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Q8N129

- CNPY4_HUMAN

UniProt

Q8N129 - CNPY4_HUMAN

Protein

Protein canopy homolog 4

Gene

CNPY4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Plays a role in the regulation of the cell surface expression of TLR4.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein canopy homolog 4
    Gene namesi
    Name:CNPY4
    ORF Names:PSEC0237, UNQ1909/PRO4354
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:28631. CNPY4.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162382618.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 248227Protein canopy homolog 4PRO_0000314018Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi38 ↔ 196By similarity
    Disulfide bondi41 ↔ 184By similarity
    Disulfide bondi94 ↔ 156By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ8N129.
    PaxDbiQ8N129.
    PRIDEiQ8N129.

    PTM databases

    PhosphoSiteiQ8N129.

    Expressioni

    Gene expression databases

    BgeeiQ8N129.
    CleanExiHS_CNPY4.
    GenevestigatoriQ8N129.

    Organism-specific databases

    HPAiHPA014166.
    HPA025240.

    Interactioni

    Subunit structurei

    Interacts with TLR4.By similarity

    Protein-protein interaction databases

    BioGridi128831. 1 interaction.
    IntActiQ8N129. 1 interaction.
    MINTiMINT-1429883.
    STRINGi9606.ENSP00000262932.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi140 – 22990Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the canopy family.Curated
    Contains 1 saposin B-type domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG288841.
    HOGENOMiHOG000030912.
    HOVERGENiHBG107736.
    InParanoidiQ8N129.
    OMAiVVEDWYF.
    OrthoDBiEOG7SBNPF.
    PhylomeDBiQ8N129.
    TreeFamiTF318951.

    Family and domain databases

    InterProiIPR021852. DUF3456.
    [Graphical view]
    PfamiPF11938. DUF3456. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8N129-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPVRLGILL FLFLAVHEAW AGMLKEEDDD TERLPSKCEV CKLLSTELQA    50
    ELSRTGRSRE VLELGQVLDT GKRKRHVPYS VSETRLEEAL ENLCERILDY 100
    SVHAERKGSL RYAKGQSQTM ATLKGLVQKG VKVDLGIPLE LWDEPSVEVT 150
    YLKKQCETML EEFEDIVGDW YFHHQEQPLQ NFLCEGHVLP AAETACLQET 200
    WTGKEITDGE EKTEGEEEQE EEEEEEEEEG GDKMTKTGSH PKLDREDL 248
    Length:248
    Mass (Da):28,310
    Last modified:October 1, 2002 - v1
    Checksum:i561CAEB4A0D7B833
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti168 – 1681G → R.
    Corresponds to variant rs60551236 [ dbSNP | Ensembl ].
    VAR_062216

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY359100 mRNA. Translation: AAQ89458.1.
    AK075537 mRNA. Translation: BAC11680.1.
    CH236956 Genomic DNA. Translation: EAL23850.1.
    BC019903 mRNA. Translation: AAH19903.2.
    BC032339 mRNA. Translation: AAH32339.1.
    CCDSiCCDS34701.1.
    RefSeqiNP_689968.1. NM_152755.1.
    UniGeneiHs.632293.

    Genome annotation databases

    EnsembliENST00000262932; ENSP00000262932; ENSG00000166997.
    GeneIDi245812.
    KEGGihsa:245812.
    UCSCiuc003uto.3. human.

    Polymorphism databases

    DMDMi74728482.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY359100 mRNA. Translation: AAQ89458.1 .
    AK075537 mRNA. Translation: BAC11680.1 .
    CH236956 Genomic DNA. Translation: EAL23850.1 .
    BC019903 mRNA. Translation: AAH19903.2 .
    BC032339 mRNA. Translation: AAH32339.1 .
    CCDSi CCDS34701.1.
    RefSeqi NP_689968.1. NM_152755.1.
    UniGenei Hs.632293.

    3D structure databases

    ProteinModelPortali Q8N129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128831. 1 interaction.
    IntActi Q8N129. 1 interaction.
    MINTi MINT-1429883.
    STRINGi 9606.ENSP00000262932.

    PTM databases

    PhosphoSitei Q8N129.

    Polymorphism databases

    DMDMi 74728482.

    Proteomic databases

    MaxQBi Q8N129.
    PaxDbi Q8N129.
    PRIDEi Q8N129.

    Protocols and materials databases

    DNASUi 245812.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262932 ; ENSP00000262932 ; ENSG00000166997 .
    GeneIDi 245812.
    KEGGi hsa:245812.
    UCSCi uc003uto.3. human.

    Organism-specific databases

    CTDi 245812.
    GeneCardsi GC07P099718.
    HGNCi HGNC:28631. CNPY4.
    HPAi HPA014166.
    HPA025240.
    MIMi 610047. gene.
    neXtProti NX_Q8N129.
    PharmGKBi PA162382618.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288841.
    HOGENOMi HOG000030912.
    HOVERGENi HBG107736.
    InParanoidi Q8N129.
    OMAi VVEDWYF.
    OrthoDBi EOG7SBNPF.
    PhylomeDBi Q8N129.
    TreeFami TF318951.

    Miscellaneous databases

    GenomeRNAii 245812.
    NextBioi 91738.
    PROi Q8N129.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8N129.
    CleanExi HS_CNPY4.
    Genevestigatori Q8N129.

    Family and domain databases

    InterProi IPR021852. DUF3456.
    [Graphical view ]
    Pfami PF11938. DUF3456. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Placenta.
    5. "A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression."
      Konno K., Wakabayashi Y., Akashi-Takamura S., Ishii T., Kobayashi M., Takahashi K., Kusumoto Y., Saitoh S., Yoshizawa Y., Miyake K.
      Biochem. Biophys. Res. Commun. 339:1076-1082(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCNPY4_HUMAN
    AccessioniPrimary (citable) accession number: Q8N129
    Secondary accession number(s): Q8WUN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3