform 2 (identifier: Q8N135-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-261: ELSWFQTVGE...YSLQRFRPEE → GGGLSRWGGR...CLPEPQFSHL
     262-537: Missing.

Show »
Length:261
Mass (Da):28,231
Checksum:i07AC514EF74512B6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009230210 – 261ELSWF…FRPEE → GGGLSRWGGRREIWGKGCQG QEARLTPCPAISRSGKTLSK QHCLPEPQFSHL in isoform 2. 2 PublicationsAdd BLAST52
Alternative sequenceiVSP_009231262 – 537Missing in isoform 2. 2 PublicationsAdd BLAST276

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467954 mRNA. Translation: AAM49552.1.
AJ487959 mRNA. Translation: CAD32306.1.
AJ487519 mRNA. Translation: CAD31787.1.
AY358121 mRNA. Translation: AAQ88488.1.
BC087848 mRNA. Translation: AAH87848.1.
BC136694 mRNA. Translation: AAI36695.1.
BC136697 mRNA. Translation: AAI36698.1.
CCDSiCCDS12444.1. [Q8N135-1]
RefSeqiNP_644813.1. NM_139284.2. [Q8N135-1]
UniGeneiHs.65256.

Genome annotation databases

EnsembliENST00000310123; ENSP00000312273; ENSG00000153902. [Q8N135-1]
ENST00000591633; ENSP00000467784; ENSG00000153902. [Q8N135-2]
GeneIDi163175.
KEGGihsa:163175.
UCSCiuc002nxx.3. human. [Q8N135-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467954 mRNA. Translation: AAM49552.1.
AJ487959 mRNA. Translation: CAD32306.1.
AJ487519 mRNA. Translation: CAD31787.1.
AY358121 mRNA. Translation: AAQ88488.1.
BC087848 mRNA. Translation: AAH87848.1.
BC136694 mRNA. Translation: AAI36695.1.
BC136697 mRNA. Translation: AAI36698.1.
CCDSiCCDS12444.1. [Q8N135-1]
RefSeqiNP_644813.1. NM_139284.2. [Q8N135-1]
UniGeneiHs.65256.

3D structure databases

ProteinModelPortaliQ8N135.
SMRiQ8N135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127855. 1 interactor.
STRINGi9606.ENSP00000312273.

PTM databases

iPTMnetiQ8N135.
PhosphoSitePlusiQ8N135.

Polymorphism and mutation databases

BioMutaiLGI4.
DMDMi32469741.

Proteomic databases

PaxDbiQ8N135.
PeptideAtlasiQ8N135.
PRIDEiQ8N135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310123; ENSP00000312273; ENSG00000153902. [Q8N135-1]
ENST00000591633; ENSP00000467784; ENSG00000153902. [Q8N135-2]
GeneIDi163175.
KEGGihsa:163175.
UCSCiuc002nxx.3. human. [Q8N135-1]

Organism-specific databases

CTDi163175.
DisGeNETi163175.
GeneCardsiLGI4.
HGNCiHGNC:18712. LGI4.
HPAiHPA042116.
HPA043556.
MIMi608303. gene.
neXtProtiNX_Q8N135.
OpenTargetsiENSG00000153902.
PharmGKBiPA38656.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJHU. Eukaryota.
ENOG4111DWK. LUCA.
GeneTreeiENSGT00860000133701.
HOGENOMiHOG000286015.
HOVERGENiHBG036744.
InParanoidiQ8N135.
OMAiYQGEPHI.
OrthoDBiEOG091G03ZX.
PhylomeDBiQ8N135.
TreeFamiTF333155.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153902-MONOMER.
ReactomeiR-HSA-5682910. LGI-ADAM interactions.

Miscellaneous databases

ChiTaRSiLGI4. human.
GenomeRNAii163175.
PROiQ8N135.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153902.
CleanExiHS_LGI4.
ExpressionAtlasiQ8N135. baseline and differential.
GenevisibleiQ8N135. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF03736. EPTP. 3 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS50912. EAR. 4 hits.
PS51450. LRR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLGI4_HUMAN
AccessioniPrimary (citable) accession number: Q8N135
Secondary accession number(s): B2RN53, B9EGS7, Q5M8T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.