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Q8N129 (CNPY4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein canopy homolog 4
Gene names
Name:CNPY4
ORF Names:PSEC0237, UNQ1909/PRO4354
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in the regulation of the cell surface expression of TLR4. Ref.5

Subunit structure

Interacts with TLR4 By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the canopy family.

Contains 1 saposin B-type domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 248227Protein canopy homolog 4
PRO_0000314018

Regions

Compositional bias140 – 22990Glu-rich

Amino acid modifications

Disulfide bond38 ↔ 196 By similarity
Disulfide bond41 ↔ 184 By similarity
Disulfide bond94 ↔ 156 By similarity

Natural variations

Natural variant1681G → R.
Corresponds to variant rs60551236 [ dbSNP | Ensembl ].
VAR_062216

Sequences

Sequence LengthMass (Da)Tools
Q8N129 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 561CAEB4A0D7B833

FASTA24828,310
        10         20         30         40         50         60 
MGPVRLGILL FLFLAVHEAW AGMLKEEDDD TERLPSKCEV CKLLSTELQA ELSRTGRSRE 

        70         80         90        100        110        120 
VLELGQVLDT GKRKRHVPYS VSETRLEEAL ENLCERILDY SVHAERKGSL RYAKGQSQTM 

       130        140        150        160        170        180 
ATLKGLVQKG VKVDLGIPLE LWDEPSVEVT YLKKQCETML EEFEDIVGDW YFHHQEQPLQ 

       190        200        210        220        230        240 
NFLCEGHVLP AAETACLQET WTGKEITDGE EKTEGEEEQE EEEEEEEEEG GDKMTKTGSH 


PKLDREDL 

« Hide

References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
[3]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Placenta.
[5]"A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression."
Konno K., Wakabayashi Y., Akashi-Takamura S., Ishii T., Kobayashi M., Takahashi K., Kusumoto Y., Saitoh S., Yoshizawa Y., Miyake K.
Biochem. Biophys. Res. Commun. 339:1076-1082(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY359100 mRNA. Translation: AAQ89458.1.
AK075537 mRNA. Translation: BAC11680.1.
CH236956 Genomic DNA. Translation: EAL23850.1.
BC019903 mRNA. Translation: AAH19903.2.
BC032339 mRNA. Translation: AAH32339.1.
CCDSCCDS34701.1.
RefSeqNP_689968.1. NM_152755.1.
UniGeneHs.632293.

3D structure databases

ProteinModelPortalQ8N129.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128831. 1 interaction.
IntActQ8N129. 1 interaction.
MINTMINT-1429883.
STRING9606.ENSP00000262932.

PTM databases

PhosphoSiteQ8N129.

Polymorphism databases

DMDM74728482.

Proteomic databases

MaxQBQ8N129.
PaxDbQ8N129.
PRIDEQ8N129.

Protocols and materials databases

DNASU245812.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262932; ENSP00000262932; ENSG00000166997.
GeneID245812.
KEGGhsa:245812.
UCSCuc003uto.3. human.

Organism-specific databases

CTD245812.
GeneCardsGC07P099718.
HGNCHGNC:28631. CNPY4.
HPAHPA014166.
HPA025240.
MIM610047. gene.
neXtProtNX_Q8N129.
PharmGKBPA162382618.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288841.
HOGENOMHOG000030912.
HOVERGENHBG107736.
InParanoidQ8N129.
OMAVVEDWYF.
OrthoDBEOG7SBNPF.
PhylomeDBQ8N129.
TreeFamTF318951.

Gene expression databases

BgeeQ8N129.
CleanExHS_CNPY4.
GenevestigatorQ8N129.

Family and domain databases

InterProIPR021852. DUF3456.
[Graphical view]
PfamPF11938. DUF3456. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi245812.
NextBio91738.
PROQ8N129.
SOURCESearch...

Entry information

Entry nameCNPY4_HUMAN
AccessionPrimary (citable) accession number: Q8N129
Secondary accession number(s): Q8WUN9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM