Q8N129 (CNPY4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein canopy homolog 4

Gene names

Name:	CNPY4
ORF Names:	PSEC0237, UNQ1909/PRO4354

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in the regulation of the cell surface expression of TLR4. Ref.5
Subunit structure	Interacts with TLR4 By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the canopy family. Contains 1 saposin B-type domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 248	227	Protein canopy homolog 4		PRO_0000314018
Regions
	Compositional bias	140 – 229	90	Glu-rich
Amino acid modifications
	Modified residue	58	1	Phosphoserine By similarity
	Disulfide bond	38 ↔ 196		By similarity
	Disulfide bond	41 ↔ 184		By similarity
	Disulfide bond	94 ↔ 156		By similarity
Natural variations
	Natural variant	168	1	G → R. Corresponds to variant rs60551236 [ dbSNP | Ensembl ].		VAR_062216

Sequences

	Sequence		Length	Mass (Da)
	Q8N129 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 561CAEB4A0D7B833	FASTA	248	28,310
	10 20 30 40 50 60 MGPVRLGILL FLFLAVHEAW AGMLKEEDDD TERLPSKCEV CKLLSTELQA ELSRTGRSRE 70 80 90 100 110 120 VLELGQVLDT GKRKRHVPYS VSETRLEEAL ENLCERILDY SVHAERKGSL RYAKGQSQTM 130 140 150 160 170 180 ATLKGLVQKG VKVDLGIPLE LWDEPSVEVT YLKKQCETML EEFEDIVGDW YFHHQEQPLQ 190 200 210 220 230 240 NFLCEGHVLP AAETACLQET WTGKEITDGE EKTEGEEEQE EEEEEEEEEG GDKMTKTGSH PKLDREDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[3]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Placenta.
[5]	"A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression." Konno K., Wakabayashi Y., Akashi-Takamura S., Ishii T., Kobayashi M., Takahashi K., Kusumoto Y., Saitoh S., Yoshizawa Y., Miyake K. Biochem. Biophys. Res. Commun. 339:1076-1082(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY359100 mRNA. Translation: AAQ89458.1. AK075537 mRNA. Translation: BAC11680.1. CH236956 Genomic DNA. Translation: EAL23850.1. BC019903 mRNA. Translation: AAH19903.2. BC032339 mRNA. Translation: AAH32339.1.
IPI	IPI00102962.
RefSeq	NP_689968.1. NM_152755.1.
UniGene	Hs.632293.
3D structure databases
ProteinModelPortal	Q8N129.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N129. 1 interaction.
MINT	MINT-1429883.
STRING	9606.ENSP00000262932.
PTM databases
PhosphoSite	Q8N129.
Polymorphism databases
DMDM	74728482.
Proteomic databases
PaxDb	Q8N129.
PRIDE	Q8N129.
Protocols and materials databases
DNASU	245812.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262932; ENSP00000262932; ENSG00000166997.
GeneID	245812.
KEGG	hsa:245812.
UCSC	uc003uto.3. human.
Organism-specific databases
CTD	245812.
GeneCards	GC07P099718.
HGNC	HGNC:28631. CNPY4.
HPA	HPA014166. HPA025240.
MIM	610047. gene.
neXtProt	NX_Q8N129.
PharmGKB	PA162382618.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG288841.
HOGENOM	HOG000030912.
HOVERGEN	HBG107736.
InParanoid	Q8N129.
OMA	CEVCKLL.
OrthoDB	EOG4CG09B.
Gene expression databases
Bgee	Q8N129.
CleanEx	HS_CNPY4.
Genevestigator	Q8N129.
Family and domain databases
InterPro	IPR021852. DUF3456. [Graphical view]
Pfam	PF11938. DUF3456. 1 hit. [Graphical view]
PROSITE	PS50015. SAP_B. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	245812.
NextBio	91738.
SOURCE	Search...

Entry information

Entry name

CNPY4_HUMAN

Accession

Primary (citable) accession number: Q8N129
Secondary accession number(s): Q8WUN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.