ID   CNPY4_HUMAN             Reviewed;         248 AA.
AC   Q8N129; Q8WUN9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 142.
DE   RecName: Full=Protein canopy homolog 4;
DE   Flags: Precursor;
GN   Name=CNPY4; ORFNames=PSEC0237, UNQ1909/PRO4354;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA   Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA   Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA   Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA   Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA   Isogai T.;
RT   "Signal sequence and keyword trap in silico for selection of full-length
RT   human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT   libraries.";
RL   DNA Res. 12:117-126(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA   Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA   Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA   Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA   Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA   Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA   Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA   Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA   Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA   Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA   Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA   Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA   Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION.
RX   PubMed=16338228; DOI=10.1016/j.bbrc.2005.11.123;
RA   Konno K., Wakabayashi Y., Akashi-Takamura S., Ishii T., Kobayashi M.,
RA   Takahashi K., Kusumoto Y., Saitoh S., Yoshizawa Y., Miyake K.;
RT   "A molecule that is associated with Toll-like receptor 4 and regulates its
RT   cell surface expression.";
RL   Biochem. Biophys. Res. Commun. 339:1076-1082(2006).
CC   -!- FUNCTION: Plays a role in the regulation of the cell surface expression
CC       of TLR4. {ECO:0000269|PubMed:16338228}.
CC   -!- SUBUNIT: Interacts with TLR4. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8N129; Q9BRQ8: AIFM2; NbExp=3; IntAct=EBI-723824, EBI-3956936;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the canopy family. {ECO:0000305}.
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DR   EMBL; AY359100; AAQ89458.1; -; mRNA.
DR   EMBL; AK075537; BAC11680.1; -; mRNA.
DR   EMBL; CH236956; EAL23850.1; -; Genomic_DNA.
DR   EMBL; BC019903; AAH19903.2; -; mRNA.
DR   EMBL; BC032339; AAH32339.1; -; mRNA.
DR   CCDS; CCDS34701.1; -.
DR   RefSeq; NP_689968.1; NM_152755.1.
DR   AlphaFoldDB; Q8N129; -.
DR   BioGRID; 128831; 21.
DR   IntAct; Q8N129; 9.
DR   STRING; 9606.ENSP00000262932; -.
DR   iPTMnet; Q8N129; -.
DR   PhosphoSitePlus; Q8N129; -.
DR   BioMuta; CNPY4; -.
DR   DMDM; 74728482; -.
DR   EPD; Q8N129; -.
DR   jPOST; Q8N129; -.
DR   MassIVE; Q8N129; -.
DR   MaxQB; Q8N129; -.
DR   PaxDb; 9606-ENSP00000262932; -.
DR   PeptideAtlas; Q8N129; -.
DR   ProteomicsDB; 71530; -.
DR   Pumba; Q8N129; -.
DR   Antibodypedia; 2588; 56 antibodies from 18 providers.
DR   DNASU; 245812; -.
DR   Ensembl; ENST00000262932.5; ENSP00000262932.3; ENSG00000166997.8.
DR   GeneID; 245812; -.
DR   KEGG; hsa:245812; -.
DR   MANE-Select; ENST00000262932.5; ENSP00000262932.3; NM_152755.2; NP_689968.1.
DR   UCSC; uc003uto.4; human.
DR   AGR; HGNC:28631; -.
DR   CTD; 245812; -.
DR   DisGeNET; 245812; -.
DR   GeneCards; CNPY4; -.
DR   HGNC; HGNC:28631; CNPY4.
DR   HPA; ENSG00000166997; Low tissue specificity.
DR   MIM; 610047; gene.
DR   neXtProt; NX_Q8N129; -.
DR   OpenTargets; ENSG00000166997; -.
DR   PharmGKB; PA162382618; -.
DR   VEuPathDB; HostDB:ENSG00000166997; -.
DR   eggNOG; KOG4052; Eukaryota.
DR   GeneTree; ENSGT00390000014072; -.
DR   HOGENOM; CLU_078068_0_1_1; -.
DR   InParanoid; Q8N129; -.
DR   OMA; QYNVHAE; -.
DR   OrthoDB; 2910833at2759; -.
DR   PhylomeDB; Q8N129; -.
DR   TreeFam; TF318951; -.
DR   PathwayCommons; Q8N129; -.
DR   SignaLink; Q8N129; -.
DR   BioGRID-ORCS; 245812; 7 hits in 1152 CRISPR screens.
DR   ChiTaRS; CNPY4; human.
DR   GenomeRNAi; 245812; -.
DR   Pharos; Q8N129; Tdark.
DR   PRO; PR:Q8N129; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q8N129; Protein.
DR   Bgee; ENSG00000166997; Expressed in stromal cell of endometrium and 182 other cell types or tissues.
DR   ExpressionAtlas; Q8N129; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IMP:UniProtKB.
DR   InterPro; IPR021852; DUF3456.
DR   Pfam; PF11938; DUF3456; 1.
DR   Genevisible; Q8N129; HS.
PE   1: Evidence at protein level;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..248
FT                   /note="Protein canopy homolog 4"
FT                   /id="PRO_0000314018"
FT   REGION          200..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..230
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..248
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        38..196
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..184
FT                   /evidence="ECO:0000250"
FT   DISULFID        94..156
FT                   /evidence="ECO:0000250"
FT   VARIANT         168
FT                   /note="G -> R (in dbSNP:rs60551236)"
FT                   /id="VAR_062216"
SQ   SEQUENCE   248 AA;  28310 MW;  561CAEB4A0D7B833 CRC64;
     MGPVRLGILL FLFLAVHEAW AGMLKEEDDD TERLPSKCEV CKLLSTELQA ELSRTGRSRE
     VLELGQVLDT GKRKRHVPYS VSETRLEEAL ENLCERILDY SVHAERKGSL RYAKGQSQTM
     ATLKGLVQKG VKVDLGIPLE LWDEPSVEVT YLKKQCETML EEFEDIVGDW YFHHQEQPLQ
     NFLCEGHVLP AAETACLQET WTGKEITDGE EKTEGEEEQE EEEEEEEEEG GDKMTKTGSH
     PKLDREDL
//