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Q8N129

- CNPY4_HUMAN

UniProt

Q8N129 - CNPY4_HUMAN

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Protein

Protein canopy homolog 4

Gene

CNPY4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role in the regulation of the cell surface expression of TLR4.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein canopy homolog 4
Gene namesi
Name:CNPY4
ORF Names:PSEC0237, UNQ1909/PRO4354
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:28631. CNPY4.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382618.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 248227Protein canopy homolog 4PRO_0000314018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 196By similarity
Disulfide bondi41 ↔ 184By similarity
Disulfide bondi94 ↔ 156By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ8N129.
PaxDbiQ8N129.
PRIDEiQ8N129.

PTM databases

PhosphoSiteiQ8N129.

Expressioni

Gene expression databases

BgeeiQ8N129.
CleanExiHS_CNPY4.
GenevestigatoriQ8N129.

Organism-specific databases

HPAiHPA014166.
HPA025240.

Interactioni

Subunit structurei

Interacts with TLR4.By similarity

Protein-protein interaction databases

BioGridi128831. 3 interactions.
IntActiQ8N129. 1 interaction.
MINTiMINT-1429883.
STRINGi9606.ENSP00000262932.

Structurei

3D structure databases

ProteinModelPortaliQ8N129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi140 – 22990Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the canopy family.Curated
Contains 1 saposin B-type domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG288841.
GeneTreeiENSGT00390000014072.
HOGENOMiHOG000030912.
HOVERGENiHBG107736.
InParanoidiQ8N129.
OMAiVVEDWYF.
OrthoDBiEOG7SBNPF.
PhylomeDBiQ8N129.
TreeFamiTF318951.

Family and domain databases

InterProiIPR021852. DUF3456.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N129-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPVRLGILL FLFLAVHEAW AGMLKEEDDD TERLPSKCEV CKLLSTELQA
60 70 80 90 100
ELSRTGRSRE VLELGQVLDT GKRKRHVPYS VSETRLEEAL ENLCERILDY
110 120 130 140 150
SVHAERKGSL RYAKGQSQTM ATLKGLVQKG VKVDLGIPLE LWDEPSVEVT
160 170 180 190 200
YLKKQCETML EEFEDIVGDW YFHHQEQPLQ NFLCEGHVLP AAETACLQET
210 220 230 240
WTGKEITDGE EKTEGEEEQE EEEEEEEEEG GDKMTKTGSH PKLDREDL
Length:248
Mass (Da):28,310
Last modified:October 1, 2002 - v1
Checksum:i561CAEB4A0D7B833
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti168 – 1681G → R.
Corresponds to variant rs60551236 [ dbSNP | Ensembl ].
VAR_062216

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY359100 mRNA. Translation: AAQ89458.1.
AK075537 mRNA. Translation: BAC11680.1.
CH236956 Genomic DNA. Translation: EAL23850.1.
BC019903 mRNA. Translation: AAH19903.2.
BC032339 mRNA. Translation: AAH32339.1.
CCDSiCCDS34701.1.
RefSeqiNP_689968.1. NM_152755.1.
UniGeneiHs.632293.

Genome annotation databases

EnsembliENST00000262932; ENSP00000262932; ENSG00000166997.
GeneIDi245812.
KEGGihsa:245812.
UCSCiuc003uto.3. human.

Polymorphism databases

DMDMi74728482.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY359100 mRNA. Translation: AAQ89458.1 .
AK075537 mRNA. Translation: BAC11680.1 .
CH236956 Genomic DNA. Translation: EAL23850.1 .
BC019903 mRNA. Translation: AAH19903.2 .
BC032339 mRNA. Translation: AAH32339.1 .
CCDSi CCDS34701.1.
RefSeqi NP_689968.1. NM_152755.1.
UniGenei Hs.632293.

3D structure databases

ProteinModelPortali Q8N129.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128831. 3 interactions.
IntActi Q8N129. 1 interaction.
MINTi MINT-1429883.
STRINGi 9606.ENSP00000262932.

PTM databases

PhosphoSitei Q8N129.

Polymorphism databases

DMDMi 74728482.

Proteomic databases

MaxQBi Q8N129.
PaxDbi Q8N129.
PRIDEi Q8N129.

Protocols and materials databases

DNASUi 245812.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262932 ; ENSP00000262932 ; ENSG00000166997 .
GeneIDi 245812.
KEGGi hsa:245812.
UCSCi uc003uto.3. human.

Organism-specific databases

CTDi 245812.
GeneCardsi GC07P099718.
HGNCi HGNC:28631. CNPY4.
HPAi HPA014166.
HPA025240.
MIMi 610047. gene.
neXtProti NX_Q8N129.
PharmGKBi PA162382618.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288841.
GeneTreei ENSGT00390000014072.
HOGENOMi HOG000030912.
HOVERGENi HBG107736.
InParanoidi Q8N129.
OMAi VVEDWYF.
OrthoDBi EOG7SBNPF.
PhylomeDBi Q8N129.
TreeFami TF318951.

Miscellaneous databases

GenomeRNAii 245812.
NextBioi 91738.
PROi Q8N129.
SOURCEi Search...

Gene expression databases

Bgeei Q8N129.
CleanExi HS_CNPY4.
Genevestigatori Q8N129.

Family and domain databases

InterProi IPR021852. DUF3456.
[Graphical view ]
Pfami PF11938. DUF3456. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Placenta.
  5. "A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression."
    Konno K., Wakabayashi Y., Akashi-Takamura S., Ishii T., Kobayashi M., Takahashi K., Kusumoto Y., Saitoh S., Yoshizawa Y., Miyake K.
    Biochem. Biophys. Res. Commun. 339:1076-1082(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCNPY4_HUMAN
AccessioniPrimary (citable) accession number: Q8N129
Secondary accession number(s): Q8WUN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3